Search clinical trials for: adenosine receptor antagonist

Total 41629 results

M.D. Anderson Cancer Center

Recruiting

Phase 1b/2 Trial of Ipilimumab, Nivolumab, and Ciforadenant (Adenosine A2a Receptor Antagonist) in First-line Advanced Renal Cell Carcinoma.

Renal Cell Carcinoma

United States
University of Florida
ALS Association

Recruiting

Adenosine 2A Receptor Antagonism and AIH in ALS

ALS

United States
Virginia Commonwealth University
Kyowa Kirin, Inc.

Recruiting

Istradefylline for Parkinson Disease With Cognitive Impairment

Parkinson Disease | Cognitive Impairment

United States
Dwight Owen
National Cancer Institute (NCI)

Recruiting

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
Randy Trumbower, PT, PhD

Not yet recruiting

Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

Spinal Cord Injuries | Myelopathy

United States
University of Messina
Natasha Irrera; Gianluca Di Bella; Antonio Micari; Roberto Licordari

Recruiting

Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction (BETA-MI)

Myocardial Infarction | Myocardial Fibrosis | Myocardial Remodeling, Ventricular

Italy
Weill Medical College of Cornell University
Arcus Biosciences, Inc.

Recruiting

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer. (PANTHER)

Rectal Cancer

United States
Arcus Biosciences, Inc.
Gilead Sciences

Active, not recruiting

Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer (ARC-6)

Prostatic Neoplasms, Castration-Resistant | Prostatic Cancer, Castration-Resistant | Castration Resistant Prostatic Neoplasms | Androgen-Resistant Prostatic Neoplasms

United States, Canada
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Terminated

An Extension of Istradefylline in North American Parkinson's Disease Patients Who Have Completed Study 6002-INT-001

Parkinson's Disease

United States
Coherus Biosciences, Inc.
Arcus Biosciences, Inc.; Surface Oncology

Terminated

Study of SRF617 With AB928 (Etrumadenant) and AB122 (Zimberelimab) in Patients With Metastatic Castration Resistant Prostate Cancer

Prostate Cancer | Metastatic Castration-resistant Prostate Cancer

United States, Canada
Kyowa Kirin, Inc.

Completed

12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa

Parkinson's Disease

United States
Kyowa Kirin, Inc.

Completed

12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa

Parkinson's Disease

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

A 12-week Randomized Study to Evaluate Oral Istradefylline in Subjects With Moderate to Severe Parkinson's Disease (KW-6002)

Idiopathic Parkinson's Disease

United States, Canada, Czechia, Germany, Israel, Italy, Poland, Serbia
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

Long Term Study of Istradefylline in Subjects With Moderate to Severe Parkinson's Disease

Idiopathic Parkinson's Disease

United States, Canada, Czechia, Germany, Israel, Italy, Poland, Serbia
Kyowa Kirin, Inc.
Kyowa Hakko Kirin UK, Ltd.

Completed

An Extension of Istradefylline in Parkinson's Disease Patients Who Have Completed Studies 6002-EU-007, 6002-US-013 or 6002-US-018

Parkinson's Disease

United States
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome

Sleep Disorder | Restless Legs Syndrome

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.

Parkinson's Disease

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

Effect of Mild Hepatic Impairment on the Pharmacokinetics of Istradefylline

Hepatic Impairment

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

A Study to Evaluate Abuse Potential of Istradefylline

Drug Abuse

United States
Kyowa Kirin, Inc.

Completed

A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy

Parkinson's Disease

United States
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

A Study of Istradefylline (KW-6002) as Monotherapy in Parkinson's Disease (PD) Patients

Parkinson's Disease | Movement Disorder Syndrome

United States
Kyowa Kirin, Inc.

Completed

A Study of Istradefylline (KW-6002) in Treating Patients With Parkinson's Disease on Levodopa

Parkinson's Disease

United States
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin UK, Ltd.

Completed

A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease

Parkinson's Disease

United Kingdom
Kyowa Kirin, Inc.

Completed

A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa

Parkinson's Disease

United States
AstraZeneca

Completed

An Open-label, Phase II Study of AZD4635 in Patients With Prostate Cancer

Prostate Cancer | Metastatic Castration-Resistant Prostate Cancer (mCRPC)

United States
Medical University of South Carolina
Kyowa Kirin, Inc.

Terminated

Effect of Istradefylline Treatment on Behavioral Measures of Apathy in Parkinson's Disease.

Parkinson Disease | Apathy

United States
Georgetown University
Kyowa Kirin, Inc.

Active, not recruiting

Istradefylline Effect Protocol on Parkinson's Disease Tremor

Parkinson Disease | Tremor

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Terminated

First in Human Study of M1069 in Advanced Solid Tumors

Metastatic or Locally Advanced Unresectable Solid Tumors

United States, Canada
Biogen

Completed

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency (TRIDENT-1)

Renal Insufficiency | Congestive Heart Failure

Israel, Italy, United States, Finland, Canada, Australia, France, Netherlands, Poland, Bulgaria, Russian Federation, India, Brazil, Sweden, Romania, Czechia, Argentina, Germany
Biogen

Terminated

Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency (POSEIDON)

Heart Failure | Renal Insufficiency

United States
Biogen

Completed

BIIB014 Effects on the Pharmacokinetics (PK) of Rosiglitazone, Warfarin, and Midazolam

Healthy

United Kingdom
Biogen

Withdrawn

BIIB014 Phase 2a Monotherapy

Parkinson's Disease
University of Sao Paulo

Completed

Platelet Aggregation and Adenosine Levels Among Patients Taking Ticagrelor or Prasugrel

Coronary Artery Disease

Brazil
Palobiofarma SL
Novartis; H. Lee Moffitt Cancer Center and Research Institute

Completed

Trial of PBF-509 and PDR001 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) (AdenONCO)

Non-small Cell Lung Cancer (NSCLC)

United States
Colorado State University

Withdrawn

Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training

Vasodilation | Vasoconstriction

United States
Centro Prevenzione Malattie Cardiovascolari N....
Gruppo Italiano Multidisciplinare per lo Studio della Sincope

Completed

Theophylline for Low Adenosine Syncope (THEO-USA)

Syncope

Italy
AstraZeneca
Parexel

Completed

A Study to Assess the Effect of Fluvoxamine and Smoking on Pharmacokinetics ( the Movement of Drugs Within the Body) of AZD4635 in Healthy Volunteers

Healthy Volunteer/DDI Study

United Kingdom
Palobiofarma SL
Clínica Universidad de Navarra

Completed

Study to Assess the Safety and Tolerability of PBF-1650 in Healthy Volunteers. (ADENOIMMUNE)

Psoriasis

Spain
Palobiofarma SL
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau; Hospital...

Completed

A Study to Assess the Efficacy of a 5-day, 10- mg PBF-680 Oral Administration on Late Asthmatic Responses (LAR) in Mild to Moderate Asthmatic Patients.

Asthma

Spain
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Platelet Aggregation in Patients With Coronary Artery Disease and Kidney Dysfunction Taking Clopidogrel or Ticagrelor

Coronary Artery Disease | Platelet Aggregation | Kidney Dysfunction | Adenosine | Antiplatelet Therapy

Brazil
Beijing Anzhen Hospital

Unknown

LOwer Maintenance Dose TICagrelor in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention (LOTIC)

Coronary Artery Disease | Percutaneous Coronary Intervention | Antiplatelet Therapy

China
Korea University Anam Hospital
AstraZeneca

Completed

Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting

Acute Coronary Syndrome

Korea, Republic of
King Saud University
King Saud Medical City

Completed

The Effect of Caffeine on the Narcoleptic Patients

Narcolepsy

Saudi Arabia
Palobiofarma SL

Completed

"First-in-human" Study To Assess the Safety and Tolerability of PBF-677 in Healthy Volunteers

Glaucoma
The Royal Wolverhampton Hospitals NHS Trust

Completed

The Effect of IV Cangrelor and Oral Ticagrelor Study

ST-segment Elevation Myocardial Infarction (STEMI) | Acute Coronary Syndrome (ACS) | Unstable Angina (UA) | High On-treatment Platelet Reactivity (HTPR) | Microvascular Obstruction (MVO) | Thrombolysis in Myocardial Infarction (TIMI)

United Kingdom
Merck Sharp & Dohme LLC

Completed

A Study to Assess Pharmacokinetics of Preladenant in Participants With Chronic Hepatic Impairment (P06513)

Chronic Hepatic Impairment
Assiut University

Unknown

Management of Supraventricular Tachycardia of Children

Supraventricular Tachycardia
Astellas Pharma Inc

Completed

Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)

Coronary Artery Disease (CAD)

United States
Ottawa Heart Institute Research Corporation

Completed

Ticagrelor vs Clopidogrel Effect on MFR in CAD Population (PATH)

Coronary Artery Disease

Canada
Erasmus Medical Center
Covance

Completed

Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH) (HI-TECH)

Cardiovascular Diseases

Spain, Netherlands, Italy, Switzerland

Search clinical trials for: adenosine receptor antagonist

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