Clinical Trials Sponsored by 4SC AG

Total 2524 results

4SC AG

Completed

A Phase 1, Open-label Study of the Absorption, Metabolism, Excretion of [14C]-Resminostat

Mycosis Fungoides | Sezary Syndrome | Cutaneous T Cell Lymphoma

United Kingdom
4SC AG

Completed

Oral Histone Deacetylase Inhibitor 4SC-202 in Patients With Advanced Hematologic Malignancies (TOPAS)

Advanced Hematologic Malignancies

Germany
4SC AG

Completed

4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma (Shelter)

Hepatocellular Carcinoma

Germany, Italy
4SC AG

Completed

Single Dose Study With 4SC-203 in Healthy Volunteers

Acute Myeloid Leukemia

Germany
4SC AG

Active, not recruiting

Resminostat for Maintenance Treatment of Patients With Advanced Stage Mycosis Fungoides (MF) or Sézary Syndrome (SS) (RESMAIN)

Lymphoma, T-Cell, Cutaneous | Mycosis Fungoides | Sezary Syndrome

Austria, Spain, Germany, United Kingdom, France, Belgium, Japan, Switzerland, Italy, Poland, Netherlands, Greece
4SC AG

Completed

4SC-202 in Combination With Pembrolizumab in Patients Primary Refractory/Non-responding to Prior Anti-PD-1 Therapy (SENSITIZE)

Malignant Melanoma

Germany, Italy
4SC AG

Completed

Open Label, Dose Escalation Trial of Oral Eg5 Kinesin-spindle Inhibitor 4SC-205 in Patients With Advanced Malignancies (AEGIS)

Malignant Lymphomas | Advanced and Incurable Solid Tumors

Germany
4SC AG

Completed

Domatinostat in Combination With Avelumab in Patients With Advanced Merkel Cell Carcinoma Progressing on Anti-PD-(L)1 (MERKLIN2)

Merkel Cell Carcinoma

Spain, Netherlands, Belgium, Germany, France, Italy
4SC AG

Completed

4SC-201 (Resminostat) in Advanced Colorectal Carcinoma (SHORE)

Advanced Colorectal Carcinoma

Germany
4SC AG

Completed

Resminostat (4SC-201) in Relapsed or Refractory Hodgkin's Lymphoma (SAPHIRE)

Hodgkin's Lymphoma

Poland, Czech Republic, Romania
4SC AG

Completed

SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (COMPONENT)

Rheumatoid Arthritis

Bulgaria, Czech Republic, Poland, Romania
4SC AG

Completed

SC12267 (4SC-101) for Treatment of Patients With Inflammatory Bowel Disease (ENTRANCE)

Inflammatory Bowel Disease (IBD)

Germany, Bulgaria, Romania
The Netherlands Cancer Institute
4SC AG

Active, not recruiting

Pre-operative Immunotherapy in Stage II-III Urothelial Cancer (TURANDOT)

Urothelial Carcinoma

Netherlands
4SC AG
Merck KGaA, Darmstadt, Germany

Withdrawn

Domatinostat in Combination With Avelumab in Patients With Treatment-naïve Metastatic Merkel Cell Carcinoma (MERKLIN 1)

Merkel Cell Carcinoma
Royal Marsden NHS Foundation Trust
Merck KGaA, Darmstadt, Germany; 4SC AG

Unknown

Epigenetic Modulation of the immunE Response in GastrointEstinal Cancers (EMERGE) (EMERGE)

Cancer | GI Cancer

United Kingdom
The Netherlands Cancer Institute
4SC

Active, not recruiting

Multicenter Phase 1b Trial Testing the Neoadjuvant Combination of Domatinostat, Nivolumab and Ipilimumab in IFN-gamma Signature-low and IFN-gamma Signature-high RECIST 1.1-measurable Stage III Cutaneous or Unknown Primary Melanoma (DONIMI)

Malignant Melanoma Stage III

Netherlands
Efferon JSC

Recruiting

Selective Lipopolysaccharide Hemosorption in Maternal Sepsis (MINERVA)

Maternal sepsIs

Russian Federation
ASC Therapeutics

Not yet recruiting

ASC930 in Patients With Steroid-Refractory Acute Graft Versus Host Disease (SR-aGVHD)

Acute-graft-versus-host Disease
Efferon JSC

Completed

Hemoperfusion Efferon СT for the Treatment of Patients With Acute Pancreatitis

Acute Pancreatitis With Uninfected Necrosis, Unspecified

Russian Federation
Efferon JSC

Completed

Hemoperfusion With the Efferon CT Extracorporeal Adsorbers in Patients With Severe Covid-19

COVID-19

Russian Federation
Efferon JSC

Completed

Efferon LPS Hemoperfusion for Treatment of Patients With Septic Shock

Septic Shock

Russian Federation
Diabetis JSC

Recruiting

FeetSee Thermal Images Collection Protocol

Diabetic Foot

Lithuania
ASC Therapeutics

Recruiting

ASC618 Gene Therapy in Hemophilia A Patients

Hemophilia A

United States
Efferon JSC

Completed

Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock

Sepsis | Septic Shock

Russian Federation
Efferon JSC

Completed

Hemoperfusion Efferon СT for the Extremely Severe Form of COVID-19

COVID-19

Russian Federation
Bottneuro AG
Hemex AG

Active, not recruiting

Evaluate the Safety and Feasibility of tACS With the Miamind Neurostimulator in Healthy Participants (MindStim)

Healthy Participants | Healthy Population

Switzerland
Efferon JSC

Recruiting

Combination of Cytokine Hemosorption and High-volume Hemofiltration in Acute Pancreatitis

Acute Pancreatitis Without Necrosis or Infection

Russian Federation
Tetec AG
Aesculap AG

Completed

Non-Interventional Study to Evaluate Safety and Efficacy of NOVOCART 3D in Patients With Cartilage Defects (NISANIK)

Cartilage Diseases

Germany
Santersus AG
ISS AG

Not yet recruiting

Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating cfDNA/NETs in Subjects With Sepsis (NUC-CAP)

Sepsis | Respiratory Failure

United Kingdom, Germany, Switzerland
SynDermix AG
ISS AG

Withdrawn

Safety and Efficacy of SDX-3101 for the Treatment of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) (SDX-3101)

Chronic Rhinosinusitis Without Nasal Polyps

Germany, Austria, Switzerland
Tetec AG
Aesculap AG

Completed

Observational Study With NOVOCART® Inject in the Reconstruction of the Hip Joint With Full Thickness Cartilage Defects (HIP-ACTION)

Cartilage Disease

Germany
Spiden AG
DCB Research AG

Completed

A Pilot Study to Assess the Feasibility of a Novel Non-invasive Technology to Measure Changing Blood Glucose Levels in Adults With Type-1 Diabetes Mellitus

Type 1 Diabetes Mellitus | Type 1 Diabetes Mellitus With Hypoglycemia | Type 1 Diabetes Mellitus With Hyperglycemia

Switzerland
iOMEDICO AG
Roche Pharma AG

Active, not recruiting

Registry for Molecular Testing, Treatment and Outcome of Patients With Solid Tumors Harboring a NTRK Gene Fusion (REALTRK)

NTRK Family Gene Mutation

Switzerland, Germany
iOMEDICO AG
Roche Pharma AG

Completed

Impact of eHealth Monitoring on Overall Survival in Patients With Metastatic NSCLC / Extensive-stage SCLC / Advanced TNBC Under First-line Treatment With Atezolizumab Plus Chemotherapy (CHAPLIN)

Extensive-stage Small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Advanced (Locally Advanced and Inoperable or Metastatic), PD-L1 IC-positive TNBC

Germany
Ataturk University
MSc Reyhan YALÇIN; MSc Meral Güven

Completed

Pain in Newborn Heel Blood Collection

Pain, Acute | Infant, Newborn, Disease

Turkey
Valenta Pharm JSC

Recruiting

Efficacy and Safety of XC8, Film-coated Tablets, in Children With Acute Respiratory Viral Infections

Acute Respiratory Infection

Russian Federation
Valenta Pharm JSC

Recruiting

Food Effect on the Bioavailability of 4-MUST, Tablets, 128 mg

Cholecystitis

Russian Federation
Valenta Pharm JSC

Recruiting

Pharmacokinetics and Bioequivalence of Doxylamine+Pyridoxine and Diclectin

Nausea

Russian Federation
Valenta Pharm JSC

Recruiting

Efficacy and Safety of Ingavirin®, Capsules, 60 mg, in Children With Influenza and Other Acute Respiratory Viral Infections

Influenza, Human | Common Cold | Acute Respiratory Infection

Russian Federation
Valenta Pharm JSC

Completed

Pharmacokinetics and Bioequivalence of XC8 10 mg and 40 mg Tablets in Fasted Volunteers

Influenza | Respiratory Viral Infection

Russian Federation
Valenta Pharm JSC

Completed

A Study to Evaluate the Safety, Tolerability and Efficacy of XC221 in Patients With Uncomplicated Influenza or Other Acute Viral Upper Respiratory Infections

Influenza | Viral Respiratory Infection | Acute Viral Upper Respiratory Infections

Russian Federation
Valenta Pharm JSC

Completed

Efficacy and Safety of XC8, Film-coated Tablets, 40 mg in Patients With Dry Non-productive Cough Against Acute Respiratory Viral Infection

Influenza, Human | Common Cold | Acute Respiratory Infection

Russian Federation
Valenta Pharm JSC

Completed

Study of the Effect of Food Intake on the Bioavailability of XC8 10 mg Film-coated Tablets

Healthy

Russian Federation
Valenta Pharm JSC

Completed

Efficacy and Safety of Buspirone, Sustained-release Tablets, 15 mg in Patients With Autonomic Dysfunction Syndrome Accompanied by Vertigo

Vertigo | Autonomic Dysfunction

Russian Federation
Valenta Pharm JSC

Completed

Study of Post-Exposure Ingavirin® Prophylaxis of Influenza and Acute Respiratory Viral Infections

Influenza, Human | Common Cold | Acute Respiratory Infection | Flu | Viral Infection

Russian Federation
Valenta Pharm JSC

Not yet recruiting

Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy Volunteers

Heartburn | Acid-dependent Diseases of the Gastrointestinal Tract | Symptomatic Treatment of Gastric and Duodenal Ulcers

Russian Federation
Valenta Pharm JSC

Not yet recruiting

Pharmacokinetics and Bioequivalence of Aterixen 100 mg Tablets and Aterixen 100 mg Film-coated Tablets in Healthy Volunteers

Viral Infection COVID-19

Russian Federation
Avva Rus, JSC

Completed

Efficacy and Safety of Natamycin and Lactulose Vaginal Suppositories in Treatment of Vulvovaginal Candidiasis

Vulvovaginal Candidiasis, Genital

Russian Federation
Valenta Pharm JSC

Completed

A Study to Evaluate the Safety and Efficacy of XC221 in Patients With Uncomplicated Influenza or Other Acute Viral Upper Respiratory Infections

Influenza | Respiratory Viral Infection

Russian Federation
Valenta Pharm JSC

Completed

Safety and Pharmacokinetics of Dioxidin, Solution for Topical and External Use, 0.25 mg/ml and Dioxidin, Solution for Infusion and External Use, 5 mg/ml in Healthy Volunteers

Infections

Russian Federation

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