Search clinical trials for: D2-receptor occupancy

Total 117 results

Janssen-Cilag G.m.b.H

Terminated

A Positron-Emission-Tomography (PET) Study to Measure the Blockade of Dopamine Receptors (D2) in Specific Areas of the Brain in Relation to the Plasma Concentrations of Paliperidone Extended Release (ER) and Oral Risperidone in Schizophrenia Patients and Healthy Controls

Schizophrenia

Germany
Asan Medical Center
Seoul National University Hospital

Completed

Early Clinical Evaluation of the Pharmacokinetics and Mechanism Based Pharmacodynamics of Haloperidol Using Positron Emission Tomography in Healthy Volunteers

Healthy

Korea, Republic of
AbbVie

Not yet recruiting

Study of Oral ABBV-932 Capsules to Evaluate Dopamine D2 and D3 Receptor Occupancy in Brain in Adult Healthy Volunteers

Healthy Volunteers
Intra-Cellular Therapies, Inc.

Recruiting

PET Study to Evaluate Brain Receptor Occupancy, Safety and Pharmacokinetics of ITI-1284 in Healthy Subjects

Healthy Volunteers

United States
Shanghai Mental Health Center
Yantai University

Recruiting

Assessing Dopamine Transporter Occupancy in the Patients With Depression Brain With Toludesvenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)

Major Depressive Disorder

China
Yale University
Janssen Scientific Affairs, LLC

Not yet recruiting

PET and MRI Imaging With Scopolamine at the Muscarinic M1 Receptor (emo_to2)

Muscarinic Receptor Occupancy

United States
Rigshospitalet, Denmark

Recruiting

LSD Occupancy of the Serotonin 2A Receptor in the Human Brain (dOccLS)

Basic Science

Denmark
Cerevel Therapeutics, LLC

Recruiting

Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Receptors in Brain Following Oral Dosing

Opioid Use Disorder

United States
New York State Psychiatric Institute

Not yet recruiting

Dopamine D3 Receptor Occupancy in Bipolar Depression

Bipolar Depression

United States
Changhai Hospital

Recruiting

Research on the Value of Genomics Research Based on Ultrasound Endoscopic Biopsy in the Differential Diagnosis and Prognostic Evaluation of Pancreatic Occupancy

Pancreatic Space Occupying

China
Charite University, Berlin, Germany
Stiftung Institut fuer Herzinfarktforschung; Deutsches Zentrum für Herz-Kreislauf-Forschung... and other collaborators

Recruiting

Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy (CLOSURE-AF)

Atrial Fibrillation

Germany
National Institute on Alcohol Abuse and Alcoholism...

Recruiting

Brain Dopaminergic Signaling in Opioid Use Disorders

Normal Physiology | Opioid Use Disorders

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Trametinib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol R)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
Asceneuron S.A.

Completed

Positron Emission Tomography Study in Healthy Subjects to Determine the Relationship Between Plasma Concentration and Brain Target Occupancy of ASN51

Alzheimer Disease

United Kingdom
Novartis Pharmaceuticals

Completed

An Open-label, Adaptive Design, Positron Emission Tomography Study in Healthy Male Participants to Characterize Receptor Occupancy by MIJ821 in the Brain

Major Depressive Disorder

United Kingdom
Biogen

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics, With Target Occupancy Study of BIIB113 in Healthy Participants

Healthy Volunteer

United Kingdom, Sweden
M.D. Anderson Cancer Center
AstraZeneca; Mirati Therapeutics Inc.

Withdrawn

A Phase I Study of Adagrasib and Durvalumab for Treatment of Advanced Non-small Cell Lung Cancers and Gastro-intestinal Cancers Harboring KRAS G12C Mutations

Lung Cancer | Gastro-intestinal Cancer

United States
Pliant Therapeutics, Inc.
Stanford University

Completed

Phase 2a Evaluation of PLN-74809 on αvβ6 Receptor Occupancy Using PET Imaging in Participants With IPF/ (IPF-201)

Idiopathic Pulmonary Fibrosis

United States
Pfizer

Completed

A Target Occupancy Study With Ritlecitinib.

Healthy

United States
Shanghai Mental Health Center
Yantai University

Completed

Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)

Major Depressive Disorder

China
Cerevel Therapeutics, LLC

Completed

PET Trial to Evaluate Target Occupancy of CVL-231 on Brain Receptors Following Oral Dosing

Schizophrenia

Belgium, United States
Centre for Addiction and Mental Health

Completed

MAO-B Occupancy in Depressed Patients (MOCP)

Major Depressive Disorder | Treatment Resistant Depression

Canada
University of Pennsylvania

Active, not recruiting

Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT

Healthy Volunteer | D3 Dopamine Receptor | Cocaine-dependent

United States
Yale University
National Institute on Aging (NIA)

Completed

Evaluating the Safety, Tolerability, Pharmacokinetics and Receptor Occupancy of BMS-984923

Alzheimer Disease

United States
Taisho Pharmaceutical Co., Ltd.

Completed

Clinical Study on Histamine H3 Receptor Occupancy of TS-091 by PET Examination in Healthy Adult Subjects

Healthy Subjects

Japan
Pipeline Therapeutics, Inc.

Completed

PET Study to Determine the Relationship Between Plasma Concentrations and Muscarinic Type 1 Receptor (M1AChR) Occupancy of PIPE-307 in Healthy Volunteers

Multiple Sclerosis

United Kingdom
AbbVie
KU Leuven; Syndesi Therapeutics

Completed

A Single Ascending Oral Dose Study of SDI-118 in Healthy Male Subjects Including an Assessment of Receptor Occupancy and Food Effect

Cognitive Disorders

Belgium
Invicro

Completed

Occupancy of Adenosine A2A Receptors Using the PET Radiotracer [18F]MNI-444

Healthy Volunteer

United States
Centre for Addiction and Mental Health

Completed

Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia.

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder | Delusional Disorder | Psychotic Disorder

Canada
LB Pharmaceuticals Inc.
Washington University School of Medicine

Completed

Receptor Occupancy of LB-102 Using Positron Emission Tomography (PET) in Healthy Volunteers

Schizophrenia

United States
Bayer

Completed

Study to Compare the Effectiveness of Rivaroxaban (Xarelto) Versus Low-molecular-weight Heparin (LMWH) and Phenprocoumon for the Treatment and Secondary Prevention of Venous Thromboembolism in Routine Clinical Practice in Germany

Venous Thromboembolism

Germany
Tetra Discovery Partners

Withdrawn

A Phase 1, Open-Label, PET Study of T2310 & BPN14770

To Determine Brain Target Occupancy of BPN14770

United States
Prilenia

Completed

A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease

Health Volunteers, Huntington Disease

Germany
AstraZeneca

Completed

PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium

Healthy Volunteers

Sweden
Takeda

Terminated

A Study With [18F]MNI-1054 to Determine Lysine -Specific Demethylase 1A (LSD1) Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Participants

Healthy Volunteers

United States
Heptares Therapeutics Limited

Completed

Study to Investigate the Receptor Occupancy of HTL0014242 Using [18F] FPEB in Healthy Male Subjects

Healthy

United Kingdom
Neurocrine Biosciences
Takeda

Completed

Study to Determine D-amino Acid Oxidase Brain Enzyme Occupancy of TAK-831 After Single-dose Oral Administration

Healthy

United Kingdom
National Institute of Mental Health (NIMH)

Completed

Title: Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)

Depression

United States
H. Lundbeck A/S

Completed

Positron Emission Tomography (PET) Study Investigating Dopamine and Serotonin Receptor Occupancy After Multiple Oral Dosing of Lu AF35700

Schizophrenia

United States
Pfizer

Terminated

Avelumab In Patients With Previously Treated Advanced Stage Classical Hodgkin's Lymphoma (JAVELIN HODGKINS)

Hodgkins Lymphoma

United Kingdom, United States, Italy
Centre for Addiction and Mental Health

Unknown

Dopamine D2 and D3 Receptor Occupancy and Clinical Response in Older Patients With Schizophrenia

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder

Canada
Janssen Research & Development, LLC

Terminated

A Study to Investigate Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA Gamma 8) Receptor Occupancy of JNJ-64140284 With Newly Developed Transmembrane AMPA Receptor Regulatory Protein (TARP)-Gamma 8 Positron Emission Tomography (PET) [18F]JNJ-64511070 in Healthy Men

Healthy

Belgium
National Institute of Mental Health (NIMH)

Completed

PET Scanning of Adults With Attention Deficit Hyperactivity Disorder (ADHD)

Attention Deficit Hyperactivity Disorder | Volunteer

United States
Seoul National University Hospital

Unknown

[18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in Psychosis (DPTP)

Schizophrenia

Korea, Republic of
Seoul National University Hospital

Unknown

Predicting Antipsychotic Discontinuation in Psychosis (PADP)

Schizophrenia

Korea, Republic of
G. d'Annunzio University

Completed

Prospective Study on the Treatment of Unsuspected Pulmonary Embolism in Cancer Patients

Unsuspected Pulmonary Embolism

Spain, France, Netherlands, Italy, United States, Austria, Canada, Germany
Invicro

Completed

D1 Receptor Occupancy (RO) Following a Single Dose of PF-06412562

Healthy Male Volunteers

United States
Seoul National University Hospital

Completed

Validation of Receptor Occupancy Simulation

Schizophrenia | Dopamine Receptor Occupancy | Medication Satisfaction | Prolactin Level

Korea, Republic of
Seoul National University Hospital

Completed

Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients

OCD

Korea, Republic of
Merck Sharp & Dohme LLC

Completed

Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)

Migraine

3

Subscribe