Search clinical trials for: Hepatic Impairment, single dose, intravenous

Total 23034 results

Ewha Womans University Mokdong Hospital

Completed

Ultrasound-guided Bilateral Rectus Sheath Block for Robotic Single-port Gynecologic Surgery

Gynecologic Disease

Korea, Republic of
Stanley Dudrick's Memorial Hospital

Completed

Parenteral Lipid Emulsions and the Liver Function

Liver Failure

Poland
Bristol-Myers Squibb
Cardioxyl Pharmaceuticals, Inc

Completed

A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers

Heart Failure
National Institute on Drug Abuse (NIDA)

Unknown

A Phase 1 Parallel-Group, Double-Blind, Placebo-Controlled Cardiovascular and Behavioral Study Assessing Interactions Between Single Doses of Oral Reserpine and Intravenous Methamphetamine - 1

Amphetamine-Related Disorders

United States
Jia Fan

Unknown

TACE as an Adjuvant Therapy After Hepatectomy for HCC

Hepatocellular Carcinoma

China
Centre Hospitalier Universitaire de Nice

Completed

Intranasal Sufentanil Pain-management at Entrance of Emergency Department : Influence on Pain-relief Delay (InSPEED)

Single Traumatic Limb Injury With Severe Pain (Score > 5/10 on Numerical Pain Scale)

France
Pfizer

Completed

Safety And Tolerability Of Escalating Intravenous Doses Of PF-05231023 In Adult Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States
Sun Yat-sen University

Completed

Assessment of Hepatic Fibrosis by Shear Wave Elastography in Patients With Liver Malignancy: A Prospective Single-center Study

Hepatic Fibrosis | Liver Tumor
Genentech, Inc.

Completed

A Phase I Bioavailability and Pharmacokinetic Study of [14C]-Ipatasertib Single Oral and Intravenous Doses in Healthy Male Subjects

Healthy Volunteer

United States
Genentech, Inc.

Completed

A Study of the Safety and Pharmacokinetics of MINT1526A, Administered Intravenously As a Single Agent and in Combination With Bevacizumab to Patients With Advanced Solid Tumors

Solid Cancers

United States
Hoffmann-La Roche

Completed

A Safety, Tolerability, and Pharmacokinetics Study of Onartuzumab as Single Agent or in Combination With Sorafenib in Participants With Advanced Hepatocellular Carcinoma

Carcinoma, Hepatocellular

United States, Hong Kong, Taiwan, Singapore
University of Zurich

Withdrawn

Evaluation of Single-dose Pharmacokinetics of Intravenous Daptomycin in Patients With Thermal Injury

Burn Injury

Switzerland
Indivior Inc.

Completed

Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects

Hepatic Impairment | Hepatic Failure | Chronic Hepatitis C Infection With Hepatic Coma

United States
Tufts University

Completed

Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose

Dyslipidemia | Impaired Glucose Tolerance
Wockhardt
Clinartis

Completed

A Single-dose Study to Investigate the Pharmacokinetics of Intravenous FEP-TAZ in Patients With Renal Impairment

Renal Impairment

United States
OSE Immunotherapeutics

Completed

Safety, Tolerability, PK, PD, and Immunogenicity of Single and Multiple Ascending Intravenous Doses of FR104

Rheumatoid Arthritis | Complication of Transplant

Belgium
Acorda Therapeutics

Completed

A Double-Blind Pharmacokinetic Interaction Study Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure

Heart Failure

United States
Astellas Pharma Europe B.V.

Completed

First-in-human: Single Ascending Dose, Food Effect, Drug-drug Interaction, Multiple Ascending Dose, Proof of Pharmacology

Healthy Volunteers

United Kingdom, Germany
Minia University
Dr Wegdan Ali Abdelrahman; Dr Haidy Salah

Unknown

Role of the Single-shot Spinal Analgesia to Control Labour Pain

Labour Analgesia

Egypt
LG Life Sciences

Unknown

Study to Evaluate the Efficacy, Safety and PK of Intravenous Single Injection LC28-0126 Immediately Before PCI in STEMI Patients

ST-segment Elevation Myocardial Infarction

Korea, Republic of
Johane Allard
University of Alberta; Hamilton Health Sciences Corporation; St. Paul's Hospital... and other collaborators

Terminated

Fish Oil for Patients With Liver Disease Due to Parenteral Nutrition

Total Parenteral Nutrition-induced Cholestasis

Canada
LG Life Sciences

Completed

Phase 2 Study to Evaluate the Efficacy, Safety and PK of Intravenous Single Injection LC28-0126 Immediately Before PCI in STEMI Patients

ST-segment Elevation Myocardial Infarction

Korea, Republic of
The Cooper Health System

Unknown

TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD

PTSD

United States
Lpath, Inc.

Completed

A Phase 1a, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate Lpathomab in Healthy Volunteers

Healthy Subjects

United States
Cuda Anesthetics, LLC

Completed

Pilot Study of Bioequivalence of Cudafol(R) and Diprivan(R) Administered as Single Intravenous Doses in Healthy Subjects

Healthy Subjects
Sanofi

Completed

Study of SAR125844 Single Agent Administered as Slow Intravenous Infusion in Adult Patients With Advanced Malignant Solid Tumors (SARMET)

Malignant Solid Tumors

France, Spain, United States, Italy
Conatus Pharmaceuticals Inc.

Terminated

Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF

Liver Cirrhosis | Acute on Chronic Hepatic Failure | Acute Liver Failure | Acute Alcoholic Hepatitis

United States, United Kingdom
Janssen Research & Development, LLC

Completed

A Pharmacokinetic Study of Single-Dose Intravenous Ustekinumab Delivered in 2 Different Liquid in Vial Formulations

Healthy

United States
Naurex, Inc, an affiliate of Allergan plc

Completed

Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder

Major Depressive Disorder

United States
Curis, Inc.

Completed

A Phase Ib Expansion Study Investigating the Safety, Efficacy, and Pharmacokinetics of Intravenous CUDC-101 in Subjects With Advanced Head and Neck, Gastric, Breast, Liver and Non-small Cell Lung Cancer Tumors

Breast Cancer | Head and Neck Cancer | Gastric Cancer | Non-Small Cell Lung Cancer | Liver Cancer

United States
Yufang Shi
Soochow University

Suspended

Mesenchymal Stem Cells Treat Liver Cirrhosis

Liver Cirrhosis

China
The Leeds Teaching Hospitals NHS Trust

Unknown

Magnetic Resonance Imaging to Assess Changes in Meniscus Vascularity (MOVE)

Meniscus Tears
AstraZeneca

Completed

To Assess Safety, Tolerability and Pharmacodynamics of Intravenous MEDI8111 After Single Ascending Doses.

Healthy Subjects

United Kingdom
Radboud University Medical Center

Completed

Penetration of Cefazolin Into Hepatic Cysts (PENTAC)

Hepatic Cyst

Netherlands
Ain Shams University

Unknown

Safety, Tolerability and Efficacy of Single Dose Low Cost Minipool Intravenous Immunoglobulins in Moderately Severe Newly Diagnosed ITP

Newly Diagnosed Pediatric ITP

Egypt
Debiopharm International SA

Completed

Mass Balance Recovery and Metabolic Profile of 14C Debio 1450 Following Single Oral and Intravenous Doses in Healthy Male Subjects

Healthy

United Kingdom
Ospedale San Raffaele

Unknown

Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery

Liver Diseases | Liver Neoplasms | Secondary Malignant Neoplasm of Liver

Italy
Daiichi Sankyo, Inc.

Completed

A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS

Healthy

United Kingdom
Mylan Pharmaceuticals Inc
Mylan GmbH

Completed

Phase 1 Study of Trastuzumab Administered as a Single Intravenous Infusion

Healthy
Bristol-Myers Squibb

Completed

Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic Impairment

Hepatic Insufficiency

United States
UCB Celltech
Parexel

Completed

A First-In-Human Study With a Single Dose UCB7665 in Healthy Volunteers

Healthy

United Kingdom
F2G Biotech GmbH
Simbec Research

Completed

F901318 Single Ascending Dose Study in Healthy Male Volunteers

Invasive Aspergillosis

United Kingdom
Tesaro, Inc.

Completed

A Phase 1, 2-Part, Single Ascending Dose Assessment of the Safety, Tolerability, and Pharmacokinetics of Rolapitant Intravenous in Healthy Volunteers

Chemotherapy-induced Nausea and Vomiting

United States
Boehringer Ingelheim

Terminated

Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of Single Escalating Doses of BI 1034020 Administered Intravenously or Subcutaneously to Male Healthy Volunteers

Healthy

Germany
Bayer

Completed

Safety, Tolerability and Pharmacokinetics of Single Dose Intravenous Moxifloxacin in Pediatric Patients

Infections

United States
University Medicine Greifswald

Completed

Single Dose Administration of Ketamine 10, 20, 40 and 80 mg and 5 mg Solution for Infusion in 15 Healthy Subjects

Healthy

Germany
Copenhagen University Hospital at Herlev

Unknown

Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl-sedation for Flexible Bronchoscopy: A Randomized, Single Blind, Controlled Study of Satisfaction and Safety.

Sedation | Satisfaction | Safety | Flexible Bronchoscopy

Denmark
Ludwig Institute for Cancer Research
Johns Hopkins University

Withdrawn

Single Dose of Intravenous rhTNF-α and Liposomal Doxorubicin in Patients With Advanced Solid Tumors or Lymphomas

Solid Tumors | Lymphomas

Germany
Concert Pharmaceuticals

Completed

A Phase 1, Single Dose Study of JZP-386 to Evaluate Safety, Pharmacokinetics and Pharmacodynamics

Narcolepsy, Excessive Daytime Sleepiness

United Kingdom
University of Michigan Rogel Cancer Center

Completed

A Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary Single Photon Emission Tomography (SPECT)

Hepatocellular Carcinoma

United States

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