Search clinical trials for: Primary Autonomic Failure

Total 42183 results

University of Thessaly

Recruiting

Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients

Circulatory Shock

Greece
King's College London

Recruiting

The Living With a Long-Term Condition Study (LTC)

Liver Diseases | Heart Diseases | Heart Failure | Stroke | Cerebrovascular Disorders | Epilepsy | Pain | Multiple Sclerosis | Hypertension | Obesity | Diabetes | Cancer | Arthritis | Osteoarthritis | Rheumatoid Arthritis | Parkinson Disease | Migraine | Hepatitis | Atrial Fibrillation | Asthma | Endometriosis | Dementia | Fibromyalgia | Celiac... and other conditions

United Kingdom
University of Calgary

Recruiting

CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study

Neurogenic Orthostatic Hypotension | Autonomic Failure

Canada
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

CPAP for the Treatment of Supine Hypertension

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Pure Autonomic Failure | Supine Hypertension | Autonomic Failure

United States
National Institute of Diabetes and Digestive and...
Ann & Robert H Lurie Children's Hospital of Chicago

Recruiting

TReatment for ImmUne Mediated PathopHysiology (TRIUMPH)

Hepatic Encephalopathy | Acute Liver Failure | Fulminant Hepatic Failure | Acute Liver Injury | Immune Dysregulation

United States
Vanderbilt University Medical Center

Recruiting

Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure | Orthostatic; Hypotension, Neurogenic | Orthostatic; Hypotension, Parkinsonism

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Vanderbilt University Medical Center

Recruiting

Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Supine Hypertension | Autonomic Failure

United States
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

Heart Failure | Pain | Pneumonia | Hypertension | Edema | Hemophilia | Insomnia | Pulmonary Arterial Hypertension | Coagulation Disorder | Asthma in Children | Down Syndrome | Attention Deficit Hyperactivity Disorder | Bronchopulmonary Dysplasia | Hypokalemia | Hyperphosphatemia | Primary Hyperaldosteronism | Adrenal Insufficiency and other conditions

United States, Canada
Daniel Claassen

Recruiting

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Parkinson Disease | Multiple System Atrophy | Pure Autonomic Failure | Dementia With Lewy Bodies | Autonomic Failure

United States
Global Healthy Living Foundation
University of Alabama at Birmingham

Recruiting

PatientSpot Formerly Known as ArthritisPower (GHLF)

Heart Failure | Stroke | Epilepsy | Multiple Sclerosis | Obesity | Diabetes | Chronic Obstructive Pulmonary Disease | Osteoarthritis | Rheumatoid Arthritis | Parkinson Disease | Peripheral Arterial Disease | Inflammatory Bowel Diseases | Amyotrophic Lateral Sclerosis | Psoriasis | Asthma | Muscular Dystrophy | Fibromyalgia | Alzheimer... and other conditions

United States
National Institute of Neurological Disorders and...

Recruiting

Clinical Laboratory Evaluation of Chronic Autonomic Failure

Parkinson's Disease | Multiple System Atrophy | Autonomic Failure

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Automated Abdominal Binder for Orthostatic Hypotension

Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Vanderbilt University Medical Center

Recruiting

Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Supine Hypertension | Autonomic Failure

United States
Vanderbilt University Medical Center

Recruiting

Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

Hypertension | Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure

United States
Children's Oncology Group
National Cancer Institute (NCI); EsPhALL Network/ BFM Study Group

Recruiting

Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | B Acute Lymphoblastic Leukemia | T Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia

United States, Canada, Puerto Rico, Australia, Finland, New Zealand, Saudi Arabia, Germany, Austria, Belgium, Chile, Czechia, France, Italy, Netherlands, Sweden, Switzerland, Hong Kong, Israel
Vanderbilt University Medical Center

Recruiting

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Parkinson Disease | Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Diane George

Recruiting

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

Acute Lymphoblastic Leukemia (ALL) | Myelodysplastic Syndrome (MDS) | Acute Myelogenous Leukemia (AML) | Chronic Myeloid Leukemia (CML) | Juvenile Myelomonocytic Leukemia (JMML) | Lymphoma (Hodgkin's and Non-Hodgkin's)

United States
CES University

Recruiting

Essential Hypotension and Allostasis Registry (ESSENTIAL)

Depression | Diabetes Mellitus | Cancer | Atrial Fibrillation | Fibromyalgia | Blood Pressure | Syncope | Coronary Heart Disease | Chronic Fatigue Syndrome | Panic Attack | Diastolic Heart Failure | POTS | Systolic Heart Failure | Vasovagal Syncope | Acute Myocardial Infarction (AMI) | Transient Ischemic Attack (TIA) | Acute... and other conditions

Colombia
NYU Langone Health

Recruiting

Natural History Study of Synucleinopathies

Parkinson Disease | Multiple System Atrophy | Neurogenic Orthostatic Hypotension | REM Sleep Behavior Disorder | Pure Autonomic Failure | Dementia With Lewy Bodies | Patients With Synucleinopathies | Shy-Drager Disease

Korea, Republic of, United States, Argentina, Spain
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
University of Maryland, Baltimore
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)

Type 1 Diabetes | Hypoglycemia Associated Autonomic Failure

United States
University of Colorado, Denver
National Institute on Aging (NIA)

Completed

Advancing Understanding of Transportation Options (AUTO)

Stroke | Multiple Sclerosis | Glaucoma | Brain Injuries | Macular Degeneration | Arthritis | Chronic Obstructive Pulmonary Disease | Parkinson Disease | Restless Legs Syndrome | Diabetic Retinopathy | Insomnia | Retinitis Pigmentosa | Obstructive Sleep Apnea | Dementia | End Stage Renal Disease | Sleep Apnea | Syncope | Seizures and other conditions

United States
National Institute of Neurological Disorders and...

Completed

Biomarkers of Risk of Parkinson Disease

Parkinson Disease | Autonomic Nervous System Diseases | Pure Autonomic Failure

United States
Chelsea Therapeutics

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) (NOH304)

Neurogenic Orthostatic Hypotension | Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Non-Diabetic Neuropathy
CND Life Sciences

Completed

Synuclein-One Study

Parkinson Disease | Multiple System Atrophy | Pure Autonomic Failure | Dementia With Lewy Bodies

United States
H. Lundbeck A/S

Active, not recruiting

A Study of Lu AF82422 in Participants With Multiple System Atrophy (AMULET)

Multiple System Atrophy

United States, Japan
Vanderbilt University Medical Center
NYU Langone Health

Completed

Norepinephrine Transporter Blockade, Autonomic Failure (NETAF) (NETAF)

Neurogenic Orthostatic Hypotension

United States
H. Lundbeck A/S

Completed

Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension (RESTORE)

Symptomatic Neurogenic Orthostatic Hypotension

United States
RWTH Aachen University

Completed

Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease (PaKogOH)

Parkinson Disease | Cognitive Impairment | Hypotension, Orthostatic | Autonomic Failure

Germany
RWTH Aachen University

Completed

Concentration and Attentional Deficits in POTS and Other Autonomic Neuropathies (POTSKog)

Cognitive Impairment | Postural Tachycardia Syndrome | Dysautonomia | Pure Autonomic Failure | Ehlers-Danlos Syndrome | Autonomic Failure

Germany
Albert Einstein College of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Active, not recruiting

Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)

Hypoglycemia | Diabetes Mellitus, Type 1 | Hypoglycemia Unawareness

United States
Theravance Biopharma

Terminated

Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (REDWOOD)

Parkinson's Disease (PD) | MSA | Symptomatic Neurogenic Orthostatic Hypotension | Pure Autonomic Failure (PAF)

United States, Spain, United Kingdom, Canada, France, Estonia, Australia, Israel, Denmark, Italy, Poland, New Zealand, Germany, Ukraine, Austria, Bulgaria, Portugal, Hungary, Russian Federation
Theravance Biopharma

Terminated

Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (OAK)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Portugal, United Kingdom, France, Denmark, Ukraine, Israel, Estonia, Poland, Italy, Russian Federation, Australia, Austria, Bulgaria, Canada, Germany, New Zealand
Brigham and Women's Hospital

Completed

The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

Fibromyalgia | Chronic Fatigue Syndrome | Orthostatic Hypotension | Postural Orthostatic Tachycardia Syndrome | Dysautonomia | Myalgic Encephalomyelitis | Exercise Intolerance | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Low Ventricular Filling Pressures (Preload Failure)

United States
University of Oxford
Medical Research Council

Completed

Deep Brain Stimulation for Autonomic and Gait Symptoms in Multiple System Atrophy (STAG-MSA)

Multiple System Atrophy | Gait Disorders, Neurologic | Bladder, Neurogenic | Autonomic Failure | Postural Hypotension

United Kingdom
Tanta University

Completed

Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron

Delayed Gastric Emptying

Saudi Arabia
Theravance Biopharma

Completed

TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)

Parkinson Disease | Orthostatic Hypotension | Neurogenic Orthostatic Hypotension | Hypotension, Orthostatic | Pure Autonomic Failure | Multiple System Atrophy (MSA) With Orthostatic Hypotension | Pure Autonomic Failure With Orthostatic Hypotension | Parkinson Disease With Orthostatic Hypotension

United States
Theravance Biopharma

Completed

Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (SEQUOIA)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Israel, Hungary, Portugal, Australia, Canada, Germany, Russian Federation, Estonia, France, Italy, United Kingdom, Denmark, Poland, New Zealand, Austria, Bulgaria, Ukraine
CENTOGENE GmbH Rostock

Completed

Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP) (TRAP2-1)

Neuropathic Pain | Orthostatic Hypotension | Cardiac Failure | Gastrointestinal Disorders | Polyneuropathy, Amyloid

Spain, Austria, Hungary, North Macedonia, Poland, Serbia
Vanderbilt University

Completed

Local Heat Stress in Autonomic Failure Patients With Supine Hypertension

Hypertension | Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure

United States
NYU Langone Health

Completed

Carbidopa for the Treatment of Excessive Blood Pressure Variability (CarbiFD)

Dysautonomia, Familial | Baroreflex Failure Syndrome

United States
Vanderbilt University

Withdrawn

The Role of Endothelin in the Supine Hypertension of Autonomic Failure

Hypertension | Multiple System Atrophy | Pure Autonomic Failure

United States
Istituto Clinico Humanitas
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Fondazione Salvatore...

Completed

Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB) (DISAUT-AB)

Amyotrophic Lateral Sclerosis | Postural Orthostatic Tachycardia Syndrome | Pure Autonomic Failure | Anti-Cholinergic Receptors Antibodies

Italy
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI); National Center for Advancing...

Terminated

Water and Sudafed in Autonomic Failure

Multiple System Atrophy | Shy-Drager Syndrome

United States
Albert Einstein College of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Unknown

Mechanisms of Hypoglycemia Associated Autonomic Failure

Diabetes Mellitus | Hypoglycemia | Autonomic Failure

United States
Vanderbilt University Medical Center

Terminated

Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure

Shy-Drager Syndrome | Pure Autonomic Failure | Orthostatic Hypotension, Dysautonomic | Autonomic Nervous System Disorders

United States
NYU Langone Health
Michael J. Fox Foundation for Parkinson's Research

Completed

Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease

Parkinson Disease | Multiple System Atrophy | REM Sleep Behavior Disorder | Pure Autonomic Failure | Dementia With Lewy Bodies

United States
Case Comprehensive Cancer Center

Completed

Combination Chemotherapy Followed By Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Severe Aplastic Anemia

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases

United States

Search clinical trials for: Primary Autonomic Failure

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