Search clinical trials for: Proton beam irradiation

Total 4740 results

Proton Collaborative Group

Recruiting

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy (COMPRO)

Breast Cancer

United States
Chang Gung Memorial Hospital

Not yet recruiting

Cognition-preserving Brain Irradiation for Treating Patients With Intracranial Meningioma in the Era of Modern Radiotherapeutic Techniques Including Proton Beam Therapy - a Prospective Study Focusing on Radiological Outcomes and Neurocognitive Endpoints

Intracranial Meningioma

Taiwan
University College, London
University of Sheffield; Asthma + Lung UK; Mesothelioma UK

Recruiting

Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma (HIT-Meso)

Malignant Pleural Mesothelioma

United Kingdom
St. Jude Children's Research Hospital

Recruiting

Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation

Wilms Tumor

United States
University Hospital Heidelberg

Recruiting

Glioblastoma Radiotherapy Using IMRT or Proton Beams (GRIPS)

Glioblastoma

Germany
Massachusetts General Hospital
National Cancer Institute (NCI)

Recruiting

Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation

Brain Tumor

United States
Massachusetts General Hospital

Recruiting

The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients

Breast Cancer Stage II | Breast Cancer Stage III

United States
M.D. Anderson Cancer Center

Active, not recruiting

Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

Malignant Solid Neoplasm | Metastatic Lung Non-Small Cell Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7

United States
St. Jude Children's Research Hospital
National Cancer Institute (NCI); Genentech, Inc.

Active, not recruiting

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Medulloblastoma

United States, Canada, Australia, New Zealand
Mayo Clinic

Active, not recruiting

A Trial of 15 Fraction vs 25 Fraction Pencil Beam Scanning Proton Radiotherapy After Mastectomy in Patients Requiring Regional Nodal Irradiation

Breast Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer

Invasive Breast Carcinoma | Stage I Breast Cancer AJCC v7 | Stage IA Breast Cancer AJCC v7 | Stage IB Breast Cancer AJCC v7 | Stage II Breast Cancer AJCC v6 and v7 | Stage IIA Breast Cancer AJCC v6 and v7 | Stage IIB Breast Cancer AJCC v6 and v7 | Breast Adenocarcinoma | Ductal Breast Carcinoma In Situ and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

3D-CRT, Proton, or Brachytherapy APBI in Treating Patients With Invasive and Non-invasive Breast Cancer

Estrogen Receptor Positive | Ductal Breast Carcinoma In Situ | Grade 1 Invasive Breast Carcinoma | Grade 2 Invasive Breast Carcinoma | Grade 3 Invasive Breast Carcinoma | Invasive Ductal and Lobular Carcinoma In Situ | Mucinous Breast Carcinoma | Tubular Breast Carcinoma

United States
Massachusetts General Hospital
National Cancer Institute (NCI); Federal Share Core

Withdrawn

Preoperative Accelerated Partial Breast Irradiation for Triple Negative Breast Cancer Using Proton Beam Scanning

Breast Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Proton Beam Re-Irradiation in Thoracic Cancers

Recurrent Disease | Thoracic Neoplasm | Metastatic Malignant Neoplasm in the Lung

United States
Massachusetts General Hospital
M.D. Anderson Cancer Center; National Cancer Institute (NCI); University of Pennsylvania and other collaborators

Completed

Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer and Cholangiocarcinoma

Liver Cancer

United States
University of California, Davis
University of California, San Francisco

Completed

ProspectiveTrial of Proton Beam Combined With Anti-VEGF Therapy for Exudative Age-related Macular Degeneration (AMD) (PBAMD2)

Exudative Age-related Macular Degeneration

United States
Massachusetts General Hospital
National Cancer Institute (NCI); Dana-Farber Cancer Institute; Brigham and Women...

Completed

Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer or Hepatic Metastases

Cholangiocarcinoma | Hepatocellular Cancer | Hepatic Metastases
Massachusetts Eye and Ear Infirmary
Genentech, Inc.

Completed

Ranibizumab in Combination With Proton Beam Irradiation for Choroidal Melanoma

Choroidal Melanoma

United States
University of California, Davis
Genentech, Inc.; University of California, San Francisco

Completed

Pilot Study of Lucentis Combined With Proton Beam Irradiation in Treating Wet Age-related Macular Degeneration

Age-related Macular Degeneration
The Christie NHS Foundation Trust
Royal Marsden NHS Foundation Trust; University College London Hospitals

Not yet recruiting

Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma (PRONTO)

Parotid Cancer
Baptist Health South Florida
Ion Beam Applications SA

Not yet recruiting

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial (POPCORN)

Glioma | Recurrent Glioma | Glioma, Malignant

United States
Mayo Clinic

Recruiting

Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment Prostate Cancer

Prostate Adenocarcinoma | Oligometastatic Prostate Carcinoma

United States
The New York Proton Center

Recruiting

Patient-Generated Health Data Collection During Chemoradiotherapy for Lung Cancer (PGHD)

Thoracic Cancer

United States
Ohio State University Comprehensive Cancer Center

Recruiting

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

Oropharyngeal Squamous Cell Carcinoma | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

United States
Thomas Jefferson University

Recruiting

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Metastatic Lung Carcinoma | Stage IV Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Breast Carcinoma

United States
St. Jude Children's Research Hospital

Recruiting

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Liposarcoma | Non-rhabdomyosarcoma | Adipocytic Neoplasm

United States
Jian Chen

Recruiting

Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Thompson Cancer Survival Center

Recruiting

Reduction of Gastrointestinal Toxicity in Prostate Cancer by Proton Spot Placement

Prostate Cancer | Prostate Adenocarcinoma | Prostate Carcinoma

United States
Emory University
National Cancer Institute (NCI)

Recruiting

Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer

Biochemically Recurrent Prostate Carcinoma | Prostate Adenocarcinoma

United States
National Cancer Institute (NCI)

Recruiting

A Study Using a New Drug, Nivolumab, in Combination With Chemotherapy Drugs to Treat a Type of Cancer Called Nasopharyngeal Carcinoma (NPC)

Stage IV Nasopharyngeal Carcinoma AJCC v8 | Stage II Nasopharyngeal Carcinoma AJCC v8 | Stage III Nasopharyngeal Carcinoma AJCC v8

United States
Centre Francois Baclesse
Région Normandie

Recruiting

Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma: (CANCER-COG)

Meningioma | Radiation Toxicity

France
Centre Antoine Lacassagne

Recruiting

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy (P1V2)

Osteosarcoma | Ewing Sarcoma | Chondrosarcoma | Chordoma

France
St. Jude Children's Research Hospital

Recruiting

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

Rhabdomyosarcoma

United States
Emory University
National Cancer Institute (NCI)

Not yet recruiting

Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma

United States
Thompson Cancer Survival Center

Recruiting

Evaluation of Radiobiological Effects in Skin Toxicities for Breast Cancer Patients With Pencil Beam Scanning Proton Therapy

Breast Cancer | Breast Cancer Stage I | Breast Cancer Stage II | Breast Cancer Stage III

United States
University Hospital Heidelberg

Recruiting

Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma (INDIGO)

Low Grade Glioma

Germany
Centre Hospitalier Universitaire de Besancon

Not yet recruiting

Comparison of Cone Beam Irradiation Versus Multi-detector Scanner for Ear Imaging (ICSI)

Irradiation; Adverse Effect
Massachusetts General Hospital
National Cancer Institute (NCI); American Society of Clinical Oncology

Recruiting

Ultrahypofractionation and Normal Tissue Toxicity

Myocardial Fibrosis | Breast Cancer | Breast Cancer Stage II | Breast Cancer Female | Breast Cancer Stage III

United States
Xin Cai

Not yet recruiting

Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon Ion

Rectal Cancer | Recurrent

China
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma

United States
Mayo Clinic

Recruiting

Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study

Glioblastoma

United States
Abramson Cancer Center at Penn Medicine

Recruiting

Whole Pelvis Proton Radiation for Gynecologic Cancer (GynWPProton)

Cervical Cancer | Uterine Cancer

United States
University of Aarhus

Recruiting

Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis (CSI ProLong)

Leptomeningeal Metastasis

Denmark
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck

Metastatic Head and Neck Squamous Cell Carcinoma | Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 | Stage IV Hypopharyngeal Carcinoma AJCC v8 | Stage IV Laryngeal Cancer AJCC v8 | Stage... and other conditions

United States
Shanghai Proton and Heavy Ion Center

Recruiting

A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer

Triple Negative Breast Cancer | HER2-positive Breast Cancer

China
Samsung Medical Center

Recruiting

Proton Beam Radiotherapy Followed by Tecentriq and Avastin for Primary Liver Cancer With Vp2-4 Portal Vein Invasion

Hepatocellular Carcinoma | Portal Vein Thrombosis

Korea, Republic of
Shanghai Proton and Heavy Ion Center

Recruiting

Carbon Ion Therapy for Peripheral Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Sanford Health
University of North Dakota

Recruiting

Evaluating the Safety and Efficacy of a Novel Accelerated Partial Breast Irradiation Regimen for patIents With Favorable Risk breaSt cancEr (APBI RISE)

Breast Cancer

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

An Imaging Agent (Fluorodopa F 18) With Positron Emission Tomography/Magnetic Resonance Imaging for Assessing Treatment Response in Patients With High-Grade Soft Tissue Sarcomas

Soft Tissue Sarcoma | Recurrent Soft Tissue Sarcoma | Resectable Soft Tissue Sarcoma

United States
P-Cure
Hadassah Medical Organization

Recruiting

Pivotal Study of Proton Radiotherapy Treatments Using Fixed Beam Chair-Based Delivery System (PPTS)

Brain Cancer | Thoracic Cancer | Head Cancer | Neck Cancer | Pancreatic Cancer Non-resectable

Israel

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