Search clinical trials for: Healthy volunteers, proof-of-concept trial, PK and PD

Total 475650 results

JW Pharmaceutical

Not yet recruiting

PK,PD and DDI of Epaminurad and Naproxen in Healthy Volunteers

Healthy

Korea, Republic of
Universidad del Desarrollo
Technical University of Munich

Recruiting

Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model (Eleved PD)

Healthy | Surgery

Chile
Haisco Pharmaceutical Group Co., Ltd.

Recruiting

A Phase I Study to Assess the Safety,Tolerability, PK, PD, and Food Effect of HSK39297 in Healthy Subjects

Healthy

China
Neuracle Science Co., LTD.
Samsung Medical Center; Korea University Anam Hospital; Severance Hospital

Recruiting

A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in Healthy Volunteers and SSNHL Patients

Sudden Sensorineural Hearing Loss | Seneorineural Deafness

Korea, Republic of
iN Therapeutics Co., Ltd.

Recruiting

A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.

Pain | Osteoarthritis | Chronic Pain | Neuropathic Pain | Post Herpetic Neuralgia

Australia
Agomab Spain S.L.

Recruiting

Phase I Study to Assess Safety, Tolerability, PK and PD of AGMB-447 in Healthy Participants and Participants With IPF

IPF

United Kingdom
Sirius Therapeutics Co., Ltd.

Recruiting

A Phase 1 Study to Evaluate the Safety, Tolerability, PK/PD of SRSD107 in Healthy Participants

Thrombosis

Australia
Aro Biotherapeutics

Recruiting

Study to Assess the Safety, Tolerability, PK and PD of ABX1100

Healthy

Canada
Empros Pharma AB
CTC Clinical Trial Consultants AB

Recruiting

A Phase 1 Study to Evaluate EMP22 PD and EMP16 PK Versus Xenical® in Healthy Volunteers

Overweight or Obesity

Sweden
Arbutus Biopharma Corporation

Recruiting

Safety, Tolerability, PK & PD of AB-101 Following Oral Administration in Healthy and CHB Subjects.

Chronic Hepatitis b

New Zealand
Wake Forest University Health Sciences
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin

Chronic Pain | Acute Pain | Healthy Volunteer

United States
Turgut Ardika PTY LTD

Recruiting

Comparative PK, Safety, Tolerability, Immunogenicity, and PD Profile Study of TUR03 and Soliris in Healthy Participants

Healthy

Australia
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Comparing of the PK, PD, Safety and Immunogenicity of HS-20090 and Xgeva® in Healthy Adults

Healthy

China
ABL Bio, Inc.

Recruiting

This is a Study to Evaluate the Safety, Tolerability, PK and PD of IV Administered ABL301 in Healthy Adult Participants

Healthy

United States
ADARx Pharmaceuticals, Inc.

Recruiting

Safety, Tolerability, PK, PD of ADX-324 in Healthy Volunteers and Hereditary Angioedema Patients

Hereditary Angioedema

Australia
Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

The Safety, Tolerability, PK, and PD of DWP213388 After SAD and MAD Administration in Healthy Adult Subjects

Healthy
Kashiv BioSciences, LLC

Recruiting

PK, PD, Safety & Immunogenicity of ADL-018 Lyo in Healthy Adult Subjects

Healthy

India
Alexion Pharmaceuticals, Inc.

Recruiting

Safety, PK/PD, and Immunogenicity Study of SC ALXN2030 in Healthy Participants

Healthy

United Kingdom
Ashvattha Therapeutics, Inc.

Recruiting

Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers

Amyotrophic Lateral Sclerosis (ALS) | Multiple Sclerosis (MS) | Parkinson Disease (PD) | Alzheimer Disease (AD)

United States
The Affiliated Hospital of Qingdao University

Recruiting

Tolerance, Pharmacokinetics / Pharmacodynamics (PK / PD) and Immunogenicity of Pegylated Uric Acid Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteers

Hyperuricemia

China
Sciwind Biosciences APAC CO Pty. Ltd.
Hangzhou Sciwind Biosciences Co., Ltd.

Not yet recruiting

XW004 To Evaluate the Safety, Tolerability, PK, and PD of Oral Ecnoglutide Tablet in Healthy Adults

Obesity | Type 2 Diabetes Mellitus

Australia
Chong Kun Dang Pharmaceutical

Recruiting

A Study to Evaluate the PK, PD and Safety of CKD-382 in Healthy Subjects

GERD

Korea, Republic of
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception

Female Contraception | Healthy Women

United States
Shenyang Sunshine Pharmaceutical Co., LTD.

Recruiting

A Study to Determine the Safety, Tolerability, PK and Preliminary PD of SSS11 in Chinese Healthy Adult Volunteers

Gout

China
Alexion Pharmaceuticals, Inc.
Celerion

Completed

Safety and Tolerability, PK, and PD Study of Single and Multiple ALXN2080 Doses in Healthy Participants

Healthy

United Kingdom
AJNA Australia Pty Ltd

Active, not recruiting

A SAD, MAD and Food Effect Study to Evaluate the Safety, Tolerability, PK, and PD of AJA001 in Healthy Subjects

Healthy Volunteers

Australia
Alebund Pharmaceuticals

Completed

A Study to Evaluate the Safety, Tolerability, PK and PD of AP303 in Healthy Chinese Participants

Healthy Subjects

China
argenx

Completed

IV Dose Study to Assess the Safety, Tolerability, PK, PD and Immunogenicity of ARGX-113 in Healthy Volunteers

Healthy Volunteers
Ono Pharmaceutical Co. Ltd

Completed

Single Ascending Dose Study to Assess the Safety, Tolerability, PK and PD of ONO-4685 in Japanese and Caucasian Healthy Adult Male Subjects

Healthy Volunteers

Japan
SFJ Pharmaceuticals, Inc.

Completed

Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects

Healthy

United States
Effector Therapeutics
Medpace, Inc.; ICON plc

Active, not recruiting

Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART) (KICKSTART)

Non-small Cell Lung Cancer

United States, Australia, Georgia
Visterra, Inc.

Terminated

A Study to Evaluate the Safety, PK and PD of VIS171 in Participants (Healthy and With Autoimmune Disease)

Autoimmune Diseases

New Zealand, Germany, Bulgaria, Moldova, Republic of, Netherlands
Forma Therapeutics, Inc.
Medpace, Inc.

Completed

A SAD/MAD to Assess the Safety, PK/PD of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients

Healthy Volunteers | Sickle Cell Disease

United States
HK inno.N Corporation

Enrolling by invitation

PK, PD and Safety of Tegoprazan 12.5 mg After Oral Administration in Healthy Subjects

Healthy

Korea, Republic of
JW Pharmaceutical

Completed

To Evaluate the PK, PD, Safety and Drug Tolerance in Healthy Volunteers

Healthy

Korea, Republic of
JW Pharmaceutical

Completed

To Evaluate the PK, PD, Safety and Drug Tolerance of JW0302 in Healthy Volunteers

Healthy

Korea, Republic of
Bio Sidus SA

Completed

PK/PD Study of 2 Agalsidase Formulations in Single Dose of 1 mg/kg Administered to Healthy Volunteers as IV Infusion

Fabry Disease

Argentina
AdAlta Limited

Completed

Safety, Tolerability, PK and PD Study of AD-214 Administered to Healthy Volunteers and Patients With Interstitial Lung Disease or Chronic Kidney Disease

Chronic Kidney Diseases | Interstitial Lung Disease

Australia
AltruBio Inc.
ICON plc

Completed

A First-In-Human SAD and MAD Study to Evaluate the Safety, Tolerability, PK and PD of SC Administered ALTB-268 in Healthy Volunteers

Healthy Volunteers

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Safety and PK/PD of RTA 1701 in Healthy Adults

Healthy

Australia
Amphastar Pharmaceuticals, Inc.

Completed

Comparison of the Pharmacokinetics (PK) and Pharmacodynamics (PD) Biosimilarity of Proposed Biosimilar Rapid-Acting Insulin Aspart (I004) and NovoLog After Single-Dose Subcutaneous Administration to Healthy Volunteers

Pharmacokinetics | Pharmacodynamics

United States
SFJ Pharmaceuticals, Inc.
SFJ Pharmaceuticals, Inc.

Terminated

Study to Evaluate the Safety, Tolerability, PK, and PD of PB2452 With and Without Ticagrelor Pretreatment in Chinese Healthy Volunteers

Healthy

China
Neutrolis

Terminated

Phase 1 Study to Assess Safety, Tolerability, PD, PK, Immunogenicity of IV NTR-441 Solution in Healthy Volunteers and COVID-19 Patients

Covid19

Austria, Ukraine
Medicines for Malaria Venture
GlaxoSmithKline; ICON plc; QIMR Berghofer Medical Research Institute; Swiss BioQuant... and other collaborators

Completed

Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum

Pathologic Processes | Infections | Systemic Inflammatory Response Syndrome | Inflammation | Vector Borne Diseases | Parasitic Diseases | Protozoan Infections | Malaria | Parasitemia | Malaria,Falciparum | Anti-Infective Agents | Antimalarials

Australia
Syneos Health
CuraTeQ Biologics Private Ltd.

Completed

Biosimilar Study Comparing PK, PD, Safety and Immunogencity of BP11 With US Licensed Xolair and EU Approved Xolair

Healthy Volunteers

New Zealand, Australia
iN Therapeutics Co., Ltd.

Completed

A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers

Pain | Osteoarthritis

Australia
HK inno.N Corporation

Completed

PK and PD Interaction Between Tegoprazan and NOACs After Multiple Oral Dosing in Healthy Volunteers

Healthy

Korea, Republic of
Guangzhou JOYO Pharma Co., Ltd

Completed

Evaluation of Safety, Tolerability, PK/PD, and Metabolism of Single-Dose Singletine(DC407) in Adults

Healthy Subjects

China
University Hospital Tuebingen
Natural and Medical Sciences Institute (NMI); Cooperative European Paediatric...

Completed

Urinary Biomarkers in Paediatric Kidney Transplantation (pKTx)

Renal Transplantation | Healthy Controls | Chronic Kidney Insufficiency

Germany
Biocad

Completed

A Study to Assess the PK, PD, Safety and Immunogenicity of Single IV Infusion of BCD-264 and Darzalex in Healthy Subjects

Healthy

Russian Federation

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