Search clinical trials for: Topoisomerase-1 Inhibitor

Total 103222 results

New Mexico Cancer Care Alliance

Completed

Clinical Benefit of Topoisomerase Downregulation

Ovarian Cancer

United States
National Cancer Institute (NCI)

Completed

Phase I Study of Intrathecal Topotecan

Lymphoma | Leukemia | Meningeal Neoplasms

United States
Novartis Pharmaceuticals

Completed

Dose-escalation Study of Gimatecan Administered in Two Different Schedules in Adult Patients With Advanced Solid Tumors

Solid Tumors

Spain, Canada, France, Denmark, Netherlands, Germany, Norway
Jules Bordet Institute
University Hospital of Crete; Gustave Roussy, Cancer Campus, Grand Paris; Centre... and other collaborators

Terminated

Topoisomerase II Alpha Gene Amplification and Protein Overexpression Predicting Efficacy of Epirubicin (TOP)

Breast Cancer

Belgium
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI); GlaxoSmithKline

Completed

Study of Melphalan and Topotecan (MT) Followed by Autologous Stem Cell Rescue in Patients With Multiple Myeloma.

Multiple Myeloma

United States
sigma-tau i.f.r. S.p.A.
Southern Europe New Drug Organization

Completed

ST1968 Intravenous (Weekly) in Solid Tumors

Solid Tumors
University of Alabama at Birmingham
Amgen; Sanofi-Synthelabo

Completed

Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin - Etoposide /Carboplatin in Extensive Small Cell Lung Cancer (SCLC)

Non-Small Cell Lung Cancer

United States
Novartis Pharmaceuticals

Completed

An Extension Trial to a Phase I Dose Escalation Study of Gimatecan Administered Orally 5 Consecutive Days to Japanese Patients With Advanced Solid Tumor

Advanced Solid Tumors

Japan
Novartis Pharmaceuticals

Completed

A Dose Escalation of Gimatecan Administered Orally to Japanese Patients With Advanced Solid Tumor.

Advanced Solid Tumors

Japan
Novartis

Completed

A Phase I Dose Escalation Study of LBQ707 (Gimatecan) Administered Orally Twice Per Week to Japanese Patients With Advanced Solid Tumors

Advanced Solid Tumors

Japan
Tianjin Medical University Cancer Institute and...

Recruiting

Study of Neoadjuvant Endocrine Therapy in HR Positive and HER2 Negative Premenopausal Breast Cancer Patients

Breast Cancer

China
National Cancer Center, Korea
Jeil Pharmaceutical Co., Ltd.

Unknown

A Study of TS-1 Plus Irinotecan and Cisplatin (IP) for Patients With Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC)

Advanced Non-Small Cell Lung Cancer

Korea, Republic of
National Cancer Institute (NCI)

Completed

Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas

Lymphoma | Solid Tumors

United States
Danish Breast Cancer Cooperative Group
Sanofi; Fonden Til Fremme af Klinisk- Eksperimentel Cancerforskning; Dako

Completed

Epirubicin or Not in Patients With TOP2A (Topoisomerase (DNA) II Alpha (170kD)) Normal Early Breast Cancer (READ)

Breast Neoplasms

Denmark
Ankara Yildirim Beyazıt University

Recruiting

Investigation of the Effects of Robot Assisted Gait Training With Virtual Reality on Cognitive Functions in Stroke Patients

Stroke | Exoskeleton Device | Locomotion

Turkey
Hokkaido Gastrointestinal Cancer Study Group
Hokkaido University Hospital

Unknown

Phase II Study of Oral S-1 Plus Irinotecan (IRIS) in Patients With Advanced Colorectal Cancer

Colorectal Cancer

Japan
National Cancer Institute (NCI)

Completed

Indenoisoquinoline LMP400 for Advanced Solid Tumors and Lymphomas

Lymphoma | Neoplasm

United States
Japan Clinical Cancer Research Organization
Taiho Pharmaceutical Co., Ltd.

Completed

Second Line Chemotherapy for S-1 Refractory Advanced Gastric Cancer

Gastric Cancer

Japan
University of Liege

Unknown

Light Therapy in Disorders of Consciousness: Behavioral, Neuroimaging and (Neuro)Physiological Assessments.

Disorder of Consciousness
Hallym University Medical Center
Pfizer; HK inno.N Corporation; Handok Inc.; Jeil Pharmaceutical Co., Ltd.

Completed

S-1, Oxaliplatin, and Irinotecan for Advanced Gastrointestinal Cancer

Gastrointestinal Neoplasms

Korea, Republic of
Taiho Pharmaceutical Co., Ltd.

Completed

A Randomized Controlled Study of Postoperative Adjuvant Therapy of Uracil-tegafur (UFT) Compared With Cyclophosphamide/Methotrexate/5-fluorouracil (CMF) in Breast Cancer (NSAS-BC)

Breast Cancer

Japan
Hasan Kalyoncu University

Recruiting

Study of the Effect of Compassion-Based Education Program Applied to Mothers of Children Diagnosed With Cerebral Palsy

Cerebral Palsy

Turkey
CONRAD
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Coital Pharmacokinetics/Pharmacodynamics (PK/PD) of Tenofovir Gel

Pharmacokinetics of 1% Tenofovir Gel Following Coitus | Pharmacodynamics of 1% Tenofovir Gel Following Coitus

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas

Neoplasms | Lymphoma

United States
Merck Sharp & Dohme LLC

Recruiting

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

Non-small Cell Lung Cancer | Solid Tumors | Programmed Cell Death-1 (PD1, PD-1) | Programmed Cell Death 1 Ligand 1(PDL1, PD-L1) | Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2)

Japan
Shimousa Hematology Study Group
Epidemiological and Clinical Research Information Network

Unknown

Discontinuation of Dasatinib in Patients With Chronic Myeloid Leukemia-CP Who Have Maintained Complete Molecular Remission for Two Years; Dasatinib Stop Trial

Chronic Myeloid Leukemia

Japan
Hokkaido Gastrointestinal Cancer Study Group

Suspended

Phase II Study of Oral S-1 Plus Irinotecan in Patients With Advanced Gastric Cancer

Gastric Cancer

Japan
Suleyman Demirel University

Recruiting

Developing a New Scale for Evaluating Shoulder Problems

Shoulder Injuries | Shoulder Pain | Shoulder Lesions

Turkey
Korean Cancer Study Group

Unknown

S-1 and Irinotecan Combination Chemotherapy for Advanced Gastric Cancer

Gastric Cancer

Korea, Republic of
Hokkaido Gastrointestinal Cancer Study Group

Completed

Phase I/II Study of Oral S-1 Plus Irinotecan in Patients With Advanced Gastric Cancer

Gastric Cancer
Ningbo No. 1 Hospital

Recruiting

Association Between Cardiovascular Diseases and Mental Illness

Cardiovascular Diseases | Mental Disorder

China
Genzyme, a Sanofi Company

Completed

Dose Escalation Study to Assess the Safety and Tolerability of Genz-644282 in Patients With Solid Tumors

Solid Tumors

United States
Cancer Institute and Hospital, Chinese Academy...

Unknown

Irinotecan Plus S1 Versus S1 in Patients With Previously Treated Advanced Esophageal Cancer: ESWN 01 Trial

Esophageal Neoplasms

China
Taiho Pharmaceutical Co., Ltd.

Completed

The Comparative Trial of UFT + TAM With CMF + TAM in Adjuvant Therapy for Breast Cancer (CUBC)

Breast Cancer

Japan
EZUS-LYON 1

Active, not recruiting

CARdioprotection in Myocardial Infarction (CARIM)

Myocardial Infarct

France
EZUS-LYON 1

Active, not recruiting

The Influence of Manual Therapy Applied to the Cervical Spine in the Prevention of Balance Disorders in the Elderly (ManEq)

Elderly | Gait | Balance, Postural

France
Shanghai Zhongshan Hospital

Not yet recruiting

Second-line Zimberelimab and SIRIOX Chemotherapy for Patient With Previously AG Chemotherapy Treated Pancreatic Cancer

Previously AG Chemotherapy Treated Pancreatic Cancer

China
National Taiwan University Hospital
TTY Biopharm

Unknown

S-1, Irinotecan, and Oxaliplatin in Locally-Advanced Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma
Hallym University Medical Center
Jeil Pharmaceutical Co., Ltd.

Unknown

Study of Oxaliplatin, Irinotecan, and S-1 in Biliary Tract Cancer

Biliary Tract Neoplasm

Korea, Republic of
National Cancer Center, Korea

Completed

A Phase II Study of Irinotecan, Oxaliplatin, Plus TS-1 in Untreated Metastatic Gastric Cancer (TIROX2)

Stomach Neoplasms

Korea, Republic of
National Cancer Center, Korea

Unknown

A Phase I Study of S-1 Plus Irinotecan and Oxaliplatin in Advanced Gastrointestinal Malignancy (TIROX)

Colorectal Neoplasm | Secondary | Gastric Neoplasm

Korea, Republic of
Uro-1 Medical

Recruiting

Use of Repris Needle in Bladder Injection

Overactive Bladder Syndrome

United States
Uro-1 Medical

Recruiting

Assessment of VMCore Biopsy Versus Standard of Care Biopsy

Prostate Cancer

United States
Alpha-1 Foundation

Recruiting

Alpha-1 Research Registry

Alpha 1-Antitrypsin Deficiency

United States
National Cancer Institute (NCI)

Recruiting

Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer

Lung Neoplasms | Small Cell Lung Cancer | Prostate Cancer | Urothelial Carcinoma | Urothelial Cancer

United States
West China Hospital

Recruiting

Fruquintinib Plus S-1 and Raltitrexed (RSF) for mCRC

Fruquintinib | S-1 | Raltitrexed

China
Eastern Mediterranean University

Not yet recruiting

The Effect of Health Education and Yoga on Menopause Symptoms and Quality of Life According to Pender's Model

Quality of Life | Health Education | Yoga | Menopause Symptoms

Cyprus
Eastern Mediterranean University

Not yet recruiting

Effect of Acupressure on Pain, Anxiety and Vital Signs in Patients With Coronary Angiography

Pain | Anxiety | Coronary Angiography | Vital Signs

Cyprus
Institut du Cancer de Montpellier - Val d'Aurelle

Completed

A Trial Assessing Several Schedules of Oral S-1 in Combination With a Fixed Dose of Oxaliplatin and Irinotecan (SIRINOX)

Digestive Cancer

France
Hallym University Medical Center
Jeil Pharmaceutical Co., Ltd.

Completed

Study of Oxaliplatin, Irinotecan, and S-1 in Gastric Cancer

Stomach Neoplasm

Korea, Republic of

Search clinical trials for: Topoisomerase-1 Inhibitor

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