Search clinical trials for: DihydroPyrimidine Dehydrogenase

Total 228 results

UNICANCER
Servier

Not yet recruiting

Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer (TRIFLUOX-DP)

Metastatic Colorectal Cancer | Metastatic Gastroesophageal Adenocarcinoma | DPD Deficiency
National Human Genome Research Institute (NHGRI)

Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic Disease | Purine-Pyrimidine Metabolism | AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2 | UNG, OMIM *191525, Hyper-IgM Syndrome 5 | NT5C3A<TAB>, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency | UMPS, OMIM *613891, Orotic Aciduria | DHODH, OMIM *126064,... and other conditions

United States
University of Chicago

Recruiting

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Breast Cancer | Head and Neck Cancer | Gastrointestinal Cancer | Dihydropyrimidine Dehydrogenase Deficiency | UGT1A1 Gene Mutation

United States
Centre Antoine Lacassagne

Recruiting

The Enzymatic Activity of Lymphocyte Dihydropyrimidine Dehydrogenase DPD in the Blood as a Predictive and Prognostic Factor in Patients With Digestive Cancer in the First or Second Metastatic Line (DPD DIG)

Metastatic or Locally-advanced Digestive Cancer

France
University of Southern Denmark
Odense University Hospital

Completed

Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.

Breast Cancer | Gastric Cancer | Rectal Cancer | Bile Duct Cancer | Colon Cancer | Pancreas Cancer | Oesophageal Cancer | Adverse Drug Event

Denmark
Institut Cancerologie de l'Ouest

Terminated

Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines (DPD côlon)

Colorectal Cancer | Intravenous 5 Fluorouracile

France
The Netherlands Cancer Institute

Unknown

Food-effect Study on Uracil and Dihydrouracil Levels as a Diagnostic Marker of Dihydropyrimidine Dehydrogenase Activity

Drug Safety Biomarkers

Netherlands
M.D. Anderson Cancer Center
Myrexis Inc.

Completed

Association of Dihydropyrimidine Dehydrogenase (DPYD) Variants With Toxicity Related to Capecitabine

Breast Cancer

United States
The Netherlands Cancer Institute

Completed

Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines

Neoplasms

Netherlands
Xijing Hospital

Unknown

Study of DPD for Predicting Efficacy and Safety to S-1 Plus Oxaliplatin in Gastrointestinal Cancer

Gastrointestinal Cancer

China
National Cancer Institute (NCI)

Completed

A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors

Neoplasms | Lymphoma

United States
University Hospital, Bordeaux

Not yet recruiting

Study of Metabolic, Transcriptomic and Proteomic Characteristics in Relapsed Glioblastoma (GBrecurr)

Relapsed Cancer | Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

France
New Valley University

Not yet recruiting

Radiological Characterization of Pulmonary Involvement in Patients With Hematological Diseases

Hematologic Diseases
Jirair Krikor Bedoyan
Ultragenyx Pharmaceutical Inc

Recruiting

Triheptanoin for Children With Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency

Pyruvate Dehydrogenase Complex Deficiency

United States
University of Rochester

Not yet recruiting

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

Age-Related Macular Degeneration | Retinitis Pigmentosa | Retinal Dystrophies | Alcohol Use Disorder | Stargardt Disease

United States
Jerry Vockley, MD, PhD
Ultragenyx Pharmaceutical Inc

Recruiting

Study of Triheptanoin for the Prevention of Hypoglycemia in Patients With Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD)

Medium-chain Acyl-CoA Dehydrogenase Deficiency

United States
Jerry Vockley, MD, PhD
Acer Therapeutics Inc.

Recruiting

Study of Sodium Phenylbutyrate (ACER-001) for the Treatment of Patients With Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD)

Medium-chain Acyl-CoA Dehydrogenase Deficiency

United States
Ultragenyx Pharmaceutical Inc

Recruiting

A Study to Determine the Effect of Triheptanoin Compared With Even-chain, MCT on MCEs in Pediatric Patients With LC-FAOD

Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)

Turkey, United Kingdom, Spain, Saudi Arabia, Poland, Czechia, Germany
West Kazakhstan Medical University

Recruiting

Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan

Ornithine Transcarbamylase Deficiency | Biotinidase Deficiency | Citrullinemia | Glutaric Acidemia Type II | Argininosuccinic Aciduria | Maple Syrup Urine Disease | Primary Carnitine Deficiency | Homocystinuria | Carnitine Palmitoyltransferase II Deficiency | Arginase Deficiency | Very Long-chain Acyl-CoA... and other conditions

Kazakhstan
Menzies School of Health Research
PATH; Indonesia University; Institute of Tropical Medicine, Belgium; UNITAID; Burnet... and other collaborators

Recruiting

Short Course Primaquine for the Radical Cure of P. Vivax Malaria - Indonesia (SCOPE)

Vivax Malaria | G6PD Deficiency

Indonesia
Orbus Therapeutics, Inc.

Recruiting

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma

Glioblastoma | Glioblastoma Multiforme | GBM | Glioblastoma, IDH-wildtype | Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

United States
Macfarlane Burnet Institute for Medical Research...
PATH; UNITAID; University of Melbourne; Menzies School of Health Research; Medicines... and other collaborators

Recruiting

Short Course Primaquine for the Radical Cure of P. Vivax - Papua New Guinea (SCOPE)

Vivax Malaria | G6PD Deficiency

Papua New Guinea
Northwestern University
Agenus Inc.; CarThera

Recruiting

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Glioblastoma Multiforme | Gliosarcoma | Newly Diagnosed Glioblastoma | Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype

United States
Robert Bok, MD, PhD
National Cancer Institute (NCI)

Recruiting

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

Adult Gliomas, Mixed

United States
Debiopharm International SA

Recruiting

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Astrocytoma, Grade III | Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

Spain, United States, Switzerland
Institut National de la Santé Et de la Recherche...

Not yet recruiting

MRS of Glioma Genomics (GLIOMRS)

Glioma

France
Assiut University

Not yet recruiting

Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and Interleukins{2,12,18}for Differentiation Between Malignant and Non Malignant Pleural Effusion

Pleural Effusion, Malignant
Centre Hospitalier Universitaire de Liege
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Régional... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
First People's Hospital of Hangzhou
College of Pharmaceutical Sciences at Zhejiang University; The Innovation Institute...

Not yet recruiting

Treatment of Advance Gastric Cancer With Disulfiram

Chemotherapy；Advanced Gastric Cancer；Cisplatin；Disulfiram

China
University of Washington

Recruiting

Disulfiram for Treatment of Retinal Degeneration

Inherited Retinal Dystrophy Primarily Involving Sensory Retina

United States
National Cancer Institute (NCI)

Recruiting

Study of Zotiraciclib for Recurrent High-Grade Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Cancer | Brain Tumor

United States
GlaxoSmithKline

Recruiting

Phase 2b Study of GSK4532990 in Adults With NASH (HORIZON)

Nonalcoholic Fatty Liver Disease

United States, Australia, Italy, Japan, Spain, Belgium, Argentina, Canada, United Kingdom, Korea, Republic of, France, Greece, India, Mexico, Puerto Rico, Turkey, Panama
University of Thessaly

Not yet recruiting

Oxidative Stress, Carbohydrate Metabolism Disorders and G6PD Deficiency

Oxidative Stress | Carbohydrate Metabolism Disorder | G6PD Deficiency
Juan M Garcia-Gomez
Hospital Universitario 12 de Octubre; Hospital Clínico Universitario de Valencia

Recruiting

BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels (BIOhabitats)

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Astrocytoma, Grade IV | Glioblastoma, IDH-mutant | Glioblastoma, IDH-wildtype | Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Glioblastoma IDH (Isocitrate Dehydrogenase) Mutant

Spain
Ain Shams University

Not yet recruiting

Alpha Lipoic Acid Effect on No-Reflow Phenomenon

No-Reflow Phenomenon
Uppsala University Hospital
Swedish Cancer Society; Lantmännen AB; Sjöbergstiftelsen; Onkologiska klinikens...

Recruiting

Role of Antisecretory Factor in Dihydropyrimidine Treatment of Colorectal Cancer (SALFLADMET)

Dihydropyrimidine Induced Gastrointestinal Toxicity in Colorectal Cancer

Sweden
Great Ormond Street Hospital for Children NHS Foundation...
National Institute for Health Research, United Kingdom; The Freya Foundation

Recruiting

Natural History Study of Pyruvate Dehydrogenase Deficiency

Pyruvate Dehydrogenase Complex Deficiency | Pyruvate Dehydrogenase E1 Alpha Deficiency | Pyruvate Dehydrogenase E1-Beta Deficiency | Pyruvate Dehydrogenase E2 Deficiency | Pyruvate Dehydrogenase Phosphatase Deficiency

United Kingdom
Case Comprehensive Cancer Center

Recruiting

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Relapsed Sarcomas

United States
Korea University Anam Hospital

Recruiting

ALDH Enzyme in CRF With Advanced GI Cancer (ALDHCRF)

Fatigue | Gastrointestinal Cancer | Aldehyde Dehydrogenase

Korea, Republic of
First Affiliated Hospital Xi'an Jiaotong University
Simcere Company

Recruiting

G6PD Deficiency in Infarction Patients in Shaanxi Province (GPS-IP)

Cerebral Infarction | G6PD Deficiency

China
University Hospital, Lille

Recruiting

Study of Cortisol Metabolism in Familial Partial Lipodystrophy Type 2 (LIPOCORT)

Familial Partial Lipodystrophy Type 2

France
Erasmus Medical Center

Not yet recruiting

Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study (N-of-1 DSD)

Disorder of Sex Development, 46,XY

Netherlands
Flemming Forsberg
National Cancer Institute (NCI)

Recruiting

Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Stage IIA Pancreatic Cancer AJCC v8 | Stage IIB Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Ductal Adenocarcinoma | Locally Advanced Pancreatic Ductal Adenocarcinoma | Unresectable...

United States, Norway
Hutchmed

Recruiting

A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH

Isocitrate Dehydrogenase Gene Mutation

Spain, United States
Institut Pasteur
Institut Pasteur de la Guyane; Centre Hospitalier Andrée Rosemon de Cayenne

Recruiting

Evaluation of the STANDARD G6PD Rapid Test for Assaying the Enzymatic Activity of G6PD in French Guiana (G6PD facile)

Paludism

French Guiana
AHS Cancer Control Alberta
Tom Baker Cancer Centre

Recruiting

Study of Niacin in Glioblastoma

Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

Canada
Ultragenyx Pharmaceutical Inc

Recruiting

Long-Chain Fatty Acid Oxidation Disorders In-Clinic Disease Monitoring Program

Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)

United States, Canada
University of Texas Southwestern Medical Center
National Cancer Institute (NCI); Howard Hughes Medical Institute

Recruiting

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

Kidney Cancer | Renal Cell Carcinoma | Urothelial Carcinoma | Hereditary Leiomyomatosis and Renal Cell Cancer | Metastatic Urothelial Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | HLRCC | Clear Cell Carcinoma | Metastatic Kidney Cancer | Fumarate Hydratase Deficiency | Succinate...

United States
Children's National Research Institute
National Center for Advancing Translational Sciences (NCATS)

Recruiting

Systemic Biomarkers of Brain Injury From Hyperammonemia

Hypoxic-Ischemic Encephalopathy | Urea Cycle Disorder | Organic Acidemia | Fatty Acid Oxidation Disorder | Maple Syrup Urine Disease | Glutaric Acidemia I

United States
Assiut University

Recruiting

Role of Ultrasound in Diagnosis of Muscle Diseases

Ultrasound | Muscle Disease

Egypt

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