Search clinical trials for: Severe heart failure

Total 86298 results

InnovHeart
MAXIS, LLC

Recruiting

Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation (CASSINI-EU)

Heart Failure

Lithuania, Poland
Help Therapeutics
TEDA International Cardiovascular Hospital

Recruiting

Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure

Heart Failure

China
Skane University Hospital
Lund University; The Swedish Research Council; ResMed; Vastra Gotaland Region; Region... and other collaborators

Not yet recruiting

Effect of HIgh-flow Therapy in Long-term Oxygen Therapy (HILOT)

Interstitial Lung Disease | Chronic Respiratory Failure With Hypoxia | Chronic Obstructive Pulmonary Disease Severe
Qilu Hospital of Shandong University

Recruiting

Effects of Levosimendan on Cardiac Function After TAVR in Patients With Heart Failure

Heart Failure | Aortic Stenosis, Severe

China
P+F Products + Features USA Inc.
P+F Products + Features GmbH; Meditrial USA Inc.

Not yet recruiting

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV) (TRICAV)

Tricuspid Regurgitation | Tricuspid Valve Disease

United States
Stanford University
Boston Children's Hospital; Duke University

Not yet recruiting

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

Heart Failure | Cardiomyopathies | Congenital Heart Disease | Cardiogenic Shock

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Severe Aplastic Anemia | Single Lineage Cytopenias, T-LGL | Hypoplastic MDS

United States
Leonardo Calò, MD

Not yet recruiting

Evaluation of a Proactive Clinical Management and Early Diagnosis of Arrhythmias in Patients With Heart Failure and Non Severely Reduced Left Ventricular Function Through a Telemonitoring System (VASCO)

Heart Failure | Arrhythmias, Cardiac
Yi Han
Qianfoshan Hospital

Recruiting

Study on the Correlation Between NAT2(N-acetyltransferase2) Gene Polymorphism and CrCl(Creatine Clreance) and the Efficacy and Safety of Levosimendan in Patients With Severe Heart Failure

Heart Failure | Efficacy | Safety | Levosimendan

China
University Hospital Freiburg

Recruiting

The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry

Medical Condition Requiring Extracorporeal Organ Support

Germany
Centre Hospitalier Universitaire de Liege
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Régional... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Recruiting

A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202) (TransIT)

Severe Aplastic Anemia

United States
Kronikgune
Odense University Hospital; Assuta Ashdod Hospital; Maccabi Healthcare Services... and other collaborators

Recruiting

Assessment of the Effectiveness, Socio-economic Impact and Implementation of a Digital Solution for Severe Patients (ADLIFE)

Heart Failure NYHA Class III | Heart Failure NYHA Class IV | Chronic Obstructive Pulmonary Disease Severe

Denmark, Germany, Israel, Spain, Sweden, United Kingdom
University Hospital Southampton NHS Foundation...
University of Southampton; British Heart Foundation

Recruiting

RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure (BRITISH)

Heart Failure

United Kingdom
Xiamen Cardiovascular Hospital, Xiamen University

Recruiting

Dawneo Neoblazar® Transcatheter Tricuspid Valve Edge-to Edge Repair System Pivotal Clinical Trial in Patients With Severe Tricuspid Regurgitation

Tricuspid Regurgitation

China
Centre Hospitalier Universitaire de Nīmes
CHU Arnaud de Villeneuve MONTPELLIER

Recruiting

Tolerability and Safety of CARDIOMEMS™ Intracardiac Continuous Cardiac Hemodynamic Monitoring Device in Patients With Cardio Renal Syndrome With Severe Renal Impairment (CARDIOMEMS)

Heart Failure | Renal Insufficiency

France
Guillermo Galeote; MD, PhD

Recruiting

Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure (CRATER)

Coronary Artery Disease | Chronic Renal Failure

Spain
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

Severe Aplastic Anemia | Telomere Biology Disorders | Inherited Bone Marrow Failure Syndromes

United States
University Hospital, Strasbourg, France

Recruiting

Health-related Quality of Life in Adults After Veno-arterial Extra-Corporeal Membrane Oxygenation Which is a Salvage Therapy Used in Patients With Severe Respiratory or Cardiac Failure Who Have Not Responded to Maximal Conventional Medical Therapy

Health Related Quality of Life | Veno-arterial Extra-Corporeal Membrane Oxygenation

France
LMU Klinikum
University of Leipzig; Heart Center Leipzig - University Hospital; Deutsches... and other collaborators

Recruiting

TRICuspid Intervention in Heart Failure Trial (TRICI-HF)

Heart Failure Attributable to Severe Tricuspid Regurgitation

Germany
China National Center for Cardiovascular Diseases
China International Medical Foundation

Recruiting

The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement

Heart Failure | Aortic Valve Stenosis | Transcatheter Aortic Valve Replacement | Cardiac Event | Safety Issues | Effect of Drug | Inotropic Agents

China
Medical University of Warsaw

Recruiting

TMAO in Patients With Severe Aortic Stenosis (TASTE)

Heart Failure | Aortic Stenosis

Poland
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Severe Aplastic Anemia

United States
Kaohsiung Veterans General Hospital.
E-DA Hospital

Recruiting

The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation

Mitral Regurgitation | Systolic Heart Failure Stage D (Disorder)

Taiwan
University of Leicester
University Hospitals, Leicester; University of Auckland, New Zealand; The University...

Recruiting

The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study (EASY-AS)

Aortic Stenosis

Australia, United Kingdom, New Zealand, Serbia
University College, London
Medical Research Council

Recruiting

Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation (ToTem)

Lymphoma | Myelodysplastic Syndromes | Leukemia | Myeloma | Graft Vs Host Disease | Severe Aplastic Anemia | Primary Immune Deficiency

United Kingdom
Kantonsspital Olten

Recruiting

Electrical Muscle Stimulation in Congestive Heart Failure

Congestive Heart Failure | Activities of Daily Living | Exercise Capacity | Elderly Person | Electric Muscle Stimulation | Severe Decondition

Switzerland
Sherief Abd-Elsalam

Recruiting

Utility of Some Novel Biomarkers of Patients With Chronic Heart Failure

Heart Failure

Egypt
Barts & The London NHS Trust
Queen Mary University of London

Recruiting

Recovery From ICUAW Following Severe Respiratory and Cardiac Failure (CLEVERER)

Respiratory Failure | Acute Respiratory Distress Syndrome | Critical Illness Myopathy | Intensive Care Unit Syndrome | Cardiac Failure | Intensive Care (ICU) Myopathy | Intensive Care Neuropathy

United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

Paroxysmal Nocturnal Hemoglobinuria (PNH) | Severe Aplastic Anemia (SAA) | Hypo-Plastic Myelodysplastic Syndrome (MDS)

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Myelodysplastic Syndrome (MDS) | Severe Aplastic Anemia | Hypo-Plastic MDS

United States
LoneStar Heart, Inc.

Not yet recruiting

A Pivotal Trial to Establish the Efficacy and Safety of Algisyl in Patients With Moderate to Severe Heart Failure (AUGMENT-HFII)

Heart Failure | Dilated Cardiomyopathy | Heart Failure With Reduced Ejection Fraction
Children's Oncology Group
National Cancer Institute (NCI); EsPhALL Network/ BFM Study Group

Recruiting

Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | B Acute Lymphoblastic Leukemia | T Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia

United States, Canada, Puerto Rico, Australia, Finland, New Zealand, Saudi Arabia, Germany, Austria, Belgium, Chile, Czechia, France, Italy, Netherlands, Sweden, Switzerland, Hong Kong, Israel
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Severe Aplastic Anemia

United States
St. Jude Children's Research Hospital
Baylor College of Medicine; Children's Hospital of Philadelphia; Dana-Farber... and other collaborators

Recruiting

Investigation of the Genetics of Hematologic Diseases

Myelodysplastic Syndromes | Sickle Cell Disease | Fanconi Anemia | Severe Congenital Neutropenia | Bone Marrow Failure Syndromes | Blood Coagulation Disorder | Erythrocyte Disorder | Leukocyte Disorder | Hemostasis | Dyskeratosis Congenita | Diamond-Blackfan Anemia | Congenital Thrombocytopenia | Myeloproliferative...

United States
Masonic Cancer Center, University of Minnesota

Recruiting

Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

Sickle Cell Disease | Severe Congenital Neutropenia | Paroxysmal Nocturnal Hemoglobinuria | Glanzmann Thrombasthenia | Shwachman-Diamond Syndrome | Diamond Blackfan Anemia | Transfusion Dependent Alpha- or Beta- Thalassemia | Non-Malignant Hematologic Disorders

United States
National Heart, Lung, and Blood Institute (NHLBI)
Novartis

Recruiting

Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

Severe Aplastic Anemia

United States
Mahidol University

Recruiting

Severe Sepsis/Septic Shock on Admission to the General Surgical ICU

Septic Shock | Multiple Organ Failure | Fatal Outcome

Thailand
Center for International Blood and Marrow Transplant...
National Marrow Donor Program

Recruiting

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Autoimmune Diseases | Hodgkin Lymphoma | Hematologic Malignancies | Acute Lymphoblastic Leukemia (ALL) | Non-hodgkin Lymphoma | Severe Aplastic Anemia | Inherited Disorders of Metabolism | Inherited Abnormalities of Platelets | Histiocytic Disorders | Acute Myelogenous Leukemia (AML or ANLL) | Other Acute... and other conditions

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

MDS (Myelodysplastic Syndrome) | Severe Aplastic Anemia

United States
Biopeutics Co., Ltd

Not yet recruiting

ALP-1 Continuous Intravenous Infusion to Maintain Clinical Stability in Advanced Heart Failure

Heart Failure

Austria
Roswell Park Cancer Institute

Active, not recruiting

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

Hodgkin Lymphoma | Waldenstrom Macroglobulinemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Myeloproliferative Neoplasm | Minimal Residual Disease | Graft Versus Host Disease | Severe Aplastic Anemia | Acute Myeloid Leukemia in Remission | Adult Acute Lymphoblastic Leukemia... and other conditions

United States
Peking University People's Hospital

Terminated

SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency

Renal Insufficiency, Chronic | Heart Failure With Reduced Ejection Fraction

China
University Medical Center Groningen
AstraZeneca; Dutch Kidney Foundation

Enrolling by invitation

The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD

Heart Failure | Death | Kidney Disease, Chronic | Kidney Failure | Renal Transplant Failure

Netherlands, Germany, Australia
Roswell Park Cancer Institute

Active, not recruiting

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

Acute Myeloid Leukemia | Polycythemia Vera | Myelofibrosis | Chronic Myelomonocytic Leukemia | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Sickle Cell Disease | Myelodysplastic Syndrome | Plasma Cell Myeloma | Chronic Granulomatous... and other conditions

United States
European Society for Blood and Marrow Transplantation
CHUGAI sanofi-aventis

Terminated

Randomized Study In Severe Aplastic Anemia Patients Receiving Atg, Cyclosporin A, With Or Without G-CSF (SAA-G-CSF) (SAA-G-CSF)

Aplastic Anaemia

France, Netherlands, Germany, United Kingdom, Switzerland, Italy, Sweden, Greece, Czechia
St. Antonius Hospital
ZonMw: The Netherlands Organisation for Health Research and Development

Enrolling by invitation

Evaluating Edge-to-edge Transcatheter Tricuspid Valve Repair in Patients With Severe Symptomatic Tricuspid Regurgitation (TRACE-NL)

Cardiac Catheterization | Tricuspid Valve Regurgitation, Nonrheumatic | Heart Failure, Right Sided | Valve Regurgitation, Tricuspid

Netherlands
Centre de Recherche de l'Institut Universitaire...

Active, not recruiting

Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial

Aortic Valve Stenosis | Prosthesis Failure | Regurgitation, Aortic

Canada
University of Pittsburgh
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Active, not recruiting

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes (TRIABETES)

Obesity | Type 2 Diabetes Mellitus

United States
University of Florida
Live Like Bella Pediatric Cancer Research

Completed

Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Sickle Cell Disease | Hurler Syndrome | Chronic Granulomatous Disease | Thalassemia | Wiskott-Aldrich Syndrome | Adrenoleukodystrophy | X-linked Lymphoproliferative Disease | Diamond Blackfan Anemia | Bone Marrow Failure Syndrome | Hemophagocytic... and other conditions

United States

Search clinical trials for: Severe heart failure

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