Search clinical trials for: Immunomodulatory therapy

Total 51760 results

University Hospital, Bordeaux

Not yet recruiting

Evaluation of the Efficacy of Immunomodulatory Therapy in Case of Psychiatric Disorders With Proven Dysimmunity. (TIM-DePisT)

Mental Disorder

France
Centre Hospitalier Universitaire de Nice

Not yet recruiting

Interferon Alfa Therapy Based on Th17 Profile in Membranous Nephropathy (ALPHAGEM)

Membranous Nephropathy

France
Lucie Heinzerling

Recruiting

Treatment of Immune-related Adverse Events Refractory to Standard Therapy and Associated Changes in Immunophenotype (PRIA)

Immune-related Adverse Event

Germany
Angelica Lindén Hirschberg

Recruiting

Immunomodulatory Therapy in Women With Autoimmune Premature Ovarian Insufficiency

Autoimmune Diseases | Premature Ovarian Insufficiency

Sweden
Biopharma Plasma LLC

Recruiting

Intravenous Immunoglobulin (IVIG, Bioven) Efficacy and Safety in Chronic Primary Immune Thrombocytopenia (ITP) in Adults

Primary Immune Thrombocytopenia

Ukraine
H. Lee Moffitt Cancer Center and Research Institute
Adaptive Biotechnologies

Recruiting

Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant

Multiple Myeloma

United States
Sun Yat-sen University

Recruiting

Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH

Vogt Koyanagi Harada Disease (VKH)

China
Alpha Tau Medical LTD.

Recruiting

A Safety and Efficacy Study for Combinational Treatment of DaRT and Check Point Inhibitor for Recurrent Unresectable or mHNSCC

Skin Cancer | Head and Neck Squamous Cell Carcinoma | Metastatic Head-and-neck Squamous-cell Carcinoma

Israel
National Cancer Institute (NCI)
Janssen Scientific Affairs, LLC

Recruiting

Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma

Multiple Myeloma

United States
Assistance Publique - Hôpitaux de Paris
URC-CIC Paris Descartes Necker Cochin; MICALIS Institute

Recruiting

Use of Crohn's Disease Exclusion Diet on Top of Standard Therapy Versus Standard Therapy Alone in Unstable Pediatric Crohn's Disease Patients. (ASCENSION)

Crohn's Disease

France
Judit Pich

Recruiting

Dendritic Cells Therapy Combined With Immunomodulatory Treatment in Multiple Sclerosis (TolDecCOMBINEM)

Relapsing-Remitting Multiple Sclerosis

Spain
National Cancer Institute (NCI)

Active, not recruiting

Romidepsin, CC-486 (5-azacitidine), Dexamethasone, and Lenalidomide (RAdR) for Relapsed/Refractory T-cell Malignancies

Cutaneous T-Cell Lymphoma | Peripheral T-Cell Lymphoma | Mature T-cell Malignancies | Relapsed/ Refractory T-cell Malignancies

United States
Janssen Biotech, Inc.

Active, not recruiting

A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease (DEVELOP)

Inflammatory Bowel Diseases | Crohn's Disease | Ulcerative Colitis | Indeterminate Colitis

United States, Canada
National Cancer Institute (NCI)

Active, not recruiting

Carfilzomib, Lenalidomide, and Dexamethasone for Smoldering Multiple Myeloma

Multiple Myeloma

United States
Bristol-Myers Squibb

Active, not recruiting

Incidence of Hyperpigmentation in Black Patients With Multiple Myeloma Treated With Immunomodulatory Drugs

Multiple Myeloma

United States
Amgen

Completed

Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus (SLE)

United States, Korea, Republic of, Australia, Spain, Hungary, Bulgaria, Italy, Mexico, Germany, Japan, France, Greece, Czechia, Argentina, Portugal, Poland, Russian Federation, Hong Kong, Canada
Janssen-Cilag Ltd.
Legend Biotech

Completed

A Study of Real-life Current Standards of Care in Patients With Relapsed and/or Refractory Multiple Myeloma Who Received at Least 3 Prior Lines of Therapy Including Proteasome Inhibitor (PI), Immunomodulatory Drug (IMID), and Cluster of Differentiation 38 (CD38) Monoclonal Antibody Treatment (LocoMMotion)

Multiple Myeloma

Belgium, United States, United Kingdom, Italy, Germany, Netherlands, Spain, France, Russian Federation, Poland
InDex Pharmaceuticals

Completed

The Efficacy and Safety of Cobitolimod (Kappaproct®) in Chronic Active Treatment Refractory Ulcerative Colitis Patients (COLLECT)

Colitis, Ulcerative

Czechia, France, Germany, Hungary, Italy, Poland, United Kingdom
University College, London
Cancer Research UK; Celgene

Active, not recruiting

Trial of Immunomodulatory Therapy in High Risk Solitary Bone Plasmacytoma (IDRIS)

Plasmacytoma

United Kingdom
Johnson & Johnson Private Limited

Completed

A Study of DARZALEX (Daratumumab) In Indian Participants With Relapsed and Refractory Multiple Myeloma, Whose Prior Therapy Included a Proteasome Inhibitor and an Immunomodulatory Agent

Multiple Myeloma

India
Bosnalijek D.D

Completed

Clinical Trial to Evaluate the Efficacy and Safety of an Immunomodulatory Therapy for the Treatment of Patients With Moderate to Severe COVID-19 Infection

COVID-19 Infection

Bosnia and Herzegovina
Famewave Ltd.

Terminated

Study of CM-24 (MK-6018) Alone and In Combination With Pembrolizumab (MK-3475) in Participants With Selected Advanced or Recurrent Malignancies (MK-6018-001)

Melanoma | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Bladder Cancer | Non-small Cell Lung Carcinoma (NSCLC)

United States, Israel
University of California, San Francisco
Pfizer; Stanford University; amfAR, The Foundation for AIDS Research; Case Western... and other collaborators

Completed

Maraviroc as an Immunomodulatory Drug for Antiretroviral-treated HIV Infected Patients Exhibiting Immunologic Failure

HIV Infection

United States
Shenzhen Geno-Immune Medical Institute
Shenzhen Children's Hospital; Shenzhen Hospital of Southern Medical University

Unknown

Immune Modulatory DC Vaccine Against Brain Tumor

Diffuse Intrinsic Pontine Glioma or Glioblastoma

China
Cell Therapy Ltd.
Royal Brompton & Harefield NHS Foundation Trust

Unknown

A Trial of Cardiac Injections of iMP Cells During CABG Surgery

Myocardial Fibrosis
National Cancer Institute (NCI)

Terminated

Combination Therapy of Interleukin-12 and Interleukin-2 to Treat Advanced Cancer

Sarcoma | Breast Neoplasm | Lung Neoplasm | Kidney Neoplasm

United States
National Cancer Institute (NCI)
Millennium Pharmaceuticals, Inc.

Withdrawn

Phase II Study of Subcutaneous (SC) Bortezomib, Lenalidomide and Dexamethasone for Relapsed and/or Refractory Multiple Myeloma; Followed by SC Bortezomib Maintenance

Multiple Myeloma
Idera Pharmaceuticals, Inc.

Completed

Placebo-controlled, Dose-escalation Study of the Safety of IMO-2125 (Immunomodulatory Oligonucleotide) in Hepatitis C-infected Patients

Hepatitis C

United States, Puerto Rico
Janssen Research & Development, LLC

Completed

An Efficacy and Safety Study of Daratumumab in Patients With Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy (Including a Proteasome Inhibitor [PI] and Immunomodulatory Drug [IMiD]) or Are Double Refractory to a PI and an IMiD

Multiple Myeloma

United States, Spain, Canada
King Abdullah International Medical Research Center
Hoffmann-La Roche

Unknown

To Study the Effect of Adding on Pegylated Interferon (PEG-INF) Therapy for Patients Diagnosed With Chronic Hepatitis B (RC14/055)

Hepatitis B

Saudi Arabia
Stanford University

Completed

Specific Carbohydrate Diet as Maintenance Therapy in Crohn's Disease (SCD)

Crohn's Disease

United States
National Cancer Institute (NCI)
Celgene Corporation

Terminated

Lenalidomide Maintenance Therapy for Multiple Myeloma

Multiple Myeloma

United States
GlaxoSmithKline

Completed

Establishing Predictors of Enlarged Prostate Treatment Adherence: Linking Symptom Improvement to Adherence

Prostatic Hyperplasia
Rabin Medical Center

Withdrawn

Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy

Graves Ophthalmopathy
Bionor Immuno AS
Celgene Corporation

Completed

Vacc-4x + Lenalidomide vs. Vacc-4x +Placebo in HIV-1-infected Subjects on Antiretroviral Therapy (ART) (IMID)

HIV-1 Infection

Germany
Emory University
Baxter Healthcare Corporation

Terminated

IVIG Treatment for Refractory Immune-Related Adult Epilepsy

Seizure Disorder | Epilepsy, Partial | Epilepsy, Cryptogenic | Autoimmune Diseases, Nervous System | Limbic Encephalitis

United States
Cytos Biotechnology AG

Completed

A Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis

House Dust Mite Allergy | Perennial Allergic Rhinoconjunctivitis
University of Roma La Sapienza

Withdrawn

Efficacy and Safety of Top-down Therapy in Pediatric Crohn's Disease

Pediatric Crohn's Disease

Italy
National Institute of Allergy and Infectious Diseases...

Withdrawn

Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)

Systemic Lupus Erythematosus

United States
Charite University, Berlin, Germany

Unknown

Cohort Study of Clinically Isolated Syndrome and Early Multiple Sclerosis (CIS-COHORT)

Multiple Sclerosis, MS | Clinically Isolated Syndrome

Germany
Academisch Medisch Centrum - Universiteit van Amsterdam...
Hoffmann-La Roche; Sanquin Research & Blood Bank Divisions

Unknown

Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study)

HIV Infection

Netherlands
Cytos Biotechnology AG

Completed

A Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis

House Dust Mite Allergy | Perennial Allergic Rhinoconjunctivitis

Switzerland
Cytos Biotechnology AG

Completed

Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis

Perennial Allergy to House Dust Mite and/or Cat

Estonia, Latvia, Lithuania
Charite University, Berlin, Germany
dfg

Unknown

New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis

Reactive Arthritis

Germany
Jonsson Comprehensive Cancer Center

Not yet recruiting

PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

Glioblastoma

United States
Peking University First Hospital

Recruiting

Fractional Flow Reserve-guided Stenting Versus Medical Therapy in Atherosclerosis Renal Artery Stenosis (FAIR)

Renal Artery Stenosis Atherosclerotic | Secondary Hypertension Renal Arterial

China
Nanfang Hospital, Southern Medical University

Recruiting

Research on the Mechanisms of Treatment Non-response in Inflammatory Bowel Disease Based on Multi-omics Technology

Inflammatory Bowel Diseases

China
Fudan University

Not yet recruiting

The Efficacy and Safety of Cadonilimab (AK104) as Induction and Consolidation Therapy for Locally Advanced/Unresectable NSCLC Patients Receiving Concurrent Chemoradiotherapy

NSCLC | Locally Advanced Lung Carcinoma

China
BioNTech SE

Not yet recruiting

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy

Triple Negative Breast Cancer | Locally Advanced Breast Cancer
BioNTech SE

Not yet recruiting

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Small-cell Lung Cancer | Extensive-stage Small-cell Lung Cancer

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