Search clinical trials for: Monotherapy

Total 1611 results

Addex Pharma S.A.

Completed

ADX10059 as a Monotherapy in Patients With Gastroesophageal Reflux (GERD)

Gastroesophageal Reflux

Austria, Belgium, France, Germany
GlaxoSmithKline

Completed

Adefovir Dipivoxil In Compensated Chronic Hepatitis B Patients

Chronic Hepatitis B
Sanofi

Completed

Insulin Glargine Combination Therapies in Type II Diabetics (LAPTOP)

Diabetes Mellitus, Type 2

France, Germany, Netherlands, Spain, Sweden, Switzerland, United Kingdom, Finland, Italy, Austria
Teva Pharmaceuticals USA

Completed

Metformin ER 750 mg Tablets, Fed

Healthy

Canada
Eisai Korea Inc.

Completed

A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies

Epilepsy

Korea, Republic of
Epix Pharmaceuticals, Inc.

Terminated

Study of PRX-03140 Monotherapy in Subjects With Alzheimer's Disease

Alzheimer's Disease

United States
Laboratorios Silanes S.A. de C.V.

Unknown

Sibutramine-metformin Combination Versus Sibutramine and Metformin Monotherapy in Obese Patients

Obesity

Mexico
Laboratorios Silanes S.A. de C.V.

Completed

Effect of DMMET-01 on Insulin Sensitivity in Naive Type 2 Diabetes Patients (CLAMP) (DMMETclamp)

Diabetes Type 2

Mexico
Solvay Pharmaceuticals

Completed

Comparison of the Combination of Fenofibrate and 40 mg Simvastatin Versus 40 mg Simvastatin Monotherapy

Cardiovascular Diseases

Australia, Estonia, Hungary, Latvia, Lithuania, New Zealand
Solvay Pharmaceuticals

Completed

Comparison of the Combination of Fenofibrate and 20 mg Simvastatin Versus 40 mg Simvastatin Monotherapy

Hyperlipidemia

Czech Republic, Denmark, France, Germany, Hungary, Netherlands, Poland, Ukraine
AstraZeneca

Completed

Drug Interaction Study Between AZD3480 and Warfarin (DDI)

Alzheimer's Disease

Sweden
University Hospital, Basel, Switzerland

Completed

Study Comparing Ranibizumab Monotherapy With Combined Verteporfin Therapy in Subfoveal CNV

Age-Related Macular Degeneration | Choroidal Neovascularization

Switzerland
AstraZeneca

Completed

Phase 3 /Seroquel SR Acute Mania Monotherapy - US

Mania | Manic Disorder | Manic State | Affective Psychosis, Bipolar | Manic-Depressive Psychosis | Psychoses, Manic-Depressive

United States
AstraZeneca

Completed

Phase III/Seroquel SR Bipolar Depression Monotherapy - US

Depression, Bipolar | Affective Psychosis, Bipolar | Manic-Depressive Psychosis | Psychoses, Manic-Depressive

United States
AstraZeneca

Completed

Quetiapine Fumarate as Monotherapy in the Maintenance Treatment of Patients With Major Depressive Disorder (AMETHYST)

Major Depressive Disorder

United States, Russian Federation, United Kingdom, Romania, Canada, Slovakia, Bulgaria, Puerto Rico
Lindner Center of HOPE
AstraZeneca; University of Cincinnati

Completed

Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms

Bipolar Disorder

United States
Samsung Medical Center

Unknown

The Change of Urinary Angiotensinogen Excretion After Valsartan Treatment in Patients With Persistent Proteinuria

Proteinuria | Chronic Kidney Disease

Korea, Republic of
IRCCS San Raffaele
Hoffmann-La Roche; Abbott

Unknown

Lopinavir/Ritonavir Monotherapy Versus Standard Highly Active Antiretroviral Therapy (HAART) in HIV/HCV Coinfected Patients Starting Treatment With Anti-Hepatitis C Virus (HCV) Therapy

HIV Infections | Hepatitis C

Italy
IRCCS San Raffaele
Hoffmann-La Roche; Abbott

Unknown

Lopinavir/Ritonavir Monotherapy Versus Standard Highly Active Antiretroviral Therapy (HAART) in HIV/HCV Coinfected Antiretroviral (ARV) Naive Patients Starting Treatment With Anti-HCV Therapy

HIV Infections | Hepatitis C

Italy
Brigham and Women's Hospital
GlaxoSmithKline

Completed

Fondaparinux as Monotherapy for DVT and/or Pulmonary Embolism

Deep Vein Thrombosis | Pulmonary Embolism

United States
Harrison Clinical Research
Merck KGaA, Darmstadt, Germany; AstraZeneca

Completed

Pharmocokinetic/Pharmacodynamic (PK/PD) Study of the Combination Cetuximab/Gefitinib

Head and Neck Cancer | Colorectal Cancer | Non Small Cell Lung Cancer (NSCLC)

Spain, Belgium
AstraZeneca

Completed

Quetiapine Fumarate Bipolar Maintenance Monotherapy (SPaRCLe)

Bipolar Disorder

United States, Bulgaria, Peru, Russian Federation, Philippines, Malaysia, Lithuania, Romania, Ukraine, Argentina, Taiwan, Mexico, Thailand, India, Colombia
AstraZeneca

Completed

Subjective Well Being of Patients Receiving Atypical Antipsychotics as Monotherapy or Cotherapy With Mood Stabilizers (DIDAXI)

Bipolar Disorder

Greece
PETHEMA Foundation

Completed

Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec®-Interferon Alpha in the Treatment of Chronic-Phase Chronic Myeloid Leukaemia

Chronic Myeloid Leukaemia

Spain
Fondation Wygrajmy Zdrowie

Unknown

Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy (GCT)

Testicular Cancer

Poland
Novartis

Completed

Safety and Efficacy of Valsartan Plus Hydrochlorothiazide and Amlodipine in Hypertensive Patients

Hypertension

Taiwan
Anhui Medical University
Peking University First Hospital; The University of Science and Technology...

Completed

Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension

Hypertension | Lower Urinary Tract Symptoms

China
University of Pavia

Unknown

Valsartan and Amlodipine Compared to Losartan and Amlodipine in Hypertensive Patients

Essential Hypertension

Italy
Nordica Fertility Clinic
Merck Serono International SA

Unknown

A Prospective Randomized Multicentre Study to Compare Crinone 8% Once Daily Versus Other Vaginal Progesterone.

IVF - Luteal Phase Support After Embryo Transfer

Denmark, Sweden
Pharmexa A/S
Syneos Health; ICON Clinical Research; ORION Clinical Services; CIRION Central... and other collaborators

Terminated

GV1001 and Gemcitabine in Sequential Combination to Gemcitabine Monotherapy in Pancreatic Cancer

Advanced Unresectable Pancreatic Cancer

United States, Spain, Australia, Netherlands, Belgium, Denmark, France, Ireland, Italy, Norway, Poland, Sweden
Hadassah Medical Organization

Suspended

Artificial Endometrial Preparation for Frozen Thawed Embryo Transfer Applying Either Endometrin or Utrogestan

Frozen Thawed Embryo Transfer

Israel
Immutep S.A.S.
SGS Aster-Cephac (CRO)

Completed

Phase I Study of IMP321 Given Alone or as an Adjuvant to a Reference Flu Antigen

Healthy

France
Sanofi

Completed

Continuous Glucose Monitoring System (CGMS) in Type 2 Diabetic Patients Inadequately Controlled by Metformine Monotherapy; Analyze of Glycemic Profile Before and After Association of Glimepiride

Diabetes Mellitus

France
Arribas, Jose R., M.D.
Abbott; Pulido, Federico, M.D.

Completed

"OK 2004 Study" (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides From Triple-Drug Therapy in HIV Subjects

HIV Infection

Spain
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Hormone Replacement Therapy on Inflammation and Stiffening of Artery Walls

Healthy | Atherosclerosis | Vascular Disease

United States
Canive, Jose M., M.D.
Eli Lilly and Company

Unknown

Open-Label Duloxetine Monotherapy in the Treatment of Posttraumatic Stress Disorder

Posttraumatic Stress Disorders

United States
Novartis

Completed

Safety and Efficacy of Oxcarbazepine Monotherapy in Adults With Partial Seizures

Epilepsy, Partial Seizures

Russian Federation
Eli Lilly and Company

Completed

2nd Line Gemcitabine Monotherapy for Transitional Cell Carcinoma of Urothelium (TCC) After CDDP Regimen

Urologic Neoplasms | Carcinoma, Transitional Cell

Japan
Wirral University Teaching Hospital NHS Trust
AstraZeneca

Completed

Bicalutamide Monotherapy Has Significant Quality of Life Benefits for Men With Advanced Prostate Cancer

Prostatic Neoplasms

United Kingdom
Copenhagen University Hospital at Herlev

Completed

Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism (T4-T3)

Depression | Quality of Life

Denmark
Saitama Medical University

Completed

Effects of Angiotensin Receptor Antagonist on Prohibiting Cardiovascular Events on Hemodialysis Patients

Cardiovascular Disease
Novartis

Completed

Bioavailability of Aliskiren and Valsartan Combined as a Single Tablet vs. the Same Medications Given Separately to Healthy Subjects.

Healthy

United States
Novartis

Completed

To Assess the Efficacy and Safety of Vildagliptin as Add-on Therapy to Sulfonylurea in Patients With Type 2 Diabetes Inadequately Controlled With Sulfonylurea Monotherapy

Diabetes Mellitus, Type 2

Japan
Japan Early Diabetes Intervention Study Group

Unknown

Japan Early Diabetes Intervention Study (JEDIS)

Diabetes Mellitus

Japan
University of Texas Southwestern Medical Center
Merck Sharp & Dohme LLC; Donald W. Reynolds Foundation

Completed

Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both

Cholesterol, LDL

United States
Poitiers University Hospital

Completed

Maintenance Neoral Monotherapy Compared to Bitherapy in Renal Transplantation

Kidney Transplantation

France
Genovate Biotechnology Co., Ltd.,
Allergan Medical

Unknown

Combigan Ophthalmic Solution(Brimonidine 0.2% and Timolol 0.5%)With Latanoprost Compared With Latanoprost Monotherapy

Glaucoma

Taiwan
Innovative Medical

Completed

Bimatoprost Monotherapy vs. Dual Therapy With Travoprost and Timolol in Patients With Glaucoma and Ocular Hypertension

Glaucoma

United States
Romark Laboratories L.C.

Completed

Study of Nitazoxanide Combined With Peginterferon Compared to Peginterferon Monotherapy in the Treatment of Hepatitis C

Chronic Hepatitis C

Egypt
AGO Study Group

Completed

Gemcitabine Plus Carboplatin Versus Carboplatin Monotherapy in Patients With Advanced Ovarian Cancer

Ovarian Cancer

3

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