Clinical Trials Sponsored by SPIRE Hospitals

Total 100088 results

Shire

Completed

The Safety and Efficacy of SPD465 in Adults With Attention Deficit Hyperactivity Disorder (ADHD)

Attention-Deficit/Hyperactivity Disorder
Shire

Completed

Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects

Hereditary Angioedema (HAE)

United States
Shire

Completed

Bioavailability Study of SPD489 Administered With Two Different Means of Administration in Healthy Adult Volunteers

Healthy Volunteers

United States
Shire

Completed

Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs (TOSCA)

Crohn's Disease | Ulcerative Colitis | Ileitis | Granulomatous Colitis | Ileo-colonic and Colonic Crohn's Disease | Regional Enteritis

France, Belgium, Austria, Germany, Netherlands
Shire

Completed

Taste Assessment Study of SHP429 in Healthy Adult Subjects

Healthy

United States
Shire

Completed

A Study To Monitor Long-Term Treatment With PF-00547659 (OPERA II)

Crohn's Disease

Korea, Republic of, United States, Spain, France, Serbia, Netherlands, Germany, Japan, Austria, Belgium, Poland, Canada, Norway, Slovakia, South Africa
Shire

Withdrawn

Pharmacokinetics of Granule and Tablet Formulations of Deferitazole (Disodium Salt) and a Capsule Formulation of Deferitazole (Magnesium Hydroxide Salt)

Healthy

United States
Shire

Completed

Safety and Pharmacology Study of VP 20629 in Adults With Friedreich's Ataxia

Friedreich's Ataxia

United States
Shire

Completed

Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

Japan
Shire

Withdrawn

Treatment of Iron Overload Requiring Chelation Therapy

Metabolic Diseases | Iron Metabolism Disorders | Iron Overload | Beta-thalassemia | Transfusional Hemosiderosis | Transfusional Iron Overload | Iron Chelation
Shire

Terminated

FST-201 In The Treatment of Acute Otitis Externa

Acute Otitis Externa

United States
Shire

Terminated

FST-201 In The Treatment of Acute Fungal Otitis Externa

Acute Fungal Otitis Externa

United States
Shire

Completed

Calcium Supplementation in Postmenopausal Women (CAP)

Osteoporosis

United States, Argentina, Mexico
Shire

Approved for marketing

Treatment Protocol of Velaglucerase Alfa for Patients With Type 1 Gaucher Disease

Gaucher Disease, Type 1

United States
Shire

Completed

EDEMA2: Evaluation of DX-88's Effect in Mitigating Angioedema

Hereditary Angioedema (HAE)
Shire

Completed

A Study to Assess the Safety and Efficacy of 3 Doses of ALX1-11 (50, 75, and 100µg) in the Treatment of Postmenopausal Osteoporosis

Osteoporosis

United States, Canada
Shire

Completed

Open Label Extension (TRES)

Osteoporosis

United States, Argentina
Shire

Completed

Maribavir for Prevention of CMV After Stem Cell Transplants

Cytomegalovirus Infection

United States
Shire

Completed

Safety, Efficacy and Pharmacokinetic Study of Teduglutide in Infants 4 to 12 Months of Age With Short Bowel Syndrome

Short Bowel Syndrome

Finland, Italy, United Kingdom, France
Shire

Terminated

Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305) (CARMEN CD 305)

Crohn's Disease

United States, Australia, Romania, Israel, Italy, Croatia, South Africa, Germany, Poland, United Kingdom, Austria, Japan, Lithuania, Netherlands, Russian Federation, Serbia
Shire

Terminated

Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)

Mucopolysaccharidosis (MPS)

United States, Canada, United Kingdom, Turkey, Italy, Mexico, Spain
Shire

Completed

Pediatric Disease Registry in Essential Thrombocythaemia (ET)

Essential Thrombocythemia (ET)

United Kingdom, Italy, Czechia, France, Germany, Greece, Spain, Switzerland
Shire

Completed

Home Therapy With Replagal in Fabry Disease

Fabry Disease

Austria, Germany
Shire

Terminated

Natural History Study of Children With Metachromatic Leukodystrophy

Metabolic Diseases | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Demyelinating Diseases | Genetic Diseases, Inborn | Metabolism, Inborn Errors | Lysosomal Storage Diseases | Lipid Metabolism Disorders | Sphingolipidoses | Hereditary Central Nervous System Demyelinating Diseases and other conditions

United States, Denmark, France, Argentina, Belgium, Brazil, Canada, Germany, Japan, Turkey
Shire

Completed

An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE) (ORBIT2)

Eosinophilic Esophagitis (EoE)

United States
Spine Wave

Completed

Annex™ Adjacent Level System for Treatment of Adjacent Level Disease

Degenerative Disc Disease | Adjacent Level Disease

United States
Shire

Completed

Study of Teduglutide in Japanese Participants With Short Bowel Syndrome

Short Bowel Syndrome

Japan
Titan Spine

Terminated

Titan Spine Endoskeleton TT/TO Study

Degenerative Disc Disease, Spondylolisthesis

United States
Stryker Spine

Terminated

AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY (APROPOS)

Degenerative Disc Disease | Spondylolisthesis, Grade 1 | Retrolisthesis

United States
Spine Wave

Terminated

Clinical Evaluation of GENEX® DS in Instrumented Posterolateral Fusion

Degenerative Disc Disease | Spondylolisthesis | Stenosis

United States
Premia Spine

Unknown

Post-market Study of the TOPS™ System (TOPS)

Lumbar Spinal Stenosis | Spondylolisthesis

United Kingdom
Paradigm Spine

Completed

A Randomized Controlled Trial Comparing Surgical Decompression With an Interlaminar Implant in Patients With Intermittent Neurogenic Claudication Caused by Lumbar Stenosis (FELIX)

Intermittent Neurogenic Claudication (INC) as a Result of Spinal Stenosis

Netherlands
DePuy Spine

Completed

CHARITE™ vs. ALIF 5-Year Follow-up

Degenerative Disc Disease

United States
Bayer
Shire

Completed

Long-term Study in Chronic Kidney Disease (Extension From Study 14817)

Hyperphosphatemia

Japan
DePuy Spine

Completed

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

Degenerative Disc Disease

United States
Mclean Hospital
Spier Family Foundation

Recruiting

Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia (CBD)

Anxiety | Alzheimer Disease | Agitation,Psychomotor

United States
Centinel Spine

Not yet recruiting

Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels (Stalif)

Degenerative Disc Disease | Symptomatic Cervical Disc Disease | Grade 1 Spondylolisthesis | Retrolisthesis
Shire

Active, not recruiting

Study of Long Term Safety and Clinical Outcomes of Idursulfase IT and Elaprase Treatment in Pediatric Participants Who Have Completed Study HGT-HIT-094

Hunter Syndrome

United States, Spain, Canada, United Kingdom, Mexico, Australia, France
Shire
Takeda

Completed

FIRAZYR General Drug Use-Results Survey (Japan)

Hereditary Angioedema (HAE)

Japan
Shire

Completed

Drug Use Study With Intuniv® in European Countries

Attention Deficit Hyperactivity Disorder (ADHD)

Germany
Shire

Completed

Post Marketing Surveillance (PMS) Study for Velaglucerase Alfa (VPRIV) in India

Gaucher Disease

India
Shire

Terminated

A Study of Replagal in Treatment-naïve Adults With Fabry Disease

Fabry Disease

Spain, Greece, Germany, Portugal, Canada, Finland, Poland, Sweden
Shire

Withdrawn

A Clinical Study of rhPTH(1-84) Treatment in Japanese Participants With Chronic Hypoparathyroidism

Chronic Hypoparathyroidism

Japan
Shire

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Maribavir Administered in Healthy Japanese Participants Compared With Matched, Healthy, Non-Hispanic, Caucasian Participants and to Assess Dose-Proportionality of 3 Doses of Maribavir in Japanese Participants

Healthy Volunteers

United States
Shire

Completed

Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dependent on Parenteral Support

Short Bowel Syndrome

Japan
Shire

Completed

Study of the Effect of Velaglucerase Alfa (VPRIV®) on Bone-related Pathology in Treatment-naïve Participants With Type 1 Gaucher Disease

Gaucher Disease

United States, Spain, United Kingdom, Israel
Shire

Completed

Drug Use Study With VYVANSE® in Australia for Binge Eating Disorder

Binge-eating Disorder

Australia
Shire

Completed

Retrospective, Observational Chart Review Study Conducted in Poland to Document the Management and Clinical Outcome of CUVITRU and HYQVIA in Pediatric Participants (< 18 Years) With Primary Immunodeficiency (PID) (IG-TATRY)

Primary Immunodeficiencies (PID)

Poland
Shire

Completed

Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)

Short Bowel Syndrome

United States, Canada, Finland, Italy, United Kingdom, Belgium
Shire

Terminated

FST-100 Ophthalmic Suspension in Acute Adenoviral Conjunctivitis

Acute Adenoviral Conjunctivitis

United States

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