Clinical Trials Sponsored by Grünenthal GmbH

Total 3287 results

Grünenthal GmbH
Grünenthal, S.A.

Withdrawn

Bioequivalence of Two Fixed-dose Combination Tablets Containing Estradiol and Nomegestrol Acetate

Bioequivalence

Mexico
Grünenthal GmbH

Completed

A Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia

Post Herpetic Neuralgia
Grünenthal GmbH

Terminated

Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS)

Complex Regional Pain Syndrome (CRPS)

United States, Canada, Czechia, Poland, Serbia, Slovakia, United Kingdom
Grünenthal GmbH

Terminated

Tapentadol in Chronic Malignant Tumour Related Pain

Pain | Cancer | Chronic Pain

Bulgaria, Hungary, Moldova, Republic of, Poland, Romania, Russian Federation, Serbia
Grünenthal GmbH

Terminated

A Study to Assess the Safety and Efficacy of 7 Days Treatment With a Novel Analgesic in Subjects With Peripheral Neuropathic Pain

Neuralgia

Germany, Hungary, Poland, United Kingdom
Grünenthal GmbH

Terminated

A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y

Painful Diabetic Neuropathy

United States
Grünenthal GmbH

Completed

Comparison of Increasing Doses of Tapentadol Versus a Combination of Tapentadol and Pregabalin

Low Back Pain | Neuropathic Pain

Austria, Belgium, Denmark, Germany, Netherlands, Poland, Spain
Grünenthal GmbH

Completed

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic

Osteoarthritis | Chronic Pain

Germany, United Kingdom, France, Poland, Spain
Grünenthal GmbH

Completed

Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections (DoSe iT)

Otitis Media | Bronchitis | Tonsillitis | Pharyngitis

Germany, Poland
Grünenthal GmbH

Terminated

A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade

Analgesia | Anesthesia, Local | Anesthesia

Netherlands
Grünenthal GmbH

Completed

Efficacy and Safety of EN3324 (Axomadol) in Subjects With Chronic Low Back Pain (CLBP)

Chronic Low Back Pain

United States
Grünenthal GmbH

Terminated

Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID 297307)

Healthy

Germany
Grünenthal GmbH

Terminated

Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID: 855509)

Healthy

Germany
Grünenthal GmbH
Grünenthal, S.A.

Completed

Characterization of the Pharmacokinetics of a Vaginal Ring With 2.0 g Progesterone in Post-menopausal Women

Pharmacokinetics

Mexico
Grünenthal GmbH
Grünenthal, S.A.

Completed

Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction

Acute Pain

Mexico
Grünenthal GmbH
Grünenthal, S.A.

Withdrawn

A Study to Investigate Differences in the Extent and Rate of Absorption of Doxylamine/Pyridoxine From 2 Different Products Under Fasting Conditions

Bioavailability
Grünenthal GmbH

Active, not recruiting

Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee

Osteoarthritis

Spain, United States, Portugal, United Kingdom, Denmark
Grünenthal GmbH

Completed

Safety of Intravenous Neridronic Acid in CRPS

Complex Regional Pain Syndrome

United States, Germany
Grünenthal GmbH

Completed

Intravenous Tapentadol in Post-Bunionectomy Pain

Pain | Bunion

United States
Grünenthal GmbH

Terminated

Lidocaine 5% Medicated Plaster in Chronic Neuropathic Postoperative Pain

Pain | Chronic Pain | Postoperative Pain | Neuropathic Pain

France
Grünenthal GmbH

Completed

Efficacy and Safety of Topical Versus Systemic Treatment in Postherpetic Neuralgia and Diabetic Polyneuropathic Pain

Neuropathic Pain

United Kingdom
Grünenthal GmbH

Completed

A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain

Pain

Belgium, Bulgaria, Chile, France, Germany, Hungary, Italy, Portugal, Spain, United Kingdom
Grünenthal GmbH

Completed

Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healthy Men and Women

Prolonged QTc Interval | Pharmacokinetic

Germany
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability

Pain | Low Back Pain | Chronic Pain | Neuropathic Pain | Nociceptive Pain

Belgium, Czechia, France, Germany, Netherlands, Poland, Spain, Switzerland
Grünenthal GmbH

Completed

Clinical Pilot Study in Healthy Men to Characterize the Uptake of Buprenorphine Into and Its Elimination From the Body After Topical Application of Two New Forms of a Skin Patch in Comparison to a Reference Patch

Pain

Switzerland
Grünenthal GmbH

Completed

Clinical Study in Healthy Men to Investigate the Uptake of Buprenorphine and Its Elimination From the Body After Dermal Application as Patches for 96 Hours and for 72 Hours

Pain | Pharmacokinetics

Germany
Grünenthal GmbH

Completed

A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT0151Y is Likely to be Abused

Pain | Acute Pain

Canada
Grünenthal GmbH

Completed

A Clinical Study in Healthy Women Which Aims to Explore the Intestinal Uptake of Two Different Tablets of GRTA9906 Into the Body and the Effect of Food on it

Pain | Chronic Pain | Neuropathic Pain | Visceral Pain

Germany
Grünenthal GmbH

Withdrawn

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults

Pain, Postoperative | Pain, Acute | Opioid-Related Disorders

United States
Grünenthal GmbH

Withdrawn

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults

Pain, Postoperative | Pain, Acute | Opioid-Related Disorders

United States
Grünenthal GmbH

Completed

Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.

Back Pain | Low Back Pain | Neuropathic Pain

Germany, Spain, Austria, Italy
Grünenthal GmbH

Recruiting

Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee

Osteoarthritis

Japan, United States, South Africa, Bulgaria, Poland, Romania, United Kingdom
Grünenthal GmbH

Active, not recruiting

Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis

Osteoarthritis

France, Poland, Japan, Czechia, Mexico, Canada, Netherlands, Germany, Italy
Grünenthal GmbH

Completed

A Study With Lido-Patch and Placebo Plaster in Patients Suffering From Postherpetic Neuralgia (PHN)

Post Herpetic Neuralgia
Grünenthal GmbH

Completed

Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain

Osteoarthritis, Knee

Belgium
Grünenthal GmbH

Terminated

Efficacy and Safety of Intravenous Neridronic Acid in CRPS

Complex Regional Pain Syndrome (CRPS)

United States, Australia, France, Germany, Korea, Republic of, New Zealand, Spain
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.

Osteoarthritis | Chronic Pain

Germany, United Kingdom, Spain, Australia, Denmark, Poland
Grünenthal GmbH

Completed

Pharmacokinetic Characterization of Two Novel CG5503 Tablet Formulations in Healthy Volunteers

Pharmacokinetics

Germany
Grünenthal GmbH

Completed

Investigation How CG5503 is Taken up and Excreted From the Body After 2 Minutes Intravenous Infusion With and Without Oral Co-administration of Charcoal

Pharmacokinetic

Germany
Grünenthal GmbH

Completed

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics

Low Back Pain | Chronic Pain

Austria, Germany, United Kingdom, Croatia, France, Italy, Poland, Spain, Switzerland
Grünenthal GmbH

Completed

Efficacy and Safety of GRT9906 Tablets Compared to Placebo in Patients With Fibromyalgia

Primary Fibromyalgia

United States
Grünenthal GmbH

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GRT9906 Prolonged Release Tablets After Dose Escalation in Healthy Subjects

Pharmacokinetics

Germany
Grünenthal GmbH

Completed

A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure

Substance Abuse

Canada
Grünenthal GmbH

Completed

A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated

Pain | Chronic Pain | Acute Pain

Canada
Grünenthal GmbH

Completed

A Clinical Study in Healthy Subjects Which Aims to Investigate the Safety, the Tolerability and the Effects of GRT0151Y and How the Compound is Taken up and Excreted From the Body

Acute Pain

France
Grünenthal GmbH

Completed

Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I

Complex Regional Pain Syndrome, Type I

United States, Germany, United Kingdom
Grünenthal GmbH

Completed

Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain

Pain | Chronic Pain | Postoperative Pain | Neuropathic Pain

Austria, Belgium, Brazil, Denmark, France, Italy, Spain, United Kingdom
Grünenthal GmbH

Terminated

Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Healthy

Germany
Grünenthal GmbH

Terminated

Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Healthy

Germany
Grünenthal GmbH

Completed

Bioequivalence Trial of a New Opioid Combination Compared to Reference

Healthy

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