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Total 668 results

ANRS, Emerging Infectious Diseases

Completed

A Community-based Intervention Among Active Drug Users in Montpellier (ICONE)

Drug Use | HCV Infection

France
Atridia Pty Ltd.

Completed

A Trial of HTI-1090 in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

Australia
Hoffmann-La Roche

Completed

A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)

Triple Negative Breast Cancer

United States, Korea, Republic of, Belgium, Canada, Germany, United Kingdom, Argentina, Australia, Brazil, Finland, France, Greece, Hungary, Poland, Slovenia, Spain, Taiwan, Turkey, Japan, Singapore, Colombia, Bosnia and Herzegovina, Guatema... and more
GE Healthcare
ICON plc

Completed

A Study to Evaluate the Effectiveness of VIZAMYL™ Reader Training Programme in Europe

Cognitive Impairment

Netherlands, Spain, Austria, Finland, Italy
SAb Biotherapeutics, Inc.
Department of Health and Human Services; JPEO, Chemical, Biological, Radiological...

Completed

Safety, Tolerability, and Pharmacokinetics of SAB-185 in Healthy Participants

COVID-19 | SARS-CoV2

United States
Bristol-Myers Squibb
ICON Clinical Research

Completed

Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting (SIMPLICITY)

Chronic Myeloid Leukemia

Germany, United States, Italy, Spain, France, Netherlands, Puerto Rico, Russian Federation
RAI Services Company
ICON plc

Completed

CSD190202: Study to Assess Elements of Abuse Liability for Two Electronic Nicotine Delivery Systems

Smoking | Tobacco Use | Tobacco Smoking

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

iConquerFear Program for the Treatment of Fear of Cancer Recurrence in Patients With Localized Renal Cell Carcinoma

Renal Cell Carcinoma
Bristol-Myers Squibb

Completed

A Study to Assess the Safety, Tolerability and Drug Levels of BMS-986172 in Healthy and Obese Participants, Including an Assessment of the Effects of Food on BMS-986172 Absorption

Healthy Participants

United States
Applied Therapeutics, Inc.

Completed

Safety and Pharmacokinetics of AT-007 in Healthy Subjects and in Adult Subjects With Classic Galactosemia

Classic Galactosemia

United States
Hacettepe University

Completed

Evaluation of Esthetic Performance of Resin Infiltration Technique on Enamel Lesions

Tooth Demineralization

Turkey
Bristol-Myers Squibb

Completed

A Study Assessing the Drug Levels, Drug Effects, and Safety of BMS-986322 in Healthy Participants

Healthy Participants

United States
DMG Dental Material Gesellschaft mbH

Completed

Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains

Fluorosis | Dental Care | Caries Infiltration

India
Merck Sharp & Dohme LLC

Completed

MK-1942/Donepezil Interactions in Participants With Alzheimer's Disease (MK-1942-005) (DDI)

Alzheimer's Disease

United States
Actinogen Medical
ICON Clinical Research

Completed

A Phase II Study to Assess the Safety, Tolerability and Efficacy of Xanamem™ in Subjects With Mild Dementia Due to AD (XanADu) (XanADu)

Dementia, Alzheimer Type

United States, Australia, United Kingdom
Xencor, Inc.
ICON plc

Completed

A Study of XmAb®18087 in Subjects With NET and GIST

Neuroendocrine Tumor | Gastrointestinal Neoplasm

United States
Bristol-Myers Squibb

Completed

A Study to Assess the Levels in Blood Plasma of BMS-986278 in Healthy Participants Following Administration of Tablets, With or Without Food, and in the Presence of an Antacid (Esomeprazole)

Healthy Participants

United States
Daré Bioscience, Inc.

Completed

Pharmacokinetic Study of DARE-BV1

Bacterial Vaginosis

United States
DMG Dental Material Gesellschaft mbH
Rio de Janeiro State Research Supporting Foundation (FAPERJ); Universidade...

Completed

Efficacy of Proximal Caries Infiltration

Caries | Dental Health

Brazil
Proof Diagnostics
ICON Clinical Research; MRI Global; ASCLEPES Research Center; Eastside Research... and other collaborators

Completed

A Clinical Evaluation of Proof Diagnostics Test System Including the Proof Diagnostics Reader and COVID-19 Test

COVID-19 | Asymptomatic COVID-19

United States
DMG Dental Material Gesellschaft mbH
Universidad de Concepcion; Universidad de La Frontera

Completed

Enamel Damages Following De-bracketing From Infiltrated Surfaces

Dental White Spots

Chile
NSABP Foundation Inc
Genentech, Inc.; US Oncology Research

Completed

A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Breast Cancer

United States, Ireland
Jazz Pharmaceuticals
ICON plc; Invitae Corporation; Wake Up Narcolepsy; Narcolepsy Network

Completed

A Web-based Observational Study of Patient-reported Outcomes in Adults With Narcolepsy

Narcolepsy

United States
AMAG Pharmaceuticals, Inc.

Completed

Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran

Nausea

United States
Pak Emirates Military Hospital

Completed

Comparison of Efficacy of Double Dose Oral Terbinafine Vs Itraconazole in Treatment of Dermatophyte Infections of Skin.

Terbinafine Adverse Reaction | Dermatophyte Infection | Itraconazole Adverse Reaction

Pakistan
Bristol-Myers Squibb

Completed

Relative Levels of BMS-986036 in Blood Plasma in Healthy, Overweight, and Obese Participants Following Subcutaneous Administration Via Auto-injector Versus Pre-filled Syringe

Healthy Participants

United States
Bristol-Myers Squibb

Completed

Study to Assess the Effect of Branebrutinib on the Drug Levels of Rosuvastatin in Healthy Participants

Healthy Participants

United States
Xencor, Inc.
ICON Clinical Research

Completed

PH 1 Study to Evaluate Safety and Tolerability of XmAb14045 in Patients With CD123-expressing Hematologic Malignancies

Acute Myelogenous Leukemia | Blastic Plasmacytoid Dendritic Cell Neoplasm | B-cell Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia, Blast Crisis

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986337 When Taken by Mouth by Healthy Participants

Healthy Volunteers

Netherlands
Fondazione Don Carlo Gnocchi Onlus

Completed

Robotic Telerehabilitation of the Upper Limb in Stroke (TELEREHAB)

Stroke

Italy
Boston Scientific Corporation
ICON Clinical Research

Completed

Heart Failure and Sudden Cardiac Death Japan Registry (HINODE)

Heart Failure | Arrhythmias, Cardiac | Sudden Cardiac Death

Japan
MEDA Pharma GmbH & Co. KG
ICON plc; Clinipace Worldwide; Trium Analysis Online GmbH

Terminated

Tepilta® Versus Oxetacaine, Antacids and Placebo

Radiation-induced Oesophagitis

Germany, Austria
Ege University

Active, not recruiting

Resin Infiltration and Fluoride Varnish Lesion Arresting Efficacy on Non-cavitated Proximal Lesion

Dental Caries | Tooth Demineralization | Dental Caries on Smooth Surface Limited to Enamel | Dentistry, Operative | Dental Caries Activity Tests | Cariogram

Turkey
Pfizer
Medivation, Inc.

Completed

A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study) (EMBRACA)

Breast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

Korea, Republic of, United States, Australia, Spain, Belgium, France, Ireland, Taiwan, Poland, Germany, Israel, Brazil, United Kingdom, Italy, Russian Federation, Ukraine
EVP Eye Care
Alcon Research; Icon Eye Care

Terminated

Visual Outcomes After Vivity Toric IOL Implantation

Refractive Assessment

United States
Bristol-Myers Squibb

Completed

Study to Assess the Effect of Acid-reducing Agent Famotidine on the Drug Levels of BMS-986256 in Healthy Participants

Healthy Participants

United States
DiaSorin Inc.
ICON Clinical Research

Completed

Helicobacter Pylori Sample Collection Protocol Pre Therapy Subjects

Nausea | Abdominal Pain | Weight Loss | Helicobacter Pylori Infection | Gastric Ulcer | Stomach Ulcer | Loss of Appetite | Bloating

United States, Italy
NorthSea Therapeutics B.V.

Active, not recruiting

A Phase 2b Study of Icosabutate in Fatty Liver Disease (ICONA)

Non Alcoholic Steatohepatitis (NASH)

United States, Puerto Rico
Regulus Therapeutics Inc.

Completed

A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Autosomal Dominant

United States
BeiGene
Myriad Genetic Laboratories, Inc.

Completed

The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors

Solid Tumors

United States, Spain, United Kingdom, France, Australia, New Zealand
Seagen Inc.
Millennium Pharmaceuticals, Inc.

Completed

ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas (ECHELON-2)

Non-Hodgkin Lymphoma | T-Cell Lymphoma | Anaplastic Large-Cell Lymphoma

United States, Korea, Republic of, Spain, United Kingdom, Taiwan, Czechia, Hungary, France, Israel, Germany, Italy, Denmark, Australia, Poland, Romania, Canada
BeiGene

Terminated

Treatment of Metastatic Castration-Resistant Prostate Cancer With Homologous Recombination Deficiency

Metastatic Castration-Resistant Prostate Cancer (mCRPC) | Homologous Recombination Deficiency (HRD)

United States, Australia, Puerto Rico, Spain
Bristol-Myers Squibb

Completed

Study to Characterize the Effects of Cytochrome p450 1A2 Inhibition on Systemic Exposure to BMS-986165

Healthy

United States
Pine Trees, Inc.
Piedmont Healthcare; ICON plc; MRI Global; ASCLEPES Research Center; Eastside Research... and other collaborators

Completed

A Clinical Evaluation of Pine Trees Health Test System Including the Pine Trees Health Reader and COVID-19 Test for Point-of-Care

Covid19 | SARS (Severe Acute Respiratory Syndrome)

United States
University of California, San Francisco
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Inpatient Clinical Trial of NAC (ICON)

Asthma

United States
Vasopharm GmbH
ICON plc

Completed

Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury (NOSTRA-III)

Traumatic Brain Injury

United Kingdom, Spain, France, Austria, Germany
Enanta Pharmaceuticals, Inc
ICON Clinical Research; Triangle Biostatistics

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Non-Alcoholic Steatohepatitis

Non-Alcoholic Steatohepatitis

United States, United Kingdom, New Zealand, Canada, France, Puerto Rico
Resverlogix Corp
PPD; ICON plc; Medidata Solutions

Completed

Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD (BETonMACE)

Coronary Artery Disease | Diabetes Mellitus, Type 2

Netherlands, Taiwan, Argentina, Israel, Poland, Russian Federation, Australia, Belgium, Serbia, Bulgaria, Hungary, Slovakia, Mexico, Croatia, Germany
Corporacion Parc Tauli

Completed

Iconographies for Risk Communication and Reduction of Patient's Anxiety in a Colorectal Cancer Screening Program

Colo-rectal Cancer

Spain
Assaf-Harofeh Medical Center
Tikun Olam

Withdrawn

Impact of Cannabis Oil on Nutrition in Hemodialysis Patients Study (ICON-HP Study) (ICON-HP)

Hemodialysis | Protein-Energy Malnutrition | Appetite Disorders

Israel

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