Search clinical trials for: Phosphodiesterase inhibitors

Total 64444 results

University of Castilla-La Mancha

Completed

Effects Of Caffeine On Cognitive Performance

Caffeine

Spain
Children's National Research Institute
Boston University; Eunice Kennedy Shriver National Institute of Child Health... and other collaborators

Completed

Intermittent Hypoxia and Caffeine in Infants Born Preterm (ICAF)

Intermittent Hypoxia

United States
Boehringer Ingelheim

Terminated

A Study in Healthy People to Compare 3 Different Formulations of Apremilast Tablets Taken With or Without Food

Healthy

Germany
Tanta University

Completed

Aminophylline on Recovery in Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia

Dexmedetomidine | Functional Endoscopic Sinus Surgery | Aminophylline

Egypt
Bristol-Myers Squibb

Completed

A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2)

Healthy Participants

United States
University of Nebraska

Withdrawn

Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm

Subarachnoid Hemorrhage | Cerebral Vasospasm

United States
Boehringer Ingelheim

Completed

A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the Blood

Healthy

Germany
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer

Recurrent Ovarian Cancer

China
University of Oregon

Completed

Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

Patent Foramen Ovale | Intrapulmonary Arteriovenous Anastamosis

United States
Universidad Francisco de Vitoria

Completed

Genetics in the Effect of Caffeine on Fat Oxidation

Genetic Predisposition | Caffeine | Fat Burn

Spain
Ipekyolu Ilac Ltd. Sti
Istanbul University - Cerrahpasa (IUC)

Completed

Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers

Behçet Disease Affecting Oral Mucosa

Turkey
Cyprus International University

Completed

Effects of Caffeine on Upper Extremity Performance

Caffeine | Sportive Performance

Turkey
Université de Sherbrooke

Completed

Ketone Production With Acute Caffeine Intake

Healthy Adults

Canada
Ain Shams University
Misr University for Science and Technology

Completed

Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate

Polycystic Ovary Syndrome | Clomiphene Citrate | Resistant Ovary Syndrome

Egypt
Mansoura University

Active, not recruiting

Efficacy of Tadalafil (5mg) For Treatment of Early Storage Symptoms and Erectile Dysfunction After Endoscopic Enucleation of Prostate

Lower Urinary Tract Symptoms | Erectile Dysfunction

Egypt
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Pentoxifylline Versus Cilostazol

Peripheral Artery Disease

United States
Stanford University

Suspended

Cognitive Effects of Vinpocetine in Healthy Adults and Patients With Epilepsy

Epilepsy

United States
National Cancer Institute (NCI)

Completed

Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic Cancers

Metastatic Colorectal Cancer | Hepatocellular Carcinoma | Hepatocellular Cancer | Metastatic Pancreatic Cancer | Liver Metastasis

United States
Jinnah Postgraduate Medical Centre

Completed

Efficacy of Oral Apremilast in the Treatment of Alopecia Areata at the Tertiary Care Hospital, Karachi.

Alopecia Areata

Pakistan
Tanta University

Completed

Aminophylline Infusion on Pain Intensity After Ureterocopic Lithotripsy

Pain | Aminophylline | Ureterocopic Lithotripsy

Egypt
University of New Mexico

Withdrawn

Evaluation of Sildenafil for the Treatment of Moderate Congestive Heart Failure

Heart Failure

United States
Taipei Medical University Hospital

Enrolling by invitation

Evaluate the Effect and Safety of Pu Yang Wan Wu Tang and Western Medicine on Chronic Kidney Disease

Chronic Kidney Diseases

Taiwan
Insel Gruppe AG, University Hospital Bern
Swiss National Science Foundation

Completed

Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function (SERVE)

Heart Defects, Congenital | Transposition of Great Vessels With Ventricular Inversion

Switzerland, Austria
Eastern Cooperative Oncology Group
National Cancer Institute (NCI); North Central Cancer Treatment Group

Completed

Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia

Leukemia

United States, South Africa, Puerto Rico
University of Texas at Austin

Completed

Examining Caffeine as a Treatment for Antidepressant-induced Arousal Dysfunction in Women

Female Sexual Arousal Disorder

United States
Washington University School of Medicine

Completed

Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma

Astrocytoma, Grade III | Astrocytoma, Grade IV | Grade IV Astrocytoma | Grade III Astrocytoma

United States
National Taiwan Sport University

Completed

Carbohydrate Rinsing and Caffeine Gum on Performance of Romanian Deadlifts Performance

Caffeine | Carbohydrate

Taiwan
zr Pharma & GmbH

Completed

Pharmacokinetic Drug-Drug Interaction Study of Rucaparib (DDI)

Neoplasms

Poland
Pfizer
Pierre Fabre Laboratories

Active, not recruiting

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Advanced Solid Tumors | Metastatic Melanoma

United States, Spain, Belgium, Canada, Netherlands
University of Zurich

Completed

Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil (HEXASH)

Hypertension, Pulmonary

Switzerland
University of Zurich

Completed

Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension (HEXABM)

Hypertension, Pulmonary

Switzerland
University of Zurich

Completed

Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension With/Without Sildenafil (HEXAS)

Hypertension, Pulmonary

Switzerland
University of Zurich

Completed

Hemodynamic Effects During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil (HEXASN)

Hypertension, Pulmonary

Switzerland
Amgen

Completed

A Phase 4 Study of Efficacy and Safety of Apremilast in Subjects With Moderate Plaque Psoriasis. (UNVEIL)

Parapsoriasis

United States
Vicore Pharma AB

Completed

A Trial to Evaluate the Impact of C21 on the Exposure of 4 Substrates in Healthy Volunteers

Drug Interaction

Sweden
MediciNova

Active, not recruiting

Efficacy, Safety, Tolerability, and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS

Pneumonia, Viral

United States
Universidad Francisco de Vitoria
Universidad de Granada; Universidad Rey Juan Carlos; Camilo Jose Cela University

Completed

Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women (CIRCAF_WOM)

Dietary Supplement

Spain
Beni-Suef University

Completed

Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness

Infertility, Female

Egypt
University of California, San Diego
Celgene; The Organization of Teratology Information Specialists

Active, not recruiting

Apremilast Pregnancy Exposure Registry

Psoriasis | Psoriatic Arthritis

United States
Universidad de Zaragoza

Completed

The Effects of Caffeine on Physical Performance of Ice Hockey Players (cafhoc)

Athletic Performance | Caffeine

Spain
Washington University School of Medicine

Completed

Smell in Covid-19 and Efficacy of Nasal Theophylline (SCENT2)

Covid19 | Anosmia | SARS-CoV-2 Infection | Olfactory Disorder | Ageusia | Covid-19 Pandemic | Hyposmia | Hypogeusia

United States
Escola Superior de Tecnologia da Saúde de Coimbra

Completed

Effects of Caffeine on Cerebral Blood Flow

Cardiovascular System

Portugal
University of Chicago

Withdrawn

Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely Reversed

Emergence From Anesthesia

United States
Andrea M. Isidori

Completed

Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs (ERGO)

Cushing's Syndrome Cardiomyopathy

Italy
University Hospital, Montpellier

Withdrawn

Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease (VU-INHIB)

Pulmonary Hypertension | Single-ventricle | Univentricular Heart
University of California, Los Angeles
National Institute on Drug Abuse (NIDA); MediciNova

Completed

Safety Interaction Trial Ibudilast and Methamphetamine

Methamphetamine-dependence | Substance Abuse

United States
Andrea M. Isidori

Completed

Endocrine Cardiomyopathy: Response to Cyclic GMP PDE5 Inhibitors in Acromegaly Cardiomyopathy (SUM)

Acromegaly Cardiomyopathy

Italy
University of Illinois at Chicago
Oregon State University

Completed

Licorice Botanical Dietary Supplements - Metabolism and Safety in Women

Food-drug Interaction

United States
Beni-Suef University

Completed

Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility

Subfertility, Female

Egypt
Enanta Pharmaceuticals, Inc

Completed

Drug-Drug Interaction Study Between EDP-235, Midazolam, Caffeine and Rosuvastatin in Healthy Subjects

COVID-19

United States

Search clinical trials for: Phosphodiesterase inhibitors

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