Search clinical trials for: ATM inhibitor

Total 73704 results

Institut Curie
Merck Sharp & Dohme LLC; ProLynx LLC

Not yet recruiting

A Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) in Patients With Advanced Solid Tumors (POP-ART)

Solid Tumor

France
Ankara City Hospital Bilkent

Recruiting

Cerebral and Peripheral Near Infrared Spectroscopy Monitoring in Low and High Flow Anaesthesia in Pediatric

Anesthesia | Child, Only | Cerebral Oxygenation | Cerebral Hypoxia | Inhalation; Vapor | Peripheral Oxygenation

Turkey
China Medical University Hospital

Not yet recruiting

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

Obstructive Sleep Apnea of Adult
Jazz Pharmaceuticals

Recruiting

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Biliary Tract Cancer | HER2 Gene Mutation

United States, Puerto Rico
University Hospital Hradec Kralove
Masaryk University

Recruiting

The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respiratory Diseases (INFURO)

Dyspnea

Czechia
Fengzhi Feng

Recruiting

Dalpiciclib Combined With Letrozole in HR+/HER2 - Gynecologic Solid Tumors

Recurrent Ovarian Carcinoma

China
Fayoum University

Not yet recruiting

I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement

TMJ Disc Disorder | TMJ Pain
Pamela Munster
National Cancer Institute (NCI)

Recruiting

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

BRCA1 Mutation | BRCA2 Mutation | PALB2 Gene Mutation | ATM Gene Mutation | BRCA Mutation | Checkpoint Kinase 2 Gene Mutation

United States
Regeneron Pharmaceuticals

Recruiting

A Trial to Learn if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Participants With Follicular Lymphoma and Marginal Zone Lymphoma (OLYMPIA-5)

Relapsed/Refractory Follicular Lymphoma | Marginal Zone Lymphoma (MZL)

Korea, Republic of, Australia, France, Spain, Malaysia, Taiwan, Italy, Poland, United States, Turkey, Thailand, United Kingdom, Belgium, Czechia
Steno Diabetes Center Copenhagen
King's College London; Juvenile Diabetes Research Foundation; Glostrup University...

Not yet recruiting

Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia (PLUTO)

Hypoxia | Diabetes Mellitus, Type 1 | Diabetic Nephropathies | Albuminuria | Nephropathy | Diabetic Complications Renal | Diabetic Complications Cardiovascular

Denmark
Alexandria University

Recruiting

Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in the Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients

Anemia in Dialysis-dependent CKD Patients

Egypt
AbbVie

Recruiting

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC) (LIVIGNO-2)

Hepatocellular Carcinoma

United States, Taiwan, Spain, France
University of North Carolina, Chapel Hill

Recruiting

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

Stroke | Brain Ischemia | Brain Injuries, Traumatic | Heart Arrest | Intracranial Hemorrhages | Brain Hypoxia | Coma | Hypoxia-Ischemia, Brain | Persistent Vegetative State | Brain Injuries, Acute

United States
Acrotech Biopharma Inc.

Recruiting

To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL (CRESCENDO)

Peripheral T Cell Lymphoma

United States
University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Managing Opioid Related Sleep Apnea With Acetazolamide (MORPHO)

Chronic Pain | Obstructive Sleep Apnea | Opioid Use | Sleep-Disordered Breathing | Central Sleep Apnea

United States
Ministry of Health, Saudi Arabia

Not yet recruiting

Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress (CAT/LPT)

Respiratory Disease | Prematurity | Ventilator Lung; Newborn
Lawson Health Research Institute
Centre hospitalier de l'Université de Montréal (CHUM); London Health Sciences...

Not yet recruiting

Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease (RESPIRE-ILD)

Lung Cancer | Interstitial Lung Disease

Canada
Flinders University
Flinders Medical Centre

Not yet recruiting

Reboxetine for Sleep Apnoea After ENT Surgery (RENTOSA)

Sleep Apnea, Obstructive
Tanta University

Not yet recruiting

Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery

Anesthesia | Opioid Use | Hypoventilation | Bariatric Surgery

Egypt
University of Melbourne
Reckitt Benckiser LLC

Recruiting

Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients With Upper Respiratory Tract Infections

Cough | Upper Respiratory Tract Infections

Australia
University of California, Los Angeles
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Endotypic Traits and Obstructive Sleep Apnea Surgery

Obstructive Sleep Apnea

United States
VA Office of Research and Development
VA Eastern Colorado Health Care System; Atlanta VA Medical Center; VA Boston... and other collaborators

Not yet recruiting

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH (BETTER COPD-PH)

Chronic Obstructive Pulmonary Disease | Pulmonary Hypertension | Dyspnea

United States
University of Arizona
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome (MOSAIC)

Obstructive Sleep Apnea | Down Syndrome

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Clinical Trial of the ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Recurrent Brain Tumors

Glioblastoma

United States
Cairo University

Recruiting

Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation (RCT)

Dislocation of Temporomandibular Joint TMJ | Subluxation of Temporomandibular Joint

Egypt
University of the Pacific

Recruiting

Topical Treatment for TMJ Arthralgia

TMJ Pain

United States
University of Heidelberg Medical Center
Sanofi; KKS Netzwerk; Deutsche Studiengruppe Multiples Myelom (DSMM)

Recruiting

Lenalidomide, Bortezomib and Dexamethasone Induction Therapy With Either Intravenous or Subcutaneous Isatuximab in Patients With Newly Diagnosed Multiple Myeloma

Multiple Myeloma

Germany, Austria
University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea (PANACEA)

Obstructive Sleep Apnea

United States
IDEAYA Biosciences

Recruiting

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Breast Cancer | Ovarian Cancer | Prostate Cancer | Pancreas Cancer | Advanced or Metastatic Solid Tumors

United States
M.D. Anderson Cancer Center
Sanofi

Recruiting

Post-Transplant Maintenance Therapy With Isatuximab Plus Lenalidomide for High-Risk Multiple Myeloma Patients

Multiple Myeloma

United States
Jozef Stefan Institute

Recruiting

Caffeine and Hypoxia During Exercise in Males and Females (HypoCaff)

Hypoxia | Caffeine

Slovenia
Duke University

Recruiting

Oxygen Toxicity: Mechanisms in Humans

Seizures | Hypercapnia | Oxygen Toxicity

United States
University of Arizona
National Cancer Institute (NCI)

Recruiting

Adaptive Symptom Self-Management Immunotherapy Study

Breast Cancer | Lung Cancer | Skin Cancer | Colon Cancer | Rectum Cancer

United States
University of California, San Francisco
GlaxoSmithKline

Recruiting

Combination Therapy in Cancers With Mutations in DNA Repair Genes

Metastatic Solid Tumor | BRCA1 Mutation | BRCA2 Mutation | PALB2 Gene Mutation | ATM Gene Mutation

United States
Nikolaj Frost MD
Roche Pharma AG; Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus...

Recruiting

Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma (ANTELOPE)

Non-Small Cell Lung Cancer Metastatic

Germany
Eye & ENT Hospital of Fudan University

Recruiting

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

Laryngeal Stenosis | Glottic Carcinoma | Glottic Web of Larynx | Laryngeal Leucoplakia | Laryngeal Polyp | Laryngeal Papilloma

China
Noos S.r.l.

Recruiting

Evaluate the Effect of Nasal Spray in the Prevention of RTI in Children With Pre-school Wheezing

Recurrent Respiratory Tract Infections | Wheezing

Italy
National Taiwan University Hospital

Recruiting

PLT and Steroid in Lateral Epicondylopathy and Supraspinatus Calcific Tendinopathy

Lateral Epicondylitis | Rotator Cuff Syndrome

Taiwan
Pfizer

Recruiting

Study of 2 Medicines (Aztreonam and Avibactam) Compared to Best Available Therapy for Serious Gram-negative Infections

Gram-negative Bacterial Infections

Spain, Taiwan, United States, Hungary, India, China, Turkey, Greece, Czechia
University of California, San Diego

Recruiting

Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health (ACE-Of-HEARTs)

Obstructive Sleep Apnea

United States
Yale University
Case Western Reserve University

Recruiting

Adipose Dysfunction, Imaging, Physiology, and Outcomes With Sodium Glucose Cotransporter 2 Inhibitor (SGLT2i) for Sleep Apnea: The ADIPOSA Study (ADIPOSA)

Sleep Apnea

United States
VA Office of Research and Development
John D. Dingell VA Medical Center

Recruiting

Sleep Disordered Breathing With Opioid Use (SDB)

Sleep Apnea | Sleep Disordered Breathing | Opioid Use

United States
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma (PLYCOM)

Multiple Myeloma

Korea, Republic of, Australia, Spain, France, Poland
Ladoke Akintola University of Technology Teaching...

Recruiting

Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at Term

Foetal Hypoxia

Nigeria
Brigham and Women's Hospital

Recruiting

Identifying Sleep Apnea Patients That Best Respond to Atomoxetine Plus Oxybutynin Therapy

Obstructive Sleep Apnea

United States
RenJi Hospital
Beijing Hospital; Second Hospital of Shanxi Medical University; Zhejiang Tumor... and other collaborators

Recruiting

Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients (SpO2)

Gastric Cancer | Gastric Ulcer | Gastrointestinal Polyp

China
Boehringer Ingelheim

Recruiting

Correlation Between Changes in Lung Function and Changes in Cough and Dyspnoea in Nintedanib-treated Connective Tissue Disease Interstitial Lung Disease (CTD-ILD) Patients

Lung Diseases, Interstitial

Greece
Nanfang Hospital of Southern Medical University
Peking University People's Hospital; Guangzhou First People's Hospital; Sun Yat-Sen... and other collaborators

Recruiting

G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for High-risk MDS Undergoing Allo-HSCT

Myelodysplastic Syndrome | Allogeneic Hematopoietic Stem Cell Transplantation | Conditioning

China
Janssen Research & Development, LLC

Recruiting

A Study of Daratumumab

Multiple Myeloma

Korea, Republic of, Russian Federation, Spain, Germany, Belgium, Denmark, Greece, France, United States, Ukraine, Poland
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Recruiting

Study of M1774 in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)

Metastatic or Locally Advanced Unresectable Solid Tumors

United States, Canada, Spain

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