Search clinical trials for: first phase insulin secretion

Total 41360 results

University of Alabama at Birmingham

Completed

Return of First-phase Insulin Secretion in Type 2 Diabetes is Associated With Depletion of Pancreas Lipid

Type 2 Diabetes Mellitus

United States
University of Aarhus
Aarhus University Hospital; University of Copenhagen; Lundbeck Foundation; Vejle... and other collaborators

Completed

Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders

Obesity | Diabetes Mellitus | Metabolic Syndrome | Hyperlipidemia | Arterial Hypertension

Denmark
Ruhr University of Bochum

Completed

Chronic Reduction of Fasting Glycaemia With Insulin Glargine Improves First and Second Phase Insulin Secretion in Patients With Type 2 Diabetes

Type 2 Diabetes

Germany
Stephanie B. Seminara, MD

Recruiting

Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance

Pregnancy | Healthy Volunteers | Insulin | Glucose | Women

United States
University Hospital, Basel, Switzerland

Recruiting

IL-1-receptor Antagonist During Cephalic Phase of Insulin Secretion in Health and Type 2 Diabetes (Cephalira)

Inflammation | Metabolic Disease | Diabetes Mellitus Type 2 in Obese | Glucose Metabolism Disorders (Including Diabetes Mellitus)

Switzerland
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Withdrawn

Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion

Healthy

United States
Eli Lilly and Company

Completed

A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk (SURPASS-4)

Type 2 Diabetes Mellitus

Russian Federation, United States, Puerto Rico, Australia, Taiwan, Israel, Spain, Canada, Greece, Argentina, Poland, Romania, Mexico, Slovakia, Brazil
University Hospital, Toulouse

Completed

Starches Digestion After Obesity Surgery. (GLUBYPASS)

Obesity

France
University of Copenhagen
Rigshospitalet, Denmark

Unknown

Studies of the Early Meal Phase in Healthy Individuals - Nutrient Absorption and Gastrointestinal Hormone Secretion

Healthy

Denmark
Novartis Pharmaceuticals

Completed

Effects of Nateglinide on Postprandial Glucose Excursion by Restoring Early Phase Insulin Secretion

Diabetes Mellitus, Type 2

China
German Diabetes Center
Heinrich-Heine University, Duesseldorf

Unknown

Probiotics as a Novel Approach to Modulate Gut Hormone Secretion and Risk Factors of Type 2 Diabetes and Complications

Obesity | Type 2 Diabetes

Germany
Hanoi Medical University
Karolinska Institutet; Swedish International Development Cooperation Agency...

Completed

Anti-diabetic Effect of Gynostemma Pentaphyllum Tea in Type 2 Diabetic Patients

Type 2 Diabetes

Vietnam
Rio de Janeiro State University
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Completed

Cephalic Phase Insulin Secretion and Capillary Recruitment in Healthy Men

Microvascular Function

Brazil
Sun Yat-sen University
Novo Nordisk A/S; Hoffmann-La Roche; Ministry of Education, China; Guangdong Science...

Completed

Evaluation of the Effects of Different Interventions on Glycemic Control in Newly-Diagnosed Type 2 Diabetic Patients

Type 2 Diabetes Mellitus

China
University Hospital, Gentofte, Copenhagen

Unknown

Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes.

Type 2 Diabetes

Denmark
Chengdu Baiyu Pharmaceutical Co., Ltd.

Recruiting

A Phase l Study of By101921, an Oral PARP7 Inhibitor, in Patients With Advanced Solid Tumors

Solid Tumor, Adult

China
Sun Yat-sen University
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

First-line Anlotinib Combined With Penpulimab for Advanced Pheochromocytoma: A Single-arm, Multicenter, Prospective Phase II Study

Pheochromocytoma

China
Mayo Clinic

Not yet recruiting

Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes

PreDiabetes

United States
Mayo Clinic

Not yet recruiting

Insulin and Insulin Pulses During Fasting

PreDiabetes

United States
BeiGene

Not yet recruiting

Phase 1 First-in-Human Study of BGB-C354 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

Advanced Solid Tumor
Jinghui Wang

Recruiting

A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

Lung Cancer

China
Bristol-Myers Squibb

Not yet recruiting

Study of BMS-986497 (ORM-6151) in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | Myelodysplastic Syndrome

United States, Canada
Jacobio Pharmaceuticals Co., Ltd.

Not yet recruiting

JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation

Advanced Non-squamous Non-small-cell Lung Cancer | Metastatic Non-squamous Non Small Cell Lung Cancer
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients

First-line Advanced NSCLC Patients

China
Qilu Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study of QLC1101 in Patients With Advanced Solid Tumors

Colorectal Cancer | Pancreatic Cancer | Solid Tumor | Non-small Cell Lung Cancer

China
Tianjin Medical University Cancer Institute and...

Not yet recruiting

A Prospective, Single-arm, Multicenter Phase II Clinical Study of HAIC in Combination With Adebrelimab and Bevacizumab for Potentially Resectable Hepatocellular Carcinoma

Hepatocellular Carcinoma | Adebrelimab

China
CDR-Life AG

Recruiting

First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors

Select Advanced Solid Tumors

United States, Denmark
Xiangya Hospital of Central South University
First People's Hospital of Chenzhou; Xiangtan Central Hospital

Recruiting

Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir

Lung Cancer | Leptomeningeal Metastasis

China
MediLink Therapeutics (Suzhou) Co., Ltd.

Not yet recruiting

A Phase 1 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Advanced Solid Tumors

Advanced Solid Tumors

China
Ferring Pharmaceuticals

Not yet recruiting

A Phase 4, Multi-center, Open Label Trial to Evaluate Efficacy of Retreatment With Nadofaragene Firadenovec in Subjects With CIS ± High-grade Ta/T1 and no Complete Response to First Nadofaragene Firadenovec Dose (ABLE-42)

Bladder Cancer | CIS | Ta/T1
Ascentage Pharma Group Inc.

Not yet recruiting

A Pivotal Phase 3 Study of APG-2575 (Lisaftoclax) Combined With Azacytidine in the Treatment of Acute Myeloid Leukemia

Acute Myeloid Leukemia

China
Akeso

Recruiting

A Phase III Study to Evaluate the Efficacy and Safety of AK120 in Patients With Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

China
Akeso

Recruiting

A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis

Ankylosing Spondylitis

China
RenJi Hospital

Recruiting

Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations

End Stage Renal Disease | Kidney Transplantation | Delayed Graft Function

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

An Phase III Study, Multicenter，Randomized Controlled Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma.

Bladder Cancer

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Phase Ib/II Trail of Neoadjuvant of Tislelizumab Combined With Palbociclib in Patients With Platinum-refractory Bladder Urothelial Carcinoma

Bladder Cancer

China
Beijing 302 Hospital
Beijing GD Initiative Cell Therapy Technology Co., Ltd.; Chinese Academy of...

Not yet recruiting

Allogeneic Gamma-delta T Cells Combined With Targeted Therapy and Immunotherapy in a Phase 1 Clinical Trial for First-line Treatment of Hepatocellular Carcinoma

Hepatocellular Carcinoma
Beijing Kanghong Biopharmaceutical Co., Ltd.

Not yet recruiting

Phase 1 Trial of KH801

Advanced Solid Tumors

China
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Recruiting

A Phase II Study of SSGJ-707 Monotherapy in First-line PD-L1 Positive Advanced NSCLC Patients

NSCLC

China
Hutchmed

Recruiting

A Phase II/III Trial to Evaluate the Efficacy and Safety of Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer

Metastatic Pancreatic Cancer

China
AstraZeneca
Daiichi Sankyo

Recruiting

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)

Non-Small Cell Lung Cancer

Spain, Italy, Japan, Brazil, Taiwan, Korea, Republic of, Australia, Austria, Canada, Poland, United States, Belgium, United Kingdom, Turkey, Hungary, Germany, India
Zhejiang Cancer Hospital

Recruiting

A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies.

Gastric Cancer | Colorectal Cancer | Pancreatic Adenocarcinoma | Biliary Tract Cancer | Gastroesophageal Junction Adenocarcinoma | Liver Cancer Stage IV

China
AstraZeneca
Daiichi Sankyo

Recruiting

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer (TROPION-Lung14)

Non-small Cell Lung Cancer

Australia, China, Korea, Republic of, Taiwan
China National Center for Cardiovascular Diseases
Peking University First Hospital; Beijing Children's Hospital

Recruiting

Etablishment of Follow-up System and End-Stage Heart Registration Platform for Pediatric Heart Failure

Heart Failure | End-stage Heart Failure | Congenital

China
West China Hospital

Not yet recruiting

Phase II Study of Irinotecan Liposomes in First-line Treatment of Metastatic Colorectal Cancer

Metastatic Colorectal Cancer
Evandro Chagas Institute of Clinical Research

Not yet recruiting

Short Benznidazole Regimen for Chronic Phase Chagas Disease Patients (Benlatino)

Chronic Chagas Disease

Brazil
University of California, Los Angeles

Recruiting

Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study

Bladder Cancer | Kidney Failure | Bladder, Neurogenic | Bladder Disease

United States
Shanghai Shengdi Pharmaceutical Co., Ltd

Not yet recruiting

A Phase II/III Study of Adebrelimab in Combination With SHR-8068 and Chemotherapy in Advanced or Metastatic NSCLC Patients

Non-squamous Non-small Cell Lung Cancer

China
Suzhou Genhouse Bio Co., Ltd.
Zhejiang Cancer Hospital; Henan Cancer Hospital; Hubei Cancer Hospital; The First...

Recruiting

A Phase Ia/Ib Study of GH2616 Tablet in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

China
Vrije Universiteit Brussel
University Ghent; Research Foundation Flanders

Not yet recruiting

Muscular Changes in the First 12 Weeks After Stroke. (StrIMuC12)

Stroke

3

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