Search clinical trials for: ZFN mediated genome editing

Total 1877 results

Sangamo Therapeutics
Sanofi

Completed

A Study to Assess the Safety, Tolerability, and Efficacy of ST-400 for Treatment of Transfusion-Dependent Beta-thalassemia (TDT)

Transfusion Dependent Beta-thalassemia

United States
Sangamo Therapeutics

Terminated

Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I

MPS I

United States
Sangamo Therapeutics

Terminated

Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II

Mucopolysaccharidosis II | MPS II

United States
HuidaGene Therapeutics Co., Ltd.
Eye & ENT Hospital of Fudan University; Tianjin Medical University Eye Hospital

Recruiting

CRISPR/cas13-medIated RNA tarGeting tHerapy for the Treatment of Neovascular Age-related Macular Degeneration Investigator-initiated Trial (SIGHT-I)

Neovascular Age-related Macular Degeneration(nAMD)

China
German Cancer Research Center
University Hospital Heidelberg; University Hospital Dresden

Not yet recruiting

Genetic Ablation of CD33 in HSC to Broaden the Therapeutic Index of CD33-directed Immunotherapy in Patients With AML (GALAXY33)

Relapsed/Refractory Acute Myeloid Leukemia (AML)

Germany
National Institute on Deafness and Other Communication...

Recruiting

Natural History of Autosomal Dominant Hearing Loss

Hearing Loss

United States
Sangamo Therapeutics

Active, not recruiting

Long Term Follow-up (LTFU) of Subjects Who Received SB-318, SB-913, or SB-FIX (LTFU)

Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II

United States
Sangamo Therapeutics

Terminated

Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia B

Hemophilia B

United States
National Human Genome Research Institute (NHGRI)

Completed

Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care

Sickle Cell Disease

United States
Memorial Ankara Hospital

Unknown

Association of Genetic Polymorphisms With Atrial Fibrosis and Thrombogenic Substrate in Patients With Non-valvular Atrial Fibrillation (ANATOLI-AF)

Heart Diseases | Stroke | Thrombosis | Atrial Fibrillation | Genetic Predisposition
Noordwest Ziekenhuisgroep
Borstkanker Onderzoek Groep; Comprehensive Cancer Centre The Netherlands; Dutch... and other collaborators

Not yet recruiting

Mitigating Toxicity by Electronic Health Portal-mediated Interactive Monitoring of Patient-reported Side Effects (eChemoCoach)

Breast Cancer | eHealth | Self Management | Symptom Monitoring
Centre Hospitalier Universitaire de Besancon
Institut de Science des Matériaux de Mulhouse IS2M; NOVOTEC labs (lyon)

Recruiting

Characterization of Capsule Inflammation in Patients Exposed to Silicone Breast Implants (INFLAMA)

Breast Implant; Complications | Breast Expansion Prosthesis

France
University of Missouri-Columbia

Recruiting

Baker Gordon Syndrome Natural History Study (BAGOS)

Epilepsy, Generalized | Sleep Disorder | Rare Diseases | Development Delay | Motor Delay | Autism or Autistic Traits | SYT-SSX Fusion Protein Expression

United States
Peking University First Hospital

Recruiting

Establishment of a Multidimensional Prediction Model for the Natural Course of VHL Disease-related Renal Cell Carcinoma

Renal Cell Carcinoma | VHL Syndrome

China
Peking Union Medical College Hospital

Not yet recruiting

A Study to Evaluate the Safety and Tolerability of GEN6050X in Duchenne Muscular Dystrophy. (GEN6050XIIT)

Duchenne Muscular Dystrophy (DMD)
University Hospital, Toulouse

Recruiting

Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases (TekAPo)

Skin Diseases | Autoimmune Bullous Dermatosis | Dysimmune Dermatological Diseases | Auto-inflammatory Dermatological Diseases

France
The First Affiliated Hospital of Zhejiang Chinese...

Recruiting

Peripheral Mechanisms of Humoral Immune Effector-mediated Tourette's Syndrome and the Role of Tuina Intervention

Inflammatory Response | Tourette Syndrome in Children | Food Intolerance

China
Instituto de Investigación Biomédica de Salamanca
Carlos III Health Institute

Recruiting

Unified platforM for a Better integRal Evaluation of MyeLodyspLastic Syndromes in SpAin-Strategy for Unraveling Personalized genoMic Medicine in Public heAlth System (UMBRELLA-SUMMA) (UMBRELLA-SUMMA)

Myelodysplastic Syndromes

Spain
Chugai Pharmaceutical

Not yet recruiting

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

Antiphospholipid Syndrome (APS) | Immune Thrombocytopenia (ITP) | Dermatomyositis (DM) | Bullous Pemphigoid (BP) | Behçet's Syndrome (BS) | Immune-mediated Necrotizing Myopathy (IMNM)

United States, Japan
Regeneron Pharmaceuticals

Recruiting

Short-Term Linvoseltamab Treatment, on Top of Chronic Dupilumab Treatment, for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy

Food Allergy

United States
Alnylam Pharmaceuticals

Recruiting

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Hereditary Amyloidosis, Transthyretin-Related | Asymptomatic Carrier State

France
Azienda Ospedaliera di Bolzano

Recruiting

Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT Study (SALT-TILT)

Syncope | Asystole | Pacemaker | Neurally Mediated Syncope

Italy
Mayo Clinic

Recruiting

Oropharynx (OPX) Biomarker Trial

Oropharyngeal Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Oropharyngeal (p16-Negative)... and other conditions

United States
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Federico II University; Istituto Auxologico Italiano; Università degli Studi...

Recruiting

Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks

Beckwith-Wiedemann Syndrome

Italy
IRCCS Eugenio Medea

Recruiting

Optical Genome Mapping for the Diagnosis of Neurodevelopmental Disorders

Neurodevelopmental Disorder (Diagnosis)

Italy
Brugmann University Hospital

Recruiting

Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure Patients at Different Stages, and Evaluation of the Role of Antiphospholipid Antibodies

Chronic Renal Failure

Belgium
University of Erlangen-Nürnberg Medical School

Recruiting

CAR-T Cells in Systemic B Cell Mediated Autoimmune Disease (CASTLE)

Systemic Lupus Erythematosus | Systemic Sclerosis | Dermatomyositis | Polymyositis

Germany
Active Genomes Expressed Diagnostics, Corp
Walter Reed National Military Medical Center; Arizona Clinical Trials

Not yet recruiting

AGED Diagnostics Liver Disease Assessment (AGEDDX)

Healthy | NAFLD | NASH With Fibrosis

United States
University of California, San Diego
Vanderbilt University Medical Center; National Human Genome Research Institute...

Recruiting

Multi-Omics for Maternal Health After Preeclampsia (MOM-Health)

Pre-Eclampsia | Pregnancy Induced Hypertension

United States
Inocras Korea Inc.

Recruiting

Whole Genome Sequencing in Breast Cancer (WGS SIT)

Breast Cancer

Korea, Republic of
Centre Hospitalier Universitaire de Nice

Recruiting

Vitiligo Treatment by Targeting TYK2 Mediated Responses (ViTYK)

Vitiligo, Generalized

France
Istituto Clinico Humanitas

Recruiting

Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (GEARCIDP)

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Italy
National Institute of Allergy and Infectious Diseases...

Recruiting

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

Chronic Granulomatous Disease (CGD) | X-Linked Chronic Granulomatous Disease

United States
Ohio State University Comprehensive Cancer Center

Recruiting

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

Oropharyngeal Squamous Cell Carcinoma | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

United States
Rady Pediatric Genomics & Systems Medicine Institute

Recruiting

An Adaptive Clinical Trial of BeginNGS Newborn Screening for Hundreds of Genetic Diseases by Genome Sequencing (BeginNGS)

Genetic Disease

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Vaginal Self-sampling for Detecting High-risk Human Papillomavirus Cervical Infection in Patients With Immune-mediated Inflammatory Diseases (APOSY)

HPV Infection | Systemic Disease

France
Institute of Hematology & Blood Diseases Hospital...

Recruiting

Detecting Minimal Residual Diseases (MRD) and Monitoring Clonal Evolution Using Ultrasensitive Chromosomal Aberrations Detection (UCAD) in Multiple Myeloma

Multiple Myeloma
University College Cork
University of Southampton; Carol Davila University of Medicine and Pharmacy; Engineering... and other collaborators

Not yet recruiting

Environmental Influence on Mental Illness Via Modifications of Genomes and Metabolomes in Adolescents With Autism (ENIGMA-I)

Autism Spectrum Disorder | Autism

Ireland, United Kingdom, Romania
Sana Biotechnology

Recruiting

Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM) (GLEAM)

Systemic Lupus Erythematosus | Microscopic Polyangiitis | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | Lupus Erythematosus | SLE (Systemic Lupus) | Granulomatous Polyangiitis

United States
University Hospital, Rouen

Not yet recruiting

Screening for Subclinical Antibody Mediated Rejection and Efficacy of Belatacept in the Context of de Novo Donor Specific Antibody After Kidney Transplantation (BELA-M-R) (BELA-M-R)

Kidney Transplant Rejection
University Hospital, Rouen

Not yet recruiting

Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura: Multicentric Non-inferiority Single-arm Study (PEX-FREE)

Thrombotic Microangiopathies
King Chulalongkorn Memorial Hospital
Chulalongkorn University

Not yet recruiting

The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis

Physical Activity | Cirrhosis | Sarcopenia | Heart Rate Variability | Physical Functional Performance | Lifestyle Modification | Autonomic Dysfunction | Endothelial Function | Autonomic Nervous System | Aerobic Exercises | Flow Mediated Dilation

Thailand
UMC Utrecht
Alfasigma S.p.A.; ReumaNederland; Autoimmune Research and Collaboration Hub

Not yet recruiting

Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases (DRIMID)

IgG4-related Disease | Idiopathic Inflammatory Myopathies | Behcet's Disease

Netherlands
Suzhou Municipal Hospital
The First Affiliated Hospital with Nanjing Medical University; Affiliated Hospital... and other collaborators

Not yet recruiting

Focused Power Ultrasound Mediated Inferior Perirenal Adipose Tissue Modification Therapy for Essential Hypertension (PARADISE HTN-III)

Cardiovascular Diseases | Hypertension | Blood Pressure

China
Kocaeli City Hospital

Recruiting

Expected Difficult Airway Management

Awake Intubation | Advanced Airway Techniques

Turkey
National Human Genome Research Institute (NHGRI)

Recruiting

Care Choreographies and the Making of the Psychosocial in Genetic Counseling

Genetic Counselor

United States
Duke University
National Human Genome Research Institute (NHGRI)

Not yet recruiting

Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase (GRACE)

Liver Diseases | Cardiovascular Diseases | Cancer | Hyperthermia

United States
Instituto de Investigación Hospital Universitario...

Not yet recruiting

Towards Telemonitoring in Immune-Mediated Inflammatory Diseases: Implementation of a Mixed Attention Model (IMIDOC) (IMIDOC)

Arthritis, Rheumatoid | Rheumatic Diseases | Spondylarthritis | Telemedicine | eHealth | Telehealth
Fundación EPIC

Not yet recruiting

Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL)

Coronary Disease
Steno Diabetes Center Greenland
Zealand University Hospital; University of Copenhagen

Recruiting

Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland

Diabetes Mellitus, Type 2 | Diabetic Neuropathies | Diabetic Retinopathy | Obstructive Sleep Apnea | Obesity, Morbid | MODY

Greenland

Search clinical trials for: ZFN mediated genome editing

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