Clinical Trials Sponsored by National Instutite of Health and Care Excellence

Total 7986 results

National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

Inflammation | Cardiovascular Disease | Psoriasis | Metabolic Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Fasting and Refeeding on T-cell Fate

Inflammation | Asthma

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers

Homozygous Familial Hypercholesterolemic

United States
National Institutes of Health Clinical Center (CC)
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effectiveness of a Stress Reduction Intervention in Caregivers of Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Stress, Psychological | Caregivers

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cardiac Function in Patients With Hereditary Hemochromatosis

Hereditary Hemochromatosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

High Image Matrix CT Reconstruction

Healthy Subjects | Pulmonary-Related Conditions | Cardiac-Related Conditions

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Genes Involved in Lipid Disorders

Lipid Disorders

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Sickle Cell Disease | Hemolytic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders

Lymphedema | Lymphangiomatosis | Lymphangiectasia | Pulmonary Lymphangiectasia

United States
Emory University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Improving Mitral Repair for Functional Mitral Regurgitation (IMPROVE-FMR)

Cardiovascular Diseases | Coronary Artery Disease | Heart Disease | Valvular Heart Disease | Congestive Heart Failure | Cardiomyopathy | Mitral Valve Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Anti-Inflammatory Effects of Time-Restricted Feeding

Psoriasis | Systemic Inflammation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hereditary Parkinson s Disease Natural History Protocol

Parkinson Disease 6, Early-Onset | Parkinson Disease (Autosomal Recessive, Early Onset) 7, Human | Parkinson Disease Autosomal Recessive, Early Onset | Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

United States
Yale University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Exercise in Genetic Cardiovascular Conditions (LIVE-HCM/LQT)

Hypertrophic Cardiomyopathy | Long QT Syndrome

United States, United Kingdom, Canada, Australia, New Zealand
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

Functional Mitral Regurgitation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Replacement

Aortic Stenosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Stem Cell Collection for Adult Volunteers

Sickle Cell

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Magnetic Resonance Imaging of the Blood Vessels of the Heart

Heart Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Withdrawn

The Effect of Inflammation in Heart Failure

Heart Failure | Inflammation | Myocardial Dysfunction

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)

Cardiomyopathy | Obstructive Hypertrophic Cardiomyopathy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation of the Causes and Disease Processes of Chronic Lung Disease

Pulmonary Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte Leukemia

T-LGL Lymphoproliferative Disorders

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia (CLL) | Small Lymphocytic Leukemia (SLL)

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelodysplastic Syndrome

Severe Aplastic Anemia (SAA) | Myelodysplastic Syndrome (MDS) With Refractory Anemia (RA)

United States
Yale University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Implementation of HIT-Enhanced Tobacco Treatment for Hospitalized Smokers

Smoking | Smoking Cessation | Tobacco Use Disorder | Tobacco Use Cessation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Cardiovascular Disease Screening

Myocardial Infarction | Myocardial Ischemia | Acquired Heart Disease | Atherosclerosis | Congenital Heart Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia

Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults

Proteomics | Lipoprotein Metabolism | PCSK9

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia

Neutropenia | Pancytopenia | Aplastic Anemia | Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants

Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Niacin Therapy on Lipoprotein Composition and Function

Cardiovascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation (BASILICA)

Native and Valve in Valve Aortic Valve Failure

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Combination Therapy of Severe Aplastic Anemia

Severe Aplastic Anemia

United States
National Institutes of Health Clinical Center (CC)
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Evaluation of Budesonide and How It Interacts With Antifungal Drugs in People With Gastrointestinal Graft-Versus-Host Disease

Stem Cell Transplantation | Graft vs Host Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia

Hepatitis-Associated Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Fasting on the Asthma Inflammasome

Asthma

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Fasting on the NLRP3 Inflammasome

Cardiovascular Disease | Inflammatory Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

An Evaluation of Safety and Efficacy of Escalating Doses of AMD3100 to Mobilize CD34+ Cells in Healthy Volunteers

Healthy Volunteers

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mutations in Genes Associated With Pentalogy of Cantrell

Pentalogy of Cantrell

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation and Treatment of Patients With Lung Disease Not Participating in Research

Pulmonary Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Niacin to Improve Blood Flow in People With Sickle Cell Disease

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Collection of Blood From Patients With Pancytopenia

Pancytopenia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Peripheral Stem Cell Transplant in Treating Patients With Metastatic Kidney Cancer

Kidney Cancer

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Sildenafil to Treat HIV-Associated Pulmonary Hypertension

HIV

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety of ON 01910.Na in Patients With Myelodysplasia

Myelodysplastic Syndrome (MDS)

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hydroxyurea for the Treatment of Patients With Sickle Cell Anemia

Sickle Cell Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Bone Marrow Stromal Cell Infusions for Stem Cell Transplant Complications

Graft-Versus-Host Disease

United States

Clinical Trials Sponsored by National Instutite of Health and Care Excellence

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