Search clinical trials for: Safety and Tolerability Study

Total 480403 results

Peking University People's Hospital
CASI Pharmaceuticals, Inc.

Recruiting

Clinical Study of Safety and Tolerability of Melphalan Hydrochloride for R/R MM

Multiple Myeloma

China
Ark Biosciences Inc.
Shanghai Ark Biopharmaceutical Co., Ltd.

Not yet recruiting

A Study to Evaluate the Safety, Tolerability and Efficacy of AK3280 Cream on Hypertrophic Scar

Hypertrophic Scar

China
BioNTech SE

Recruiting

A Clinical Trial in Healthy Volunteers to Study the Safety, Tolerability, and Immune Responses After Vaccination With an Investigational Vaccine Designed to Prevent Genital Herpes Lesions

Genital Herpes Simplex Type 2

United States
Novartis Pharmaceuticals

Recruiting

Study of Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With an Allergy to Peanuts

Allergy, Peanut

United States, Spain
Eleusis Therapeutics
Beckley Psytech Pty Ltd

Recruiting

ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression

Depression | Healthy Volunteers | Major Depressive Disorder

United Kingdom
Drugs for Neglected Diseases

Recruiting

Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients (OXA005)

Trypanosomiasis, African | Sleeping Sickness | Trypanosoma Brucei Gambiense; Infection

Congo, The Democratic Republic of the
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

First-in-Human Study to Investigate the Safety and Tolerability and Pharmacokinetics of HS-10383

Cough

China
Faron Pharmaceuticals Ltd

Recruiting

A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies (BEXMAB)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia | Relapsed/Refractory AML

United States, Finland
GC Biopharma Corp

Recruiting

A Study to Evaluate the Safety, Tolerability, PK and PD of Intracerebroventricular GC1123 in Patients With MPS Ⅱ

Mucopolysaccharidosis II | Hunter Syndrome

Korea, Republic of
ViiV Healthcare

Recruiting

A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants

HIV Infections

United States
GlaxoSmithKline
Affinivax, Inc.

Recruiting

A Phase 2 Study to Evaluate the Safety, Tolerability, and Immunogenicity of AFX3772 Vaccine in Healthy Infants

Pneumococcal Infections | Pneumonia, Pneumococcal | Pneumonia, Bacterial

United States, Puerto Rico
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Recruiting

A Study of TQH2722 Injection to Evaluate the Safety, Tolerability, Pharmacokinetics, Efficacy and Immunogenicity in Healthy Adult Subjects

Atopic Dermatitis

China
Hanmi Pharmaceutical Company Limited

Not yet recruiting

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HCP1904 in Healthy Male Volunteers.

Healthy

Korea, Republic of
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

A Study of the Safety, Tolerability, and Pharmacokinetics of Dolutegravir in Neonates Exposed to HIV-1

HIV

United States, Brazil, Puerto Rico, South Africa, Thailand
J Ints Bio

Recruiting

A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC

EGFR Mutant Advanced Non-small Cell Lung Cancer

Korea, Republic of, United States, Thailand
Regeneron Pharmaceuticals

Recruiting

A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP) (OPTIMA)

Fibrodysplasia Ossificans Progressiva

Japan, United States, Korea, Republic of, Spain, France, Australia, United Kingdom, China, Poland, Malaysia, Italy, Finland, Hong Kong, South Africa, Chile, Brazil, Netherlands, Colombia
Shanghai Henlius Biotech

Recruiting

A Study Evaluating the Safety, Tolerability, Pharmacokinetic and Efficacy of HLX301(TIGIT×PDL1 Bispecific) in Locally Advanced/Metastatic Solid Tumors or Lymphoma (HLX301)

Lymphoma | Advanced Tumors | Metastatic Tumors

China
Angion Biomedica Corp

Not yet recruiting

Study to Assess the Safety and Tolerability of ANG-3070 in Subjects With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF)
Ashvattha Therapeutics, Inc.

Recruiting

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in Subjects With Neovascular (Wet) Age-Related Macular Degeneration (AMD) or Subjects With Diabetic Macular Edema (DME) (Tejas)

Diabetic Macular Edema | Neovascular Age-related Macular Degeneration

United States
Zhejiang Doer Biologics Co., Ltd.

Recruiting

A First in Human (FIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DR10624

Healthy, Obesity, Metabolically

New Zealand
Washington University School of Medicine
Wugen, Inc.

Recruiting

Dose-Escalation and Dose-Expansion Study to Evaluate the Safety and Tolerability of Anti-CD7 Allogeneic CAR T-Cells (WU-CART-007) in Patients With CD7+ Hematologic Malignancies

Acute Myeloid Leukemia | Sezary Syndrome | Anaplastic Large Cell Lymphoma | Angioimmunoblastic T-cell Lymphoma | Adult T Cell Leukemia | Adult T Cell Lymphoma | Hepatosplenic T-cell Lymphoma | Peripheral T Cell Lymphoma | Extranodal NK/T-cell Lymphoma | Enteropathy-Associated T-Cell Lymphoma | T-Cell Non-Hodgkin... and other conditions

United States
Yabao Pharmaceutical Group

Not yet recruiting

A Phase Ia Clinical Study to Evaluate the Safety, Tolerability, PK and Immunogenicity of YBSW015 in Healthy Subjects

Coronavirus Disease 2019
Astellas Pharma Global Development, Inc.

Recruiting

A Study of ASP2138 in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, Pancreatic Cancer

Pancreatic Adenocarcinoma | Gastric Adenocarcinoma | Gastroesophageal Junction (GEJ) Adenocarcinoma

United States, Japan, Korea, Republic of
Sage Therapeutics

Recruiting

A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor

Essential Tremor

United States
Xfibra, Inc.

Not yet recruiting

A First-in-human Study of the Safety, Tolerability, and PK of XFB-19 in Healthy Adult Volunteers

Idiopathic Pulmonary Fibrosis (IPF)
Mustang Bio
National Cancer Institute (NCI)

Recruiting

Study to Assess Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory B-Cell NHL or CLL

Mantle Cell Lymphoma Recurrent | Mantle Cell Lymphoma Refractory | Small Lymphocytic Lymphoma, Relapsed | Waldenstrom's Macroglobulinemia Recurrent | Follicular B-cell Non-Hodgkin's Lymphoma | B-cell Lymphoma Refractory | Waldenstrom's Macroglobulinemia Refractory | Chronic Lymphoid Leukemia in Relapse

United States
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

A Phase I Single- and Multiple- Ascending Dose and Food Effect Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-7535 in Healthy Subjects

Healthy Subjects
Betta Pharmaceuticals Co., Ltd.

Recruiting

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of BPI-21668

Advanced Solid Tumor

China
Aptissen SA
Azidus Brasil

Recruiting

A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee

Osteoarthritis | Osteoarthritis, Knee

Brazil
McGill University Health Centre/Research Institute...

Recruiting

Tolerability and Safety of Nintedanib in Myositis Associated Interstitial Lung Disease: a Pilot Study

Interstitial Lung Disease | Myopathy, Inflammatory

Canada
Genor Biopharma Co., Ltd.

Recruiting

A Safety, Tolerability, PK and Preliminary Activity Study of GB263T in Advanced NSCLC and Other Solid Tumor

NSCLC | Other Solid Tumors

Australia
Beijing Suncadia Pharmaceuticals Co., Ltd

Not yet recruiting

Single Ascending Dose and Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-1816 in Healthy Subjects

Diabetes
RetroLead (Shanghai) BioPharma Co., Ltd.

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral HRS5685 in Healthy Subjects

Human Immunodeficiency Virus-1 (HIV-1) Infection
Alzinova AB
CRST Oy

Recruiting

A Study on the Safety, Tolerability and Immunogenicity of ALZ-101 in Participants With Early Alzheimer's Disease

Alzheimer Disease | Dementia Alzheimers | Dementia, Mild

Finland
Xuanzhu Biopharmaceutical Co., Ltd.

Not yet recruiting

A Study of KM257 in Patients With Advanced HER2-positive or Expressing Solid Tumors.

Advanced Solid Tumor

China
Takeda
Takeda Development Center Americas, Inc.

Recruiting

A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Children and Teenage Transplant Recipients With CMV Infection

Cytomegalovirus (CMV)

France, United Kingdom, Israel, Germany, Spain, Belgium, Australia, Brazil, China, Japan, United States
Gliknik Inc.

Recruiting

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

First in Man Study to Evaluate Initial Safety

United Kingdom
Jiangsu Aosaikang Pharmaceutical Co., Ltd.

Recruiting

Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of ASKC202

Advanced Solid Tumor

China
Gannex Pharma Co., Ltd.
Ascletis Pharmaceuticals Co., Ltd.

Recruiting

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC61in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

United States
Kiora Pharmaceuticals, Inc.

Recruiting

A Phase I/II Dose-escalating Study of the Safety, Tolerability and Efficacy of KIO-301 Administered Intravitreally to Patients With Retinitis Pigmentosa and Choroideremia (ABACUS) (ABACUS)

Retinitis Pigmentosa | Choroideremia

Australia
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Recruiting

A Safety and Tolerability Study of Jaktinib

Myelofibrosis

United States
Vir Biotechnology, Inc.
GlaxoSmithKline

Recruiting

Relative Bioavailability, Safety, and Tolerability of Single-dose Sotrovimab Injection in Adults (COSMIC) (COSMIC)

Covid19

United States
Chengdu Easton Biopharmaceuticals Co,Ltd

Recruiting

a Safety and Tolerability Study of EP-9001A in Healthy Volunteers

Healthy Volunteers

China
TransThera Sciences (Nanjing), Inc.

Recruiting

Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

B-Cell Malignancies

United States
Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.

Recruiting

A Study Evaluating Safety, Tolerability and Clinical Activity of FHND6091 in Patients With Multiple Myeloma

Multiple Myeloma

China
Nanjing Zenshine Pharmaceuticals

Recruiting

A Study to Evaluate Activity, Safety and Tolerability of ZX-101A in Relapsed/Refractory Hematological Malignancies

Non Hodgkin Lymphoma | Peripheral T Cell Lymphoma | CLL/SLL

China
Zhejiang Haichang Biotech Co., Ltd.

Recruiting

A Phase I First in Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of WGI-0301 in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Nanjing Zenshine Pharmaceuticals

Not yet recruiting

A Study to Evaluate the Activity, Safety and Tolerability of ZX-101A in Advanced Solid Tumors

Advanced Solid Tumor

China
Onconic Therapeutics Inc.

Not yet recruiting

Study to Assess the Safety, Tolerability of JPI-547 in Combination With Modified FOLFIRINOX or Gemcitabine-nab-paclitaxel in Patients With Locally Advanced and Metastatic Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of Relatlimab Plus Nivolumab in Pediatric and Young Adults With Hodgkin and Non-Hodgkin Lymphoma (RELATIVITY-069)

Lymphoma, Non-Hodgkin | Hodgkin Disease

United States, France, Netherlands, Australia, United Kingdom, Italy, Spain, Germany

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