Search clinical trials for: MULTIPLE DOSE

Total 31450 results

GlaxoSmithKline

Active, not recruiting

A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Participants With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody

Multiple Myeloma

United States, Spain, France, Germany, Australia, United Kingdom, Canada, Italy
Jazz Pharmaceuticals

Active, not recruiting

A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JZP441 in Healthy Participants

Healthy Participants

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant

Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Hodgkin Lymphoma | Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Acute Leukemia | Myelodysplastic Syndrome | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Myeloproliferative... and other conditions

United States
NeuroTherapia, Inc.
CRU Early Phase Unit Kistarcsa

Completed

A Multiple Dose Study of the Safety and Pharmacokinetics of NTRX-07

Alzheimer Disease

United States, Hungary
Kinaset Therapeutics Inc

Active, not recruiting

Single and Multiple Ascending Dose Study of KN-002 (KN-002)

Asthma COPD

United Kingdom
AstraZeneca

Completed

Multiple Dose Study of Safety and Pharmacokinetics of MEDI0618 in Healthy Volunteers

Chronic Pain

Germany
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Dose Escalation Trial of WT1-specific Donor-derived T Cells Following T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma

United States
Haisco Pharmaceutical Group Co., Ltd.

Completed

Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C

Healthy | Elevated LDL-C

China
SK Life Science, Inc.
Covance; Spaulding Clinical Research LLC

Completed

Single-Dose Escalation Study Followed by a Multiple-Dose Escalation Study of SKL24741 in Healthy Subjects

Healthy

United States
Barbara Ann Karmanos Cancer Institute

Completed

COVID-19 VAX Booster Dosing in Patients With Hematologic Malignancies

Multiple Myeloma | AL Amyloidosis | Chronic Lymphocytic Leukemia

United States
Melinta Therapeutics, Inc.

Completed

Multiple Oritavancin Doses on Safety, Tolerability, and Pharmacokinetics in Healthy Subjects

Healthy

United States
Pfizer

Completed

Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease

Healthy | Sickle Cell Anemia

United States
Paul Richardson, MD
M.D. Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; Massachusetts... and other collaborators

Active, not recruiting

Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 (DFCI 10-106)

Multiple Myeloma

United States
Atrogi AB
Key2Compliance; CRS Clinical Research Services

Completed

First-in-human Single and Multiple Dose Trial of ATR-258

Type 2 Diabetes Mellitus

Germany
Bliss Biopharmaceutical (Hangzhou) Co., Ltd

Active, not recruiting

A First-in-human Study of Multiple Doses of BB-1701 in Subjects With Locally Advanced/Metastatic HER2 Expressing Solid Tumors

Locally Advanced/Metastatic HER2 Positive Solid Tumors

China, United States
TenNor Therapeutics (Suzhou) Limited

Completed

Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants

Helicobacter Pylori Infection

China
NeuroBo Pharmaceuticals Inc.

Completed

A Single and Multiple Ascending Dose Study of Niclosamide in Healthy Volunteers

Healthy

United States
Boehringer Ingelheim

Completed

Safety, Tolerability and Pharmacokinetics of Single Rising and Multiple Oral Doses of Telmisartan / Hydrochlorothiazide (HCTZ) in Healthy Male Volunteers

Healthy
Boehringer Ingelheim

Completed

3 TPV/RTV Doses in Multiple ARV Experienced Patients - Tipranavir Dose Defining Study

HIV Infections

Netherlands, United States, Canada, Italy, Spain, Australia, Germany, France, United Kingdom
Boehringer Ingelheim

Completed

A Multiple Dose Comparison of Tiotropium Inhalation Capsules and Salmeterol Inhalation Aerosol.

Pulmonary Disease, Chronic Obstructive

United Kingdom, Turkey, United States, Greece, Portugal, Finland, Italy, Sweden
Enterome
Covance

Active, not recruiting

First-in-Human, Phase 1b/2a Trial of a Multipeptide Therapeutic Vaccine in Patients With Progressive Glioblastoma (ROSALIE)

Glioblastoma, Adult

United States, Spain, France, Germany
Hackensack Meridian Health

Terminated

Auto Transplant High Dose Melphalan vs High Dose Melphalan+Bortezomib in Pts With Multiple Myeloma Age 65 Years or Older

Multiple Myeloma

United States
TenNor Therapeutics (Suzhou) Limited

Completed

A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules

Helicobacter Pylori Infection

China
Memorial Sloan Kettering Cancer Center
Celgene; Onyx/Amgen

Active, not recruiting

High Dose Carfilzomib for Newly Diagnosed Myeloma

Multiple Myeloma

United States
BioVersys AG
CRU Hungary Kft

Completed

To Evaluate the Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of BV100

Bacterial Infections

Hungary
Otsuka Pharmaceutical Development & Commercialization...
PRA Health Sciences

Completed

A Trial of Multiple-doses of Aripiprazole in Adults With Schizophrenia or Bipolar 1 Disorder

Schizophrenia | Bipolar I Disorder

United States
TransThera Sciences (Nanjing), Inc.

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Dose of TT-00920 in Healthy Subjects

Healthy

United States
PHARMENTERPRISES LLC

Completed

Double-blind, Randomized, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Doses of XC243 After Single and Multiple Oral Administration in Healthy Volunteers.

Healthy Volunteers

Russian Federation
Otsuka Pharmaceutical Development & Commercialization...
Bill and Melinda Gates Foundation

Completed

A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis

Pulmonary TB

South Africa
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Multiple Ascending Dose Study of PCSK-9 Inhibitor (IBI306) in Chinese Patients With Hypercholesterolemia

Hypercholesterolemia

China
GlaxoSmithKline

Active, not recruiting

An Open-label, Dose Escalation Study in Japanese Participants With Relapsed/Refractory Multiple Myeloma Who Have Failed Prior Anti Myeloma Treatments

Multiple Myeloma

Japan
Changchun GeneScience Pharmaceutical Co., Ltd.

Completed

To Evaluate the Safety and Tolerability of Multiple Doses of GS3-007a Oral Solution in Healthy Subjects.

Healthy Subject

China
MicuRx
Worldwide Clinical Trials

Completed

Single Dose and Multiple Dose Escalation Trial of an Oral Formulation of MRX-4

Safety
AstraZeneca

Completed

Chinese Multiple Dose Escalation (MDE) High Dose Study (COTA China PK)

Diabetes

China
Ascendis Pharma A/S

Active, not recruiting

A Dose Escalation Trial Evaluating Safety, Efficacy, and Pharmacokinetics of Multiple Subcutaneous Doses of TransCon CNP Administered Once Weekly in Children With Achondroplasia

Achondroplasia

China
Sanofi

Completed

Study of the Tolerability and Pharmacokinetics of Oral Doses of SAR442168 With a Food Effect Investigation in Healthy Adult Participants

Multiple Sclerosis

United States
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants

Healthy Participants

Canada
AbbVie

Completed

A Study to Assess Adverse Events and How Single and Multiple Ascending Doses of ABBV-903 Move Through the Body in Healthy Adults

Healthy Volunteer

United States
Dr. Noah Biotech Inc.

Completed

Multiple Dose Study to Evaluate Drug-drug Interactions, Safety and Tolerability of NDC-002 in Healthy Volunteers

Stroke | Stroke Sequelae

Korea, Republic of
University of Nebraska
Astex Pharmaceuticals, Inc.

Completed

Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant

Myelodysplastic Syndromes | Multiple Myeloma | Chronic Lymphocytic Leukemia | Peripheral T-cell Lymphoma | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Non-Hodgkins Lymphoma | Hodgkins Disease

United States
Machaon Biotherapeutics, Inc.

Active, not recruiting

Multiple Ascending Dose Study of CG200745 'Ivaltinostat' Oral Capsule

Fibrosis | Solid Tumor | Hematologic Malignancy

Korea, Republic of
Pieris Australia Pty Ltd

Completed

Study of Single and Multiple Doses of PRS-220 Administered by Oral Inhalation in Healthy Subjects

Healthy

Australia
Eli Lilly and Company

Completed

A Multiple Dose Study of LY3502970 in Healthy Overweight and Obese Participants

Healthy | Obese

United States
Telavant, Inc.
Pfizer

Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Intravenous and Multiple Subcutaneous and Intravenous Doses of PF-06480605 in Healthy Subjects.

Healthy

United States
Achieve Life Sciences

Completed

Study to Evaluate Effect of Food on Bioavailability of Single 3 mg Tablet and Pharmacokinetics (PK) of Multiple 3 mg Doses in Healthy Adult Smokers

Smoking Cessation

Portugal
Merck KGaA, Darmstadt, Germany

Completed

First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Participants

Healthy

Australia
Kashiv BioSciences, LLC

Completed

Open Label, Sequential Dosing , Single Ascending Dose and Multiple Dose Safety Tolerability and Pharmacokinetic Study

Metastatic Breast Cancer

Jordan
Pfizer

Completed

Study to Evaluate the Effect of Multiple-Dose Ritlecitinib on the Pharmacokinetics (PK) of Tolbutamide

Healthy Volunteers

United States
Madrigal Pharmaceuticals, Inc.

Completed

Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects

Hepatic Impairment | NASH - Nonalcoholic Steatohepatitis | Cirrhosis, Liver

United States
Memorial Sloan Kettering Cancer Center
Spectrum Pharmaceuticals, Inc

Active, not recruiting

Study of Captisol Enabled Melphalan and Pharmacokinetics for Patients With Multiple Myeloma or Light Chain Amyloidosis That Are Receiving an Autologous Transplant.

Multiple Myeloma | Amyloidosis

United States

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