Clinical Trials Sponsored by Medicines for Malaria Venture (MMV), Switzerland

Total 120 results

Medicines for Malaria Venture

Completed

A Dose-escalation Study to Investigate Safety and Toleration of OZ439

Malaria

United Kingdom
Medicines for Malaria Venture

Completed

Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria.

Uncomplicated Plasmodium Falciparum Malaria

Uganda, Benin, Burkina Faso, Congo, The Democratic Republic of the, Gabon, Mozambique, Vietnam
Medicines for Malaria Venture

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of OZ439 in Healthy Male and Female Subjects

Healthy Volunteers | Malaria Falciparum | Malaria Vivax

United States
Medicines for Malaria Venture

Completed

Piperaquine Granule Formulation Relative Bioavailability and Food Effect Study in Healthy Volunteers. (PedPQP(BA/FE))

Malaria

Tanzania
Medicines for Malaria Venture

Completed

Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study

Malaria

Netherlands
Medicines for Malaria Venture

Completed

OZ439 PhIIa Study in Plasmodium Falciparum: Extended Observation

Malaria

Thailand
Medicines for Malaria Venture

Completed

A Comparison of the Bioavailability of OZ439 When Delivered Directly to the Small Intestine, or Via the Oral Route

Healthy Volunteers

United Kingdom
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria

Malaria, Vivax

Thailand, Vietnam, Colombia, Brazil, Ethiopia, Peru
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse

Malaria, Vivax

Thailand, India, Brazil, Ethiopia, Peru, Bangladesh, Cambodia, Philippines
Medicines for Malaria Venture
AbbVie

Terminated

Bioavailability and Effect of Food on DSM265 Granules in Healthy Adult Subjects

Healthy Volunteers | Bioavailability

United States
GlaxoSmithKline
Medicines for Malaria Venture

Recruiting

A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants

Malaria, Falciparum

United Kingdom
Sanofi
Medicines for Malaria Venture

Completed

Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria

Plasmodium Falciparum Infection

Benin, Burkina Faso, Gabon, Kenya, Uganda
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria

Malaria, Vivax

Indonesia
Medicines for Malaria Venture
AbbVie

Completed

Malaria: Relative Bioavailability and Food Effect of DSM265

Healthy Volunteers

United States
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)

Malaria, Vivax

United States
GlaxoSmithKline
Medicines for Malaria Venture

Completed

A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate

Malaria, Vivax

United States
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Tafenoquine/Chloroquine DDI Study

Malaria

United States
GlaxoSmithKline
Medicines for Malaria Venture

Completed

G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)

Malaria

Thailand
Sanofi
Medicines for Malaria Venture

Terminated

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria (FALCI)

Plasmodium Falciparum Infection

Benin, Burkina Faso, Gabon, Kenya, Mozambique, Uganda, Vietnam
GlaxoSmithKline
Medicines for Malaria Venture

Completed

A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria

Malaria, Vivax

Vietnam, Colombia
GlaxoSmithKline
Medicines for Malaria Venture

Completed

Single-Blind, Placebo-Controlled, Randomized Study Testing Single Ascending Doses Of GSK369796 In Healthy Subjects

Malaria

United Kingdom
Sanofi
Medicines for Malaria Venture

Completed

Artesunate Plus Amodiaquine in Malaria in Cote d'Ivoire

Malaria

Côte D'Ivoire
GlaxoSmithKline
Parexel; Medicines for Malaria Venture

Completed

A Study to Assess the Effects of Dissolution Profile on the Pharmacokinetics of Single Oral Doses of Tafenoquine Tablets and Tafenoquine Stable Isotope Labelled Solution

Malaria, Vivax

United States
Medicines for Malaria Venture
Quotient Clinical

Completed

Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQP) Tablets

Malaria

United Kingdom
Medicines for Malaria Venture
Quotient Clinical

Completed

Bioavailability Study of Oral OZ439 Prototype Formulations Administered With Piperaquine Phosphate (PQP)

Malaria

United Kingdom
Medicines for Malaria Venture
Mahidol University

Completed

Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-infection

Malaria, Falciparum | Malaria, Vivax
Treague Ltd
Medicines for Malaria Venture

Completed

Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 [(+)-Mefloquine] Compared With Racemic Mefloquine

Healthy Subjects

United Kingdom
Medicines for Malaria Venture
Richmond Pharmacology Limited

Completed

Atoguanil BA Study

Bioavailability

United Kingdom
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria

Malaria

Indonesia, Cambodia, India, Thailand
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine - Artesunate (3:1) Versus Mefloquine Plus Artesunate in Plasmodium Falciparum Malaria Patients

Falciparum Malaria

Cambodia, India, Thailand, Burkina Faso, Côte D'Ivoire, Tanzania, Vietnam
Medicines for Malaria Venture
Richmond Pharmacology Limited

Completed

Determine the Tolerability and Safety of Atovaquone-proguanil (ATV-PG) Co-administered With Amodiaquine (AQ)

Malaria

United Kingdom
Medicines for Malaria Venture
Richmond Pharmacology Limited

Completed

A Study to Evaluate the Pharmacokinetics of Oral Formulations of MMV390048 Administered Fasted to Healthy Volunteers

Malaria

United Kingdom
Medicines for Malaria Venture
Richmond Pharmacology Limited

Completed

A FIH Study to Investigate the Safety, Tolerability and PK of P218

Malaria

United Kingdom
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Efficacy, Safety and Pharmacokinetics of Artemether-lumefantrine Dispersible Tablet in the Treatment of Malaria in Infants < 5 kg

Acute Uncomplicated Falciparum Malaria

Burkina Faso, Benin, Congo, Nigeria, Togo
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Drug Interaction Study of Pyronaridine-artesunate & Metoprolol, & Redosing Study of Pyronaridine-artesunate

Malaria

Switzerland
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Efavirenz

Malaria

United Kingdom
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir

Malaria

United Kingdom
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients

Malaria

Burkina Faso, Congo, The Democratic Republic of the, Kenya, Mali, Mozambique, Philippines, Côte D'Ivoire, Gabon
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Bioequivalence of Pyronaridine Artesunate To-be-marketed Tablet to the Clinical Trial Reference Tablet (SP-C-009-07)

Malaria

Switzerland
Medicines for Malaria Venture
Richmond Pharmacology Limited

Completed

Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State

Malaria

United Kingdom
Medicines for Malaria Venture
Cross Research S.A.

Completed

Safety Tolerability & Pharmacokinetics of Co-administered Single Doses of OZ439 & Piperaquine to Healthy Subjects

Healthy

Switzerland
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine/Artesunate -Ritonavir Drug Drug Interaction Study

Malaria

Switzerland
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole

Malaria

United Kingdom
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria

Acute Uncomplicated Plasmodium Falciparum Malaria

Thailand, Gabon, Mali, Uganda, Burkina Faso, India, Kenya, Mozambique, Vietnam
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Human Mass Balance Study of Pyronaridine

Malaria

Switzerland
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Terminated

Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria

Malaria

Korea, Republic of
Medicines for Malaria Venture
Shin Poong Pharmaceuticals

Completed

Pyronaridine Artesunate (3:1) Versus Coartem® in P Falciparum Malaria Patients

Malaria

Congo, The Democratic Republic of the, Gambia, Ghana, Indonesia, Kenya, Mali, Mozambique, Philippines, Senegal
Medicines for Malaria Venture
Richmond Pharmacology Limited

Completed

Open Label Pharmacokinetic Study of OZ439 and Piperaquine on Administration of OZ439+TPGS Granules for Oral Suspension Alone or With Either Piperaquine Phosphate Tablets or Granules for Oral Solution in Healthy Volunteers

Malaria

United Kingdom
Novartis Pharmaceuticals
Medicine for Malaria Venture

Terminated

Effectiveness of KAE609 in Reducing Asexual & Sexual Blood-stage P.Falciparum Infection & Infectivity to Mosquitos

Plasmodium Falciparum Malaria

Australia
Medicines for Malaria Venture
Institute of Tropical Medicine, University of Tuebingen

Completed

DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria

Plasmodium Falciparum, Malaria

Germany

Clinical Trials Sponsored by Medicines for Malaria Venture (MMV), Switzerland

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Russia

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Rare Diseases

Drug Interventions

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