Search clinical trials for: Adenosine A2a receptor (A2AR)

Total 18166 results

Assistance Publique Hopitaux De Marseille

Recruiting

Detection of Significant Coronary Artery Disease by Promising Biomarker: A2A Adenosine Receptor (A2AR) Assays (ADOCAD)

Chronic Coronary Syndromes

France
AstraZeneca

Completed

An Open-label, Phase II Study of AZD4635 in Patients With Prostate Cancer

Prostate Cancer | Metastatic Castration-Resistant Prostate Cancer (mCRPC)

United States
AstraZeneca
Parexel

Completed

A Study to Assess the Effect of Fluvoxamine and Smoking on Pharmacokinetics ( the Movement of Drugs Within the Body) of AZD4635 in Healthy Volunteers

Healthy Volunteer/DDI Study

United Kingdom
MedImmune LLC

Active, not recruiting

Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study

Carcinoma, Non-Small-Cell Lung

United States, Korea, Republic of, Taiwan
Novartis Pharmaceuticals

Terminated

A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma

Melanoma | Head and Neck Cancer | Pancreatic Cancer | Urothelial Cancer | NSCLC, Non Small Cell Lung Cancer | RCC, Renal Cell Cancer | DLBCL, Diffused Large B Cell Lymphoma | MSS, Microsatellite Stable Colon Cancer | TNBC, Triple Negative Breast Cancer | mCRPC, Metastatic Castration Resistant Prostate...

Belgium, Italy, Taiwan, Germany, Spain, United States, Argentina, Australia, Austria, Czechia, France, Japan, Netherlands, Switzerland, Singapore
Novartis Pharmaceuticals

Terminated

A Phase I/Ib Study of NZV930 Alone and in Combination With PDR001 and /or NIR178 in Patients With Advanced Malignancies.

Ovarian Cancer | Non-small Cell Lung Cancer (NSCLC) | Renal Cell Carcinoma (RCC) | Triple Negative Breast Cancer (TNBC) | Pancreatic Ductal Adenocarcinoma (PDAC) | Metastatic Castration Resistant Prostate Cancer (mCRPC) | Colorectal Cancer Microsatellite Stable (MSS)

Canada, Australia, Singapore, United States, Japan, Spain, United Kingdom
Portage Biotech
Tarus Therapeutics, Inc.

Active, not recruiting

TT-10 as a Single Agent in Subjects With Advanced Selected Solid Tumors

Non Small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Renal Cell Cancer | Castrate Resistant Prostate Cancer

United States
Palobiofarma SL
Novartis; H. Lee Moffitt Cancer Center and Research Institute

Completed

Trial of PBF-509 and PDR001 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) (AdenONCO)

Non-small Cell Lung Cancer (NSCLC)

United States
M.D. Anderson Cancer Center

Recruiting

Phase 1b/2 Trial of Ipilimumab, Nivolumab, and Ciforadenant (Adenosine A2a Receptor Antagonist) in First-line Advanced Renal Cell Carcinoma.

Renal Cell Carcinoma

United States
Randy Trumbower, PT, PhD

Not yet recruiting

Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

Spinal Cord Injuries | Myelopathy

United States
Assistance Publique Hopitaux De Marseille

Recruiting

Role of A2A Receptor in Hypercholesterolemic Patients (RASCAS)

Hypercholesterolemia

France
Assistance Publique Hopitaux De Marseille

Recruiting

Contribution of the Pharmacological Profile of the A2A Receptor to Adenosine in the Diagnosis of Myocardial Ischemia (RIMACI)

Chronic Coronary Artery Disease

France
Coherus Biosciences, Inc.
Arcus Biosciences, Inc.; Surface Oncology

Terminated

Study of SRF617 With AB928 (Etrumadenant) and AB122 (Zimberelimab) in Patients With Metastatic Castration Resistant Prostate Cancer

Prostate Cancer | Metastatic Castration-resistant Prostate Cancer

United States, Canada
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Terminated

First in Human Study of M1069 in Advanced Solid Tumors

Metastatic or Locally Advanced Unresectable Solid Tumors

United States, Canada
Invicro

Completed

Occupancy of Adenosine A2A Receptors Using the PET Radiotracer [18F]MNI-444

Healthy Volunteer

United States
Turku University Hospital
University of Bonn

Completed

Adenosine and A2A Receptors in Human Brown Adipose Tissue (AdenoBAT)

Obesity
University of Aarhus

Unknown

The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo

Retinal Artery Occlusion

Denmark
Institute for Neurodegenerative Disorders

Completed

Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects. (MNI-420)

Parkinson Disease | Huntington Disease

United States
Fundació Institut de Recerca de l'Hospital de la...
Palo Biofarma, S.L

Completed

Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF -509 (80 mg, 160 mg and 240 mg) "After Multiple Oral Doses" in Healthy Volunteers

Parkinson Disease

Spain
Fundació Institut de Recerca de l'Hospital de la...
Palo Biofarma, S.L

Completed

Study To Assess the Safety and Tolerability of PBF-509 in Male Healthy Volunteers

Parkinson Disease

Spain
Swedish Orphan Biovitrum

Completed

Efficacy and Tolerability of Novel A2A Agonist in Treatment of Diabetic Neuropathic Pain

Diabetic Neuropathic Pain

Czech Republic, Germany, South Africa
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia

Blood Flow in Healthy Volunteers

Netherlands
German Heart Institute
GE Healthcare

Not yet recruiting

Use of Stress-CMR Using Regadenoson and GE-267 in Adult Patients With Known or Suspected Coronary Artery Disease

Coronary Artery Disease

Germany
Johannes Gutenberg University Mainz

Recruiting

Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition (MICRO-SNAPE)

Coronary Vasospasm | Coronary Microvascular Disease

Germany
Korea University Anam Hospital

Recruiting

Sex Difference of Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease

Microvascular Angina

Korea, Republic of
Sohag University

Not yet recruiting

Assessment of Serum Levels of Adenosine Deaminase and Immunoglobulin E in Patients With Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria
Artios Pharma Ltd

Recruiting

Study of ART6043 in Advanced/Metastatic Solid Tumors Patients

Advanced Solid Tumor | Metastatic Solid Tumor

United States
Imperial College London
Merck Sharp & Dohme LLC

Not yet recruiting

ATP and P2X3 Receptor in Chronic Cough

Cough
St. Jude Children's Research Hospital

Recruiting

Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

Sickle Cell Disease

United States
Hospices Civils de Lyon

Not yet recruiting

Evaluation of the Functional Impact of Coronary Stenoses in Diabetics by Spectral CT (EURECAS)

Coronary Stenosis | Diabetic

France
University of Florida
ALS Association

Recruiting

Adenosine 2A Receptor Antagonism and AIH in ALS

ALS

United States
Virginia Commonwealth University
Kyowa Kirin, Inc.

Recruiting

Istradefylline for Parkinson Disease With Cognitive Impairment

Parkinson Disease | Cognitive Impairment

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

Cardiac Outcomes With Near-Complete Estrogen Deprivation (CROWN)

Breast Cancer | Triple Negative Breast Cancer | Cardiovascular Complications

United States
Cancer Research UK
Teon Therapeutics, Inc.

Recruiting

TT-702 in Patients With Advanced Solid Tumours. (CURATE)

Advanced Solid Tumors

United Kingdom
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

Acute Myeloid Leukemia | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia

United States
Dwight Owen
National Cancer Institute (NCI)

Recruiting

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
University of Messina
Natasha Irrera; Gianluca Di Bella; Antonio Micari; Roberto Licordari

Recruiting

Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction (BETA-MI)

Myocardial Infarction | Myocardial Fibrosis | Myocardial Remodeling, Ventricular

Italy
iTeos Belgium SA
GlaxoSmithKline; iTeos Therapeutics

Recruiting

Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors (TIG-006)

Melanoma | Head and Neck Cancer | Lung Cancer | Advanced Cancer

Spain, Italy, France, United States, United Kingdom, Belgium
Weill Medical College of Cornell University
Arcus Biosciences, Inc.

Recruiting

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer. (PANTHER)

Rectal Cancer

United States
Korea University Anam Hospital

Recruiting

Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

Heart Failure With Preserved Ejection Fraction (HFpEF)

Korea, Republic of
Vastra Gotaland Region
Göteborg University

Recruiting

BROKEN-SWEDEHEART- Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome.

Takotsubo Syndrome

Norway, Denmark, Sweden
GE Healthcare
Covance

Recruiting

A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients (Rapiscan PIP)

Myocardial Ischemia | Coronary Artery Disease

France, Greece, Italy, United Kingdom
University of Utah
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

MRI Scans

United States
University of Maryland, Baltimore
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Regadenoson Infusion of Marginalized Donor Lungs in an EVLP System

Lung Transplant

United States
Asan Medical Center

Recruiting

FFR and Inducible Myocardial Ischemia During Adenosine Stress Testing

Coronary Artery Stenosis

Korea, Republic of
Emory University
Siemens Medical Solutions

Recruiting

The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI

Coronary Artery Disease

United States
University Hospital Inselspital, Berne

Recruiting

The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke (BEHABIS)

Acute Stroke

Switzerland
Rahul Aggarwal
AstraZeneca

Recruiting

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Clear Cell Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | Endometrial Cancer | Stage III Renal Cell Cancer | Locally Advanced Malignant Solid Neoplasm | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | Metastatic Malignant Solid Neoplasm | Metastatic Urothelial Carcinoma | Stage IV... and other conditions

United States
NYU Langone Health

Recruiting

A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction

Myocardial Ischemia | Ischemic Heart Disease | Coronary Microvascular Disease

United States
Weill Medical College of Cornell University

Recruiting

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Premature Ventricular Contraction (PVC)

United States

Search clinical trials for: Adenosine A2a receptor (A2AR)

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