Search clinical trials for: Ascending

Total 1217 results

UCB Biopharma SRL

Completed

A Study to Test Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intravenous Doses of Zampilimab in Healthy Participants

Healthy Study Participants

United Kingdom
Altavant Sciences GmbH
Parexel; Altavant Sciences, Inc.

Completed

Multiple-Ascending Dose in Japanese Patients Bridging Study

Healthy

United States
Pfizer

Completed

Study Of Single And Multiple Ascending Doses Of PF-07054894 In Healthy Adult Participants

Healthy

Belgium
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects

Healthy

Netherlands
SQ Innovation, Inc.
EB Medical Research; Quartesian

Completed

A Safety/Tolerance Phase, Ascending Single Dose Study to Evaluate the Safety and Tolerability of G3P-01, a Food-Grade Pectic Product, in Healthy Volunteers (G3P-01-01)

Gastrointestinal Discomfort | Performance Status

Netherlands
AstraZeneca
Takeda; Covance; Catalent; MMS Holdings, Inc

Completed

Single Ascending Dose Study of MEDI1341 in Healthy Volunteers

Parkinson's Disease

United States
AstraZeneca
Takeda

Completed

Multiple Ascending Dose Study of MEDI1341 in Patients With Parkinson's Disease

Parkinson's Disease

United States
Vigonvita Life Sciences

Completed

Safety and Pharmacokinetics Study of Single Ascending Doses of VV116 in Healthy Volunteers

Healthy Subjects

China
CARE Pharma Shanghai Ltd.

Completed

Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Single Ascending Dose (SAD) of CAN106 Administered Intravenously (IV) in Healthy Subjects

PNH

Singapore
CrystalGenomics, Inc.

Completed

CG400549 Single Ascending Dose Study

Healthy

Netherlands
Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Completed

Multiple Ascending Doses of SY-008 in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

China
Dana-Farber Cancer Institute
AbbVie

Completed

Study of ABT-199 (GDC-199) In Patients With Relapsed Or Refractory Waldenström Macroglobulinemia

Waldenstrom Macroglobulinemia

United States
Kadmon Corporation, LLC

Completed

A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Polycystic Kidney, Autosomal Recessive

United States
Wyeth is now a wholly owned subsidiary of Pfizer
Solvay Pharmaceuticals

Terminated

Study Evaluating Safety and Tolerability of Ascending Multiple Dose of SLV-313 in Schizophrenia Patients

Healthy
Affinivax, Inc.

Completed

Single Ascending Dose of ASP3772 Study in Japanese Healthy Male and Female Adults, and Single Ascending Dose Study of ASP3772 in Comparison With PPSV23 in Japanese Elderly Male and Female Subjects

Healthy Volunteers

Japan
Eli Lilly and Company
Quotient Sciences

Completed

A Multiple Dose Study of LY3502970 in Healthy Participants

Healthy

United Kingdom
Sanofi

Completed

Single Ascending Dose Study of SAR443820 in Healthy Adult Chinese and Japanese Female and Male Participants

Multiple Sclerosis Healthy Subjects

United Kingdom
Sanofi

Completed

A Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis

Progressive Multiple Sclerosis

Germany
AstraZeneca
Parexel

Completed

A Study to Evaluate the Safety and Pharmacokinetics With MEDI8367 Administered in Healthy Subjects, and in Subjects With Chronic Kidney Disease

Chronic Kidney Disease

United States
Synthetic Biologics Inc.
Spaulding Clinical Research LLC

Completed

Multiple Ascending Dose Study to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered SYN 020

Enteritis Caused by Radiation

United States
SoftOx Solutions AS

Completed

Safety of Ascending Single and Multiple Doses of Nebulised SoftOx Inhalation Solution in Healthy Subjects

Healthy Volunteers | Safety

Denmark
Keymed Biosciences Co.Ltd

Completed

Single Ascending Dose Study of CM326 in Healthy Volunteers

Asthma

China
Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Completed

Multiple Ascending Doses of SY-009 in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

China
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending and Multiple Doses of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Healthy Japanese Participants

Healthy Participants

United States
Bacainn Therapeutics, Inc.

Completed

A Phase 1, Single-Ascending-Dose Study of BT051 in Healthy Subjects

Healthy Volunteers

United States
Heptares Therapeutics Limited

Terminated

A Study in Healthy Subjects to Assess the Safety, Tolerability and Pharmacokinetics of HTL0022562

Healthy

United Kingdom
Enterprise Therapeutics Ltd

Completed

A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled ETD001 in Healthy Subjects

Cystic Fibrosis

United Kingdom
EpiEndo Pharmaceuticals

Completed

Single and Multiple Ascending Dose Study With EP395

Adult ALL

United Kingdom
Sangamo Therapeutics

Terminated

Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia B

Hemophilia B

United States
Genzyme, a Sanofi Company

Completed

Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency (ASCEND-Peds)

Sphingomyelin Lipidosis

Brazil, France, Italy, United States, Germany, United Kingdom
Guangzhou JOYO Pharma Co., Ltd

Completed

Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics of DC371739 Single-Dose Treatment in Healthy Subjects

Hyperlipidemia

China
Guangzhou JOYO Pharma Co., Ltd
The First Hospital of Jilin University

Completed

Multiple Ascending Dose Study to Evaluate the Safety, Tolerability of DC371739 Treatment in Hypercholesterolemic

Hypercholesterolemia

China
Tiziana Life Sciences LTD

Withdrawn

Phase 1b Multiple Ascending Dose Study of Foralumab in Primary and Secondary Progressive MS

Multiple Sclerosis | Primary Progressive Multiple Sclerosis | Secondary Progressive Multiple Sclerosis
Matthew Eagleton
Massachusetts General Hospital

Enrolling by invitation

Endovascular Treatment of Thoracic Aortic Disease (EVOLVE Aorta)

Aortic Dissection | Ascending Aortic Dissection | Thoracoabdominal Aortic Aneurysm | Thoracic Aortic Aneurysms | Dissecting, Aneurysm | Ascending Aorta Aneurysm | Aortic Arch; Aneurysm, Dissecting | Renal Artery Aneurysm | Superior Mesenteric Artery Aneurysm

United States
Enanta Pharmaceuticals, Inc

Terminated

A 2 PART STUDY EVALUATING EDP-721 IN HEALTHY SUBJECTS AND EDP-721 IN COMBINATION WITH EDP-514 IN PATIENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION.

Chronic Hepatitis B Virus Infection

New Zealand
LCMC Health

Terminated

Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection (CENERDD)

Gastroesophageal Reflux | Non-erosive Reflux Disease

United States
Vigonvita Life Sciences

Completed

Safety and Pharmacokinetics Study of Multiple Ascending Doses of VV116 in Healthy Volunteers

Healthy Subjects

China
Corcept Therapeutics

Completed

Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants

Healthy

United Kingdom
TFF Pharmaceuticals, Inc.

Completed

Single Ascending Dose and Multiple Ascending Dose Study of Niclosamide Inhalation Powder in Healthy Adult Subjects

Healthy

Canada
Corcept Therapeutics

Completed

Single and Multiple Ascending Dose Study of CORT113176 in Healthy Participants

Healthy Adults

United Kingdom
Pfizer

Terminated

Study of Single and Multiple Ascending Doses of PF-07059013 in Healthy Adult Participants

Healthy

Belgium
Idorsia Pharmaceuticals Ltd.

Completed

Pharmacokinetics of Omeprazole and Midazolam When Co-administered With ACT-1014-6470

Healthy | Drug Drug Interaction

Czechia
ASLAN Pharmaceuticals

Completed

A Multi-center, Randomized, Double-blind, Placebo-controlled, Multiple Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneously Delivered ASLAN004 in Adults With Moderate-Severe Atopic Dermatitis

Atopic Dermatitis

Australia, Singapore, United States
Takeda

Completed

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single Ascending Dose and Multiple Doses With Titration of TAK-935 in Healthy Japanese Participants

Healthy Volunteer

Japan
Enanta Pharmaceuticals, Inc
Pharmaceutical Research Associates

Completed

A Study of EDP-514 in Patients With Chronic Hepatitis B Virus Infection Who Are Not Currently on Treatment

Chronic HBV Infection

Hong Kong, Taiwan
Enanta Pharmaceuticals, Inc
Pharmaceutical Research Associates

Completed

A Study of EDP-514 in Healthy Subjects (Part 1) and Patients With Chronic Hepatitis B Virus Infection (Part 2)

Chronic HBV Infection

United States, Canada
Alar Pharmaceuticals Inc.

Completed

Single Ascending Dose Study of ALA-1000

Opioid-use Disorder

United States
Tetraphase Pharmaceuticals, Inc.
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Phase 1 TP-271 Oral PK Multiple Ascending Dose Study

Bacterial Infections

United States
Viriom

Completed

Study to Evaluate Safety, Tolerability and Pharmacokinetics of VM-1500A-LAI Single and Multiple Ascending Doses in Healthy Subjects

HIV-1-infection

Russian Federation
Tetraphase Pharmaceuticals, Inc.
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Phase 1 TP-271 Oral PK Single Ascending Dose Study

Bacterial Infections

United States

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