Clinical Trials Sponsored by GTC Biotherapeutics

Total 898 results

Zhejiang University
UTC Therapeutics Inc.

Recruiting

UCLM802 (Anti-Mesothelin CAR-T) Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors

Mesothelin-positive Advanced Malignant Solid Tumors

China
Ruijin Hospital
UTC Therapeutics Inc.

Recruiting

Anti-mesothelin CAR-T Cells With Advanced Refractory Solid Tumors (Amaretto)

Refractory Malignant Solid Neoplasm

China
Nationwide Children's Hospital
PTC Therapeutics

Active, not recruiting

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

High Grade Glioma | Diffuse Intrinsic Pontine Glioma

United States
NYU Langone Health
PTC Therapeutics

Completed

Ataluren for Nonsense Mutation in CDKL5 and Dravet Syndrome

Epilepsy

United States
Havah Therapeutics Pty Ltd
GTx

Completed

Enobosarm and Anastrozole in Pre-menopausal Women With High Mammographic Breast Density

Mammographic Density

Australia
PTC Therapeutics
Muscular Dystrophy Association

Completed

Safety and Efficacy Study of PTC124 in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United States
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Second Affiliated Hospital of Soochow University

Recruiting

UTAA17 Injection in the Treatment of Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

China
Shanghai EpimAb Biotherapeutics Co., Ltd.
Labcorp Corporation of America Holdings, Inc

Recruiting

EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers

Neoplasms | Neoplasm Metastasis | Metastatic Gastrointestinal Carcinoid Tumor

United States, China
Richard Wu
Iovance Biotherapeutics, Inc.

Active, not recruiting

Neoadj Admin Autologous Tumor Infiltrating Lymphocytes & Pembrolizumab for Treatment of Adv Melanoma Patients

Locally Advanced Melanoma | Stage IV Melanoma | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8

United States
Atara Biotherapeutics
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center

Completed

Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies

EBV-induced Lymphomas | EBV-associated Malignancies | Transplant Patients With EBV Viremia at High Risk of Developing a Recurrent EBV Lymphoma

United States
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Second Affiliated Hospital of Suzhou University

Unknown

The Clinical Application of Chimeric Antigen Receptor T Cells in the Treatment of CD19 Positive Recurrent Refractory B Cell-derived Hematological Malignancies

Follicular Lymphoma | Mantle Cell Lymphoma | B Acute Lymphoblastic Leukemia

China
Peking University
UTC Therapeutics Inc.

Not yet recruiting

UCLM802 (Anti-Mesothelin CAR-T) Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors

Solid Tumor
Boston Sight
EYEdeal scanning, LTC

Completed

Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting

Dry Eye Syndromes | Keratoconjunctivitis Sicca | Keratoconus | Sjogren's Syndrome | Ocular Surface Disease | Ectasia | Pellucid Marginal Corneal Degeneration | Corneal Trauma | Corneal Scar

United States
PTC Therapeutics
Cystic Fibrosis Foundation

Completed

Extension Study of Ataluren (PTC124) in Cystic Fibrosis

Cystic Fibrosis

United States, France, Belgium, Spain, Canada, Germany, Israel, Italy, Netherlands, Sweden, United Kingdom
PTC Therapeutics
Axio Research. LLC

Completed

Safety and Efficacy Study of EPI-743 in Children With Leigh Syndrome

Leigh Syndrome

United States
Hoffmann-La Roche
PTC Therapeutics

Completed

A Study to Collect Blood Samples From Patients With Spinal Muscular Atrophy for Biomarker Analysis

Muscular Atrophy, Spinal

United States
Pennington Biomedical Research Center
GNC

Completed

Efficacy of Olibra: A 12 Week Controlled Trial

Obesity | Overweight

United States
Shanghai EpimAb Biotherapeutics Co., Ltd.
Labcorp Corporation of America Holdings, Inc

Not yet recruiting

EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Advanced Lung Non-Small Cell Carcinoma | EGFR Mutation-Related Tumors

United States, China
Children's Hospital of Philadelphia
Friedreich's Ataxia Research Alliance; Stealth BioTherapeutics Inc.

Active, not recruiting

FRDA Investigator Initiated Study (IIS) With Elamipretide (ELViS-FA)

Friedreich Ataxia

United States
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Second Affiliated Hospital of Suzhou University

Unknown

Clinical Trial of BCMA CAR T Cell Infusion in Patients With BCMA-positive r/r Multiple Myeloma

Multiple Myeloma

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Iovance Biotherapeutics, Inc.

Active, not recruiting

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

Malignant Solid Neoplasm | Soft Tissue Sarcoma | Recurrent Ovarian Carcinoma | Triple Negative Breast Cancer | Recurrent Osteosarcoma | Refractory Osteosarcoma | Bone Sarcoma | Giant Cell Tumor of Bone | Ovarian Carcinosarcoma | Platinum-Resistant Ovarian Carcinoma | Dedifferentiated Chondrosarcoma | Malignancy... and other conditions

United States
Changhai Hospital
UTC Therapeutics Inc.

Recruiting

Anti-CD70 CAR-T Cell Injection in Patients With CD70-positive Advanced Urologic Neoplasms

CD70-positive Advanced Urologic Neoplasms

China
University of Oklahoma
PTC Therapeutics

Completed

Unesbulin in Women With Ovarian Cancer Receiving Neoadjuvant Chemotherapy (PTC-001)

Ovarian Cancer

United States
PTC Therapeutics
Cystic Fibrosis Foundation

Completed

Study of Ataluren (PTC124™) in Cystic Fibrosis

Cystic Fibrosis

United States, France, Belgium, United Kingdom, Spain, Canada, Germany, Israel, Italy, Netherlands, Sweden
PTC Therapeutics
ICON Development Solutions

Completed

Food Effect and Bioavailability of Deflazacort Formulations in Healthy Volunteers

Healthy Volunteers

United States
TC Biopharm

Terminated

ImmuniCell® in Patients With Advanced Cancers

Non-small Cell Lung Cancer | Renal Cell Cancer | Malignant Melanoma

United Kingdom
Shanghai Pudong Hospital
UTC Therapeutics Inc.

Withdrawn

Exploratory Study of Novel MSLN CAR-T Cell Therapy in Patients With MSLN-positive Advanced Refractory Solid Tumors

Mesothelin-positive Advanced Refractory Solid Tumors

China
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Soochow University

Recruiting

CD7 CAR-T in the Treatment of CD7 Positive Refractory Relapsed Acute Leukemia

T-ALL

China
Shanghai General Hospital, Shanghai Jiao Tong University...
Innostellar Biotherapeutics

Active, not recruiting

Safety and Efficacy Study of LX102-C01 Treatment of Neovascular Age-Related Macular Degeneration (nAMD)

Neovascular Age-related Macular Degeneration

China
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Zhengzhou University

Unknown

CD19-CART in the Treatment of R/R CD19 Positive Non-Hodgkin's Lymphoma

Non Hodgkin Lymphoma

China
GC Aesthetics

Not yet recruiting

Post-market Prospective Clinical Study of Nagor Perle Mammary Implants (PERLE10PMCF)

Breast Augmentation | Breast Reconstruction | Breast Reconstruction Following Mastectomy | Breast Reconstruction Surgery | Breast Implants | Breast Revision | Breast Reconstruction With Silicone Implants | Breast Reconstruction After Mastectomy
TC Biopharm

Recruiting

ACHIEVE - Efficacy and Effectiveness of Adoptive Cellular tHerapy wIth Ex-Vivo Expanded Allogeneic γδ T-lymphocytes (TCB-008) for Patients With Refractory or Relapsed Acute Myeloid Leukaemia (AML) (ACHIEVE)

Acute Myeloid Leukemia

United Kingdom
TC Biopharm

Withdrawn

A Phase II Safety and Tolerability Study of TCB008 in Patients With COVID-19

COVID - 19

United Kingdom
University of Kansas Medical Center
National Cancer Institute (NCI); Iovance Biotherapeutics, Inc.

Recruiting

Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanoma

Metastatic Melanoma | Unresectable Melanoma | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Zhengzhou University

Unknown

CD7 CAR-T Cells for Patients With R/R CD7+ NK/T Cell Lymphoma,T-lymphoblastic Lymphoma and Acute Lymphocytic Leukemia

Acute Lymphocytic Leukemia | T-lymphoblastic Lymphoma | NK/T Cell Lymphoma

China
Shanghai General Hospital, Shanghai Jiao Tong University...
Innostellar Biotherapeutics

Recruiting

Safety and Efficacy Study of LX103 Treatment of X-Linked Retinoschisis (XLRS)

X-linked Retinoschisis

China
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Zhengzhou University

Not yet recruiting

Clinical Study of CD276 Targeted Autologous Chimeric Antigen Receptor T Cell Infusion in Patients With CD276 Positive Advanced Solid Tumor

Gastric Cancer | Lung Cancer | Osteosarcoma | Neuroblastoma
The First Affiliated Hospital of Soochow University
PersonGen BioTherapeutics (Suzhou) Co., Ltd.

Recruiting

Humanized CD7 CAR T-cell Therapy for r/r CD7+ Acute Leukemia

Acute Myeloid Leukemia | Mixed Phenotype Acute Leukemia | T Lymphoblastic Leukemia/Lymphoma

China
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Zhengzhou University

Unknown

CD7-CART in the Treatment of r / r CD7 Positive Hemolymph System Malignancies on Increasing Dose and Open Label Study

Angioimmunoblastic T-cell Lymphoma | Enteropathy-Associated T-Cell Lymphoma | Anaplastic Large Cell Lymphoma, ALK-negative | T Lymphoblastic Leukemia/Lymphoma | Extramedullary NK-T-cell Lymphoma, Nasal Type | Peripheral T-cell Lymphoma, Nonspecific | T-cell Lymphoblastic Leukemia

China
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
The First Affiliated Hospital of Soochow University

Unknown

γδT Cell Infusion to Prevent Relapsed/Refractory Leukemia Rescue Relapse (γδT)

Leukemia, B-cell

China
National Taiwan University Hospital
PTC Therapeutics

Completed

A Phase I/II Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC (AADC)

Aromatic L-amino Acid Decarboxylase (AADC) Deficiency

Taiwan
PTC Therapeutics
Genzyme, a Sanofi Company

Terminated

Ataluren for Nonsense Mutation Methylmalonic Acidemia

Amino Acid Metabolism, Inborn Errors

France, United Kingdom, Italy, Belgium, Germany, Switzerland
TC Biopharm

Completed

Ex-vivo Expanded γδ T-lymphocytes (OmnImmune®) in Patients With Acute Myeloid Leukaemia (AML)

Acute Myeloid Leukemia

Czechia
Shanghai Pudong Hospital
UTC Therapeutics Inc.

Withdrawn

Novel CAR-T Cell Therapy in the Treatment of Hematopoietic and Lymphoid Malignancies

Acute Myeloid Leukemia (AML) | Multiple Myeloma (MM) | B-cell Non-Hodgkin's Lymphoma (B-NHL) | T-Cell Leukemia/Lymphoma, Adult | B-cell Acute Lymphoblastic Leukemia (B-ALL)

China
National Taiwan University Hospital
PTC Therapeutics

Completed

A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion

Aromatic Amino Acid Decarboxylase Deficiency

Taiwan
PTC Therapeutics
Genzyme, a Sanofi Company

Terminated

Phase 2a Extension Study of Ataluren (PTC124) in Duchenne Muscular Dystrophy (DMD)

Duchenne Muscular Dystrophy

United States
PTC Therapeutics
Genzyme, a Sanofi Company

Terminated

Study of Ataluren (PTC124) in Nonambulatory Participants With Nonsense-Mutation-Mediated Duchenne/Becker Muscular Dystrophy (nmDMD/BMD)

Duchenne Muscular Dystrophy | Becker Muscular Dystrophy

United States, United Kingdom
PTC Therapeutics
Genzyme, a Sanofi Company

Terminated

Phase 2B Extension Study of Ataluren (PTC124) in Duchenne/Becker Muscular Dystrophy (DMD/BMD)

Duchenne Muscular Dystrophy | Becker Muscular Dystrophy

United States, Belgium, Australia, Canada, France, Germany, Israel, Italy, Spain, Sweden, United Kingdom
PTC Therapeutics
Genzyme, a Sanofi Company

Terminated

Study of Ataluren (PTC124) in Hemophilia A and B

Hemophilia A | Hemophilia B

United States, Canada, France, Italy
M.D. Anderson Cancer Center
Bristol-Myers Squibb; National Cancer Institute (NCI); Iovance Biotherapeutics

Active, not recruiting

Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma

Malignant Solid Neoplasm | Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Platinum-Resistant Ovarian Carcinoma | Metastatic Pancreatic Ductal Adenocarcinoma | Metastatic Ovarian Carcinoma and other conditions

United States

Clinical Trials Sponsored by GTC Biotherapeutics

Sponsors and Collaborators

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