Search clinical trials for: Long-term Safety

Total 45507 results

Genelux Corporation
Newsoara Biopharma Co., Ltd.

Not yet recruiting

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's of Choice Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer (VIRO-25) ((VIRO-25))

Non-small Cell Lung Cancer Stage III | Non-small Cell Lung Cancer | Advanced Non-squamous Non-small-cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Metastatic Squamous Non-Small Cell Lung Carcinoma | Non-small Cell Lung Cancer Recurrent | Metastatic Non-squamous Non Small Cell Lung Cancer and other conditions
ResoTher Pharma

Recruiting

A Study of RTP-026 to Assess Safety, Tolerability and Efficacy in Patients With ST-Elevation Myocardial Infarction (STEMI)

ST Elevation Myocardial Infarction

Denmark
Biocodex
Exystat

Not yet recruiting

Evaluation of the Efficacy and Safety of Stiripentol in Patients 6 Years and Older With Primary Hyperoxaluria Type 1, 2 or 3 (CRYSTAL)

Primary Hyperoxaluria Type 3 | Primary Hyperoxaluria Type 2 | Primary Hyperoxaluria Type 1
InventVacc Biologicals Inc.
Hia Consortium

Recruiting

A Study to Evaluate Safety and Immunogenicity of Haemophilus Influenzae Serotype A Vaccine

Haemophilus Influenzae Meningitis | Invasive Haemophilus Influenzae Disease

Canada
MBX Biosciences

Recruiting

Safety, Pharmacokinetics and Efficacy of MBX 2109 in Patients With Hypoparathyroidism

Hypoparathyroidism

United States
Wuhan Union Hospital, China
Wuhan Hamilton Biotechnology Co., Ltd; Guangzhou Hamilton Biotechnology Co....

Recruiting

Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Knee Osteoarthritis

China
Inozyme Pharma

Not yet recruiting

ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency

Pseudoxanthoma Elasticum | Arterial Calcification | Gene Mutations | Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency | Autosomal Recessive Hypophosphatemic Rickets Type 2
Beijing 302 Hospital

Not yet recruiting

Safety and Efficacy of Autologous Tumor-infiltrating Lymphocytes Therapy in Patients With Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Emory University
University of California, San Diego; Ventrix, Inc.

Not yet recruiting

Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients With Hypoplastic Left Heart Syndrome (HLHS)

Hypoplastic Left Heart Syndrome

United States
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Eisai Inc.

Not yet recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1

Narcolepsy Type 1 (NT1)
TC Biopharm

Not yet recruiting

ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML (ACHIEVE2)

Acute Myeloid Leukemia | Myelodysplastic Syndromes
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

Efficacy and Safety of Anti-PD-1, Thymosin, and SOX in Neoadjuvant Treatment of cStage III Gastric/GEJ Adenocarcinoma

Gastric Cancer | Esophagogastric Junction Adenocarcinoma
Guangzhou University of Traditional Chinese Medicine
Jiangsu Province Hospital of Traditional Chinese Medicine; The First Affiliated...

Not yet recruiting

Acupuncture for Enhancing Immunotherapy in Advanced NSCLC：a Pilot Study

Non-small Cell Lung Cancer | Non-Small-Cell Lung Carcinoma

China
Zheng Liu
National Natural Science Foundation of China

Not yet recruiting

Efficacy and Safety of Arbidol in the Treatment of Allergic Rhinitis

Allergic Rhinitis

China
University of Pittsburgh
University of Oregon; National Institute of Mental Health (NIMH)

Recruiting

Testing an Intergenerational Model of Suicide Risk in Mother-child Dyads

Emotion Regulation

United States
Rgenta Therapeutics Inc

Recruiting

Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)

Adenoid Cystic Carcinoma | Colorectal Cancer

United States
Canadian Blood Services

Not yet recruiting

Surveillance of Emerging Pathogens to Ensure Blood Supply Safety

Babesioses, Human
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L) (DESAR-L)

Low-to-intermediate-risk Prostate Carcinoma

Korea, Republic of
Novartis Pharmaceuticals

Recruiting

Study of Efficacy and Safety of Ruxolitinib in Patients With Grade II to IV Steroid-refractory Acute Graft vs. Host Disease

Steroid-refractory Acute Graft Versus Host Disease

China
Kaplan Medical Center

Recruiting

Intra-articular Allocetra in Osteoarthritis of the 1st Carpo-metacarpal Joint

Osteoarthritis Thumb

Israel
Ray Therapeutics, Inc.

Not yet recruiting

Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa Patients

Retinitis Pigmentosa

United States
Vertex Pharmaceuticals Incorporated

Not yet recruiting

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

Cystic Fibrosis
Tongji Hospital
The First People's Hospital of Jingzhou; Wuhan Central Hospital; Wuhan No.1 Hospital and other collaborators

Recruiting

Safety, Efficacy, and Compliance of Telitacicept in the Treatment of Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

China
Il-Yang Pharm. Co., Ltd.

Not yet recruiting

Clinical Trial to Investigate the Effects of Food on the Pharmacokinetics and Safety of Orally Administered Radotinib

Drug Kinetics

Korea, Republic of
Jennifer Hughes
American Foundation for Suicide Prevention

Recruiting

SAFETY-Parent: Online Learning Module to Support Parents of Suicidal Youth (SAFETY-P)

Suicide, Attempted | Suicide | Suicide Threat | Suicide and Self-harm

United States
Institute of Hematology & Blood Diseases Hospital...

Not yet recruiting

the Efficacy and Safety of Total Myeloid Irradiation (TMI) in the Treatment of Adult Acute Lymphoblastic Leukemia (TMI)

Acute Lymphoblastic Leukemia
Duke Street Bio Ltd

Not yet recruiting

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Advanced Malignancies With Homologous Recombination Deficiency (HRD) (Breast, Ovarian, mCRPC, Brain Metastases)
Xijing Hospital

Not yet recruiting

Efficacy and Safety of Neoadjuvant Sintilimab Plus FLOT Versus Sintilimab Plus SOX Phase II Clinical Trial for Patients With Locally Advanced Gastric Cancer

Sintilimab | Neoadjuvant Chemotherapy | Locally Advanced Gastric Cancer
Sumitomo Pharma Co., Ltd.

Not yet recruiting

First-in-human Study to Assess the Safety, Tolerability and Immunogenicity of the Adjuvanted Universal Influenza Vaccine fH1/DSP-0546LP

Influenza

Belgium
Xuanwu Hospital, Beijing
Beijing Tiantan Hospital; Qilu Hospital of Shandong University; The Affiliated... and other collaborators

Recruiting

Pipeline Embolization Device for the Treatment of Intracranial Aneurysms on the Long Term Safety and Efficacy

Treatment

China
Chengdu Origen Biotechnology Co., Ltd.

Not yet recruiting

Safety and Tolerability of KH658 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)

Age-related Macular Degeneration

China
Abivax S.A.

Not yet recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease (ENHANCE-CD)

Moderately to Severely Active Crohn Disease
Shanghai General Hospital, Shanghai Jiao Tong University...

Not yet recruiting

Efficacy and Safety of Ureteroscopic Lithotripsy (Including Flexible Ureteroscopy) Without Indwelling Urinary Catheter

Urolithiasis | Catheter-related Bladder Discomfort

China
Yuwei Qiu

Not yet recruiting

To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain

Analgesia
Qifu Li
Second Affiliated Hospital, School of Medicine, Zhejiang University; The First... and other collaborators

Recruiting

Finerenone for Patients With Primary Aldosteronism (FAIRY)

Primary Aldosteronism

China
Rejukon Biopharm Inc.

Not yet recruiting

An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis
MicroPort CRM

Not yet recruiting

Safety and Performance Evaluation of a New Catheter Range for Lead Implantation at Interventricular Septum (POLARIS)

Bradycardia | Cardiac Resynchronization Therapy | Left Bundle Branch Area Pacing
Shanghai Chest Hospital

Not yet recruiting

Efficacy and Safety of Multimode Thermal Therapy in the Treatment of Early Peripheral Lung Cancer

Lung Cancer

China
AstraZeneca

Not yet recruiting

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis) (JASMINE)

Polymyositis, Dermatomyositis

United States, Denmark, France, Italy, Spain, Belgium, India, Vietnam, Japan, China, Israel, Austria, Canada, Germany, Taiwan, United Kingdom, Australia, Hungary, Netherlands, Sweden, Brazil, Bulgaria, Poland, Mexico, Czechia
Fujian Cancer Hospital
Zhangzhou Municipal Hospital of Fujian Province

Recruiting

Efficacy and Safety of AK104 Combined With Chemotherapy and Recombinant Human Adenovirus 5 Injection in Cervical Cancer

Cervical Cancer Recurrent

China
GCS Co., Ltd
Eurofins Laboratoire Dermscan

Not yet recruiting

Clinical Study to Evaluate Safety and Effectiveness of Noble Lift® Lifting Threads

Aesthetic

France
MDI Therapeutics, Inc.

Recruiting

SAD Evaluation of Safety, Tolerability, PK, and PD of MDI-2517 in Healthy Participants

Safety and Tolerability

United States
Chun Pan

Not yet recruiting

Efficacy and Safety Studies of Oliceridine Fumarate

Analgesia
Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd.

Not yet recruiting

Pharmacokinetics, Safety and Tolerability of Clascoterone Cream 1% in Healthy Chinese Adult Subjects

Acne Vulgaris
DermBiont, Inc.
Fortrea

Recruiting

A Randomized, Observer-Blinded, Placebo-Controlled Study on Safety and Efficacy of SM-030 in Adults With Melasma

Melasma

El Salvador
Shanghai Bovax Biotechnology Co., Ltd.

Not yet recruiting

A Phase I Clinical Trial to Evaluate the Safety of 15-valent HPV Vaccine in Healthy Chinese People Aged 18-45 Years

HPV Infection | HPV-Related Carcinoma | Genital Wart | HPV-Related Intraepithelial Neoplasia

China
Biogen

Not yet recruiting

A Study to Determine the Biodistribution, Safety, and Tolerability of a Microdose of Radiolabeled BIIB080 Co-administered With BIIB080 in Healthy Adults

Healthy Volunteer

United States
Khondrion BV

Not yet recruiting

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases (KH176-301)

Mitochondrial Diseases | Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation | Maternally Inherited Diabetes and Deafness (MIDD) | Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
Regional Cardiology Center, The Copper Health Centre...
Department of Cardiology, Provincial Specialized Hospital in Legnica, 59-200...

Recruiting

Lower Silesian Orbital Atherectomy Registry (LOAR) (LOAR)

Safety Issues | Efficacy, Self

Poland

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