Search clinical trials for: Human Infection Challenge

Total 71535 results

Humanitas Clinical and Research Center
European Society of Intensive Care Medicine

Not yet recruiting

Fluid Challenge in Intensive Care The FENICE II Study (FENICE II)

Critical Illness | Septic Shock

Italy
Hvivo
Pfizer

Recruiting

Dose, Safety, and Pathogenicity of a New Influenza B Strain

Influenza B

United Kingdom
Ifakara Health Institute
University of Oxford

Not yet recruiting

In-vivo Transmission Model in Semi-immune Adults

Controlled Human Malaria Infection | Malaria Transmission | Induced Blood Stage Malaria Infection | Malaria Challenge

Tanzania
Cocrystal Pharma, Inc.
hVIVO Services Limited

Recruiting

Influenza Viral Challenge Study of CC-42344 in Healthy Participants

Influenza A

United Kingdom
Academisch Medisch Centrum - Universiteit van Amsterdam...
ZonMw: The Netherlands Organisation for Health Research and Development

Recruiting

The Uninfected Ixodes Scapularis Human Tick Challenge Model (TICK ME)

Tick Bites | Tick Immunity

Netherlands
Imperial College Healthcare NHS Trust
Imperial College London; University of Oxford; PATH; University of Liverpool

Recruiting

Challenge Non-Typhoidal Salmonella (CHANTS) Study (CHANTS)

Gastroenteritis | Salmonella Infections | Infections, Bacterial | Communicable Disease | Salmonella Typhimurium | Non-typhoidal Salmonella (NTS) | Invasive Non-Typhoidal Salmonella Disease | Enteric Fever (Not Typhoid)

United Kingdom
Wake Forest University Health Sciences
National Institute on Aging (NIA); Health Resources and Services Administration...

Recruiting

Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

HIV | Aging

United States
University of Southampton

Recruiting

Periscope Phase C Bordetella Pertussis Human Challenge Study With Delayed Antibiotic Therapy for 6 Weeks

Pertussis/Whooping Cough

United Kingdom
Liverpool School of Tropical Medicine
University of Oxford

Recruiting

Using BCG Vaccine to Understand Tuberculosis Infection (Pilot BCG CHIM)

Tuberculosis

United Kingdom
Liverpool School of Tropical Medicine
Merck Sharp & Dohme LLC

Recruiting

Experimental Human Pneumococcal Challenge With SPN3 (Challenge3)

Streptococcus Pneumonia

United Kingdom
National Institute of Allergy and Infectious Diseases...

Recruiting

Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge Model

Influenza Infection

United States
Emory University

Recruiting

Influenza Human Challenge Model

Influenza

United States
Dalhousie University
National Institute of Allergy and Infectious Diseases (NIAID); Vanderbilt University... and other collaborators

Recruiting

Establishing a Controlled Human Infection Model of Bordetella Pertussis

Pertussis

Canada
Humanitas Clinical and Research Center

Recruiting

"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools" (MINI3)

Sepsis | Shock, Septic | Critically Ill

Italy
National Institute of Allergy and Infectious Diseases...

Recruiting

Inpatient Challenge Study of rRSV A/Maryland/001/11, a Human Respiratory Syncytial Virus Challenge Strain, Administered to Healthy Adult Volunteers

Respiratory Syncytial Virus Infections

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

Malaria

United States
Janssen Research & Development, LLC

Suspended

A Study of JNJ-64281802 Against Dengue Serotype 1 Infection in a Dengue Human Challenge Model in Healthy Adult Participants

Healthy

United States, United Kingdom
University of Oxford
Sanaria Inc.; KEMRI-Wellcome Trust Collaborative Research Program; Kenya Medical...

Suspended

Controlled Human Malaria Infection Transmission Model - Phase A (CHMI-TransMod)

Malaria,Falciparum

Kenya
Merck Sharp & Dohme LLC

Completed

Respiratory Syncytial Virus (RSV) Human Challenge Study of Molnupiravir in Healthy Participants (MK-4482-017)

Respiratory Syncytial Virus

United Kingdom
GlaxoSmithKline

Completed

Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma

Pulmonary Disease, Chronic Obstructive

United Kingdom
National Institute of Allergy and Infectious Diseases...

Enrolling by invitation

Long-term Observation of Hemagglutinin and Neuraminidase Inhibition Antibody Titers After Influenza Challenge

Post Influenza

United States
State University of New York - Upstate Medical...
Walter Reed Army Institute of Research (WRAIR); U.S. Army Medical Research...

Completed

Dengue 3 Human Infection Model (DENV-3)

Dengue

United States
State University of New York - Upstate Medical...
U.S. Army Medical Research and Development Command; Janssen Pharmaceutica N...

Completed

Expansion of a Dengue-1 Live Virus Human Challenge

Dengue

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z)

Ebola Disease | Immunisation

United States
University of Maryland, Baltimore
Medical Technology Enterprise Consortium (MTEC)

Completed

Dengue 4 Human Infection Model (Dengue CVD 11000; DHIM-4)

Dengue

United States
State University of New York - Upstate Medical...
Walter Reed Army Institute of Research (WRAIR); U.S. Army Medical Research...

Active, not recruiting

Homologous Re-infection With Dengue 1 or Dengue 3

Dengue

United States
USDA, Western Human Nutrition Research Center

Active, not recruiting

Induction of Gut Permeability by an Oral Vaccine

Inflammation | Typhoid Fever | Vaccine | Intestinal Permeability

United States
National Institute of Allergy and Infectious Diseases...

Completed

Influenza Challenge Study to Determine the Optimal Infection Dose and Safety of a Recombinant H3N2 (A/Texas/71/2017 (H3N2, Clade 3C3a) Influenza Strain

Influenza

United States
University of York
Medical Research Council; Department for International Development, United...

Completed

A Clinical Study to Develop a Controlled Human Infection Model Using Leishmania Major-infected Sand Flies (LEISHChallenge)

Leishmaniasis | Cutaneous Leishmaniases | Insect Bites

United Kingdom
PATH
United States Department of Defense; Johns Hopkins University Center for Immunization...

Completed

Controlled Human Infection Model Challenge/Rechallenge

Shigellosis

United States
Merck KGaA, Darmstadt, Germany

Completed

First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Participants

Healthy

Australia
National Institute of Allergy and Infectious Diseases...

Completed

Trial to Evaluate L9LS in Healthy Adults (VRC 614)

Malaria

United States
Hvivo
Pfizer

Completed

Dose, Safety, and Pathogenicity of a New Influenza H1N1 Challenge Strain

Influenza A H1N1

United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Respiratory Syncytial Virus Human Challenge in Healthy Adult Volunteers

Upper Respiratory Tract Infection

United States
Cidara Therapeutics Inc.
Janssen Pharmaceuticals

Completed

The Effectiveness of CD388 to Prevent Flu in an Influenza Challenge Model in Healthy Adults

Influenza

United Kingdom
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Terminated

Safety and Efficacy of NF135 CPS Immunization (CPS135)

Malaria,Falciparum | Controlled Human Malaria Infection | Immunization; Infection

Netherlands
University of Oxford
Ifakara Health Institute

Completed

A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania

Malaria | Plasmodium Falciparum

Tanzania
Pneumagen Ltd.

Completed

Safety, Tolerability and Prophylactic Antiviral Activity of Neumifil Against Influenza Via a Human Viral Challenge Model

Influenza Viral Infections

United Kingdom
Atea Pharmaceuticals, Inc.

Terminated

Study of AT-752 in Healthy Subjects in a Dengue Human Challenge Model

Dengue

United States
National Institute of Allergy and Infectious Diseases...

Completed

Trial to Evaluate CIS43LS in Healthy Adults

Malaria

United States
Poolbeg Pharma plc

Completed

Effects of p38 MAPK Inhibitor POLB 001 on in Vivo LPS Challenge Responses

Influenza, Human

Netherlands
University of Oxford

Active, not recruiting

Aerosol BCG Challenge Study in Historically BCG-vaccinated Volunteers

Tuberculosis

United Kingdom
ENA Respiratory Pty Ltd

Completed

INNA-051 Influenza Challenge Study

Influenza Prophylaxis

United Kingdom
Lumen Bioscience, Inc.
University of Maryland; Naval Medical Research Center; Pharmaron

Completed

LMN-101 in a Campylobacter Human Challenge Model

Campylobacter Infections

United States
University of York
Medical Research Council

Completed

A Clinical Study to Develop an Uninfected Sand Fly Biting Protocol (FLYBITE)

Leishmaniasis, Cutaneous | Insect Bites

United Kingdom
Vaxart
Biomedical Advanced Research and Development Authority

Completed

A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine

Influenza

United States
Merck Sharp & Dohme LLC

Completed

Phase 2a Respiratory Syncytial Virus (RSV) Human Challenge Study of Clesrovimab (MK-1654) in Healthy Participants (MK-1654-005)

Respiratory Syncytial Viruses

United Kingdom
Merck Sharp & Dohme LLC

Completed

Hepatitis B Challenge Dose in Adults (V232-059-10)

Hepatitis B
University of Southampton
University of Edinburgh; University Hospital Southampton NHS Foundation Trust

Completed

Lactamica 9: Neisseria Lactamica Inoculation in Late Pregnancy

Microbial Colonization

United Kingdom
Meissa Vaccines, Inc.
Hvivo

Completed

Human Challenge Study to Evaluate the Efficacy of MV-012-968 Vaccine

RSV Infection

United Kingdom

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