Clinical Trials Sponsored by Alnylam Pharmaceuticals Inc

Total 5066 results

Agios Pharmaceuticals, Inc.

Completed

A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

Anemia, Hemolytic | Pyruvate Kinase Deficiency

United States, United Kingdom, Netherlands, Canada, Denmark, France, Italy, Ireland, Thailand
Vallon Pharmaceuticals, Inc.

Completed

Study to Evaluate the Abuse Liability, Pharmacokinetics, Safety and Tolerability of an Abuse-Deterrent d-Amphetamine Sulfate Immediate Release Formulation (ADAIR) (SEAL)

ADHD | Narcolepsy

United States
Supernus Pharmaceuticals, Inc.

Terminated

Exploratory fMRI Study on the Treatment for Impulsive Aggression in Children With Attention-Deficit/Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder (ADHD) | Impulsive Aggression

United States
Cyclacel Pharmaceuticals, Inc.

Terminated

A Phase I Pharmacologic Study of CYC116, an Oral Aurora Kinase Inhibitor, in Patients With Advanced Solid Tumors

Solid Tumors

United States
Adamas Pharmaceuticals, Inc.

Completed

Safety and Efficacy of ADS-5102 in Multiple Sclerosis Patients With Walking Impairment

Multiple Sclerosis | Walking Impairment

United States, Canada
Spectrum Pharmaceuticals, Inc

Terminated

Study of Zevalin Versus Observation in Participants at Least 60 Years Old With Newly Diagnosed Diffuse Large B-cell Lymphoma in Positron Emission Tomography (PET)-Negative Complete Remission After Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) or R-CHOP-like Therapy

Diffuse Large B-cell Lymphoma | Follicle Center Lymphoma

United States, France, United Kingdom, Ireland, Israel, Belgium, Spain, Netherlands, Australia, Puerto Rico, Canada, Italy, Austria
Faraday Pharmaceuticals, Inc.

Completed

A Study of Acute Myocardial Infarction Using FDY-5301

Acute Myocardial Infarction | STEMI

United Kingdom, United States, Hungary, Poland
Rocket Pharmaceuticals Inc.

Withdrawn

A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I

Leukocyte Adhesion Defect - Type I

Spain
Spectrum Pharmaceuticals, Inc

Terminated

A Study of Intravesical Apaziquone as a Surgical Adjuvant in Participant Undergoing Transurethral Resection Bladder Tumor (TURBT)

Bladder Cancer

United States
Spectrum Pharmaceuticals, Inc

Terminated

Safety and Efficacy Study of Lucanthone When Used in Combination With Temozolomide(TMZ) and Radiation to Treat Glioblastoma Multiforme(GBM)

Glioblastoma Multiforme

United States, India
ACADIA Pharmaceuticals Inc.

Terminated

Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine

Parkinson's Disease

United States
Spectrum Pharmaceuticals, Inc

Terminated

Phase 2 Study of Zevalin Versus Zevalin and Motexafin Gadolinium in Patients With Rituximab-Refractory Low-grade or Follicular B-cell Non-Hodgkin's Lymphoma

Non-Hodgkin's Lymphoma

United States
Venatorx Pharmaceuticals, Inc.

Completed

Safety and Intrapulmonary Pharmacokinetics of Cefepime and Taniborbactam in Healthy Subjects

Healthy Subjects

United States
Spectrum Pharmaceuticals, Inc

Completed

A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult Participants

Healthy

United States
Ironwood Pharmaceuticals, Inc.

Terminated

A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)

Gastroesophageal Reflux Disease (GERD)

Canada, United States
ACADIA Pharmaceuticals Inc.

Terminated

The INSYTE (Management of Parkinson's Disease Psychosis in Actual Practice) Study

Parkinson Disease Psychosis

United States
Corvus Pharmaceuticals, Inc.

Completed

Study of CPI-006 as Immunotherapy for Hospitalized COVID-19 Patients

COVID-19

United States
Agios Pharmaceuticals, Inc.

Completed

A Study to Compare the Relative Bioavailability of Two AG-881 Formulations and Evaluate the Effect of Food and Omeprazole on the Pharmacokinetics of AG-881

Healthy Volunteers

United States
Crinetics Pharmaceuticals Inc.

Completed

A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Evolve)

Acromegaly

United States, United Kingdom, Slovakia, Australia, Italy, Hungary, Brazil, Germany, Greece, New Zealand, Poland, Romania, Serbia
Mirum Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS) (ICONIC)

Alagille Syndrome

France, Belgium, Poland, Australia, Spain, United Kingdom
Supernus Pharmaceuticals, Inc.

Completed

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects (MYSTICOL)

Sialorrhea

United States, Ukraine, Russian Federation
Pacira Pharmaceuticals, Inc

Completed

Safety and Pharmacokinetics Study of Redosing EXPAREL in Healthy Volunteers

Healthy Volunteers

United States
Pacira Pharmaceuticals, Inc

Terminated

EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries (TRANSCEND)

Pain

United States
Rhythm Pharmaceuticals, Inc.

Completed

An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes (NHS)

POMC Deficiency Obesity | PCSK1 Deficiency Obesity | LEPR Deficiency Obesity

Turkey
Rhythm Pharmaceuticals, Inc.

Completed

A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment

Renal Insufficiency

United States
ACADIA Pharmaceuticals Inc.

Completed

Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis

Dementia-related Psychosis

United States, Spain, Poland, Ukraine, Chile, Czechia, United Kingdom, Bulgaria, France, Germany, Italy, Serbia, Slovakia
Spectrum Pharmaceuticals, Inc

Terminated

A Mass Balance and Pharmacokinetics Study of 14C-Labeled Poziotinib in Cancer Patients Suitable for Treatment With Poziotinib

Solid Tumor

United States
Progenics Pharmaceuticals, Inc.

Completed

Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer (CONDOR)

Prostate Cancer | Prostate Adenocarcinoma | Prostate Cancer Recurrent | Prostate Cancer Metastatic

United States, Canada
Eagle Pharmaceuticals, Inc.

Completed

Study to Evaluate the Safety, Tolerability, and PK of Fulvestrant After IM Administration

Pharmacokinetics

United States
Eagle Pharmaceuticals, Inc.

Completed

Study to Assess the Efficacy and Safety of Ryanodex as Adjuvant Treatment in Subjects With EHS

Exertional Heat Stroke

Saudi Arabia
Pacira Pharmaceuticals, Inc

Terminated

Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers

Healthy

United States
TFF Pharmaceuticals, Inc.

Completed

Single Ascending Dose and Multiple Ascending Dose Study of Voriconazole Inhalation Powder in Healthy Adult Subjects

Healthy

Canada
Enanta Pharmaceuticals, Inc

Completed

Drug-Drug Interaction Study Between Fluconazole and EDP-938 in Healthy Subjects

RSV Infection

United States
Rhythm Pharmaceuticals, Inc.

Completed

The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry

Genetic Forms of Extreme Obesity

United States, Canada
Stargazer Pharmaceuticals, Inc.

Completed

Study of STG-001 in Subjects With Stargardt Disease

Stargardt Disease-1

United States
EyePoint Pharmaceuticals, Inc.

Completed

Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert (FAI)

Non-Infectious Uveitis

United States, United Kingdom, Israel, Hungary, Germany, India
Scilex Pharmaceuticals, Inc.

Completed

Pharmacokinetic Study of SP-103 in Healthy Adult Human Subjects

Healthy

United States
Pacira Pharmaceuticals, Inc

Terminated

EXPAREL Administered Into the TAP for Analgesia in Subjects Undergoing Open Total Abdominal Hysterectomy

Postoperative Pain
Afferent Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009)

Asthma
Pacira Pharmaceuticals, Inc

Completed

Safety, Efficacy, and Pharmacokinetics of SKY0402 Administered as a Nerve Block in Subjects Undergoing Bunionectomy

Postoperative Pain
Spectrum Pharmaceuticals, Inc

Terminated

A Study of Poziotinib in Combination With T-DM1 in HER2-Positive Breast Cancer

Breast Cancer

United States
Spectrum Pharmaceuticals, Inc

Completed

Study of the Absorption, Metabolism, and Excretion Following a Single Dose of [14C]-Poziotinib in Healthy Male Subjects

Healthy

United States
Astex Pharmaceuticals, Inc.

Completed

SGI-110 in Adults With Untreated Acute Myeloid Leukemia (AML), Not Considered Candidates for Intensive Remission Induction

Leukemia, Myeloid, Acute

United States, Spain, Korea, Republic of, Taiwan, Australia, Canada, Denmark, Hungary, Japan, Finland, Italy, Serbia, Czechia, France, Germany, Sweden, Netherlands, Poland, Russian Federation, Austria, United Kingdom, Romania, Belgium, Bulgar...
Ampio Pharmaceuticals. Inc.

Completed

Study of Ampion for the Treatment of Adult COVID-19 Patients Requiring Oxygen Supplementation

COVID-19

United States
Pacira Pharmaceuticals, Inc

Completed

Evaluate the Safety and Efficacy of EXPAREL When Administered Via Infiltration Into the TAP vs. Bupivacaine Alone in Subjects Undergoing Elective C-Sections (C-Section)

Pain Management | C-Section

United States
Pacira Pharmaceuticals, Inc

Completed

Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL (PLAY)

Postoperative Pain Management

United States
Kala Pharmaceuticals, Inc.

Completed

Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease (Kauai)

Dry Eye Syndromes | Keratoconjunctivitis Sicca

United States
ACADIA Pharmaceuticals Inc.

Completed

Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia (ADVANCE)

Schizophrenia

United States, Spain, Hungary, Bulgaria, Russian Federation, Serbia, Ukraine, Poland, Canada, Czechia
Kunming Pharmaceuticals, Inc.

Unknown

Comparing of the Pharmacokinetics, Immunogenicity and Safety of MV088 and Prolia® in Healthy Adults.

Healthy
Eyegate Pharmaceuticals, Inc.

Completed

Safety and Effectiveness of OBG vs.a Bandage Contact Lens for Large Corneal Epithelial Defects in Patients Post-PRK.

Corneal Epithelial Wound

United States

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