Search clinical trials for: Rapid Genetic Sequencing

Total 25331 results

Calithera Biosciences, Inc

Terminated

KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC (KEAPSAKE)

Non-Small Cell Lung Cancer | Non-squamous Non-small-cell Lung Cancer | Non-Squamous Non-Small Cell Neoplasm of Lung | KEAP1 Gene Mutation | NRF2 Gene Mutation | NFE2L2 Gene Mutation

United States
Centre Hospitalier Universitaire Dijon

Completed

Study of the Diagnostic Value of "Rapid" High Throughput Genome Sequencing Analysis in Diagnostic Emergency Situations (FASTGEN)

Developmental Anomalies

France
Novartis Gene Therapies
PRA Health Sciences

Completed

Pre-Symptomatic Study of Intravenous Onasemnogene Abeparvovec-xioi in Spinal Muscular Atrophy (SMA) for Patients With Multiple Copies of SMN2 (SPR1NT)

Spinal Muscular Atrophy

United States, United Kingdom, Australia, Belgium, Canada, Japan
LMU Klinikum

Completed

Musculoskeletal Nociceptive Pain in Participants With Neuromuscular Disorders

Healthy | Myotonic Dystrophy Type 2 | Pompe Disease (Late-onset) | Spinal Muscular Atrophy Type 3 | Myotonic Dystrophy Type 1 (DM1) | Facioscapulohumeral Muscular Dystrophy 1 | Inclusion Body Myositis, Sporadic

Germany
Chang Gung Memorial Hospital
Ministry of Science and Technology, Taiwan

Completed

Genetic Biomarkers Associated With Child Language Development in Taiwan (II)

Child Language

Taiwan
Idorsia Pharmaceuticals Ltd.

Completed

Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease (MODIFY)

Fabry Disease

United States, Spain, Belgium, Australia, Austria, Canada, Germany, Ireland, Italy, Netherlands, Norway, Poland, Switzerland, United Kingdom
Atlas Biomed

Terminated

Study of the Genome, Gut Metagenome and Diet of Patients With Incident Parkinson's Disease

Parkinson Disease | Genetic Predisposition

Russian Federation
Atlas Biomed

Completed

Study of the Genome, Gut Metagenome and Lifestyle of Patients With Incident Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2 | Genetic Predisposition | Metagenome

Russian Federation
Pfizer

Completed

Study of Abrocitinib Compared With Dupilumab in Adults With Moderate to Severe Atopic Dermatitis on Background Topical Therapy

Atopic Dermatitis

Spain, Taiwan, United States, Korea, Republic of, Poland, Canada, Australia, Hungary, Germany, Latvia, Finland, Chile, Bulgaria, Slovakia, Italy
National Heart, Lung, and Blood Institute (NHLBI)

Completed

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Hypertension | Cardiovascular Disease

United States
University of Utah
Genzyme, a Sanofi Company

Completed

Pre-Clinical White Matter Changes and Associated Connectivity Effects in Fabry Disease

Fabry Disease

United States
Sensor Technology for Deafblind
Central Clinical Hospital under President Affairs; Deaf-Blind Support Foundation... and other collaborators

Completed

Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa (RU-RP)

Retinitis Pigmentosa | Usher Syndromes

Russian Federation
Pfizer

Completed

Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis

Healthy | Chronic Rhinosinusitis With Nasal Polyps | Atopic Dermatitis

United States
University of British Columbia

Suspended

Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project

Exostoses, Multiple Hereditary

Canada
University of Copenhagen
Rigshospitalet, Denmark; Hvidovre University Hospital; Herlev Hospital; Steno Diabetes... and other collaborators

Enrolling by invitation

Translating Genetic Knowledge Into Clinical Care in Non-Autoimmune Diabetes (TRANSLATE)

Diabetes Mellitus, Type 2 | Diabetes, Gestational

Denmark
Mayo Clinic

Terminated

A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing

Lung Neoplasms | Carcinoma Non-small-cell Lung

United States
Children's Hospital of Chongqing Medical University
The First Hospital of Jilin University; Xuzhou Maternity and Child Health Care... and other collaborators

Completed

The Pilot Study of High-throughput Sequencing in Neonatal Birth Defects

Genetic Diseases | Birth Defect | Congenital Malformation | Multiple Malformation | Newborn; Fit

China
Cara Therapeutics, Inc.

Completed

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis (KARE)

Pruritus | Atopic Dermatitis

United States, Canada
Mylan Inc.
Cystic Fibrosis Foundation

Completed

Observational Study in Cystic Fibrosis Patients Using TOBI® PODHALER® or Other FDA Approved Inhaled Antipseudomonal Antibacterial Drugs

Pseudomonas Aeruginosa in Cystic Fibrosis

United States
Eisai Inc.

Terminated

Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut Syndrome

Lennox-Gastaut Syndrome (LGS)

Korea, Republic of, United States, Australia, Belgium, Japan, Czechia, India
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes

Secondary Acute Myeloid Leukemia | Childhood Acute Erythroleukemia (M6) | Childhood Acute Megakaryocytic Leukemia (M7) | Childhood Acute Monoblastic Leukemia (M5a) | Childhood Acute Monocytic Leukemia (M5b) | Childhood Acute Myeloblastic Leukemia With Maturation (M2) | Childhood Acute Myeloblastic... and other conditions

United States, Canada, Australia, Puerto Rico
Reproductive & Genetic Hospital of CITIC-Xiangya

Terminated

A Study of Preimplantation Genetic Screening With Next Generation Sequencing Technology on Advanced Age Women

Infertility

China
Vertex Pharmaceuticals Incorporated

Terminated

A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy

Cystic Fibrosis

United States, Spain, Ireland, Australia, Israel, United Kingdom, Germany, Canada, Denmark, Poland, Switzerland
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma

Recurrent Neuroblastoma | Recurrent Rhabdomyosarcoma | Wilms Tumor | Recurrent Malignant Peripheral Nerve Sheath Tumor | Recurrent Synovial Sarcoma | Pleuropulmonary Blastoma

United States
Rennes University Hospital

Completed

Retrospective Study Using Next Generation Sequencing (NGS) on Biological Samples to Improve Genetic Counseling for Patients With Previously Explored Craniofacial Midline Defects. (EXOMEDIANE)

Holoprosencephaly

France
Changhai Hospital

Active, not recruiting

An Observational Study on the Natural Course of Chronic Pancreatitis

Chronic Pancreatitis | Smoking, Tobacco | Drinking, Alcohol | Genetic Mutation
AbbVie

Completed

A Study to Evaluate Risankizumab in Adults and Adolescents With Moderate to Severe Atopic Dermatitis

Dermatitis

United States, Australia, Canada, Japan, Puerto Rico
Centre Hospitalier Universitaire Dijon

Completed

Contribution of High Throughput RNA Sequencing Combined With Sequencing of Whole Genomes in the Diagnosis of Intellectual Disability (DI-WA)

Patients With Intellectual Disabilities Without an Obvious Clinical Diagnosis | Patients With Normal Array CGH and Previous Negative Genetic Investigations (WES-solo or WES-trio)

France
Sequenom, Inc.

Completed

Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies (CHARMM-AP)

Down Syndrome | Aneuploidy

United States
Pfizer

Completed

Study to Investigate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years and Over With Moderate to Severe Atopic Dermatitis With the Option of Rescue Treatment in Flaring Subjects

Skin Diseases | Immune System Diseases | Hypersensitivity | Hypersensitivity, Immediate | Genetic Diseases, Inborn | Skin Diseases, Genetic | Dermatitis | Eczema | Skin Diseases, Eczematous | Dermatitis, Atopic

United States, Spain, Taiwan, Germany, Canada, China, Poland, Belgium, Serbia, Brazil, Russian Federation, Israel, Latvia, Italy, Romania, Mexico, Argentina, Bulgaria, Chile, Netherlands, Slovakia
Brain and Cognition Discovery Foundation

Completed

Pharmacogenetics Associated With IV Ketamine

Treatment Resistant Depression

Canada
Clinical Hospital Center Rijeka
Karolinska Institutet; University Medical Centre Ljubljana; Croatian Science...

Enrolling by invitation

The Epidemiology of Parkinson's Disease in Croatia and the Influence of Genetic Factors and Microbiota on the Progression and Treatment Outcomes of the Disease (GiOPARK) (GiOPARK)

Parkinson Disease | Genetic Disease | Microbiota | Neuro-Degenerative Disease | Neuroinflammatory Response

Croatia
Second Affiliated Hospital, School of Medicine,...

Completed

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria

Lynch Syndrome

China
University Hospital, Caen

Completed

Search for New Genetic Causes of Hypercalcemia by Massively Parallel Sequencing of a Genes Panel (HyCaGene)

Hypercalcemia

France
Parion Sciences
Vertex Pharmaceuticals Incorporated

Completed

A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation

Cystic Fibrosis

United Kingdom, United States, France, Ireland
Second Affiliated Hospital, School of Medicine,...
Guangzhou Burning Rock Medical Examination Institute Co., Ltd.

Completed

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer

Lynch Syndrome

China
Steven M Rowe

Completed

G551D Observational Study- Expanded to Additional Genotypes and Extended for Long Therm Follow up (GOAL-e2) (GOAL- e2)

Cystic Fibrosis

United States
Seattle Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI); Cystic Fibrosis Foundation; CF Therapeutics Development Network Coordinating Center

Completed

Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF) (TEACH)

Cystic Fibrosis

United States
Assistance Publique - Hôpitaux de Paris
Bristol-Myers Squibb

Terminated

Tumor Mutational Burden in Lung Cancer Patients (MUBULUC)

Non Small Cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Non Small Cell Lung Cancer Stage III | Non-Small Cell Carcinoma of Lung

France
Regeneron Pharmaceuticals
Sanofi

Terminated

Long Term Safety Study of PRALUENT

Heterozygous Familial Hypercholesterolemia | Non-familial Hypercholesterolemia

United States, Bulgaria, Estonia, Russian Federation, South Africa, Ukraine
Galderma R&D

Completed

Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT)

Actinic Keratosis

United Kingdom
Shire

No longer available

Treatment Protocol of Replagal for Patients With Fabry Disease

Fabry Disease

United States
Nantes University Hospital

Completed

Study of cardiovAscular Contrasted Phenotypes in Patients With FamIliaI hypercholesteRolemia (SAFIR)

Homozygous Familial Hypercholesterolemia

France
Brigham and Women's Hospital
United States Department of Defense

Completed

Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force (MilSeq)

Genetic Predisposition to Disease | Healthy Adults

United States
University of Leicester

Active, not recruiting

A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases (ReST)

Genetic Disease | Screening | Aortic Aneurysm and Dissection

United Kingdom
Vertex Pharmaceuticals Incorporated

Completed

A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis

Cystic Fibrosis

United States, Israel, Ireland, United Kingdom
Eisai Inc.
Pfizer

Completed

Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome

Down Syndrome

United States
Incyte Corporation

Completed

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Phosphate Cream Applied Topically to Adults With Atopic Dermatitis

Atopic Dermatitis

United States, Canada
Eisai Inc.
Pfizer

Terminated

Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome - Follow-Up To A 10-Week, Double-Blind, Placebo-Controlled Trial

Down Syndrome

United States
Pfizer

Completed

Dose Ranging Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics of PF-06700841 Topical Cream in Participants With Mild or Moderate Atopic Dermatitis

Atopic Dermatitis

Germany, United States, Canada, Denmark, Hungary, Australia, Latvia, Poland, Bulgaria, Japan

Search clinical trials for: Rapid Genetic Sequencing

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