Search clinical trials for: Signal of Efficacy

Total 431629 results

Nested Therapeutics, Inc

Recruiting

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628)

Glioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene Mutation

United States, Australia
Chulalongkorn University
King Chulalongkorn Memorial Hospital

Recruiting

Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG (CMD03DIPG)

Diffuse Intrinsic Pontine Glioma | DIPG Brain Tumor

Thailand
AVB Biotechnology

Recruiting

Investigation of Efficacy and Safety of Electrical Signal Therapy Provided by Dr Biolyse® Device in COVID-19 Disease (DoBiC-19)

Virus Diseases | COVID-19 | COVID-19 Pneumonia

Turkey
Daiichi Sankyo

Recruiting

A Study to Explore Safety, Pharmacokinetics, and Early Clinical Signal of Efficacy of DS-2325a in Patients With Netherton Syndrome

Netherton Syndrome

France
Azienda Sanitaria-Universitaria Integrata di Udine
University of Udine

Recruiting

Efficacy and Safety of Anakinra in Acute Respiratory Distress Syndrome (ESKA)

Acute Respiratory Distress Syndrome

Italy
Cairo University

Not yet recruiting

Enamel Abrasion and Stain Removal Efficacy of Two Whitening Toothpastes: An In-vitro and In-vivo Trial

Tooth Abrasion
Q32 Bio Inc.

Recruiting

Evaluating Safety and Efficacy of ADX-914 in Patients With Moderate to Severe Atopic Dermatitis (SIGNAL-AD)

Atopic Dermatitis

United States
University Hospital, Bordeaux

Recruiting

Evaluation of the Efficacy of the Individually Adjusted Therapy Scale (ATI) on the Addiction Severity (AjusT)

Substance-Related Disorders | Addictive Behavior

France
Novartis Pharmaceuticals

Active, not recruiting

Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA

Osteoarthritis (OA)

Netherlands
NuCana plc

Completed

A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment

Colorectal Neoplasms | Colorectal Cancer | Colorectal Tumors | Colorectal Carcinoma | Neoplasms, Colorectal

United States, France, United Kingdom
Biosplice Therapeutics, Inc.

Completed

A Long-Term Safety and Efficacy Study of Lorecivivint in Subjects With Osteoarthritis of the Knee

Osteoarthritis, Knee

United States
West Cancer Center
Puma Biotechnology, Inc.; Celcuity Inc

Active, not recruiting

Evaluating the Efficacy of Neratinib on Live Cell HER2 Signaling Transduction Analysis Positive Triple Negative Breast (FACT-2)

Triple Negative Breast Cancer | HER2-positive Breast Cancer | Early-stage Breast Cancer

United States
Universidad de Almeria

Completed

Efficacy of Therapy Using Monopolar Dielectric Radiofrequency Signals on the Symptoms of Myofascial Trigger Points in Patients With Chronic Nonspecific Low Back Pain.

Chronic Pain

Spain
Novartis Pharmaceuticals

Terminated

Study Efficacy and Safety of INC280 in Patients With Advanced Hepatocellular Carcinoma.

Advanced Hepatocellular Carcinoma With c-MET Dysregulation

China, Hong Kong, Thailand, Singapore
Morphotek
Eisai Europe Ltd. (United Kingdom)

Terminated

Efficacy and Safety of Farletuzumab (MORAb-003) in Combination With Carboplatin and Taxane in Participants With Platinum-sensitive Ovarian Cancer in First Relapse

Ovarian Cancer

United States, Hong Kong, Netherlands, Spain, Korea, Republic of, Belgium, Taiwan, Israel, Japan, France, United Kingdom, Singapore, Italy, Argentina, India, Germany, Hungary, Australia, Portugal, Russian Federation, Canada, Poland, Greec... and more
AbbVie
Roche-Genentech

Completed

A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy

Chronic Lymphocytic Leukemia

United States
Shanghai Mental Health Center
Shanghai Jiao Tong University School of Medicine; Shanghai Municipal Science...

Completed

Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients

Mental Disorders | Obsessive-Compulsive Disorder | Anxiety Disorders

China
Vaccinex Inc.
Huntington Study Group

Completed

A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi (SIGNAL-HD)

Huntington's Disease

United States, Canada
Biosplice Therapeutics, Inc.

Completed

A Study Utilizing Patient-Reported Outcomes to Evaluate the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis (STRIDES-1)

Knee Osteoarthritis

United States
Biosplice Therapeutics, Inc.

Terminated

3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Subjects With Osteoarthritis of the Knee

Osteoarthritis of the Knee

United States
Biosplice Therapeutics, Inc.

Terminated

A Study Utilizing Imaging Techniques and Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis

Knee Osteoarthritis

United States
Biosplice Therapeutics, Inc.

Completed

A Study Utilizing Patient-Reported and Radiographic Outcomes and Evaluating the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis (STRIDES-X-ray)

Knee Osteoarthritis

United States
Biosplice Therapeutics, Inc.

Completed

A Study Evaluating the Safety, Tolerability and Efficacy of Two Injections of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis

Knee Osteoarthritis

United States
Helsinn Healthcare SA
Parexel

Completed

An Efficacy and Safety Study of Oral and Intravenous Palonosetron for the Prevention of Nausea and Vomiting

Chemotherapy-Induced Nausea and Vomiting

Italy, United States, Argentina, Bulgaria, Croatia, Germany, Hungary, India, Poland, Romania, Russian Federation, Ukraine
OmicsWay Corp.
Oncobox Ltd., Russia; Vitamed LLC, Russia; Republican Oncological Dispensary...

Active, not recruiting

Molecular Pathway Activation Markers Predicting Efficacy of Trastuzumab Therapy for HER2-positive Breast Cancer

HER2-positive Breast Cancer

United States, Russian Federation
OmicsWay Corp.
Oncobox Ltd; Vitamed LLC; N.N. Blokhin National Medical Research Center of Oncology and other collaborators

Active, not recruiting

Identification of Molecular Biomarkers for Cancer Target Therapy Efficacy

Cancer

Russian Federation, United States
Tourcoing Hospital
Eric SENNEVILLE M.D. Ph.D.

Completed

Tedizolid Prolonged Treatment for Prosthetic Joint Infections (TEDIZOAM)

Prosthetic Joint Infection

France
Pfizer

Terminated

A Study To Investigate Tanezumab In Patients With Interstitial Cystitis/ Painful Bladder Syndrome

Cystitis, Interstitial

Canada, United States, Spain, Belgium, Slovakia, Korea, Republic of, Finland, Hong Kong, Japan, Poland, Romania, Russian Federation, Sweden, Taiwan
Biosplice Therapeutics, Inc.

Completed

A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis

Knee Osteoarthritis

United States
Genervon Biopharmaceuticals, LLC
Massachusetts General Hospital; Columbia University

Completed

GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) (GALS)

Amyotrophic Lateral Sclerosis

United States
Spectrum Pharmaceuticals, Inc

Completed

Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment

Non-small Cell Lung Cancer

United States, Czechia, India, Brazil, Argentina, Hungary
Novartis Pharmaceuticals

Completed

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Metastatic Colorectal Cancer | Gastric Cancer | Advanced Solid Tumors | Metastatic Breast Cancer | Gastroesophageal Junction Cancer | Recurrent Glioblastoma Multiforme | Advanced Pancreatic Adenocarcinoma | Safety | Triple Negative Metastatic Breast Cancer | Dose Escalation | Preliminary Efficacy | Hormone Receptor...

Canada, United Kingdom, Spain, Germany, Italy, Belgium, Australia, United States
Changhai Hospital
Qilu Hospital of Shandong University; Changhai Hospital, Naval Medical University... and other collaborators

Completed

Efficacy and Safety of Vibrating Capsule in Patients With Functional Constipation

Functional Constipation | Gastrointestinal Disease | Capsule Endoscopy

China
Azienda Ospedaliera Universitaria Policlinico Paolo...

Unknown

Efficacy and Safety of Acetyl L-Carnitine in COVID-19 Patients With Mild-to-Moderate Disease

Covid19
Arbor Life Labs

Completed

A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Male Subjects With Hair Loss (REBOOT-MEN)

Androgenetic Alopecia | Androgenic Alopecia | Hair Loss/Baldness | Hair Thinning | Telogen Effluvium | Thinning Hair

United States
Arbor Life Labs

Completed

A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Female Subjects With Hair Loss (REBOOT-WOMEN)

Androgenetic Alopecia | Androgenic Alopecia | Hair Loss/Baldness | Hair Thinning | Telogen Effluvium | Thinning Hair

United States
Novartis Pharmaceuticals

Completed

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Bone Marrow Diseases | Hematologic Diseases | Blood Coagulation Disorders | Hemorrhagic Disorders | Primary Myelofibrosis | Myeloproliferative Disorders | Polycythemia Vera | Thrombocytosis | Essential Thrombocythemia | Blood Platelet Disorders

United Kingdom, Belgium, Canada, France, Australia, Netherlands, Spain, Denmark, Ireland, Italy, Germany
BrainsGate

Completed

THE IMPACT- 24M TRIAL (IMPlant Augmenting Cerebral Blood Flow in Mild Strokes Trial 24 Hours From Stroke Onset) (ImpACT-24M)

Ischemic Stroke

Georgia
Gilead Sciences

Completed

Safety, Tolerability, and Efficacy of GS-4997 Alone or in Combination With Simtuzumab (SIM) in Adults With Nonalcoholic Steatohepatitis (NASH) and Fibrosis Stages F2-F3

Non-Alcoholic Steatohepatitis (NASH)

United States, Canada
Gilead Sciences

Terminated

Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in Colorectal Adenocarcinoma

Colorectal Cancer

Spain, United States, Germany, Italy, Russian Federation, Poland, France
Rigel Pharmaceuticals

Completed

A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) (FIT)

Immune Thrombocytopenic Purpura

United States, Australia, United Kingdom, Canada, Italy, Denmark, Hungary, Netherlands
Hoffmann-La Roche

Completed

Study To Evaluate the Efficacy and Safety Of Bevacizumab, and Associated Biomarkers, In Combination With Paclitaxel Compared With Paclitaxel Plus Placebo as First-line Treatment Of Patients With Her2-Negative Metastatic Breast Cancer

Metastatic Breast Cancer

United States, Korea, Republic of, United Kingdom, Italy, Russian Federation, Argentina, Belgium, Brazil, Panama, Germany, Japan, Ukraine, Chile, South Africa, Bulgaria, Romania
Gilead Sciences

Terminated

Efficacy and Safety of Idelalisib in Combination With Bendamustine and Rituximab in Adults With Previously Untreated Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia

United States, Canada, Spain, Australia, Italy, United Kingdom, Belgium, Croatia, France, Hungary, Poland, Romania, Czechia
Gilead Sciences

Terminated

Efficacy and Safety of Idelalisib (GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas (Bridalveil)

Indolent Non-Hodgkin's Lymphomas

United States, Korea, Republic of, Canada, Spain, Taiwan, France, Australia, United Kingdom, Poland, Italy, Israel, Czechia, Germany, Russian Federation, Sweden
Gilead Sciences

Terminated

Efficacy and Safety of Idelalisib (GS-1101) in Combination With Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas (Yosemite)

Indolent Non-Hodgkin's Lymphomas

United States, Korea, Republic of, Hungary, United Kingdom, Australia, Singapore, Japan, Taiwan, Israel, Italy, Spain, Czechia, Russian Federation, France, Poland, Romania, Germany, Portugal, Sweden
Fondazione Don Carlo Gnocchi Onlus
Istituto Di Ricerche Farmacologiche Mario Negri

Completed

Efficacy Study of FES Controlled by Electromyographic Signal for the Treatment of Upper Limb in Post-stroke Patients (RiSES)

Stroke
Loyola University

Terminated

Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis (CRO-OSTEO)

Osteomyelitis

United States
Threshold Pharmaceuticals
PRA Health Sciences

Completed

Study of the Safety and Efficacy of TH-302 in Combination With Gemcitabine Compared With Gemcitabine Alone in Previously Untreated Patients With Pancreatic Adenocarcinoma

Pancreatic Adenocarcinoma

United States
Chulalongkorn University

Completed

Efficacy of Inhalation of Essential Oil on the Reduction of Inhalants Craving

Inhalants Craving

Thailand
Bioniche Life Sciences Inc.

Terminated

Efficacy and Safety Evaluation of EN3348 (Mycobacterial Cell Wall-DNA Complex [MCC]) as Compared With Mitomycin C in the Intravesical Treatment of Subjects With BCG Recurrent/Refractory Non-muscle Invasive Bladder Cancer (EMBARC-RF)

Carcinoma in Situ | Neoplasm Recurrence, Local | Bladder Neoplasm | Mycobacterium | Transitional Cell, Carcinoma

United States, Canada, Poland, Germany, Netherlands, United Kingdom

Search clinical trials for: Signal of Efficacy

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