Search clinical trials for: Maximum Tolerated Dose

Total 21174 results

Boehringer Ingelheim

Completed

A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver Problems

Hepatic Insufficiency | Healthy

United States
Boehringer Ingelheim

Completed

This Study Tests BI 1467335 in Healthy Japanese and Caucasian Men. The Study Tests How Different Doses of BI 1467335 Are Taken up in the Body and How Well They Are Tolerated

Healthy

Japan
Novartis Pharmaceuticals

Completed

Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt

Advanced Solid and Hematological TP53wt Tumors

France, Netherlands, Spain, Germany, Singapore, Japan, Taiwan, United States
Boehringer Ingelheim

Completed

A Study to Test How Well Different Doses of BI 1356225 Are Tolerated by Men and Women With Obesity or Overweight

Obesity

Germany
Boehringer Ingelheim

Completed

A Study to Test How Different Doses of BI 456906 Are Tolerated in Japanese Men With a Body Mass Index (BMI) Between 23 and 40 kg/m2

Healthy

Japan
Bayer

Completed

Study to Test the Safety of Increasing Multiple Doses of BAY2328065 Given by Mouth, How the Drug is Tolerated and Acts in the Human Body of Healthy Male Participants. Alteration of the Study Drug Effects by Another Drug and the Availability of the Drug Given in Different Formulations is Also Tested.

Endometriosis

Germany
Boehringer Ingelheim

Terminated

This Study Tests How Different Doses of BI 1291583 Are Taken up in the Body and How Well They Are Tolerated

Healthy

Germany
Boehringer Ingelheim

Completed

This International Study Tests BI 690517 in Patients With Diabetic Kidney Disease. The Study Tests How 3 Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated

Diabetic Nephropathies

Spain, Germany, United Kingdom, France, Greece, Portugal, Sweden, Russian Federation, Denmark, Slovakia
Boehringer Ingelheim

Completed

This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam

Healthy

Germany
Universidad Autonoma de Nuevo Leon

Completed

Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis.

Plantar Fascitis | Botulinum Toxins, Type A

Mexico
Bayer

Completed

Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight

Clinical Pharmacology

Germany
Bayer

Completed

Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Clinical Pharmacology

Germany
Esperion Therapeutics, Inc.

Completed

A Study Evaluating the Safety and Efficacy of Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared to Bempedoic Acid, Ezetimibe, and Placebo in Patients Treated With Maximally Tolerated Statin Therapy

Hyperlipidemias

United States
Bayer

Terminated

Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose in Participants With Liver Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Pharmacology, Clinical

Germany
Bayer

Terminated

Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose of 10 mg Immediate Release Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Pharmacology, Clinical

Germany
Menzies School of Health Research
National Health and Medical Research Council, Australia

Completed

Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life (PREV-IX_B)

Cough | Otitis Media | Lower Respiratory Tract Infection | Febrile Illness | Upper Respiratory Tract Infection

Australia
Asan Medical Center

Completed

Study of Docetaxel, Capecitabine and Oxaliplatin in Advanced Stomach Cancer

Stomach Cancer

Korea, Republic of
Boehringer Ingelheim

Completed

This Study Tests a New Medicine Called BI 685509 in Patients That Have Kidney Problems Because of Diabetes. The Study Tests How BI 685509 is Taken up in the Body and How Well it is Tolerated (Multiple Rising Doses)

Diabetic Nephropathies

United States, Canada, Belgium, Czechia, Germany
National Cancer Institute (NCI)

Terminated

Depsipeptide/Flavopiridol Infusion for Cancers of the Lungs, Esophagus, Pleura, Thymus or Mediastinum

Carcinoma, Non-Small-Cell Lung | Esophageal Neoplasms | Mesothelioma | Carcinoma, Small Cell

United States
Celgene

Completed

Japanese Phase 1 Study to Evaluate Tolerated Dose, Safety, and Efficacy of Pomalidomide in Patients With Refractory or Relapsed and Refractory Multiple Myeloma

Multiple Myeloma

Japan
Boehringer Ingelheim

Completed

This Study Tests Different Doses of BI 1015550 in Patients With Idiopathic Pulmonary Fibrosis (IPF). The Study Tests How BI 1015550 is Taken up by the Body and How Well it is Tolerated.

Idiopathic Pulmonary Fibrosis

Spain, United Kingdom, Italy, Belgium, Germany, Netherlands, Finland, Denmark
Hospices Civils de Lyon

Completed

Cystic Fibrosis Related Diabetes Screening. (D2M)

Cystic Fibrosis-related Diabetes
Memorial Sloan Kettering Cancer Center
Tufts Medical Center; Lahey Clinic

Completed

Lenalidomide (Revlimid®) Plus Low-dose Dexamethasone (Ld x 4 Cycles) Then Stem Cell Collection Followed by Randomization to Continued Ld or Stem Cell Transplantation (SCT) Plus Maintenance L

Multiple Myeloma

United States
Boehringer Ingelheim

Completed

This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Looks at How Food Influences the Amount of BI 1358894 in the Blood

Healthy

Germany
Boehringer Ingelheim

Completed

A Study in Healthy Japanese Men to Test How Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated

Healthy

Japan
Grünenthal GmbH

Completed

A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated

Pain | Chronic Pain | Acute Pain

Canada
Radboud University Medical Center
European and Developing Countries Clinical Trials Partnership (EDCTP); Department... and other collaborators

Completed

Safety, Tolerability, Extended Early Bactericidal Activity and PK of Higher Doses Rifampicin in Adults With Pulmonary TB (HR1)

Pulmonary Tuberculosis (TB)

South Africa
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study to Evaluate Whether BLI-489 Can be Safely Tolerated by Healthy Subjects Given Multiple Doses

Healthy

United States
Novartis Pharmaceuticals

Terminated

Phase I Study to Determine the Maximum Tolerate Dose (MTD) of BGT226 in Advanced Solid Tumors in Japan

Cancer | Solid Tumor | Advanced Solid Tumor

Japan
Hanlim Pharm. Co., Ltd.

Completed

A Single Ascending Dose Clinical Trial to Find the Maximum Tolerable Dose of HL237 in Healthy Male Subject

Rheumatoid Arthritis

Korea, Republic of
GlaxoSmithKline

Completed

Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer

Cancer

United States
Boehringer Ingelheim

Completed

This Study Tests BI 685509 in Healthy Chinese and Japanese Men; the Study Tests How Different Doses of BI 685509 Are Taken up in the Body and How Well They Are Tolerated

Healthy

Korea, Republic of, Japan
University Medical Center Groningen

Completed

Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach. (SAFE-ACS)

Acute Coronary Syndrome

Netherlands
Pfizer

Completed

A Multiple Dose Study Of PF-04950615 (RN316) In Subjects On Maximum Doses Of Statins

Dyslipidemia | Hypercholesterolemia

United States, Canada
GlaxoSmithKline

Completed

Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809

Substance Dependence

United Kingdom
LEO Pharma

Completed

Vasoconstriction Trial With LEO 90100 Aerosol Foam

Psoriasis Vulgaris

France
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Pharmacokinetics and the Effect on Cardiac Repolarization of Odalasvir Administered as a Single Dose Tablet Under Fed Conditions in Healthy Participants

Healthy

United States
Boehringer Ingelheim

Completed

A Study of Intermittent, High-dose Afatinib to Determine the Maximal Tolerated Dose and Assess Activity of This Dose Against Non-small Cell Lung Cancer With T790M Mutations

Carcinoma, Non-Small-Cell Lung

United States
St. Jude Children's Research Hospital
Genzyme, a Sanofi Company

Completed

Haploidentical Hematopoietic Stem Cell Transplantation Using A Novel Clofarabine Containing Conditioning Regimen For Patients With Refractory Hematologic Malignancies

Hematologic Malignancies

United States
Carol Fabian, MD
BTR Group

Completed

Modulation of Breast Cancer Risk Biomarkers by High Dose Vitamin D

Breast Cancer

United States
Assistance Publique - Hôpitaux de Paris
Action Research Group

Terminated

Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin (ANDROS)

Depression | Coronary Artery Disease

France
Regionshospitalet Silkeborg

Completed

The Analgesic Effect of Combined Nerve Block and Systemic High Dose Glucocorticoid After Total Knee Arthroplasty. (HOBSALIplus)

Pain | Peripheral Nerve Block
Hellenic Oncology Research Group

Terminated

Bevacizumab in Combination With Chemotherapy in the Neo-adjuvant Setting for HER2 (-) Breast Cancer

Breast Cancer

Greece
Hellenic Oncology Research Group

Terminated

Trial of Panitumumab Cisplatin, Fluourouracil and Docetaxel in Locally Advanced or Metastatic Gastric Cancer

Gastric Cancer

Greece
Hellenic Oncology Research Group

Completed

Pazopanib in Relapsed and Refractory Small Cell Lung Cancer

SCLC

Greece
Eisai Inc.

Completed

A Study to Explore the Safety And Tolerability of Doses of E2007 Up to a Maximum of 8 mg In Patients With Parkinson's Disease Who Experience End-of-Dose Wearing Off Motor Fluctuations

Parkinson's Disease

United States
Nemours Children's Clinic

Completed

Dose-response of Albuterol in Asthmatics

Asthma

United States
Emotional Brain NY Inc.

Completed

Lybridos in Pre-and Postmenopausal Women With Hypoactive Sexual Desire Disorder

Hypoactive Sexual Desire Disorder

United States
Roswell Park Cancer Institute

Completed

Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity For PDT Treatment Of High Grade Dysplasia,CIS or Early Adenocarcinoma In Barrett's Esophagus

Barrett's Esophagus | CIS | HGD

United States
Duke University
National Institute of Mental Health (NIMH)

Completed

Treatment of Obsessive Compulsive Disorder in Children

Obsessive-Compulsive Disorder

United States

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