Search clinical trials for: Challenge dose

Total 22228 results

University of Oxford

Recruiting

COV-CHIM02: SARS-CoV-2 Omicron BA.5 Subvariant Dose Finding Infection Study

SARS-CoV-2 Infection

United Kingdom
Duke University
United States Department of Defense; Owlstone Ltd; Darwin Biosciences

Not yet recruiting

Single Dose Texas 2017 (H3N2) Challenge Study

Influenza Viral Infections
Craig Erickson
Healx Limited

Recruiting

Placebo-Controlled, Single-Dose Challenge Study of Gaboxadol in Adult Males With Fragile X Syndrome (FXS)

Fragile X Syndrome

United States
James Tarbox, MD
Texas Tech University Health Sciences Center

Recruiting

Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge

Penicillin Allergy

United States
Scandinavian Biopharma AB
Johns Hopkins Bloomberg School of Public Health

Recruiting

Pre-Study of Wild Type Enterotoxigenic E. Coli (ETEC) Strain for Verification of a Planned Challenge Dose

ETEC Diarrhea

United States
Hvivo
Pfizer

Recruiting

Dose, Safety, and Pathogenicity of a New Influenza B Strain

Influenza B

United Kingdom
Northern Ontario School of Medicine

Recruiting

Evaluation of a Direct Oral Penicillin Challenge in a Rural Community (DOC)

Allergy Penicillin

Canada
Ifakara Health Institute
University of Oxford

Not yet recruiting

In-vivo Transmission Model in Semi-immune Adults

Controlled Human Malaria Infection | Malaria Transmission | Induced Blood Stage Malaria Infection | Malaria Challenge

Tanzania
Enanta Pharmaceuticals, Inc
hVIVO Services Limited

Recruiting

A Controlled Phase 2a Study to Evaluate the Efficacy of EDP-323 Against Respiratory Syncytial Virus Infection in a Virus Challenge Model

RSV Infection

United Kingdom
Children's Hospital Medical Center, Cincinnati
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge

Fragile X Syndrome

United States
Assistance Publique - Hôpitaux de Paris
BTG International Inc.

Recruiting

Dose Dense Re-challenge of High Dose Methotrexate With Glucarpidase for Relapsed Primary Central Nervous System Lymphoma (METHOGLU)

Primary Central Nervous System Lymphoma

France
Murdoch Childrens Research Institute

Recruiting

Low Dose Multi-Nut Oral Immunotherapy in Pre-schoolers With a Multi-Nut Allergy (LMNOP)

Allergy, Nut

Australia
National Institute of Allergy and Infectious Diseases...
National Institutes of Health (NIH); Janssen, LP

Recruiting

An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 Challenge

Dengue

United States
Dr. Diane Lougheed

Recruiting

Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol

Cough | Asthma | Cough Variant Asthma

Canada
Janssen Research & Development, LLC

Suspended

A Study of JNJ-64281802 Against Dengue Serotype 1 Infection in a Dengue Human Challenge Model in Healthy Adult Participants

Healthy

United States, United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Phase I Norovirus Challenge Model

Gastroenteritis Norovirus

United States
University of Manitoba
The Hospital for Sick Children; University of British Columbia; McGill University

Enrolling by invitation

Predictors of Persistent Peanut Allergy at Age 5 Years

Allergy to Peanut
University of Maryland, Baltimore
Medical Technology Enterprise Consortium (MTEC)

Completed

Dengue 4 Human Infection Model (Dengue CVD 11000; DHIM-4)

Dengue

United States
National Institute of Allergy and Infectious Diseases...

Completed

Influenza Challenge Study to Determine the Optimal Infection Dose and Safety of a Recombinant H3N2 (A/Texas/71/2017 (H3N2, Clade 3C3a) Influenza Strain

Influenza

United States
University of Vermont
World Health Organization

Active, not recruiting

Intradermal Fractional Dose IPV (fIPV) in Combination With dmLT

Poliomyelitis

United States
Merck KGaA, Darmstadt, Germany

Completed

First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Participants

Healthy

Australia
Hvivo
Pfizer

Completed

Dose, Safety, and Pathogenicity of a New Influenza H1N1 Challenge Strain

Influenza A H1N1

United Kingdom
Orion Corporation, Orion Pharma

Completed

Use of Buventol Easyhaler and Bufomix Easyhaler in Methacoline Challenge Testing (EASYRELIEF)

Asthma

Finland
Merck Sharp & Dohme LLC

Completed

Hepatitis B Challenge Dose in Adults (V232-059-10)

Hepatitis B
Marinomed Biotech AG

Completed

Therapeutic Effect of Tacrosolv in Patients With Allergic Rhinoconjunctivitis

Allergic Rhinitis | Allergic Conjunctivitis

Austria
MedSIR

Completed

Molecular Mechanisms of Resistance and Sensitivity to Palbociclib Re-challenge in ER+ mBC (BioPER)

Metastatic Breast Cancer

Spain, Italy
University Hospital Inselspital, Berne

Completed

Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS (FLOW-AS)

Aortic Valve Stenosis

Switzerland
Enanta Pharmaceuticals, Inc
hVIVO Services Limited

Completed

A Phase 2a Study to Evaluate EDP-938 in the Virus Challenge Model

RSV Infection

United Kingdom
Dr. Diane Lougheed
The Ontario Thoracic Society of the Ontario Lung Association; Queen's University...

Completed

Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests

Asthma | Cough Variant Asthma

Canada
Sage Therapeutics

Completed

A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

Healthy Volunteer

United States
Cerevel Therapeutics, LLC

Completed

A Trial of the Effect of CVL-865 on Panic Symptoms Induced by Carbon Dioxide Inhalation in Healthy Subjects

Panic Disorder

Netherlands
Chiesi Farmaceutici S.p.A.

Completed

Dose Response AMP Challenge Study With Beclometasone Dipropionate (BDP)/Formoterol Pressurised Metered Dose Inhaler (pMDI)

Mild Persistent Asthma

United Kingdom
University of Oxford

Completed

VAC 072-An Efficacy Study of R21/MM in Different Dose Schedules

Malaria

United Kingdom
Regeneron Pharmaceuticals

Completed

Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge

Cat Allergy | Mild Asthma

France
National Institute of Allergy and Infectious Diseases...
Sanaria Inc.

Completed

Dose Escalation PfSPZ-CVac

Malaria

United States
Christina West
Nutricia, Inc.; The Västerbotten county council; State Government founding for... and other collaborators

Completed

New Validated Recipes for Double-blind Placebo-controlled Low Dose Food Challenges

Allergy

Sweden
National Institute of Allergy and Infectious Diseases...

Completed

H1N1v Virus Challenge Study in Healthy Subjects

Influenza

United States
Amsterdam UMC, location VUmc

Terminated

Iressa Re-challenge in Advanced NSCLC EGFR-mutated Patients (IRENE)

Lung Cancer

Netherlands
GlaxoSmithKline
The PATH Malaria Vaccine Initiative (MVI)

Completed

Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve Adults

Malaria

United States
GlaxoSmithKline
PATH

Completed

A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccinated Healthy Malaria-naïve Adults

Malaria

United States
Central Adelaide Local Health Network Incorporated
Vaxine Pty Ltd

Unknown

Study of Sting Challenge and Serological Responses to Jack Jumper Venom Immunotherapy With Inulin as Adjuvant (Jumpvax) (Jumpvax)

Immunotherapy | Ant Sting

Australia
GlaxoSmithKline

Completed

Phase 2a, AMP Challenge, Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects

Asthma

United Kingdom, Germany
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI); QIMR Berghofer Medical Research...

Completed

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2 (CHMI-trans2)

Transmission | Malaria,Falciparum | Controlled Human Malaria Infection | Gametocytes

Netherlands
Janssen BioPharma, Inc.

Completed

A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses, and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants

Healthy

United Kingdom
GlaxoSmithKline

Completed

A Study to Evaluate Persistence of Hepatitis B Antibodies, Immunogenicity and Safety of Engerix™-B Kinder Challenge Dose, in Adolescents Vaccinated With Four Doses of Infanrix™ Hexa During Infancy

Hepatitis B

Germany
WCCT Global
National Institutes of Health (NIH); Stanford University

Completed

Single Ascending Dose Challenge Study to Determine Safety and Reactogenicity of an Influenza Challenge Virus

Influenza
National Institute of Allergy and Infectious Diseases...

Completed

Influenza A H3N2 Human Challenge Study in Healthy Adult Volunteers

Determine Minimally to Moderately Infective Dose (MMID) of Influenza A H3N2

United States
Braeburn Pharmaceuticals

Completed

A Multiple Dose Opioid Challenge Study

Moderate or Severe Opioid Use Disorder

United States
GlaxoSmithKline

Completed

Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB)

Asthma

United States, Canada
GlaxoSmithKline
Walter Reed Army Institute of Research (WRAIR); The PATH Malaria Vaccine Initiative...

Completed

Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults

Malaria

United States

3

Subscribe