Search clinical trials for: Peripheral serotonin

Total 45094 results

Instituto Brasileiro de Controle do Cancer

Completed

Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer (OLNEPA)

Nausea Post Chemotherapy

Brazil
Otsuka Pharmaceutical Development & Commercialization...

Completed

A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects

Drug-drug Interaction

Australia
Organon and Co

Completed

Efficacy and Safety of Asenapine Using an Active Control in Subjects With Schizophrenia or Schizoaffective Disorder (25520)(P05846) (ACTAMESA)

Schizophrenia | Schizoaffective Disorder
Kristian Kjær Petersen
Aalborg University Hospital; CCBR, Aalborg

Completed

A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain

Osteoarthritis, Knee

Denmark
Organon and Co

Completed

Long-Term Efficacy and Safety of Asenapine Using Olanzapine as a Positive Control (41512)(COMPLETED)(P05784)

Schizophrenia
Alberta Children's Hospital

Completed

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Pain, Postoperative | Testicle Undescended

Canada
Organon and Co

Completed

Efficacy and Safety of Asenapine With Placebo and Olanzapine (41021)(P05933)

Schizophrenia
Organon and Co

Completed

Efficacy and Safety of Asenapine Using an Active Control in Subjects With Schizophrenia or Schizoaffective Disorder (25517)(P05935)

Schizophrenia | Schizoaffective Disorder
Organon and Co

Completed

Efficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (25543)(COMPLETED)(P05817)

Schizophrenia
The University of Texas Health Science Center at...

Terminated

Reducing the Abuse of Opioids in Drug Users

Opioid Dependence | Opioid Abuse, Unspecified

United States
Organon and Co

Completed

Efficacy and Safety of Asenapine With Placebo and Olanzapine (41022)(P05947)

Schizophrenia
Indiana University
Kyowa Kirin, Inc.

Withdrawn

Open Label Transdermal Granisetron to Relieve Chronic Nausea and Emesis

Gastroparesis

United States
Organon and Co

Completed

6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777)

Schizophrenia
Organon and Co
Pfizer

Completed

40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857)

Bipolar Disorder
Organon and Co

Completed

6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772)

Schizophrenia
Solasia Pharma K.K.

Completed

Bioequivalence Study in Healthy Chinese Subjects Comparing SP-01 (Granisetron Patch) Manufactured at Two Different Sites

Healthy Volunteers

Hong Kong
Organon and Co

Completed

Efficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (A7501013)(COMPLETED)(P05771)

Schizophrenia
Organon and Co
Pfizer

Completed

9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED)

Bipolar Disorder
Organon and Co
Pfizer

Completed

3-Week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07008)

Bipolar Disorder
Organon and Co

Completed

An Observational Drug Utilization Study of Asenapine in the United Kingdom (P08308)

Bipolar Disorder
Organon and Co
Pfizer

Completed

3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)

Bipolar Disorder
Rajavithi Hospital

Completed

Olanzapine for Chemotherapy-induced Nausea and Vomiting Prophylaxis (OLN-EME)

Complete Response Rate to Chemotherapy-induced Nausea and Vomiting Prophylaxis

Thailand
University of Maryland, Baltimore
University of Pennsylvania

Completed

Pharmacogenetic Study of Ondansetron in Alcohol Use Disorder

Alcohol Use Disorder

United States
Instituto do Cancer do Estado de São Paulo

Completed

Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients

Postoperative Nausea and Vomiting | Postoperative Nausea

Brazil
HealthPartners Institute

Completed

Olanzapine for Acute Headaches (Olanzapine)

Headache

United States
Northwestern University

Withdrawn

Enhanced Recovery Pathway for Endoscopy

Endoscopy | Enhanced Recovery Pathway

United States
Roswell Park Cancer Institute

Completed

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 | Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Completed

Study of Desvenlafaxine in Treating Major Depressive Disorder.

Major Depressive Disorder

China
Janssen Scientific Affairs, LLC

Completed

A Study to Compare Disease Progression and Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics in Participant's With Recent-onset Schizophrenia or Schizophreniform (DREaM)

Psychotic Disorders | Schizophrenia

United States, Brazil, Mexico
Hospital Clinic of Barcelona

Completed

Risk Factors for AD-Associated Switch to Mania

Bipolar Disorder

Spain
Ostfold Hospital Trust

Completed

Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair

Pain, Postoperative | Inguinal Hernia

Norway
Joint Stock Company "Farmak"

Completed

Fasted Bioequivalence Study of 2 Olanzapine Film-coated Tablets, 5 mg, in Healthy, Adult Male and Female Subjects.

Pharmacokinetics

Czechia
University of Virginia
National Institute on Drug Abuse (NIDA)

Completed

New Medication Treatment for Stimulant Dependence

Cocaine Dependence

United States
Xijing Hospital
Xi'an Central Hospital; First Affiliated Hospital Xi'an Jiaotong University; Tang-Du... and other collaborators

Terminated

Optimizing Early Enteral Nutrition in Severe Stroke (OPENS)

Dysphagia | Acute Stroke | Severe Stroke

China
National Institute of Allergy and Infectious Diseases...

Terminated

Combination Pain Therapy in HIV Neuropathy

HIV Infections | Peripheral Neuropathy

United States
Seattle Children's Hospital
Seattle Children's Research Institute Center for Clinical and Translational...

Terminated

Post Operative Pain Control After Pediatric Hip Surgery

Hip Surgery | Post Operative Pain Control
University of Saskatchewan

Completed

Postoperative Vomiting in Children - Is Dextrose an Effective Prophylactic Anti-emetic? (DEXPO)

Postoperative Vomiting

Canada
Shahid Beheshti University of Medical Sciences

Completed

Effects of Ondansetron, Metoclopramide and Granisetron on Perioperative Nausea and Vomiting in Patients Undergone Bariatric Surgery (PONV)

Nausea | Drug Effect | Bariatric Surgery Candidate | Vomiting, Postoperative | Perioperative Complication

Iran, Islamic Republic of
King Khaled Eye Specialist Hospital

Completed

Late Onset Postoperative Nausea and Vomiting

Postoperative Nausea and Vomiting

Saudi Arabia
Assiut University

Completed

Duloxetine Role in Reducing Opioid Consumption After Thoracotomy

Post-thoracotomy Pain

Egypt
The George Institute
National Health and Medical Research Council, Australia; Takeda; Conselho Nacional... and other collaborators

Completed

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) (ENCHANTED)

Ischemic Stroke | High Blood Pressure

Australia
Tehsil Headquarter Hospital

Completed

Ondansetron Versus Domperidone for Treating Vomiting in Acute Gastroenteritis in Children

Acute Gastroenteritis | Vomiting in Infants and/or Children

Pakistan
Florida Gulf Coast University

Completed

Adjunctive Treatment of Major Depression Utilizing Auricular Acupuncture

Major Depressive Disorder

United States
Alkermes, Inc.

Completed

A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder

Schizophrenia | Alcohol Use Disorder

United States, Bulgaria, Poland
University of Ottawa
Allergan

Active, not recruiting

Levomilnacipran in Healthy Males

None (i.e. Healthy Volunteers)

Canada
Alkermes, Inc.

Completed

A Study of ALKS 3831 in Adults With Schizophrenia

Schizophrenia

United States, Bulgaria, Czechia
University of Ulm
Anticancer Fund, Belgium; Reliable Cancer Therapies

Completed

A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

Glioblastoma

Germany
New York State Psychiatric Institute
National Institute on Aging (NIA)

Completed

Treating Hearing Loss to Improve Mood and Cognition in Older Adults

Depression | Hearing Loss

United States
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression (TRANSFORM-3)

Depressive Disorder, Treatment-Resistant

United States, France, Belgium, Spain, Poland, Bulgaria, South Africa, Finland, Brazil, Sweden, United Kingdom, Lithuania
Stanford University

Completed

Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

Breast - Female

United States

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