Search clinical trials for: Pharmacodynamic biomarkers

Total 8879 results

Presage Biosciences
AstraZeneca

Recruiting

PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC

Head and Neck Squamous Cell Carcinoma

United States
Anavex Life Sciences Corp.
Cognitive Research Corporation; COGNISION; Hassman Research Institute

Recruiting

A Study of ANAVEX3-71 in Adults With Schizophrenia (SZ-001)

Schizophrenia

United States
Peking University First Hospital

Not yet recruiting

Imapct of bioMarkers on Pharmacodynamics and Bleeding Risk of Direct Oral AntiCoagulants and Ticagrelor Study II

Bleeding | Pharmacodynamics | Apixaban | Pharmacogenomics | Biomarker | Ticagrelor | Rivaroxaban | Novel Oral Anticoagulants | NOACs | Dabigatran | Edoxaban | RNA Profile

China
Gliknik Inc.

Recruiting

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

First in Man Study to Evaluate Initial Safety

United Kingdom
Vaccinex Inc.
Merck Sharp & Dohme LLC

Recruiting

Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (KEYNOTE-B84)

Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC)

United States
Presage Biosciences
Merck Sharp & Dohme LLC

Recruiting

Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Solid Tumor

United States
University of Wisconsin, Madison
National Cancer Institute (NCI)

Recruiting

Pharmacodynamic Biomarkers of Standard Anti-microtubule Drugs as Assessed by Early Tumor Biopsy

Breast Cancer | Breast Neoplasms

United States
Presage Biosciences
Merck Sharp & Dohme LLC

Completed

PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS

Soft Tissue Sarcoma | Head and Neck Squamous Cell Carcinoma

United States
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Pharmacodynamic Biomarkers to Support Biosimilar Development: Interferon Beta-1A Products

Healthy Subjects | Pharmacokinetics | Pharmacodynamics

United States
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors

Healthy Subjects | Pharmacokinetics | Pharmacodynamics

United States
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Pharmacodynamic Biomarkers to Support Biosimilar Development: Interleukin-5 Antagonists

Healthy Subjects | Pharmacokinetics | Pharmacodynamics

United States
Presage Biosciences
Takeda

Completed

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC

Head and Neck Squamous Cell Carcinoma

United States
Merck Sharp & Dohme LLC

Completed

Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)

Cognitive Impairment Associated With Schizophrenia

United States
Presage Biosciences
Takeda

Withdrawn

CIVO Intratumoural Microdosing of Anti-Cancer Therapies in Australia

Solid Tumour

Australia
Kami Maddocks, MD
Novartis

Completed

Study of BKM120 & Rituximab in Patients With Relapsed or Refractory Indolent B-Cell Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone... and other conditions

United States
Presage Biosciences
Bristol-Myers Squibb; Celgene

Terminated

Intratumoral Microdosing of Motolimod in HNSCC

HNSCC

United States
UDA Centro Nacional Hepato-Bilio-Pancreático
University Hospital, Limoges; Universidad de la Republica; INSERM UMR-S850, Limoges... and other collaborators

Terminated

Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant Patients (3PIGREF)

End Stage Liver Disease | Diabetes | Toxicity | Rejection | Infection | Malignancy

Uruguay
AstraZeneca
Parexel

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

Hypercholesterolemia

United States
Cui Yimin

Unknown

Impact of Biomarkers on Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants

Pharmacokinetics | Pharmacodynamics | Apixaban | Pharmacogenomics | Accurate Medication | Rivaroxaban | Novel Oral Anticoagulants | NOACs | Dabigatran

China
Cui Yimin

Unknown

Impact of Biomarkers on Pharmacokinetics and Pharmacodynamics of Ticagrelor

Pharmacokinetics | Pharmacodynamics | Pharmacogenomics | Accurate Medication | Ticagrelor

China
Cambridge University Hospitals NHS Foundation Trust
AstraZeneca

Completed

Study of Olaparib (± Degarelix) Given to Men With Intermediate/High Risk Prostate Cancer Before Prostatectomy (CaNCaP03)

Prostate Cancer

United Kingdom
GlaxoSmithKline

Completed

A Study to Examine the Pharmacodynamic Effects of GSK1034702 on Neurophysiological Biomarkers of Cognition in Nicotine Abstained Otherwise Healthy Smokers (MAA113746)

Mental Disorders

United Kingdom
University of Pittsburgh

Withdrawn

Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma
National Cancer Institute (NCI)

Terminated

Birinapant for Advanced Ovarian, Fallopian Tube, and Peritoneal Cancer

Fallopian Tube Neoplasms | Peritoneal Neoplasms | Epithelial Ovarian Cancer

United States
GlaxoSmithKline

Completed

A Phase I, Randomized, Placebo-controlled, Double Blind, Repeat Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Gastrointestinal Transit Time and Pharmacodynamic Biomarkers of GSK3179106 in Normal Subjects

Irritable Bowel Syndrome

Australia
Annovis Bio Inc.

Terminated

Study of the Pharmacokinetics and Pharmacodynamics of POSIPHEN® in Subjects With Amnestic Mild Cognitive Impairment

Alzheimer's Disease | Amnestic Mild Cognitive Impairment

United States
Pierluigi Porcu
Millennium Pharmaceuticals, Inc.; Celgene Corporation

Completed

Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma

Peripheral T-cell Lymphoma | Anaplastic Large Cell Lymphoma | Angioimmunoblastic T-cell Lymphoma | Adult Nasal Type Extranodal NK/T-cell Lymphoma | Hepatosplenic T-cell Lymphoma | Post-transplant Lymphoproliferative Disorder | Recurrent Adult T-cell Leukemia/Lymphoma | Recurrent Cutaneous T-cell... and other conditions

United States
AstraZeneca

Completed

To Assess the Effect of Administration of 2 Formulation of AZD3241 on Blood Concentration in Healthy Volunteers

Parkinson's Disease

United Kingdom
John F. Foley, MD
Biogen

Completed

Longitudinal Pharmacokinetic, Pharmacodynamic, Immunological, and Biochemical

Multiple Sclerosis

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Thalidomide, Prednisone, and Cyclophosphamide in Treating Patients With Myelofibrosis and Myeloid Metaplasia

Chronic Myeloproliferative Disorders | Secondary Myelofibrosis
University of Cologne
University Hospital, Bonn; ZKS Köln

Completed

An Explorative Study on the Pharmacokinetics and Pharmacodynamics of Sunitinib in Healthy Volunteers

Blood Pressure
Nordic Bioscience A/S
Novartis

Completed

Pharmacokinetics/Pharmacodynamics of Oral Salmon Calcitonin in Patients With Osteoarthritis

Osteoarthritis

Denmark
University Hospital Ostrava
University Hospital, Motol

Recruiting

Invasive Candidiasis in Critical Care

Invasive Candidiasis

Czechia
GCS CIPS
Callyope

Not yet recruiting

Evaluation of Response to a Course of Repetitive Transcranial Magnetic Stimulation Using Vocal Biomarkers (SPEECHTMS)

Major Depressive Disorder
Institut Pasteur

Recruiting

Cellular and Molecular Biomarkers in Patients With Lichen Planus (HELP)

Lichen Planus

France, Finland
Universität des Saarlandes

Recruiting

Pharmacokinetics of Bisoprolol and SGLT2i in Acutely Decompensated Heart Failure (BISO-ADHF)

Acute Decompensated Heart Failure

Germany
Institut Investigacio Sanitaria Pere Virgili

Recruiting

Early Diagnosis of Colorectal Cancer Based on a Non-invasive Metabolomics Profile (EarlyCRC)

Healthy | Colorectal Cancer | Colorectal Adenoma | Colorectal Polyp

Spain
Centre Hospitalier Universitaire, Amiens
Groupe Hospitalier Pitie-Salpetriere

Recruiting

Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue (ClimaBio)

Squamous Cell Carcinoma | Proton Magnetic Resonance Spectroscopy | Transcriptomics | Soft Tissue Tumors of the Tongue

France
BioMérieux

Recruiting

VIDAS® TBI Performance in Subjects With Mild Traumatic Brain Injury (mTBI)

Mild Traumatic Brain Injury

United States
Universitas Diponegoro
Dr. Kariadi General Hospital Medical Center

Recruiting

Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation (BI-PACED)

Heart Block | Biomarkers | Antibiotic Prophylaxis | CIED Related Infection | CIED-related Infections

Indonesia
Hospital Universitario Getafe

Recruiting

Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries (IMACORN-INFLI)

Myocardial Infarction | Inflammation | Biomarkers | Endothelial Dysfunction | MINOCA

Spain
NHS Greater Glasgow and Clyde
University of Glasgow; Roche Diagnostics GmbH

Not yet recruiting

Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)

Cardiomyopathies | Genetic Predisposition | Cardiomyopathy, Primary
University Hospital, Toulouse
Aristotle University Of Thessaloniki; European Union; University Hospital Carl...

Not yet recruiting

AI-PROGNOSIS - Digital Biomarkers Development Study (dBM-DEV) (dBM-DEV)

Parkinson Disease

Spain, France, Germany, United Kingdom
LEO Pharma

Not yet recruiting

A Study to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of LEO 158968

Joint Pain | Gout Flares | Joint Inflammation
Academisch Medisch Centrum - Universiteit van Amsterdam...

Not yet recruiting

Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers (CURIE)

ARDS, Human | Transfusion-Related Acute Lung Injury
Guangdong Hengrui Pharmaceutical Co., Ltd

Not yet recruiting

A Study to Evaluate the Long-term Safety, Pharmacodynamics and Efficacy of SHR-1703 in Eosinophilic Asthma Patients

Eosinophilic Asthma Patients
University of Minnesota

Recruiting

Feasibility of Conducting a Pilot Telehealth Study Assessing the Removal of Filter Ventilation on Smoking Behavior and Biomarkers in Menthol Smokers Switched to Non-menthol Cigarettes

Smoking

United States
Arizona State University

Recruiting

Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults

Mood Disorders | Cognitive Change | LPS

United States
Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

to Evaluate the Safety/Tolerability and Pharmacokinetics, and Pharmacodynamics of DWP14012 Injection

Erosive Gastroesophageal Reflux Disease
AstraZeneca

Not yet recruiting

A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma (ARTEMISIA)

Asthma

Canada, Denmark, Germany, Spain, United Kingdom

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