Search clinical trials for: drug repurposing

Total 260704 results

Shirley Ryan AbilityLab
Rady Children's Hospital, San Diego

Not yet recruiting

Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy

Cerebral Palsy | Contracture
State University of New York at Buffalo
The Cure Parkinson's Trust

Not yet recruiting

Repurposing Lithium for Parkinson's Disease: a RCT

Parkinson Disease

United States
Ziauddin University

Not yet recruiting

Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial (MROSF)

Oral Submucous Fibrosis

Pakistan
International Centre for Diarrhoeal Disease Research...

Recruiting

Repurposing Ivermectin for PKDL Treatment

Post-kala-azar Dermal Leishmaniasis

Bangladesh
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Repurposing Valsartan May Protect Against Pulmonary Hypertension (REVAMP-PH)

Pulmonary Arterial Hypertension | Right Ventricular Dysfunction | Right Heart Failure | Pulmonary Vascular Disorder

United States
Centre Hospitalier Universitaire Vaudois
University College, London; Great Ormond Street Hospital for Children NHS Foundation...

Not yet recruiting

Repurposing Empagliflozin and Dapagliflozin for Paediatric Heart Failure: Translational Approach and Dose Rationale

Heart Failure

Switzerland, United Kingdom
Emory University
National Cancer Institute (NCI)

Recruiting

Repurposing Atovaquone for the Treatment of Platinum-Resistant Ovarian Cancer

Ovarian High Grade Serous Adenocarcinoma | Platinum-Resistant Ovarian Carcinoma

United States
Filip Krag Knop
Juvenile Diabetes Research Foundation; University of Copenhagen

Recruiting

Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes (REC1TE)

Cardiovascular Diseases | Type 1 Diabetes | Chronic Inflammation

Denmark
Emory University
CURE Drug Repurposing Collaboratory (CDRC)

Recruiting

Treatment of Long CoronaVirus Disease (COVID) (TLC) Feasibility Trial

COVID-19

United States
Tanta University
Eman Ibrahim Elberri, Faculty of Pharmacy, Tanta University; Fedaa Abd El-monem... and other collaborators

Recruiting

Repurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative Colitis

Inflammatory Bowel Diseases

Egypt
Maastricht University

Recruiting

Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE (REPO-STROKE II)

Ischemic Stroke, Acute

Germany
Luca Cardone
University of Pisa; Azienda Ospedaliera Universitaria Integrata Verona; Catholic... and other collaborators

Recruiting

tailOred dRug repurposIng of dEcitabine in KRAS-dependeNt refracTory pAncreaTic cancEr (ORIENTATE)

Pancreatic Adenocarcinoma Metastatic | Pancreatic Adenocarcinoma Recurrent

Italy
German University in Cairo

Recruiting

Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients

Multiple Sclerosis

Egypt
Imperial College London
Karolinska University Hospital; Karolinska Institutet; Merck KGaA, Darmstadt,... and other collaborators

Recruiting

METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia (MET-FINGER)

Cognitive Impairment | Dementia | Cognitive Decline

United Kingdom, Finland, Sweden
Universitaire Ziekenhuizen KU Leuven
Vlaams Instituut Biotechnologie (VIB)

Recruiting

Drug Repurposing - Statins as Microbiota Modulating Agents in Ulcerative Colitis (ReMiDy)

Ulcerative Colitis

Belgium
Aurora Health Care

Recruiting

Repurposing Low-Dose Clonidine for PTSD in Veterans

PTSD | Sleep | Posttraumatic Stress Disorder

United States
Cairo University
German University in Cairo

Recruiting

Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)

Chemotherapy-induced Peripheral Neuropathy

Egypt
Kyoto University
Pfizer; Kitasato University; Tokushima University; Tottori University

Recruiting

iPSC-based Drug Repurposing for ALS Medicine (iDReAM) Study

Amyotrophic Lateral Sclerosis

Japan
Kirsten Grønbæk
Zealand University Hospital; University of Copenhagen; Herlev Hospital; Steno Diabetes... and other collaborators

Recruiting

Repurposing Metformin as a Leukemia-preventive Drug in CCUS and LR-MDS

Preleukemia | Cytopenia | Myelodysplastic Neoplasm | Preleukemic Anemia

Denmark
Butler Hospital
Brown University; The Miriam Hospital; Alzheimer's Association

Recruiting

Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD (LINE-AD)

Mild Cognitive Impairment | Alzheimer Disease, Early Onset | Moderate Dementia

United States
Marco G Paggi, MD, PhD
Istituto Oncologico Veneto IRCCS; Regina Elena Cancer Institute; Carlo Besta...

Recruiting

Repurposing Chlorpromazine in the Treatment of Glioblastoma (RACTAC)

Glioblastoma Multiforme | MGMT-Unmethylated Glioblastoma

Italy
Gynaecologisch Oncologisch Centrum Zuid
Radboud University Medical Center; Maastricht University Medical Center; Erasmus... and other collaborators

Recruiting

Signal TrAnsduction Pathway Activity Analysis in OVarian cancER (STAPOVER)

Recurrent Ovarian Cancer | Therapy-Associated Cancer | Signal Transduction Pathway Deregulation

Netherlands
Joyce Teng

Recruiting

Computational Drug Repurposing for All EBS Cases

Healthy | Epidermolysis Bullosa | Genetic Skin Disease | Epidermolysis Bullosa Dystrophica | Epidermolysis Bullosa Simplex | Epidermolysis Bullosa, Junctional

United States
Fundación FLS de Lucha Contra el Sida, las Enfermedades...
National Department of Health, Papua New Guinea; School of Medicine and Health...

Active, not recruiting

Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws) (Trep-AByaws)

Yaws | Cutaneous Ulcer

Papua New Guinea
Haukeland University Hospital

Completed

IMPACT: A Randomized WOO Study of Novel Therapeutic Agents in Women Triaged to Primary Surgery for EOC (IMPACT)

Ovarian Cancer

Norway
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - PDE5 Inhibitors vs Endothelin Receptor Antagonist

Pulmonary Arterial Hypertension

United States
Nottingham University Hospitals NHS Trust

Active, not recruiting

REpurposing SirolimUS in Compensated Advanced Chronic Liver Disease. The RESUS Proof of Concept Study (RESUS)

Advanced Chronic Liver Disease

United Kingdom
Dartmouth-Hitchcock Medical Center

Active, not recruiting

The Safety of Repurposing Daratumumab for Relapsed or Refractory Autoimmune Antibody Mediated Hemolytic Anemia (DARA-AIHA)

Hemolytic Anemia

United States
State University of New York at Buffalo

Enrolling by invitation

Repurposing Lithium for Parkinson's Disease

Parkinson's Disease

United States
All India Institute of Medical Sciences, Bhubaneswar

Completed

Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder

Major Depressive Disorder

India
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Pentoxifylline Versus Cilostazol

Peripheral Artery Disease

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol

Hypertension

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors

Diabetes

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Montelukast vs Fluticasone

Asthma

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Anastrozole vs Exemestane/Letrozole

Breast Cancer

United States
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension (REHAB-PH)

Pulmonary Arterial Hypertension | Right Heart Failure

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene

Hypertension

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - (DREAM) Probenecid vs Allopurinol

Gout

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Salbutamol vs Long-acting Muscarinic Antagonists

Chronic Obstructive Pulmonary Disease

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Active, not recruiting

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide

Hypertension

United States
University of Copenhagen
University of Aarhus

Completed

Repurposing Colchicine to Improve Vascular Function in Hypertension (RECTIFHY)

Essential Hypertension

Denmark
Sadat City University

Withdrawn

Repurposing the Antipsychotic Drug Chlorpromazine as Adjuvant Therapeutic Agent for Resected Stage III Colon Cancer

Colon Cancer Stage III

Egypt
Nucleo De Pesquisa E Desenvolvimento De Medicamentos...
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Completed

Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia

Schizophrenia | Oxidative Stress

Brazil
Kyoto University
Osaka University; Mie University; Tokushima University; Tokyo Metropolitan Geriatric... and other collaborators

Completed

Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease (REBRAnD)

Familial Alzheimer Disease (FAD) | PSEN1 Mutation

Japan
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - TNFi vs Abatacept (DREAM)

Rheumatoid Arthritis

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine

Rheumatoid Arthritis

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tocilizumab vs Abatacept (DREAM)

Rheumatoid Arthritis

United States
Brigham and Women's Hospital
Johns Hopkins University; National Institute on Aging (NIA); Rutgers University

Completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept (DREAM)

Rheumatoid Arthritis

United States
University of Oxford
Wellcome Trust; Department of Health, United Kingdom; 180 Therapeutics LP

Completed

Repurposing Anti-TNF for Treating Dupuytren's Disease (RIDD)

Dupuytren's Disease

United Kingdom, Netherlands
Temple University

Withdrawn

RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM (STORM)

SARS-CoV-2 | Cytokine Storm

United States

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