Search clinical trials for: multiple ascending dose healthy volunteers

Total 56290 results

Hoffmann-La Roche

Completed

A Double-Blind Single-Ascending Dose (SAD) and Multiple-Ascending Dose (MAD) Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7049389 in Healthy Chinese Participants

Hepatitis B Virus

China
Hoffmann-La Roche

Completed

A Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Doses of Balovaptan in Healthy Volunteers

Healthy Volunteers

Netherlands
Alkermes, Inc.
QPS Netherlands B.V.

Completed

Single and Multiple Ascending Dose and Food Effect PK Study in Healthy Adult and Elderly Subjects

Healthy

Netherlands
Xi'an Xintong Pharmaceutical Research Co.,Ltd.

Unknown

A Study to Investigate the Safety, Tolerability, Pharmacokinetics of Single and Multiple Doses of Hepenofovir Fumarate Tablets in Healthy Volunteers.

Chronic Hepatitis b
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Completed

Safety of Single Intravenous Administration of S95010 in Human Healthy Volunteers

Cardiovascular Diseases

Belgium
Acanthas Pharma Inc

Withdrawn

A Study of Single Ascending Doses of STAR-101 in Healthy Participants

Healthy Volunteers
Midas Pharma GmbH

Completed

Drug-drug-interaction Study of Ramipril, Amlodipine and Atorvastatin

Healthy Volunteers

Jordan
Midas Pharma GmbH

Completed

Drug-drug-interaction Study of Candesartan, Amlodipine and Atorvastatin

Healthy Volunteers

Jordan
Gabather AB
Smerud Medical Research International AS

Completed

Study of Ascending Single Oral Dose of GT-002 in Healthy Volunteers (GAB-001)

Safety and Tolerability

Finland
Cytokinetics

Completed

A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects

Healthy Subjects | Symptomatic Obstructive Hypertrophic Cardiomyopathy

United States
Janssen BioPharma, Inc.

Completed

A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses, and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants

Healthy

United Kingdom
Bristol-Myers Squibb

Withdrawn

A Single and Multiple Ascending Dose Study of BMS-986318 in Healthy Participants

Healthy Participants

United States
Pfizer

Completed

Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants

Healthy Volunteers | Adult | Drug Interactions | Humans

Belgium
Spero Therapeutics
Clinical Network Services (CNS) Pty Ltd

Completed

A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers

Healthy Volunteers

Australia
Biogen

Completed

Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Single Doses Of PF-04958242 In Healthy Volunteers

Healthy

United States
Biocodex

Completed

Pharmacokinetic Study of Stiripentol and Its Metabolites After Multiple Dose Oral Administration in Healthy Male Volunteers

Healthy Volunteers

Belgium
Merck KGaA, Darmstadt, Germany

Completed

Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of M5049 in Healthy Participants

Healthy

Germany
Heptares Therapeutics Limited
Allergan

Completed

A Two Part Study to Assess Safety, PK, PD, and Food Effect of Oral HTL0016878

Healthy

United Kingdom
Boehringer Ingelheim

Completed

BI 443651 Multiple Rising Dose in Healthy Volunteers Followed by a Cross-over in CF Subjects

Cystic Fibrosis

Germany, United Kingdom
Biogen

Completed

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Repeated Doses of PF-04958242 in Healthy Volunteers

Schizophrenia

United States
Celgene

Completed

A Multiple-ascending-dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Pomalidomide (CC-4047) in Healthy Male Subjects

Healthy

United States
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers

Healthy Volunteers

Netherlands
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunteers

Healthy Volunteers

Netherlands
Agios Pharmaceuticals, Inc.

Completed

Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants

Healthy Volunteers

United States
Emerald Health Pharmaceuticals

Completed

To Evaluate the Safety and Tolerability, Pharmacokinetics, Food-effect and Pharmacodynamics of EHP-101 in Healthy Volunteers

Healthy

Australia
Alios Biopharma Inc.

Completed

First in Human Study of AL-335; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1

Chronic Hepatitis C

France, Moldova, Republic of, Georgia
Momenta Pharmaceuticals, Inc.

Completed

An Ascending Dose Study to Evaluate M281 Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD)

Healthy Volunteers

Netherlands
Intas Pharmaceuticals, Ltd.
Lambda Therapeutic Research Ltd.

Completed

Comparative Immunogenicity Study of Multiple Doses of Proposed Pegfilgrastim Biosimilar, INTP5 of Intas Pharmaceuticals Ltd., India Against Neulasta of Amgen Inc., USA in Healthy, Adult Human Subjects.

Healthy Volunteers | Immunogenicity

India
Guangzhou Henovcom Bioscience Co. Ltd.

Completed

A Study of HNC042 in Healthy Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics.

Healthy

United States
Global Alliance for TB Drug Development

Terminated

A Multiple Ascending Dose Study With a Dose Formulation Comparison Cohort to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects

Tuberculosis
HK inno.N Corporation

Completed

Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers

Healthy

Korea, Republic of
UCB Biopharma S.P.R.L.

Completed

A First-In-Human Study With a Single Ascending Dose of UCB7858 in Healthy Volunteers

Healthy Volunteers

United Kingdom
NGM Biopharmaceuticals, Inc

Completed

Single and Multiple Ascending Dose Study of NGM120 in Healthy Adult Subjects

Cachexia

Australia
Proclara Biosciences, Inc.

Terminated

Multiple Ascending Dose Study in Healthy Subjects

Amyloidosis

Netherlands
Metabolic Technologies Inc.
National Institute on Aging (NIA); Vanderbilt University

Completed

2-HOBA: Multiple Dosing Study in Healthy Humans (2-HOBA)

Healthy Volunteers

United States
Corcept Therapeutics

Completed

CORT125134 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)

Healthy

United Kingdom
Pfizer

Completed

A Single Dose Study Of PF-05161704 In Healthy Volunteers

Diabetes Mellitus, Type 2

United States
Takeda

Terminated

A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of TAK-828 Escalating Multiple-Doses in Healthy Participants

Healthy Volunteers

United States
Medicines for Malaria Venture
University of Cape Town

Completed

Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers

Malaria

South Africa
GlaxoSmithKline

Completed

First Time in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of GSK3389404 in Healthy Subjects

Hepatitis B

United Kingdom
Janssen Sciences Ireland UC

Completed

A Study of Orally Administered JNJ-56136379 to Evaluate Safety, Tolerability and Pharmacokinetics After Single Ascending Doses and One Multiple Dose Regimen in Healthy Participants (Part I), and After Multiple Dose Regimens in Participants With Chronic Hepatitis B (Part II)

Healthy | Hepatitis, Chronic

France, Taiwan, Spain, Belgium, Bulgaria, Malaysia, Romania, Germany, Georgia, Moldova, Republic of
Eli Lilly and Company

Terminated

A Multiple-dose Study of LY3031207 in Healthy Participants

Healthy Volunteers

United States
Pfizer

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects

Healthy Volunteers

United States
AstraZeneca
Parexel

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Japanese Healthy Participants With Single and Multiple Ascending Dose Administration

Heart Failure

United Kingdom
Wockhardt

Completed

The Safety, Tolerability And Pharmacokinetics Of Single Ascending Doses And The Effect Of Food On Oral WCK 4873 In Healthy Adult Volunteers

Healthy
Astellas Pharma Inc

Completed

ASP8302 Single and Multiple Ascending Oral Dose Study in Non-elderly Healthy Japanese Subjects

Healthy Subjects

Japan
Mirum Pharmaceuticals, Inc.

Completed

Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion

Healthy Volunteers

United States
Esperion Therapeutics, Inc.

Completed

A Multiple Ascending Dose Study of ETC-1002 in Healthy Subjects

Safety Evaluation of Escalating Doses

United States
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects

Cardiovascular Disease | Healthy Male Subjects

United Kingdom
Vivozon, Inc.

Completed

A Single Ascending Dose Escalation to Investigate Safety and PK of VVZ-149 Injection in Healthy Older Male Volunteers

Healthy

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