Search clinical trials for: Severe chronic kidney disease

Total 385110 results

Eli Lilly and Company

Recruiting

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Type 2 Diabetes

United States, Argentina, United Kingdom, Puerto Rico
Chinese PLA General Hospital

Recruiting

Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease (ESPTCSCKD)

COVID-19 | Renal Insufficiency, Chronic

China
University Hospital, Tours

Recruiting

Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease (THINK)

Uncontrolled Hypertension | Chronic Kidney Disease(CKD)

France
Centre Hospitalier Universitaire de Liege
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Régional... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
Guillermo Galeote; MD, PhD

Recruiting

Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure (CRATER)

Coronary Artery Disease | Chronic Renal Failure

Spain
Odense University Hospital
Novo Nordisk A/S; Department of Nephrology, Odense University Hospital; The A... and other collaborators

Recruiting

Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease (ENRICH)

Kidney Failure, Chronic | Kidney Injury | Risk Reduction | Contrast-induced Nephropathy

Denmark
University Hospital, Strasbourg, France

Recruiting

Patients With Acute Renal Failure During Severe COVID-19 (IR-EST-POSTCOV)

Renal Failure Chronic

France
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD

Vascular Diseases | Blood Pressure | Oxidative Stress | Kidney Disease

United States
The University of Texas at Arlington

Recruiting

L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients

Chronic Kidney Disease

United States
Assistance Publique Hopitaux De Marseille

Recruiting

TicagRelor Or Clopidogrel in Severe and Terminal Chronic Kidney Disease Patients Undergoing PERcutaneous Coronary Intervention for an Acute Coronary Syndrome. (TROUPER)

Acute Coronary Syndrome

France
University of California, Davis

Recruiting

Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD (ESTEEM-VIDA)

Moderate-severe Chronic Kidney Disease Not Treated With Dialysis | Diabetic Kidney Disease, HgbA1c Less Than 8.5

United States
University Medical Center Groningen
AstraZeneca; Dutch Kidney Foundation

Enrolling by invitation

The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD

Heart Failure | Death | Kidney Disease, Chronic | Kidney Failure | Renal Transplant Failure

Netherlands, Germany, Australia
Bayer

Active, not recruiting

An Observational Study, Called FINEGUST, to Learn More About How People With Chronic Kidney Disease and Type 2 Diabetes Are Treated and How the Introduction of New Treatment Options, Like Finerenone, Impacts Clinical Practice (FINEGUST)

Type 2 Diabetes Mellitus | Chronic Kidney Disease

Japan, Spain, Netherlands, Denmark, United States
Cara Therapeutics, Inc.

Terminated

A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus

Chronic Kidney Diseases | Pruritus

United States
Cara Therapeutics, Inc.

Terminated

CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus

Chronic Kidney Diseases | Pruritus

United States, Hungary, Australia, Germany, Korea, Republic of, Poland, Argentina, Brazil, Bulgaria, Italy, Mexico, Romania, Spain
Peking University People's Hospital

Terminated

SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency

Renal Insufficiency, Chronic | Heart Failure With Reduced Ejection Fraction

China
Vifor Fresenius Medical Care Renal Pharma
Tigermed Consulting Co., Ltd

Active, not recruiting

Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus

Uremic Pruritus

China
Galderma R&D

Completed

To Evaluate the Efficacy and Safety of Nemolizumab for 12 Weeks in Participants With Chronic Kidney Disease With Associated Moderate to Severe Pruritus (NemoCKDaP)

Chronic Kidney Disease Associated Moderate to Severe Pruritus

Spain, United States, Hungary, Poland
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States
University Medical Center Groningen

Completed

RECOVAC - Long Term Efficacy and Safety of COVID-19 (SARS-CoV-2) Vaccination in Kidney Disease Patients (LESS CoV-2)

Covid19 | Chronic Kidney Diseases | SARS-CoV Infection

Netherlands
AbbVie

Completed

Chronic Plaque Psoriasis (Ps) Registry

Chronic Plaque Psoriasis

United States, Austria, Canada, Czechia, Denmark, France, Germany, Greece, Ireland, Netherlands, Puerto Rico, Spain, Sweden, United Kingdom
KBP Biosciences

Active, not recruiting

Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe CKD (Clarion-CKD)

Chronic Kidney Diseases

China, Spain, Australia, Hungary, Malaysia, United States, Germany, Bulgaria, Serbia, Hong Kong, Georgia, Bosnia and Herzegovina, Croatia, Czechia, South Africa, Canada, Israel, Korea, Republic of, Latvia, Lithuania, Poland, Taiwan
UnicoCell Biomed CO. LTD
Protech Pharmaservices Corporation (PPC)

Completed

Adipose-derived Stem Cells (ADSCs) for Moderate to Severe Chronic Kidney Disease

Moderate to Severe Chronic Kidney Disease

Taiwan
Cara Therapeutics, Inc.

Completed

A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus

Chronic Kidney Diseases | Pruritus

United States
University of Michigan
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Controlling Hypertension Through Education and Coaching in Kidney Disease (CHECK-D)

Chronic Kidney Diseases | Chronic Disease | Chronic Kidney Disease Stage 5 | Chronic Kidney Disease, Stage 4 (Severe) | Chronic Kidney Disease, Stage 3 (Moderate)

United States
Takeda

Completed

A Phase 3, Randomized, Double-blind, Parallel-group, Comparative Study and a Phase 3, Multicenter, Open-label, Long-term Study of SYR-472 (25 mg) in Patients With Type 2 Diabetes Mellitus Complicated by Severe Renal Impairment or End-stage Renal Disease

Type 2 Diabetes Mellitus

Japan
University of Vermont
Medical University of South Carolina; University of Washington; University of...

Active, not recruiting

Communication During Hospitalization About Resuscitation Trial (CHART)

End Stage Renal Disease | Severe Life-limiting COPD | Severe Life-limiting Heart Failure | Severe Life-limiting Cirrhosis | Severe Life-limiting Malignancy | Severe Functional Impairment

United States
Takeda

Completed

Specified Drug-Use Survey of Trelagliptin Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Severe Renal Impairment or End-stage Renal Disease"

Type 2 Diabetes Mellitus

Japan
Chiesi Farmaceutici S.p.A.

Completed

PK of CHF6001 in Subjects With Mild, Moderate and Severe Renal Impairment vs. Healthy Volunteers

Chronic Obstructive Pulmonary Disease

Bulgaria
Rush University Medical Center
John H. Stroger Hospital

Completed

Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging (ASSUAGE-CKD)

Patients With Severe Chronic Kidney Disease Being Evaluated With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson

United States
3-C Institute for Social Development
University of North Carolina, Chapel Hill

Completed

Living With CKD: An E-Learning Platform for Adolescents With CKD About the Disease and Its Management (CKD Delp)

Chronic Kidney Diseases | Chronic Kidney Disease Stage 5 | Chronic Kidney Disease stage4 | Pediatric Kidney Disease | Chronic Kidney Disease stage3 | Chronic Kidney Disease Stage V | Chronic Kidney Disease, Stage IV (Severe) | Chronic Kidney Disease Stage 2 | Chronic Kidney Disease, Stage I

United States
University of Milano Bicocca

Completed

Comorbidities and Risk Score in COVID-19 Patients (Comorbidities)

Covid19

Italy
Amgen

Completed

Estimation Study to Assess the Effect of Severe Renal Impairment and End-stage Renal Disease Hemodialysis on the Pharmacokinetics of Evolocumab

Hyperlipidemia | Mixed Dyslipidemia

United States
Patient Care America
Baxter Healthcare Corporation

Active, not recruiting

Impact of IDPN on Nutrition Markers in Patients Receiving ICHD

End-stage Renal Disease | Malnutrition; Protein

United States
Albert Einstein College of Medicine

Withdrawn

Safety and Efficacy of Apixaban in Severe Renal Impairment

Anticoagulant-induced Bleeding | Renal Disease, End Stage

United States
Karolinska Institutet

Active, not recruiting

Cardiovascular Risk Factors and Severe COVID-19. A Nationwide Registry-based Case-Control Study

COVID-19

Sweden
Cara Therapeutics, Inc.

Completed

A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)

Uremic Pruritus

United States
Cara Therapeutics, Inc.

Completed

CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-2)

Uremic Pruritus

United States, Canada, Czechia, Australia, Germany, Hungary, Korea, Republic of, New Zealand, Poland, Taiwan, United Kingdom
Acacia Pharma Ltd

Completed

PK Study of IV and Oral Amisulpride in Subjects With Severe Renal Impairment

Renal Disease, End Stage

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Development of a Decision-making Aid for Referring Severe Kidney Injury Patients for Nephrology Consultations (IRA Cible)

Chronic Kidney Diseases | Acute Kidney Injury

France
Cara Therapeutics, Inc.

Completed

CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus

Uremic Pruritus

United States, Czechia, Hungary, Poland
Cara Therapeutics, Inc.

Completed

Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus

Uremic Pruritus

United States, Puerto Rico
Imperial College London
National Institute for Health Research, United Kingdom; Imperial College Healthcare...

Withdrawn

MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure (CM3)

Myocardial Fibrosis | Heart Failure | End Stage Renal Failure on Dialysis | Chronic Kidney Disease Stage V | Chronic Kidney Disease, Stage IV (Severe)

United Kingdom
DiaMedica Therapeutics Inc

Completed

Study to Assess PK, Safety and Tolerability in Patients With DM and CKD

Diabetes | Chronic Kidney Disease | Chronic Kidney Disease, Stage 4 (Severe) | Chronic Kidney Disease, Stage 3 (Moderate)

United States
Lakehead University

Completed

The Effect of Previous Pneumococcal Immunization on the Immune Response of Patients With Severe CKD to Prevnar 13

Chronic Kidney Diseases

Canada
AbbVie (prior sponsor, Abbott)

Completed

A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients

Moderate to Severe Secondary Hyperparathyroidism | Stage 5 Chronic Kidney Diseases
Lexicon Pharmaceuticals
Sanofi

Completed

A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control (SOTA-CKD4)

Type 2 Diabetes Mellitus | Chronic Kidney Disease Stage 4

United States, Argentina, Brazil, Colombia, Germany, Hungary, Israel, Italy, Mexico, Poland, Romania, Russian Federation, South Africa, Spain, Ukraine
Novartis Pharmaceuticals

Completed

PK of Serelaxin in Severe Renal Impairment and ESRD (CRLX030A2102)

End-Stage Renal Disease | Renal Failure, Chronic

Germany
University of Florida
American Society of Nephrology

Withdrawn

Severe Sepsis in Children - IMPRESS-C (IMPRESS-C)

Hypertension | Chronic Kidney Disease | Acute Kidney Injury

United States
Centre Hospitalier Universitaire, Amiens

Withdrawn

Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study (METsuiviIRC)

Renal Insufficiency, Chronic

France

Search clinical trials for: Severe chronic kidney disease

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