Search clinical trials for: Immunotherapy resistance

Total 10908 results

Federation Francophone de Cancerologie Digestive

Recruiting

Prospective Cohort Study of Immunotherapy Resistance in Metastatic Colorectal Cancer Patients With MSI (CORESIM)

Colorectal Cancer Metastatic | Microsatellite Instability-High Colorectal Cancer

France
Huashan Hospital

Recruiting

The Role of B7-H4 in Tumor Vaccine

Glioma

China
Chuangzhen Chen

Recruiting

Intestinal Low Dose Radiotherapy Combined With Immunotherapy in Immune-resistant Metastatic Solid Tumors (ILDRV1)

Radiotherapy | Immune Checkpoint Blockade | Metastatic Extracranial Malignant Solid Neoplasm | Resistance to Immunotherapy

China
RenJi Hospital
Shanghai Zhongshan Hospital; Ruijin Hospital

Recruiting

A Study of Cadonilimab（AK104） Plus Lenvatinib in Previous Immunotherapy Treated Advanced/Metastatic Clear Cell Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma、Resistance to Immunotherapy

China
University Hospital, Bordeaux

Not yet recruiting

Role of Cancer-associated Fibroblast, MDSCs and Immune Cell Interplays in the Resistance of Non-small Cell Lung Cancer to Anti-PD1/PD-L1 Therapies (COCKPI-T)

Lung Neoplasm | Cancer Associated Fibroblast | Myeloid-Derived Suppressive Cells Immunosuppression

France
Qianfoshan Hospital

Recruiting

Low-dose Radiotherapy Combined With Conventional Fractionated Radiotherapy in Lung Cancer After Immunotherapy Resistance (FL002)

Cancer Patients

China
H. Lee Moffitt Cancer Center and Research Institute
Cancer and Aging Research Group

Recruiting

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

Lymphoma | Leukemia | Myeloma

United States
Michael Dill
University of Cologne; German Cancer Research Center; Heidelberg University; Universitätsmedizin... and other collaborators

Not yet recruiting

Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA) (FLORA)

Immunotherapy

Germany
Werewolf Therapeutics, Inc.

Recruiting

WTX-330 in Patients With Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma | Advanced or Metastatic Solid Tumors

United States
German Cancer Research Center
University Hospital Heidelberg; University Hospital Dresden

Not yet recruiting

Genetic Ablation of CD33 in HSC to Broaden the Therapeutic Index of CD33-directed Immunotherapy in Patients With AML (GALAXY33)

Relapsed/Refractory Acute Myeloid Leukemia (AML)

Germany
The Fourth Affiliated Hospital of Zhejiang University...
Second Affiliated Hospital, School of Medicine, Zhejiang University

Recruiting

Analysis of the Microenvironment of Lung Cancer and Exploration of the Mechanism of Resistance to Immunotherapy

Lung Cancer

China
Marengo Therapeutics, Inc.

Recruiting

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors (START-001)

Neoplasms | Urogenital Neoplasms | Neoplasms by Site | Carcinoma | Epstein-Barr Virus Infections | Advanced Solid Tumors | Vulvar Neoplasms | Vulvar Diseases | Abdominal Neoplasm | Lung Neoplasm | Papillomavirus Infection | Genital Neoplasm, Female

United States, Canada
Centre Hospitalier Universitaire de Nice

Recruiting

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma (MEL-META)

Melanoma (Skin)

France
Dr. Ronnie Shapira

Not yet recruiting

Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma (MK3475-C01)

Metastatic Melanoma | Malignant Melanoma | Immunotherapy | Malignant Melanoma Stage IV | BRAF V600E
Genelux Corporation
GOG Foundation

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Fallopian Tube Cancer | Platinum-resistant Ovarian Cancer | Platinum-refractory Ovarian Cancer | Primary Peritoneal Cancer | High-grade Serous Ovarian Cancer | Endometrioid Ovarian Cancer | Ovarian Clear Cell Carcinoma

United States
University of Erlangen-Nürnberg Medical School
Wuerzburg University Hospital; University Hospital Regensburg

Recruiting

Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy (PROMIT)

Immunotherapy

Germany
National Cancer Institute (NCI)

Recruiting

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

Hepatocellular Carcinoma | Cholangiocarcinoma | Liver Cancer

United States
MedImmune LLC

Active, not recruiting

A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors

Advanced Solid Tumors

United States, Spain, Belgium, Italy, Korea, Republic of, Canada, Australia, Hungary, United Kingdom, France, New Zealand
Pfizer

Active, not recruiting

Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma (COLUMBUS)

Melanoma

Canada, United States, Spain, Germany, Korea, Republic of, Australia, Czechia, Netherlands, France, Hungary, United Kingdom, Switzerland, Singapore, Russian Federation, Italy, Japan, Israel, Brazil, Portugal, Mexico, Greece, Argen... and more
Duke University

Completed

Understanding Immunotherapy Resistance Mechanisms in Advanced Melanoma

Melanoma

United States
OSE Immunotherapeutics

Terminated

OSE2101 Versus Chemotherapy in HLA-A2 Positive Patients With Advanced NSCLC After Immune Checkpoint Inhibitor Failure (ATALANTE-1)

Non Small Cell Lung Cancer

France, Spain, Israel, United States, United Kingdom, Italy, Poland, Czechia, Germany, Hungary
Asan Medical Center
Hoffmann-La Roche

Completed

Treatment of Colorectal Liver Metastases With Immunotherapy and Bevacizumab (CLIMB)

Neoplasm Metastasis | Colorectal Neoplasms | Rectal Neoplasms | Colonic Neoplasms

Korea, Republic of
Novartis Pharmaceuticals

Terminated

A Phase I/Ib Study of NIZ985 Alone and in Combination With Spartalizumab

In Escalation: All Patients With Solid Tumors and Lymphoma | In Expansion: Melanoma, Non-small Cell Lung Cancer

United States, Italy, Taiwan, Belgium, Spain, Germany, Japan
University College, London
Hoffmann-La Roche

Active, not recruiting

Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity (DARWINII)

Non-small Cell Lung Cancer

United Kingdom
Chipscreen Biosciences, Ltd.

Active, not recruiting

Trial of Chidamide in Combination With Envafolimab in Patients With PD-1 Inhibitor Resistant Advanced NSCLC.

Non Small Cell Lung Cancer

China
Netherlands Working Group on Immunotherapy of Oncology
Hoffmann-La Roche; Amsterdam UMC, location VUmc; The Netherlands Cancer Institute

Terminated

Vemurafenib Plus Cobimetinib in Metastatic Melanoma (REPOSIT)

Metastatic Melanoma

Netherlands
GlaxoSmithKline
Parexel

Terminated

First-time-in-human (FTIH) Study of GSK3145095 Alone and in Combination With Other Anticancer Agents in Adults With Advanced Solid Tumors

Neoplasms, Pancreatic

United States
Shanghai Pulmonary Hospital, Shanghai, China

Unknown

Chromosomal Instability as a Surrogate Biomarker of Drug Resistance in Immunotherapy for Lung Cancer Patients (CINSBDRILCP)

Lung Cancer

China
Dendreon

Completed

Concurrent vs. Sequential Sipuleucel-T & Abiraterone Treatment in Men With Metastatic Castrate Resistant Prostate Cancer

Hormone Refractory Prostate Cancer | Castration-resistant Prostate Cancer | Prostate Cancer Metastatic

United States
Fondazione IRCCS Istituto Nazionale dei Tumori,...
Merck Sharp & Dohme LLC

Unknown

Immunotherapy +/- EGFR Inhibitor In Advanced/Metastatic cSCC: Tackling Primary And Secondary Resistance (I-Tackle)

Skin Neoplasm

Italy
Pontificia Universidad Catolica de Chile
Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

Unknown

Resistance to Immunotherapy in Gastric Cancer (MERIT)

Metastatic Gastric Cancer

Chile
Hoffmann-La Roche

Completed

A Study of Oseltamivir (Tamiflu) for Treatment of Influenza in Immunocompromised Participants.

Influenza, Human

United States, Spain, Belgium, Poland, Germany, United Kingdom, Chile, Estonia, Hungary, Italy, France, South Africa, Mexico, Israel, Brazil, Guatemala, Czechia, Lithuania, Argentina, Bulgaria, Canada, Colombia, Latvia, Romania, Switzer... and more
AstraZeneca

Terminated

Observational Study of Patients With Locally Advanced or Metastatic NSCLC (Non-Small Cell Lung Cancer) (PANORAMA)

Carcinoma, Non-Small-Cell Lung

France, Spain, United Kingdom, China, Canada, Taiwan
Netherlands Working Group on Immunotherapy of Oncology

Completed

Rotating Pazopanib and Everolimus to Avoid Resistance (ROPETAR)

Clear Cell Renal Carcinoma

Netherlands
National Cancer Institute (NCI)

Completed

A Randomized Study of EPOCH II Versus EPOCH II and Immunotherapy in Lymphomas

Non Hodgkin's Lymphoma | Hodgkin's Disease

United States
Central South University

Not yet recruiting

Investigating the Insulin Resistance in Individuals With Type 2 Diabetes

Type 2 Diabetes

China
Necmettin Erbakan University
Health Institutes of Türkiye (TUSEB)

Not yet recruiting

The Impact of Probiotic on Survival and Treatment Response in Metastatic Non-small Cell Lung Cancer Patients

Metastatic Non-small Cell Lung Cancer

Turkey
Khyber Medical University Peshawar

Recruiting

Impact of FTO Gene Variation on Body Composition, Lipid Profile, Insulin Resistance, Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric, Protein Rich-Diet

Inflammation | Obesity | Insulin Resistance | Dyslipidemias | Advance Glycation

Pakistan
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM

Gastric Cancer, Metastatic
University of Sao Paulo General Hospital
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Not yet recruiting

Effect of Resistance Training in Patients on the Waiting List for Heart Transplant

Heart Failure | Heart Transplant

Brazil
Tongji Hospital

Not yet recruiting

A Study of Cadonilimab（AK104）Combined With Standard Treatment for Function Preservation in Urinary System Tumors

Urinary System Tumor
Georgiamune Inc

Not yet recruiting

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

Solid Tumor | Melanoma Stage IV
Peking University People's Hospital
Akeso Pharmaceuticals, Inc.

Not yet recruiting

Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma

Locally Advanced Esophageal Squamous Cell Carcinoma
Universidade Federal do Rio Grande do Norte

Not yet recruiting

Preference of Women With Fibromyalgia Undergoing a Three Different Volumes of Resistance Training

Chronic Pain | Exercise Addiction | Fibromyalgia, Primary

Brazil
National Cancer Institute (NCI)

Not yet recruiting

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Undifferentiated Pleomorphic Sarcoma | Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

Remote Exercise and Nutritional Prehabilitation for Pancreatic Cancer

Pancreatic Cancer

United States
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Not yet recruiting

Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING PUMA) (ROVING-PUMA)

ART Adherence

South Africa
University of South Carolina

Recruiting

Resistance Exercise and Creatine in Colorectal Cancer

Colorectal Cancer

United States
Odense University Hospital

Recruiting

Long Term Effect of AIT in Children

Allergy in Children

Denmark
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Induction Chemoimmunotherapy Combined With Chemoradiotherapy in Esophageal Cancer

Esophageal Cancer | Surgery | Immunotherapy | Chemoradiotherapy | Induction Therapy

China

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