Search clinical trials for: Low Alkaline Phosphatase

Total 22164 results

Alexion Pharmaceuticals, Inc.

Completed

Study of ALXN1850 in Participants With Hypophosphatasia (HPP)

Hypophosphatasia

United States
TriHealth Inc.

Completed

Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight

Low Birth Weight Infants

United States
Alexion Pharmaceuticals

Completed

Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, France, United Kingdom, Canada, Netherlands, Russian Federation, Turkey, Australia
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada, United Arab Emirates, United Kingdom
Alexion Pharmaceuticals

Completed

A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Taiwan, United Kingdom, Australia, Canada, Germany, Spain
Alexion Pharmaceuticals

Completed

Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Completed

Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Approved for marketing

Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP)

Hypophosphatasia

United States, France
Alexion Pharmaceuticals

Completed

Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09

Hypophosphatasia | Bone Disease

United States
Alexion Pharmaceuticals

Completed

Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)

Hypophosphatasia

United States, Spain, Australia, United Kingdom, Italy, France, Canada, Germany, Japan, Russian Federation, Saudi Arabia, Turkey
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP)

Hypophosphatasia

United States, Canada
Alexion Pharmaceuticals

Completed

Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP)

Hypophosphatasia

United States, United Arab Emirates, United Kingdom
Alexion Pharmaceuticals

Completed

Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Shaare Zedek Medical Center

Terminated

The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders

Gallstones | Hemolytic Disorders

Israel
Alexion Pharmaceuticals

Completed

Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in Japan

Hypophosphatasia
University of Bonn

Recruiting

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology (COHIR)

Hypophosphatasia

Germany
CymaBay Therapeutics, Inc.

Recruiting

IDEAL: Intended to Determine the Effects of Seladelpar on Normalization of Alkaline Phosphatase Levels in Subjects With Primary Biliary Cholangitis (PBC) and an Incomplete Response or Intolerance to Ursodeoxycholic Acid (UDCA) (IDEAL)

Primary Biliary Cholangitis

United States
Cairo University

Not yet recruiting

Salivary Alkaline Phosphatase as a Biomarker for Dental Caries in A Group of Egyptian Children With Different Growth Rates: A Descriptive Cross-Sectional Study

Dental Caries in Children
Nanjing Medical University

Not yet recruiting

Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer

Cancer of Pancreas | Ossification, Heterotopic

China
Alloksys Life Sciences B.V.
Aix Scientifics

Recruiting

Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase (APPIRED-III)

Systemic Inflammation | Cardiopulmonary-bypass

Australia, Austria, Belgium, Germany, Italy, Malaysia, Portugal, Netherlands, Russian Federation, Singapore, Spain
Centre Hospitalier Universitaire de Nice

Completed

Tissue-nonspecific Alkaline Phosphatase in Phosphate and Pyrophosphate Homeostasis. (PIPAL)

Chronic Kidney Disease

France
Alexion

Withdrawn

Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP)

Hypophosphatasia
AM-Pharma

Terminated

(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI

Acute Kidney Injury Due to Sepsis

Belgium, Spain, United States, Austria, Denmark, France, United Kingdom, Finland, New Zealand, Australia, Germany, Canada, Netherlands, Ireland, Japan
Ethan Weinberg
American Association for the Study of Liver Diseases; Meridian Bioscience,...

Terminated

Ursodeoxycholic Acid (UDCA) for Hepatic Sarcoidosis

Hepatic Sarcoidosis, Elevated Alkaline Phosphatase

United States
AM-Pharma

Completed

Recombinant Human Alkaline Phosphatase in Healthy Japanese Subjects

Healthy

Japan
Synthetic Biologics Inc.
Spaulding Clinical Research LLC

Completed

Pharmacokinetics, Safety, and Tolerability of SYN-020

Enteritis Caused by Radiation (Disorder)

United States
National Cancer Institute, Egypt

Completed

The Prognosis of Lipid Reprogramming With Rosuvastatin, in Castrated Egyptian Prostate Cancer Patients

Prostate Cancer Metastatic

Egypt
Bezmialem Vakif University
Didem Ertorul

Completed

The Status of Parathyroid Hormone Secretion in Covid-19 Patients

COVID-19 Infection | Parathyroid Hormone | Parathyroid Gland | Calcium | Phosphorus | Alkaline Phosphatase

Turkey
Zagazig University

Completed

Evidence Based Management of Acute Biliary Pancreatitis

Acute Pancreatitis

Egypt
Cairo University

Completed

Gingival Crevicular Fluid Alkaline Phosphatase as Skeletal Growth Indicator

Growth Indictaor

Egypt
AM-Pharma
PPD

Completed

A Safety, Tolerability, Efficacy and QoL Study of Human recAP in the Treatment of Patients With SA-AKI (STOP-AKI)

Acute Kidney Injury

Spain, United States, France, United Kingdom, Austria, Ireland, Finland, Netherlands, Belgium, Czechia, Germany
Gazi University

Completed

THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS WITH OSTEOPOROSIS AND PERIODONTITIS

Periodontitis | Osteoporosis

Turkey
Genfit

Completed

Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid

Primary Biliary Cholangitis (PBC)

United States, United Kingdom, France, Germany, Spain
Security Forces Hospital
King Saud University

Completed

Vitamin D Levels in Adolescent Idiopathic Scoliosis

Vitamin D Deficiency | Scoliosis Idiopathic | BMD
University Hospital, Lille

Completed

Search Elevated Serum Alkaline Phosphatase as a Marker of Prenatal Intervillositis Chronic Histiocytic (IHC)

Chronic Histiocytosis

France
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Single Dose of 5 mg Zoledronic Acid in Chinese Patients With Paget's Disease of Bone (PDB)

Paget's Disease of Bone

China
Alloksys Life Sciences B.V.
Aix Scientifics

Completed

Efficacy and Safety of Bovine Intestinal Alkaline Phosphatase (bIAP) During Heart Surgery (APPIRED-II)

Inflammation

Netherlands
Alloksys Life Sciences B.V.
Aix Scientifics

Completed

Bovine Intestinal Alkaline Phosphatase (bIAP) Modulating Rheumatoid Arthritis (ALS-003-2008)

Acute Rheumatoid Arthritis

United Kingdom
Nemours Children's Clinic
Novo Nordisk A/S; Children's Hospital Los Angeles

Completed

Pharmacodynamics of CNP During Growth Hormone Treatment

Pituitary Dwarfism | Idiopathic Short Stature

United States
TNO
Alloksys Life Sciences B.V.

Completed

Microdose and First-In-Human (FIH) Study of Recombinant Human Placental Alkaline Phosphatase (hRESCAP)

Healthy

Netherlands
Beijing 302 Hospital

Unknown

Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis

Primary Biliary Cirrhosis

China
Baskent University

Completed

Paracetamol Versus Dipyrone After Pediatric Lower Abdominal Surgery in Children With Spinal Anesthesia

Other Acute Postoperative Pain
Mayo Clinic
Abbott

Completed

Oral Paricalcitol in Kidney Transplant Recipients

Hyperparathyroidism, Secondary | Renal Disease, End Stage | Transplant; Failure, Kidney

United States
Oslo University Hospital
University of Oslo

Completed

Nutritional Risk Factors for Hip Fracture: a Case Control Study

Hip Fracture

Norway
University of Cologne

Completed

Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants

Nephrocalcinosis

Germany
AM-Pharma
CRM Biometrics GmbH; Sintesi Research Srl; Vigilex BV

Completed

Safety/Efficacy Study of Bovine Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis

Ulcerative Colitis

Czech Republic, Italy
AM-Pharma

Completed

Bovine Intestinal Alkaline Phosphatase for the Treatment of Patients With Sepsis

Sepsis | Multiple Organ Dysfunction Syndrome

Netherlands, Belgium
AM-Pharma

Terminated

A Study in Sepsis Patients With Renal Failure

Sepsis | Bacterial Infections and Mycoses

Netherlands, Belgium
Radboud University Medical Center

Completed

Effects of Alkaline Phosphatase on Renal Function in Septic Patients

Shock | Septic | Severe

Netherlands
University of Tennessee

Not yet recruiting

Enteral Zinc Supplementation in VLBW Infants

Nutritional Deficiency | Very Low Birth Weight Infant

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