Search clinical trials for: Renal impairment

Total 21038 results

Takeda

Completed

A Study to Evaluate the Effect of Renal Impairment and Dialysis Treatment on the Pharmacokinetics (PK) of a Single Intravenous (IV) TAK-954

Renal Impairment | Healthy Volunteers

Czechia, Hungary
Genfit

Completed

Elafibranor Pharmacokinetic Parameters in Renal Impaired Patients

Kidney Diseases | Renal Insufficiency | Renal Impairment | Pharmacokinetics

France, Romania
GlaxoSmithKline

Completed

Pharmacokinetic Study of Gepotidacin in Subjects With Varying Degrees of Renal Impairment and in Subjects With Normal Renal Function

Infections, Bacterial

United States
Sihuan Pharmaceutical Holdings Group Ltd.

Completed

Pharmacokinetics of Benapenem in Subjects With Renal Impairment

Complicated Urinary Tract Infection; Cuti

China
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Study to Assess the Efficacy and Safety of Liraglutide in the Treatment of Type 2 Diabetes

Type 2 Diabetes

China
GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of Rivipansel on Subjects With Renal Impairment and in Healthy Subjects

Healthy | Renal Impairment

United States
CSL Behring

Completed

A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction

Acute Myocardial Infarction | Moderate Renal Impairment

United States, Germany, Hungary, Israel, Netherlands
Bayer

Completed

Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Clinical Pharmacology

Germany
MedImmune LLC

Completed

A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated

Renal Insufficiency | Type II Diabetes Mellitus

United Kingdom, Germany
Ipsen

Completed

Study to Compare a Dose of Telotristat Etiprate in Subjects With Renal Impairment With Matched Subjects With Normal Renal Function

Renal Impairment

Moldova, Republic of, Belgium, Germany, Romania
Assistance Publique Hopitaux De Marseille

Unknown

Blood-Brain Barrier Evaluation In Nephrology (BREIN) (BREIN)

End Stage Renal Disease and Cognitive Impairment

France
Bayer

Terminated

Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose of 10 mg Immediate Release Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight

Pharmacology, Clinical

Germany
Gilead Sciences

Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Renal Function and Severe Renal Impairment

HCV Infection

United States, New Zealand, Germany
Bayer

Completed

Renal Impairment Study

Clinical Trial, Phase I

Germany
Eisai Inc.
Purdue Pharma LP

Completed

Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Normal Renal Function or With Severe Renal Impairment

Renal Impairment

United States
ObsEva SA

Completed

Safety and Pharmacokinetics of Linzagolix in Female Subjects With Normal and Impaired Renal Function

Renal Impairment | Healthy Participants

United States
Gilead Sciences

Completed

Open-label Safety Study of E/C/F/TAF (Genvoya®) in HIV-1 Positive Patients With Mild to Moderate Renal Impairment

HIV Infections | HIV

United States, Netherlands, Spain, Mexico, France, Thailand, Australia, United Kingdom, Dominican Republic
Assiut University

Unknown

Serum Ceramides Level in Systemic Lupus Erythematosus (SLE) Patients as a Novel Marker for Renal Impairment

Systemic Lupus
Novo Nordisk A/S

Completed

Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment (PIONEER 5)

Diabetes Mellitus, Type 2 | Diabetes

United States, Israel, Poland, Russian Federation, United Kingdom, Denmark, Finland, Sweden
Chang Gung Memorial Hospital

Completed

Pulmonary Function, Voice and Swallowing Symptoms After Parathyroidectomy

Secondary Hyperparathyroidism Due to Renal Causes

Taiwan
Capricor Inc.

Completed

Safety Study of Cenderitide in Chronic Stable Heart Failure With Moderate Renal Impairment

Heart Failure | Renal Insufficiency

United States
Heart of England NHS Trust
National Institute for Health Research, United Kingdom

Unknown

Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage KD (E-CHECKED)

Cognitive Impairment

United Kingdom
Natalie Garratt

Completed

The Kidney and The Brain Study - Assessment of Cognitive Impairment in Advanced CKD

Chronic Kidney Diseases | Cognitive Impairment | Dementia | End Stage Renal Disease | Hemodialysis Complication | Renal Transplant | Peritoneal Dialysis Complication

United Kingdom
IlDong Pharmaceutical Co Ltd

Unknown

Pharmacokinetics of Besifovir in Adults With Normal and Impaired Renal Function

Renal Impairment
Progenity, Inc.

Unknown

Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women

Hypertension | Renal Insufficiency | Thrombocytopenia | Headache | Pre-Eclampsia | Pulmonary Edema | Visual Impairment | Impaired Liver Function | Proteinuria in Pregnancy

United States
Astellas Pharma Inc

Completed

ASP1517 Pharmacokinetics Study in Anemia Patients on Hemodialysis

Anemia | Hemodialysis | Renal Impairment

Japan
Daewoong Pharmaceutical Co. LTD.

Unknown

Type 2 Diabetes Patients With Renal Impairment

Type2 Diabetes
Mallinckrodt

Terminated

Pharmacokinetic Assessment of Sodium Sulfide in Subjects With Impaired Renal Function

Renal Impairment

United States
The Hospital for Sick Children

Completed

Canadian Hemophilia Prophylaxis Study (CHPS)

Severe Hemophilia A

Canada
Bayer

Completed

Pharmacokinetics and Safety of Vilaprisan in Renal Impairment

Endometriosis | Uterine Fibroids

United States
Bausch Health Americas, Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function

Renal Impairment

United States
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Evaluate ID-085 in People With Mild, Moderate, and Severe Kidney Disease

Renal Impairment

Germany
Acrotech Biopharma Inc.
Axis Clinicals Limited

Terminated

To Evaluate Safety and Pharmacokinetics of Belinostat in Patients Who Have Mild, Moderate and Severe Renal Impairment.

Relapsed/Refractory Solid Tumors/Hematological Malignancies

United States
Celgene

Completed

Pharmacokinetics and Safety Study of Azacitidine in Cancer Patients With and Without Impaired Renal Function (RENAL)

Multiple Myeloma | Non-Hodgkin's Lymphoma | AML | Solid Tumors | MDS | Hodgkin's Disease

United States
Daiichi Sankyo, Inc.

Completed

A Phase 2 Exploratory Study of CS-3150 in Japanese Hypertensive Patients With Moderate Renal Impairment

Hypertension

Japan
H. Lundbeck A/S

Terminated

Pharmacokinetics of Lu AF35700 in Subjects With Renal Impairment

Renal Failure

Germany
Eisai Inc.

Completed

Pharmacokinetic Properties of Lorcaserin in Subjects With Renal Impairment

Renal Impairment

United States
Pfizer

Completed

Glasdegib Renal Impairment Study

Renal Impairment

United States
Aurobindo Pharma Ltd
Axis Clinicals Limited

Completed

Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition

Visceral Leishmaniasis

Bangladesh, India
University of Maryland, Baltimore
National Institute of Mental Health (NIMH); University of California, Los Angeles and other collaborators

Completed

Adjunctive Treatment for Decreasing Symptoms of Schizophrenia

Schizophrenia | Schizoaffective Disorder

United States, Israel
Vasopharm GmbH
Winicker Norimed GmbH

Completed

Effects of the NO-synthase Inhibitor VAS203 on Renal Function in Healthy Volunteers

Renal Function Impairment in Healthy Volunteers

Germany
GlaxoSmithKline

Terminated

Assessment of the Pharmacokinetics of GSK1278863 and Metabolites in Normal Subjects and Subjects With Renal Impairment

Anaemia

United States
Merck Sharp & Dohme LLC

Completed

The Pharmacokinetics of Grazoprevir (MK-5172) and Elbasvir (MK-8742) in Participants With Renal Insufficiency (MK-5172-050)

Renal Impairment | Chronic Hepatitis C
Millennium Pharmaceuticals, Inc.

Completed

Pharmacokinetics Study of Oral Ixazomib (MLN9708) in Relapsed/Refractory Multiple Myeloma and Advanced Solid Tumors Participants With Normal Renal Function or Severe Renal Impairment

Multiple Myeloma | Advanced Solid Tumors

United States, Canada
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of ASP8232 in Subjects With Renal Impairment and in Type 2 Diabetes Mellitus Subjects With Chronic Kidney Disease

Healthy Subjects | Type 2 Diabetes Mellitus (T2DM) | Chronic Kidney Disease (CKD) | Pharmacokinetics of ASP8232 | Pharmacodynamics of ASP8232

Bulgaria, Moldova, Republic of, Romania
Akcea Therapeutics
Ionis Pharmaceuticals, Inc.

Completed

Study of ISIS 681257 in Patients With Renal Impairment Compared to Healthy Patients

Renal Impairment

United States, Canada
Merck KGaA, Darmstadt, Germany

Completed

Effect of Renal Impairment on Evobrutinib Pharmacokinetics (PK)

Renal Impairment

Germany
Sahlgrenska University Hospital, Sweden

Completed

Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB) (ECCSTUD)

Renal Impairment | Complication of Extracorporeal Circulation

Sweden
GE Healthcare

Withdrawn

Renal Effects of Three Iodinated Contrast Media (CM) in Patients at Risk Undergoing Coronary Angiography

Diabetes Mellitus | Renal Impairment | Coronary Artery Disease (CAD)

United States, Germany
Astellas Pharma Inc

Completed

A Study to Assess Efficacy and Safety of ASP1941 in Diabetic Patients With Renal Impairment

Type 2 Diabetes Mellitus

Japan

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