Clinical Trials Sponsored by London Health Sciences Center, Children's Hospital

Total 1241 results

Exsar Corporation
The Hospital for Sick Children; NYU Langone Health; University Hospitals Cleveland...

Withdrawn

A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis

G(M2) Ganglioside | Tay-Sachs Disease Ganglioside | Sandhoff Disease Ganglioside

United States, Canada
University Health Network, Toronto
University College London Hospitals; Brigham and Women's Hospital; University... and other collaborators

Recruiting

The STOP-MED CTRCD Trial (STOP-MED)

Heart Failure | Cancer | Cardiotoxicity | Cardiac Toxicity | Antineoplastics Toxicity

Canada, United States, United Kingdom, Australia
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) (CHD GENES)

Congenital Heart Defects

United States, United Kingdom
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome (DYMOSA)

Obstructive Sleep Apnea | Down Syndrome

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Using MRI to Observe Lung Changes in Infants With CF Compared to Infants Without CF (MRIinfantCF)

Cystic Fibrosis

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mechanisms Mediating Cardiovascular Disease in Children With Obstructive Sleep Apnea

Heart Diseases | Cardiovascular Diseases | Sleep Apnea Syndromes | Lung Diseases | Hypertension
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Airway Clearance Therapy on Hyperpolarized 129Xenon and MRI

Cystic Fibrosis

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Environmental Exposures, Genetics, and Exhaled Nitric Oxide in Pediatric Asthma

Asthma

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)

Heart Disease Congenital

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparing Chest Images From MRI to CT in Patients With Cystic Fibrosis (CF)

Cystic Fibrosis

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Role of Placenta Growth Factor in Sickle Acute Chest Syndrome

Anemia, Sickle Cell

United States
National Heart, Lung, and Blood Institute (NHLBI)
Children's Hospital Medical Center, Cincinnati

Completed

Blood Cell Collection for Future Use in Individuals With Fanconi Anemia

Fanconi Anemia

United States
Tufts University
Massachusetts General Hospital; Boston Children's Hospital; Wake Forest University... and other collaborators

Recruiting

Targeting Surgeons' Decision-Making for Cleft Lip Surgery

Cleft Palate | Cleft Lip

United States
University Health Network, Toronto
Queen Elizabeth II Health Sciences Centre; Rockyview General Hospital; Niagara... and other collaborators

Recruiting

Evaluating the Effectiveness of the Nurse Ned Clinic (NurseNed)

Prostate Cancer

Canada
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Realizing Effectiveness Across Continents With Hydroxyurea (REACH)

Children | Sickle Cell Disease

Congo, The Democratic Republic of the, Angola, Kenya, Uganda
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRI

Cystic Fibrosis

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100

Fanconi Anemia

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Adolescent Controlled Text Messaging to Improve Asthma Medication Adherence in Primary Care (ACT Me)

Persistent Asthma

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)

Obstructive Sleep Apnea

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease

Anemia, Sickle Cell

United States
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

CV Disease in Adolescents With Type 2 Diabetes

Heart Diseases | Cardiovascular Diseases | Obesity | Diabetes Mellitus

United States
Insel Gruppe AG, University Hospital Bern
The Hospital for Sick Children; Children's Hospital of Philadelphia; Charite... and other collaborators

Recruiting

Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2) (OPTIMISE-2)

Airway Management

Switzerland, Canada, Germany
The Hospital for Sick Children
Centre for Addiction and Mental Health

Completed

Mapping Psychosocial Screening to Services for Children With Cancer

Cancer

Canada
University of North Carolina, Chapel Hill
The Hospital for Sick Children; Washington University School of Medicine; McGill... and other collaborators

Recruiting

Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults

Primary Ciliary Dyskinesia | Kartagener Syndrome | Primary Immune Deficiency

United States, Canada
University of Toronto
University Health Network, Toronto; Sunnybrook Health Sciences Centre; Unity... and other collaborators

Completed

De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL) (CHORAL)

Mortality | Oral Health | Pain, Orofacial | Dryness, Mouth

Canada
Wayne State University
Children's Hospital of Philadelphia; Washington University School of Medicine; National Heart, Lung, and Blood Institute (NHLBI) and other collaborators

Completed

Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)

Dilated Cardiomyopathy | Hypertrophic Cardiomyopathy | Restrictive Cardiomyopathy

United States, Canada
University of Toronto
University Health Network, Toronto; Sunnybrook Health Sciences Centre; Mount... and other collaborators

Unknown

Vitamin D Effects on Prostate Pathology (DProstate)

Prostate Cancer

Canada
Guy's and St Thomas' NHS Foundation Trust
London School of Hygiene and Tropical Medicine; King's College London; St Thomas... and other collaborators

Recruiting

Controlled Trial of High-risk Coronary Intervention With Percutaneous Left Ventricular Unloading (CHIP-BCIS3)

Coronary Artery Disease | Ischemic Heart Disease

United Kingdom
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI); Rare Diseases Clinical Research... and other collaborators

Recruiting

A National Registry For Pulmonary Alveolar Proteinosis

Pulmonary Alveolar Proteinosis

United States
Unity Health Toronto
University Health Network, Toronto; Sunnybrook Health Sciences Centre; Sinai... and other collaborators

Active, not recruiting

Prone Positioning for Patients on General Medical Wards With COVID19 (COVID-PRONE)

Covid-19 | ARDS

Canada
The Hospital for Sick Children
Labatt Family Heart Centre

Recruiting

Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia (FAST Registry)

Atrial Flutter | Tachycardia, Supraventricular | Tachycardia, Atrioventricular Nodal Reentry | Tachycardia Atrial | Tachycardia, Reciprocating | Tachycardia, Paroxysmal | Fetal Hydrops | Tachycardia, Atrial Ectopic

United States, Hong Kong, Canada, Netherlands, Sweden, Australia, Brazil, Finland, France, Russian Federation, Spain, Czechia, Switzerland, United Kingdom
First Affiliated Hospital Xi'an Jiaotong University
Health Science Center of Xi'an Jiaotong University; The Second Affiliated Hospital...

Recruiting

Imaging of Injury Mechanism and Interaction of Intestinal Bacteria in Children With Mild Traumatic Brain Injury

MTBI - Mild Traumatic Brain Injury

China
Hospital Miguel Servet
Fondo de Investigacion Sanitaria; Carlos III Health Institute; Aragon Health... and other collaborators

Completed

Role of Positron Emission Tomography in the Evaluation of Response to Sorafenib in Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma

Spain
Yale University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Terminated

Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial (CRETE)

Deep Venous Thrombosis

United States
Zhengzhou University
Göteborg University; The First Affiliated Hospital of Zhengzhou University; Zhengzhou... and other collaborators

Completed

Erythropoietin Protects Very Preterm Infants Against Necrotizing Enterocolitis

Premature Infant

China
Longeveron Inc.
The University of Texas Health Science Center, Houston; National Heart, Lung... and other collaborators

Recruiting

Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. (ELPIS II)

Hypoplastic Left Heart Syndrome

United States
University Health Network, Toronto
Sunnybrook Health Sciences Centre; CHU de Quebec-Universite Laval; University... and other collaborators

Recruiting

The Canadian Glomerulonephritis Registry and Translational Research Initiative (CGNR)

Glomerular Nephritis

Canada
Society for Applied Studies
All India Institute of Medical Sciences, New Delhi; National Institutes of... and other collaborators

Completed

Safety and Immunogenicity Study of Live Attenuated Indian Rotavirus Vaccine Candidate Strains 116E and I321 in Infants

Rotavirus Infections

India
Children's Hospital of Fudan University
Shanghai Children's Hospital; Shanghai Children's Medical Center; Xinhua Hospital... and other collaborators

Recruiting

Study on Early Genetic Screening and Precise Strategy of Neonatal Critical Illness

Newborn | Stillbirth | Genetic Screening | Hereditary Disease

China
The University of Texas Health Science Center at...
Massachusetts General Hospital; 59th Medical Wing; Uniformed Services University... and other collaborators

Recruiting

Chronic Pain Management In Primary Care Using Behavioral Health Consultants

Chronic Pain

United States
Appili Therapeutics Inc.
University Health Network, Toronto; Sunnybrook Health Sciences Centre; University... and other collaborators

Terminated

Control of COVID-19 Outbreaks in Long Term Care

COVID-19 | SARS-CoV-2

Canada
University of California, Los Angeles
University of Colorado, Denver; Baylor College of Medicine; Albert Einstein College... and other collaborators

Not yet recruiting

Real-world Effectiveness of HPV Vaccine in Women Living With HIV and Its Impact on Cervical Cancer Screening Accuracies (LiVes-LLC)

Hiv | Hpv

United States
University Health Network, Toronto
Centre for Addiction and Mental Health; The Ottawa Hospital; Ryerson University; Humber River Hospital and other collaborators

Recruiting

Tele-BARICARE to Manage COVID-19-Related Distress (TELE-BARICARE)

Obesity | Mental Health Disorder | Bariatric Surgery Candidate | Eating Disorders

Canada
Peking University
Centers for Disease Control and Prevention, China; Beijing Pinggu District... and other collaborators

Completed

Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination (Trial 1)

SARS-CoV-2

China
St. Jude Children's Research Hospital
National Cancer Institute (NCI); National Institute of General Medical Sciences...

Recruiting

Pharmacogenetic Determinants Of Treatment Response In Children

All Malignancies | Children Being Treated for Catastrophic Illness

United States
The University of Texas Health Science Center,...
Children's Hospital of Philadelphia; National Institute of Diabetes and Digestive...

Completed

Assessing the Feasibility of N-of-1 Trials in Children With Hypertension and Chronic Kidney Disease

Hypertension | Chronic Kidney Diseases

United States
Marie Luise Bisgaard, MD
Rigshospitalet, Denmark; St Thomas' Hospital, London; National Cancer Centre,... and other collaborators

Recruiting

Screening for Endolymphatic Sac Tumours (ELSTs) in Von Hippel-Lindau (vHL) Patients

Von Hippel-Lindau Disease

Denmark
Peking University
Centers for Disease Control and Prevention, China; Beijing Pinggu District... and other collaborators

Completed

Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination (Trial 2)

SARS-CoV-2

China
McGill University Health Centre/Research Institute...
The Hospital for Sick Children

Recruiting

Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety (IMPROVES)

Egg Allergy | Peanut Allergy | Milk Allergy, Cow's

Canada
Children's Hospital Medical Center, Cincinnati
Medical University of South Carolina; The Hospital for Sick Children; Baylor... and other collaborators

Terminated

Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (TWiTCH)

Sickle Cell Anemia

Clinical Trials Sponsored by London Health Sciences Center, Children's Hospital

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Mauritius

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Rare Diseases

Drug Interventions

Dietary Supplements

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