Search clinical trials for: randomized phase II

Total 53451 results

University of Florida

Completed

Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis

Lactic Acidosis
Children's Hospital Medical Center, Cincinnati

Completed

Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients With Gaucher's Disease

Osteopenia | Gaucher's Disease

Israel, United States
United Therapeutics

Completed

Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension

Pulmonary Hypertension

United States
Association for Innovation and Biomedical Research...

Completed

Prospective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen® (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation and PRP (Monotherapy) in the Treatment With High Risk PDR.

Diabetes Mellitus Type II | Diabetes Mellitus Type I | High Risk Proliferative Diabetic Retinopathy

Portugal
Genzyme, a Sanofi Company

Completed

An Open-label, Prospective, Randomized, Multi-center, Phase II Comparative Trial of Thymoglobulin Versus Simulect for the Prevention of Delayed Graft Function and Acute Allograft Rejection in Renal Allograft Recipients.

Cadaveric Donor Renal Transplantation | Acute Renal Allograft Rejection | Induction Therapy

United States, France, Spain, United Kingdom, Germany
Seagen Inc.
Genentech, Inc.

Terminated

A Randomized Phase IIb Placebo-Controlled Study of R-ICE Chemotherapy With and Without SGN-40 for Patients With DLBCL

Lymphoma, Large B-Cell, Diffuse | Lymphoma, Non-Hodgkin

United States, France, Spain, Belgium, Australia, Germany, Poland, Italy, Czech Republic, Hungary
BioCryst Pharmaceuticals

Completed

A Phase II, Multicenter, Randomized, Placebo -Controlled, Study To Evaluate The Efficacy and Safety Of Intramuscular Peramivir 600 mg In Subjects With Uncomplicated Acute Influenza

Acute, Uncomplicated Human Influenza

United States, Australia, New Zealand, South Africa
European Lung Cancer Working Party

Completed

Randomized Study of Cisplatin-Etoposide Versus an Etoposide Regimen Without Cisplatin in Extensive Small-Cell Lung Cancer

Small Cell Lung Carcinoma, Extensive Disease

Belgium, France, Greece, Spain
Ass. Prof. Jan Nyman

Terminated

Phase II Randomized Study on Locally Advanced NSCLC Escalated Dose on Individual Basis Treatment With Radiochemotherapy (PLANET)

Non Small Cell Lung Cancer | Locally Advanced Disease

Sweden
Pfizer

Completed

Pharmacokinetics/Pharmacodynamics Biomarker Study in Active Ulcerative Colitis Patients

Colitis, Ulcerative

Canada, United States, France, Netherlands, Germany, Spain, Austria, Hungary, Bulgaria, Poland, Romania
Rick Hansen Institute
University of Calgary; Alberta Paraplegic foundation

Unknown

Minocycline in Acute Spinal Cord Injury (MASC)

Spinal Cord Injuries

Canada, Australia
Repros Therapeutics Inc.

Completed

A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62%

Secondary Hypogonadism

United States
Repros Therapeutics Inc.

Completed

A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62%

Secondary Hypogonadism

United States
Asan Medical Center

Completed

Study of Sunitinib Administered as 4/2 vs. 2/1 Schedule in Advanced Renal Cell Carcinoma (RCC)

Metastatic Renal Cell Carcinoma

Korea, Republic of
Hospital Clinico Universitario de Santiago
Fundación Ramón Domínguez

Terminated

Phase II-b Randomized Clinical Trial of Cabazitaxel in Metastatic Colorectal Cancer Resistant to Standard Treatment (COMETA)

Colorectal Cancer

Spain
EMD Serono

Terminated

STRIDE - STimulating Immune Response In aDvanced brEast Cancer (STRIDE)

Breast Cancer

Czech Republic, Korea, Republic of, Russian Federation, South Africa, Germany, Slovakia, Austria, United States, Belgium, Poland, Israel, Australia
Eisai Limited

Terminated

An Open-label, Randomized, Phase II Study of the Efficacy and Safety of Indisulam (E7070) in Combination With Capecitabine

Metastatic Breast Cancer

Russian Federation, United Kingdom, Germany, Italy, Spain
Kissei Pharmaceutical Co., Ltd.

Completed

A Phase II Randomized Open Label Study of KLH-2109 in Patients With Endometriosis

Endometriosis

Japan
Azienda Ospedaliera Sant'Anna

Unknown

Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis (SCAVIT-K2)

Atherosclerosis | Carotid Disease
H. Lee Moffitt Cancer Center and Research Institute
Novartis

Terminated

Phase III Randomized Trial of Thalidomide/Dexamethasone Versus Vincristine+Adriamycin+Dexamethasone (VAD)

Multiple Myeloma

United States, Puerto Rico
Ansun Biopharma, Inc.
National Institutes of Health (NIH)

Completed

Randomized, Double-blind, Placebo Controlled Phase II Study to Examine the Effects of DAS181 in Healthy Adult Subjects With Laboratory Confirmed Influenza

Influenza

United States
PETHEMA Foundation

Terminated

A Prospective, Open, Non-randomized Phase I/II Study of Therapeutic Angiogenesis in Diabetic Patients With Critic Ischemia of Lower Limbs While Administering Positive CD133 Mobilized With G-CSF

Diabetic Patients With Critic Ischemia in Lower Limbs Who Are Administered With CD133+ Cells Mobilized by G-CSF

Spain
PD Dr. med. Matthias Dollinger

Unknown

Sorafenib Plus Doxorubicin Versus Sorafenib Alone for the Treatment of Advanced Hepatocellular Carcinoma: a Randomized Phase II Trial (SoraDox)

Liver Carcinoma

Germany
Louisiana State University Health Sciences Center...
National Center for Complementary and Integrative Health (NCCIH)

Terminated

Safety and Neuroprotective Effects of Polyphenon E in MS; Phase II (POEMS)

Multiple Sclerosis

United States
Novartis
Novartis Vaccines

Completed

A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults

Japanese Encephalitis | Rabies | Yellow Fever | Meningococcal Disease | Typhoid | Meningococcal Meningitis

Czech Republic, Germany
Centre Leon Berard
Gustave Roussy, Cancer Campus, Grand Paris

Completed

Prospective Multicentric Randomized Study of Glivec® in Advanced GIST Expressing C-kit: Interruption After 5 Years vs Maintenance

Sarcoma | Gastro-intestinal Stromal Tumors (GIST)

France
Telik

Terminated

Phase 3 Randomized Study of Telcyta + Doxorubicin Versus Doxorubicin in Platinum Refractory or Resistant Ovarian Cancer (ASSIST-5)

Ovarian Neoplasms

United States, United Kingdom, Belgium, Brazil
Hospital Authority, Hong Kong
Vigconic (International) Ltd.

Completed

A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis

Liver Cirrhosis | Hepatitis B | Hepatitis C

China
AIO-Studien-gGmbH

No longer available

A Randomized, Open-label Phase III Trial of Mapisal® Versus an Urea Hand-foot Cream as Prophylaxis for Capecitabine-induced Hand-foot Syndrome in Patients With Gastrointestinal Tumors or Breast Cancer (PROCAPP)

the Treatment Hand-foot Syndrome Patients With Gastrointestinal Tumors or Breast Cancer, Who Are Treated With Capecitabine

Germany
Clavis Pharma

Completed

Study of Elacytarabine Versus Investigator's Choice in Patients With Late Stage Acute Myeloid Leukaemia (AML) (CLAVELA)

Acute Myeloid Leukemia (AML)

United States, Spain, France, Ireland, United Kingdom, Australia, Belgium, Canada, Germany, Italy, Norway, Poland, Romania
Atlantic Health System

Terminated

High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study

Brain Injury | Intraventricular Hemorrhage | Randomized Clinical Trial | Infant, Premature | Periventricular Leukomalacia | Neurodevelopmental Outcomes | Erythropoietin

United States
Samsung Medical Center

Terminated

Phase I/II Study of Neoadjuvant Chemoradiotherapy With S-1/ Oxaliplatin in Patients With Gastric Cancer: Randomized Phase II Study of S-1/RT vs. S-1/Oxaliplatin/RT

Phase I: To Determine the Maximum Tolerated Dose (MTD) | Phase II: To Assess the Pathologic CR Rate and Feasibility Following Neoadjuvant Chemoradiation Therapy With S1/Oxaliplatin

Korea, Republic of
Stanford University
Cystic Fibrosis Foundation

Completed

NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients

Cystic Fibrosis

United States
GlaxoSmithKline

Withdrawn

A Phase II, Randomized, Open-label Study of Lapatinib Plus Chemotherapy Versus Trastuzumab Plus Chemotherapy in HER2-positive and p95HER2-positive Metastatic Breast Cancer

Neoplasms, Breast
AIO-Studien-gGmbH
iOMEDICO AG

Terminated

Study to Evaluate the Effects of Panitumumab if Combined With Chemotherapy for 2nd Treatment of Colorectal Cancer (VOXEL)

Colorectal Neoplasms

Germany
Hellenic Oncology Research Group
University Hospital of Crete

Terminated

Randomized Phase II Study of Epirubicin vs Caelyx in Pretreated Metastatic Breast Cancer

Breast Cancer

Greece
Wyeth is now a wholly owned subsidiary of Pfizer

Terminated

Study Comparing Sirolimus With Cyclosporine in a Calcineurin Inhibitor (CNI)-Free Regimen in Kidney Transplant Recipients

Kidney Transplant

Spain, Italy, Argentina, Greece, Taiwan, Singapore, United States, Canada, United Kingdom, Chile, South Africa, Hungary, Turkey, Austria, Germany, France, Norway, Australia, Sweden, Portugal, Cyprus
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation

Chronic Constipation

United States, Canada
Taiho Pharmaceutical Co., Ltd.
Yakult Honsha Co., LTD

Completed

Randomized Phase II Study of SOL for Untreated Metastatic Colorectal Cancer

Colorectal Cancer

Japan
AstraZeneca

Completed

A Randomized, Open Label Study to Compare the Current Phase II and Planned Phase III Capsule Formulation of AZD6244 (AZD6244Formula)

Healthy Volunteers

United States
Quark Pharmaceuticals
Pfizer

Terminated

Study Evaluating Efficacy and Safety of PF-04523655 Versus Laser in Subjects With Diabetic Macular Edema (DEGAS)

Diabetes Complications | Diabetic Retinopathy

United States, United Kingdom, Italy, Israel, Germany, Peru, Denmark, India
Capnia, Inc.

Completed

The Effect of Nasal Carbon Dioxide (CO2) Used As-Needed in the Symptomatic Treatment of Seasonal Allergic Rhinitis

Seasonal Allergic Rhinitis

United States
Capnia, Inc.

Completed

The Effect of Nasal Carbon Dioxide (CO2) in the Treatment of Mild Headache in People Who Experience Migraines

Migraine

United States
Capnia, Inc.

Completed

The Effect of Nasal Carbon Dioxide (CO2) in the Symptomatic Treatment of Seasonal Allergic Rhinitis

Seasonal Allergic Rhinitis

United States
M.D. Anderson Cancer Center
Ligand Pharmaceuticals

Completed

Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata

Alopecia Areata

United States
European Organisation for Research and Treatment...

Completed

A Randomized Phase III Study of Intensive Consolidation With High Dose Cytosine Arabinoside in Acute Myelogenous Leukemia (AML-8B)

Leukemia
Alejandra Guillermina Miranda Diaz

Completed

The Effect of Rosuvastatin in Diabetic Polyneuropathy: A Phase IIa Randomized Double-blind Placebo-controlled Study

Diabetic Polyneuropathy

Mexico
University of Regensburg
ClinAssess GmbH

Unknown

Phase I and Consecutive Phase II, Two-arm, Randomized Multi-center Trial in Patients With Advanced Melanoma

Advanced Melanoma

Germany
Moberg Pharma AB

Completed

A Double-blind, Randomized, Single Centre, Vehicle-controlled Study to Evaluate the Safety and Tolerability of a New Topical Formulation Containing 0,09% Imiquimod (Limtop) in Healthy Subjects (Limsafe)

Healthy

Germany
QLT Inc.

Terminated

A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of Tariquidar + Paclitaxel/Carboplatin as First-Line Therapy in Non-Small Cell Lung Cancer (NSCLC)

Stage IV Non-small Cell Lung Cancer | Stage IIIb Non-small Cell Lung Cancer

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