Search clinical trials for: open label

Total 9430 results

ProQR Therapeutics

Recruiting

An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. (BRIGHTEN)

Eye Diseases | Neurologic Manifestations | Retinal Degeneration | Retinal Dystrophies | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

Belgium, Brazil, Canada, Germany, Italy, Netherlands, United Kingdom
Sun Yat-sen University

Recruiting

A Multi-center, Non-randomized, Open-label Phase II Clinical Study on the Treatment of Newly Diagnosed Advanced Hodgkin's Lymphoma With PD-1 Antibody (Tislelizumab) Combined With AVD Regimen (Doxorubicin, Vindesine, Dacarbazine) Under the Guidance of PET/CT

Hodgkin Lymphoma | Chemotherapy Effect

China
Turku University Hospital

Recruiting

Open-Label Prospective Study Comparing Long-Term Outcome With or Without HFNC in Patients With Stable Hypercapnic COPD (MyAirvo)

COPD

Finland
University of Saskatchewan
Saskatoon City Hospital

Recruiting

Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?

Carpal Tunnel Syndrome

Canada
GB002, Inc., a wholly owned subsidiary of Gossamer...

Recruiting

Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

United States, Australia, Spain, Czechia, France, Germany, United Kingdom, Belgium
Charite University, Berlin, Germany
Janssen-Cilag G.m.b.H; Labor Berlin-Charité Vivantes G.m.b.H; Deutsches Rheuma-Forschungszentrum... and other collaborators

Not yet recruiting

An Open Label Study to Evaluate Daratumumab in Participants With Moderate to Severe Systemic Lupus Erythematosus (DARALUP)

Systemic Lupus Erythematosus
Immutep S.A.S.
Merck Sharp & Dohme LLC

Recruiting

Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC (TACTI-003)

HNSCC

United States, Belgium, Spain, United Kingdom, Denmark, Germany, Australia, Romania, Ukraine
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Trametinib Combined With Everolimus and Lenvatinib for Recurrent/Refractory Advanced Solid Tumors

Hepatocellular Carcinoma | Solid Tumor, Adult

China
National Institute of Neurological Disorders and...

Recruiting

Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

HAM/TSP

United States
Novartis Pharmaceuticals

Recruiting

Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS (STHENOS)

Multiple Sclerosis

Germany, Spain, Italy, France, United Kingdom
Universitair Ziekenhuis Brussel

Recruiting

Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot Study

Depressive Disorder, Treatment-Resistant | Old Age

Belgium
Fidia Farmaceutici s.p.a.

Recruiting

An Open Label, Randomized-controlled Trial to Assess Efficacy Safety of HYALODISC With Physical Exercise Program

Degenerative Disc Disease(DDD)

Italy, Switzerland
Sidney Kimmel Comprehensive Cancer Center at Johns...
Merck Sharp & Dohme LLC

Recruiting

Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer.

Metastatic Pancreatic Cancer

United States
National Cancer Center Hospital East
Merck Sharp & Dohme LLC

Recruiting

An Open Label Phase 2 Study to Evaluate the Safety and Efficacy of Lenvatinib With Pembrolizumab or Lenvatinib, Pembrolizumab and FLOT in the Neoadjuvant / Adjuvant Treatment for Patients With Gastric Cancer

Gastric Cancer

Japan
St. Jude Children's Research Hospital
National Cancer Institute (NCI); Conquer Cancer Foundation; St. Baldrick's Foundation

Recruiting

An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer

PreDiabetes | Adult Children

United States
Shanghai Bensen Pharmaceutical Co., Ltd.

Not yet recruiting

A Phase I, Open-Label, Dose Escalation and Cohort Expansion Study of BS HH 002.SA in Patients With AML and MDS

Acute Myeloid Leukemia, Myelodysplastic Syndrome
St. Jude Children's Research Hospital
National Cancer Institute (NCI); National Institutes of Health (NIH)

Recruiting

An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer

Frailty | Childhood Cancer

United States
Astellas Pharma Global Development, Inc.

Recruiting

Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients With Advanced Prostate Cancer

Prostate Cancer | mCRPC | mCSPC

United States
Corin

Recruiting

Open Label Study to Collect Clinical Data to Document Clinical Performance and Safety in Total Knee Arthroplasty

Osteo Arthritis Knee | Total Knee Arthroplasty | Total Knee Replacement | Knee Disease

France
ES Therapeutics Australia Pty Ltd

Recruiting

Efficacy, Safety and Pharmacokinetics of ES-481 in Adult Patients With Drug Resistant Epilepsy

Drug Resistant Epilepsy

Australia
Teclison Ltd.
Merck Sharp & Dohme LLC

Recruiting

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

Colorectal Cancer; Lung Cancer

Taiwan, United States
Menoufia University

Not yet recruiting

Timing of Initiation of Parenteral Nutrition for Critically Ill Children (TPN)

Critical Illness
Beijing Boren Hospital

Recruiting

Multi-centers, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Donor-Derived CD7 CAR T Cells in Subjects With Relapsed or Refractory T-cell Leukemia/Lymphoma

Relapse/Recurrence | T-cell Leukemia/Lymphoma | Refractory T Lymphoblastic Leukemia/Lymphoma

China
Tongji Hospital

Recruiting

Open-label Study of Neuraminidase Inhibitor Treatment in STEMI Patients

ST Elevation Myocardial Infarction | STEMI

China
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer

Breast Cancer | Metastatic Breast Cancer | Triple Negative Breast Cancer | TNBC - Triple-Negative Breast Cancer

United States
Jiangsu Simcere Pharmaceutical Co., Ltd.

Recruiting

An Open Label, Multi-center, Phase I Clinical Study to Evaluate the Safety, Effectiveness and Pharmacokinetic Characteristics of SIM1803-1A in Patients With Locally Advanced/Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion Mutations.

Advanced or Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Fulvestrant or Capecitabine Combined With Pyrotinib in HR+/HER2+ Metastatic Breast Cancer

Breast Cancer

China
Novartis Pharmaceuticals

Recruiting

Secukinumab Open Label Roll-over Extension Protocol

Autoimmunity, Inflammation

China, United States, Spain, Czechia, Bulgaria, Colombia, Brazil, Russian Federation, Guatemala, South Africa, India, Malaysia, Korea, Republic of, Mexico, Poland, Greece
Masonic Cancer Center, University of Minnesota
University of Minnesota

Not yet recruiting

A Phase II, Open Label Study of ONC201 in Adults With EGFR-low Glioblastoma

Glioblastoma

United States
Lupin Ltd.

Recruiting

Open Label Study in Adolescents and Children With Myotonic Disorders

Myotonic Dystrophy

France
Ruijin Hospital
The First Affiliated Hospital with Nanjing Medical University; First Affiliated... and other collaborators

Not yet recruiting

Asymmetric DBS for PD : A Multicenter, Prospective, Single Arm, Open Label Study (ADP)

Parkinson Disease
Göteborg University

Recruiting

Open-label Trial of IVIG in Children With PANS

PANS Pediatric Acute-Onset Neuropsychiatric Syndrome

Sweden
Swiss Group for Clinical Cancer Research

Recruiting

Assessing a ctDNA and PET-oriented Therapy in Patients With DLBCL A Multicenter, Open-label, Phase II Trial.

Diffuse Large B-cell Lymphoma

Switzerland, Italy
Eman Nada

Recruiting

Comparison of Quadratus Lumborum Block Types

Pain | Lumbar Disc Herniation | Opioid Use

United States
AbbVie

Recruiting

Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder

Schizophrenia | Bipolar I Disorder | Autism Spectrum Disorder (ASD)

United States, Puerto Rico
Hamad Medical Corporation

Recruiting

Nebulized Lidocaine and Intranasal Midazolam for NGT Insertion in Children

Procedural Pain | Procedural Anxiety

Qatar
Novartis Pharmaceuticals

Recruiting

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

Primary IgA Nephropathy

Japan, Korea, Republic of, United States, Denmark, France, Taiwan, Belgium, Israel, Thailand, Germany, India, Czechia, Malaysia, Argentina, Singapore, China, Australia, Norway, Turkey, United Kingdom, Brazil, Hong Kong, Netherlands, C... and more
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Almonertinib as Upfront Treatment for Uncommon EGFR Mutation Harboring Non-Small-Cell Lung Cancer Patients: A Multicenter, Open-Label, Phase II Trial (AUTUMN)

Non Small Cell Lung Cancer

China
Assistance Publique - Hôpitaux de Paris

Recruiting

Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses. (POOMA)

Osteomyelitis

France
Keio University
Merck Sharp & Dohme LLC; Ohara Pharmaceutical Co., Ltd.

Recruiting

Imatinib Mesylate in Combination With Pembrolizumab in Patients With Melanoma

Melanoma

Japan
Ottawa Hospital Research Institute

Not yet recruiting

One Versus Two Unit Transfusions in Oncology Patients - The OTTOP Trial: A Randomized Open-label Pragmatic Controlled Trial (OTTOP)

Anemia | Oncology
University of Pennsylvania
Novartis

Recruiting

Open Label Study of the Effects of Secukinumab on Nail Psoriasis and Non-Invasive Measures of Enthesitis (Phase IV)

Psoriasis

United States
Innervate Radiopharmaceuticals LLC (Formerly: Illumina...
Icahn School of Medicine at Mount Sinai

Recruiting

Open-Label Study of 18F-mFBG for Imaging Myocardial Sympathetic Innervation

Cardiovascular Diseases

United States
Yunfei Yuan

Recruiting

TACE-HAIC Plus Lenvatinib for Patients With Unresectable HCC: an Open-label, Single-arm, Phase 2 Trial (Thalen)

Hepatocellular Carcinoma | Transarterial Chemoembolization

China
Asan Medical Center
REDNVIA Co., Ltd.

Not yet recruiting

Randomized, Open-label Trial of Inhibitory Effect of Evogliptin on Progression of CAVD

CAVD

Korea, Republic of
Centre de Recherches et d'Etude sur la Pathologie...

Recruiting

HIV-1 Infected Patients, Phase II Trial, Dual Combination Doravirine/Raltegravir Open Label (DORAL)

HIV Infections

France
NovoCure Ltd.

Recruiting

Open-Label Pilot Study of OPTUNE® With High Density Transducer Arrays for the Treatment of Recurrent GBM

Glioblastoma Multiforme

Czechia
Kartos Therapeutics, Inc.

Recruiting

An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Ruxolitinib in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post ET-MF) Who Have a Suboptimal Response to Ruxolitinib

Myelofibrosis

United States, France, Australia, Spain, Germany, Bulgaria, Israel, Italy, Poland
Advanced Imaging Projects, LLC
University of Witwatersrand, South Africa; Postgraduate Institute of Medical...

Not yet recruiting

A Phase I/II Multicenter, Open-Label Study of Lu-177-DOTAGA-IAC, for the Treatment of Angiogenic Breast Cancer Patients. (Heroine01)

Breast Cancer Stage IV

India, South Africa
Shenzhen Ionova Life Sciences Co., Ltd.
Merck Sharp & Dohme LLC

Recruiting

An Open-Label Study of INV-1120 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Advanced Solid Tumors

Cancer | Solid Tumor, Adult | Solid Carcinoma | Solid Tumor, Unspecified, Adult | Cancer Metastatic | Tumor, Solid

United States

Search clinical trials for: open label

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