Search clinical trials for: After first-line treatment failed

Total 83508 results

Tianjin Medical University Cancer Institute and...

Recruiting

Adebrelimab and Fruquintinib Combined With Paclitaxel/Albumin Paclitaxel for Advanced Gastric Cancer After PD-1 Antibody Failed

Gastric Cancer

China
Nanfang Hospital of Southern Medical University

Recruiting

Alternating Treatment With Fruquintinib and Bevacizumab Plus Capecitabine as Maintenance Therapy After First-Line Treatment in Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

China
Beijing Hospital
Chinese Society of Clinical Oncology

Recruiting

Apatinib Combined With SHR-1210 as Second-line Treatment in Solid Tumors With Only Liver Metastases

Solid Tumor

China
SynCore Biotechnology Co., Ltd.

Completed

EndoTAG-1+GEM vs GEM in Patients With Locally Advanced/Metastatic Pancreatic Adenocarcinoma Failed on FOLFIRINOX

Pancreatic Adenocarcinoma | Metastatic Pancreas Cancer | Locally Advanced Pancreatic Cancer

United States, Korea, Republic of, Taiwan, France, Hungary, Israel, Russian Federation
Universidade Católica Portuguesa

Completed

Digital Assessment at Peri-implant Tissues After Immediate Implants With Customized Healing Abutments and Connective Tissue Grafts

Dental Implant Failed

Portugal
Samsung Medical Center

Completed

Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy

Colo-rectal Cancer

Korea, Republic of
Samsung Medical Center

Withdrawn

FOLFIRI as Salvage Treatment in Metastatic Biliary Tract Cancer (BTC) Patients Who Were Failed After Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study

Biliary Tract Cancer

Korea, Republic of
Samsung Medical Center

Active, not recruiting

Pemetrexed Alone as Salvage Treatment in Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy: A Phase II Single Arm Prospective Study

Colorectal Cancer

Korea, Republic of
Diakoniekrankenhaus Friederikenstift

Completed

Can Secondary Total Elbow Arthroplasty After Failed Internal Fixation or Non-operative Treatment of Distal Humeral Fractures Achieve Equal Results as Primary Arthroplasty?

Elbow Fracture | Elbow Arthropathy
Hoffmann-La Roche

Terminated

A Study to Assess the Survival of Non-small Cell Lung Cancer Patients Treated With Tarceva After Failed Chemotherapy Treatment (STAR)

Non-Squamous Non-Small Cell Lung Cancer

Romania
Sun Yat-sen University

Completed

Study of Combination of Sorafenib With Cisplatin and 5-fluorouracil as First-line Treatment of Recurrence After Radiotherapy Patients Who Failed With Radiotherapy in Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)

Nasopharyngeal Neoplasms

China
Nanfang Hospital, Southern Medical University

Not yet recruiting

PD-L1 Inhibitor Combined With Apatinib as First-line Maintenance Treatment for Extensive-stage Small Cell Lung Cancer

Small Cell Lung Cancer Extensive Stage
Beijing Cancer Prevention & Treatment Society
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Recruiting

A Prospective, Multicenter, Non-interventional, Real-world Study to Characterize Changes in Molecular Markers After Three Weeks of Targeted Therapy With Oxitinib in EGFRm NSCLC (pre-FLAME)

Non Small Cell Lung Cancer

China
Tris Pharma, Inc.

Not yet recruiting

A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomy (ALLEVIATE2)

Acute Pain

United States
MOSS S.p.A.

Not yet recruiting

NovoX®Cup as Primary Dressing After Breast Reduction

Mammaplasty | Wound Healing Disorder | Post-Surgical Complication

Austria
University of Cologne
AstraZeneca

Not yet recruiting

Maintenance Durvalumab (MEDI4736) and Olaparib (AZD2281) After Standard 1st Line Treatment (Carboplatin/Cisplatin, Etoposide, Durvalumab) in HRD Positive Extensive Disease (ED) Small-cell Lung Cancer (SCLC) (GUIDANCE)

Small Cell Lung Carcinoma
China-Japan Friendship Hospital

Recruiting

Combining Chinese Medicine and Nutrition to Enhance Weight Loss After Bariatric Surgery

Weight Change | Traditional Chinese Medicine Treatment

China
AlaMab Therapeutics (Shanghai) Inc.

Not yet recruiting

A Study to Evaluate the Efficacy of ALMB-0168 in Solid Tumor Patients With Bone Metastatic Whose Prior Standard Treatment Have Failed

Advanced Solid Tumors With Bone Only Metastasis
XIANG YANQUN

Not yet recruiting

Irinotecan Liposomes in Combination With Nituzumab for the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma After Failure of First-Line or Higher Immunotherapy

Nasopharyngeal Cancer

China
Tianjin Medical University Cancer Institute and...

Recruiting

Nimotuzumab Combined With ICIs for the Treatment of Advanced Liver Cancer After First Line Treatment Failure

HCC

China
Jaseng Medical Foundation

Recruiting

Integrative Korean Medicine Treatment for Pediatrics After Traffic Accident: Retrospective Chart Review Study and Survey

Pediatric ALL | Traffic Accident

Korea, Republic of
Universidad Complutense de Madrid

Recruiting

To Evaluate Postoperative Pain and Quality of Life After Taking a Deephethelized Gingival Graft and Covering it With Different Treatments

Quality of Life | Pain, Postoperative | Palate; Wound

Spain
Hospital General Universitario de Alicante
Hospital Universitario Ramon y Cajal; Hospital Universitario Reina Sofia de... and other collaborators

Not yet recruiting

PrEveNtion of Biliary Events After Acute Pancreatitis In NonSUrgicaL pAtients: PENINSULA Trial (PENINSULA)

Acute Pancreatitis | Acute Pancreatitis Due to Gallstones

Spain
Nazmy Edward Seif

Recruiting

Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy

Renal Impairment | Prostate Cancer | Surgery | Bladder Cancer | Renal Injury, Acute

Egypt
University of Nebraska

Recruiting

MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology

Peripheral Arterial Disease

United States
University of New Mexico

Not yet recruiting

Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose

Opioid Overdose | Opiate Overdose

United States
University of Aarhus

Not yet recruiting

Dysphagia and Quality of Life in Patients With Oral Squamous Cell Carcinoma Before and After Treatment

Quality of Life | Dysphagia | Oral Cavity Cancer

Denmark
Riphah International University

Not yet recruiting

Three Phase Physical Therapy in Children With Relapsed Club Foot After Ponseti Treatment

Club Foot
Odense University Hospital
Aarhus University Hospital; Rigshospitalet, Denmark; Aalborg University Hospital and other collaborators

Recruiting

Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)

Atrial Fibrillation | Left Atrial Appendage Absent | Anticoagulant Adverse Reaction

Denmark
Royal Brompton & Harefield NHS Foundation Trust

Not yet recruiting

A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure

Heart Failure | Decompensated Heart Failure
Consorci Sanitari de Terrassa

Recruiting

Trimodality Treatment in Bladder Cancer

Urinary Bladder Neoplasms | Bladder Cancer | Bladder Disease

Spain
Prof. Dr. Daniel Pecos Martín

Recruiting

Changes in the Quadriceps Muscle After Dry Needling Treatment

Muscle Tightness | Muscle Strain

Spain
Diakonhjemmet Hospital
Vestre Viken Hospital Trust; Hormone Laboratory, Aker University Hospital,...

Not yet recruiting

Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint Disease (BOOGIE)

Osteoporosis | Inflammatory Rheumatism | Osteoporosis, Steroid Induced
Changhai Hospital
Shanghai Chest Hospital; Shanghai Changzheng Hospital; First Affiliated Hospital... and other collaborators

Recruiting

High-dose Furmonertinib in the Treatment in Patients With Advanced, Metastatic NSCLC With Progressed After First- or Second-line Treatment With Osimertinib

Non-Small Cell Lung Cancer

China
RenJi Hospital

Not yet recruiting

Label-free Raman Spectroscopy for Discrimination Between Breast Cancer Tumor and Adjacent Tissues After Neoadjuvant Treatment

Diagnosis
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

Evaluation of The Efficacy And Safety of PD-1 + IL-2 Combined With Capox Treatment After Loop Colostomy Surgery in Left-sided Colorectal Cancer Patients Complicating Acute Obstruction

Left-sided Colorectal Cancer Complicating Acute Obstruction
VA Office of Research and Development

Not yet recruiting

Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization (CAD in sPAD)

Coronary Artery Disease | Peripheral Artery Disease

United States
General Hospital of Shenyang Military Region

Not yet recruiting

Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion

Ischemic Stroke

China
Yonsei University

Recruiting

Intestinal Ultrasound, Magnetic Resonance Enterography, and Conventional Assessment Tools Before and After Treatment of Intestinal Behcet's Disease

Intestinal Behcet Disease

Korea, Republic of
Sebastien Knecht
Boston Scientific Corporation

Not yet recruiting

VEin of MArshall Ethanolization vs Extended Pulmonary Vein PULSEd Field Ablation After Failed PVI for Persistent AF (VEMAPULSE)

Persistent Atrial Fibrillation

Belgium
Assaf-Harofeh Medical Center

Not yet recruiting

The Effect of a Prolonged Peripheral Nerve Block on the Level of Pain After a Knee Replacement

Knee Replacement Surgery
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
Rigshospitalet, Denmark

Recruiting

Whole Body Metabolism in Children Before and After Treatment of CNS Tumor

CNS Tumor, Childhood

Denmark
University Hospital, Basel, Switzerland
Sana Kliniken Düsseldorf GmbH

Recruiting

An Integrated Algorithm for Surgical Intervention in Chronic Lymphedema After Breast Cancer Treatment: The Basel Lymphedema Protocol

Breast Cancer | Lymphedema

Switzerland
Yehua Shen

Not yet recruiting

HAIC Combined With PD-L1 Plus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma After Immunotherapy Failure

HCC - Hepatocellular Carcinoma
Lee's Pharmaceutical Limited

Recruiting

Study of AU409 Capsule in Advanced Hepatocellular Carcinoma Patients Who Failed Standard Treatment

Advanced Hepatocellular Carcinoma

China
Sun Yat-sen University
Kousai Bio Co., Ltd.

Not yet recruiting

KSD-101 Therapy for Standard Treatment Failed EBV-associated NPC: an Exploratory Clinical Trial

Nasopharyngeal Carcinoma

China
Chengdu University of Traditional Chinese Medicine

Recruiting

Comparative Clinical Efficacy Between Multi-layer Bandage Pressure Therapy and Gradient Pressure Elastic Stocking Treatment After Endovenous Radiofrequency Ablation

Vascular Diseases, Peripheral | Venous Insufficiency of Leg | Varicose Veins of Lower Limb

China
Necmettin Erbakan University

Not yet recruiting

Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs

Periodontitis, Adult
Nantes University Hospital
Janssen Pharmaceutica

Not yet recruiting

Minimal Residual Disease-based Strategy With T-Cell Redirector After Treatment With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma (IFm2022-01)

Multiple Myeloma

France

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