Search clinical trials for: DDI with CYP3A4 inhibitors

Total 192146 results

Karolinska University Hospital
AstraZeneca

Completed

Cholesterol Metabolites as Markers for CYP3A Induction

CYP3A4 Induction

Sweden
University of Michigan Rogel Cancer Center

Withdrawn

Phase IV Multi-arm Study of CDK4/6 Pharmacokinetics in Healthy Volunteers With Known CYP3A4*22 Genotype

CYP3A4*22
Pfizer

Completed

Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects

Pharmacokinetics | Cytochrome P-450 CYP2D6 | CYP3A4 Protein, Human

United States
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir

Malaria

United Kingdom
University Hospital, Geneva

Completed

DAPHNE Study: Direct Anticoagulant PHarmacogeNEtic (DAPHNE)

Anticoagulants and Bleeding Disorders

Switzerland
Jazz Pharmaceuticals

Completed

Study to Evaluate the Effect of Rifampicin, Ketoconazole, and Omeprazole on the Pharmacokinetics of Sativex

Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Known Inducer of CYP3A4 | Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Potent Inhibitor of CYP3A4 | Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a CYP2C19...

United Kingdom
Zhujiang Hospital

Completed

Drug Interaction Study of Azithromycin and Theophylline

Chronic Obstructive Pulmonary Disease | Asthma

China
Toray Industries, Inc

Completed

TRK-700 Drug-Drug Interaction Study With Digoxin and Midazolam

Healthy

Japan
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men

Healthy Subjects | Drug-Drug Interaction (DDI) | Pharmacokinetics of Enzalutamide

Germany
University Hospital Bispebjerg and Frederiksberg

Completed

Metabolism of Chlordiazepoxide in the Treatment of Alcohol Withdrawal Symptoms

Alcohol Withdrawal

Denmark
Theravance Biopharma

Completed

Drug-Drug Interaction (DDI) Study for TD-9855

Drug Drug Interaction (DDI)

United States
Vantia Ltd

Completed

Study in Healthy Male Subjects to Evaluate the Effect of Itraconazole and Rifampicin on the PK of Fedovapagon

Nocturia

Germany
Eisai Inc.

Completed

Phase 1 Study to Determine the Effect of Lenvatinib (E7080) on the Pharmacokinetics of Midazolam in Subjects With Advanced Solid Tumors

Tumors

United States
Boehringer Ingelheim

Completed

DDI Strong CYP3A4 Inducer

Healthy

Germany
Natalia Valadares de Moraes
University of Sao Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo

Enrolling by invitation

Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol

Obesity | Bariatric Surgery | Roux-en Y Gastric Bypass

United States
Shirley M. Tsunoda

Unknown

Drug Interaction With Envarsus XR and Grapefruit Juice

Kidney Transplant; Complications | Drug Interaction Food
GlaxoSmithKline

Completed

Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).

Atherosclerosis

United States
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078

Cachexia

United States
Genelex Corporation
University of Utah

Completed

YouScript IMPACT Registry (IMPACT)

Drug Interaction Potentiation | Adverse Drug Events | Adverse Drug Reactions | Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 Enzyme Deficiency | Cytochrome P450 CYP2D6 Enzyme Deficiency | Cytochrome... and other conditions

United States
University of Southern Denmark
Odense University Hospital

Completed

Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans

Healthy

Denmark
Lawson Health Research Institute

Completed

Coffee Interaction With the Antihypertensive Drug Felodipine

Food-Drug Interactions

Canada
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity (FLUOXETINE)

Healthy Volunteers | Drug-Drug Interaction
Janssen Research & Development, LLC

Completed

A Study to Assess the Effect of Rifampin on the Pharmacokinetics of PCI-32765 in Healthy Participants

Healthy Participants

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of Abiraterone Following Administration of Abiraterone Acetate Tablets in Healthy Adult Men

Healthy Volunteers

Belgium
PMV Pharmaceuticals, Inc

Recruiting

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Healthy Volunteers

United States
Jill M Kolesar
National Cancer Institute (NCI); Novartis

Recruiting

Nilotinib Plus Dabrafenib/Trametinib in Metastatic Melanoma

Metastatic Melanoma | BRAF Gene Mutation

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults

Healthy Volunteers

United States
The Netherlands Cancer Institute

Completed

CYP3A4 Activity in Patients With Prostate Cancer Versus Male Patients With Other Solid Tumours

Prostate Cancer | Solid Tumor, Adult

Netherlands
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

CYP3A4 Activity and Mineral Homeostasis

Vitamin D and Calcium Homeostasis

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants

Healthy Participants

United States
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

Completed

A Study to Evaluate the Effect of a Dual CYP2C19 and CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Healthy Volunteers

United States
Helwan University
Ain Shams University

Completed

Effect of Genetic Polymorphism on Calcineurin Inhibitors Levels in Egyptian Renal Transplant Patients

Renal Transplantation

Egypt
Pfizer

Completed

Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single-Dose of PF-06651600 in Healthy Participants

Healthy Participants

Belgium
Genelex Corporation

Completed

Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM

Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 CYP2D6 Enzyme Deficiency | Cytochrome P450 CYP2C9 Enzyme Deficiency | Cytochrome P450 CYP2C19 Enzyme Deficiency | Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant | CYP2D6 Polymorphism | Ultrarapid... and other conditions

United States
Millennium Pharmaceuticals, Inc.

Completed

Ketoconazole Administration: How it is Affected by the Body and Broken Down and How it Acts on the Body When Used With Velcade

Tumors

United States
Chong Kun Dang Pharmaceutical

Completed

CKD-506 Drug-Drug Interaction Study in Healthy Male Subjects

Drug Drug Interaction

Netherlands
Children's Mercy Hospital Kansas City
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Biomarkers of CYP2D6 and CYP3A4 Variability in Pediatrics

Drug Metabolism Phenotype

United States
Huazhong University of Science and Technology

Completed

Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal Surgery

Pain | Surgery

China
Bristol-Myers Squibb

Recruiting

A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam

Healthy Participants

United States
Radboud University Medical Center

Completed

Determining the Clinical Relevance of the inTeraction Between AprepitaNt aNd EtoposiDe (TANNED)

Testicular Cancer

Netherlands
Odense University Hospital
Novartis; Danish Research Agency

Completed

Induction of Drug Metabolism: In Vivo Comparison of Carbamazepine and Oxcarbazepine.

Metabolic Clearance Rate

Denmark
Janssen Research & Development, LLC

Completed

A Study to Determine the Absorption, Metabolism, and Routes of Excretion of (14C) Radiolabeled Ibrutinib in Healthy Male Participants

Healthy Participants

Belgium
National Institutes of Health Clinical Center (CC)

Completed

Drug Interaction Study of Tegretol (Carbamazepine) and St. John's Wort in Normal Volunteers

Healthy

United States
Chiesi Farmaceutici S.p.A.

Recruiting

Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers

Chronic Obstructive Pulmonary Disease

Bulgaria
Epizyme, Inc.

Completed

Study to Describe the Interaction Between Tazemetostat and Itraconazole and Between Tazemetostat and Rifampin in Participants With Advanced Cancer

Solid Tumor | Mesothelioma | Rhabdoid Tumor | Hematologic Malignancy | Advanced Malignancies | Synovial Sarcoma | Renal Medullary Carcinoma | Diffuse Large B-Cell Lymphoma (DLBCL) | Follicular Lymphoma (FL) | Non-Hodgkin Lymphoma (NHL) | All Malignancies | Epithelioid Sarcoma (ES)

Spain, United States
Genelex Corporation
Harding University

Completed

Pharmacogenetic Testing Among Home Health Patients

Drug Interaction Potentiation | Adverse Drug Events | Adverse Drug Reactions | Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant | Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 Enzyme... and other conditions

United States
Vanda Pharmaceuticals

Completed

Pharmacokinetics of Tasimelteon Alone and in Combination With a CYP3A4 Inhibitor, Ketoconazole, or a CYP3A4 Inducer, Rifampin.

Healthy

United States
Pfizer

Completed

Drug-Drug Interaction Study Assessing Effect of Carbamazepine on PF-07321332 Boosted With Ritonavir

Healthy Participant

United States
Xianwei Zhang

Completed

Association of CYP3A4 rs2242480 With Sufentanil Plasma Concentration and PCA Consumption

Surgery | Individuality

China
Pfizer

Completed

Drug-Drug Interaction Study Assessing Effect of Itraconazole on PF-07321332/Ritonavir in Healthy Participants

Healthy Participant

Belgium

Search clinical trials for: DDI with CYP3A4 inhibitors

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