Search clinical trials for: intestinal bile acid transporter inhibitor

Total 115834 results

GlaxoSmithKline

Available

Linerixibat Compassionate Use for Cholestatic Pruritus Adult Patients With Primary Biliary Cholangitis (PBC)

Pruritus
GlaxoSmithKline

Completed

Food Effect Study of Linerixibat Tablets in Healthy Adult Participants

Pruritus

United Kingdom
University of Maryland, Baltimore

Completed

Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition

Bile Salt Export Pump (BSEP) Transporter | Polysorbate 80

United States
Michael Camilleri, MD
National Center for Research Resources (NCRR)

Completed

Effect of Ileal Bile Acid Transporter Inhibitor in Functional Constipation

Functional Constipation

United States
Mirum Pharmaceuticals, Inc.

Terminated

Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)

Non-Alcoholic Steatohepatitis

United States, United Kingdom, Canada, Puerto Rico
GlaxoSmithKline

Completed

A Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 Administered With Metformin to Type 2 Diabetes Patients

Diabetes Mellitus, Type 2

United States
GlaxoSmithKline

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetic a Single Day of Dosing With GSK1614235.

Diabetes Mellitus, Type 2

United States
Region Stockholm
Amgen

Not yet recruiting

Studies to Gain Insight How the Drugs PCSK9-inhibitors and Statins Affect Cholesterol and Bile Acid Metabolism

Acute Metabolic Effects of Evolocumab and Atorvastatin
Centre Hospitalier Universitaire de Liege
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Régional... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
Columbia University

Recruiting

Bile Acids in Acute Insulin Resistance

Cancer | Insulin Resistance | MTOR Gene Mutation | PI3K Gene Mutation | AKT Gene Mutation

United States
Xiaoli Fan

Recruiting

A Randomised Clinical Trial Assessing the Efficacy and Safety of Mycophenolate Mofetil Versus Azathioprine for Induction of Remission in Treatment Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome

Autoimmune Hepatitis | Primary Biliary Cirrhosis

China
National Cancer Institute (NCI)

Recruiting

Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

AL Amyloidosis

United States
West China Hospital

Recruiting

Mycophenolate Mofetil Versus Cyclosporin A in the Treatment of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Due to Nonresponse to Standard Therapy

Hepatitis, Autoimmune | Immunosuppression | Primary Biliary Cholangitis

China
Mats Heyman
Assistance Publique - Hôpitaux de Paris; Karolinska Institutet; Pfizer; The Swedish... and other collaborators

Recruiting

A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

Leukemia, Acute Lymphoblastic

Belgium, United Kingdom, Denmark, Germany, Portugal, Netherlands, Estonia, France, Finland, Iceland, Norway, Sweden, Lithuania, Ireland
Bayer

Active, not recruiting

An Observational Study, Called FINEGUST, to Learn More About How People With Chronic Kidney Disease and Type 2 Diabetes Are Treated and How the Introduction of New Treatment Options, Like Finerenone, Impacts Clinical Practice (FINEGUST)

Type 2 Diabetes Mellitus | Chronic Kidney Disease

Japan, Spain, Netherlands, Denmark, United States
CHU de Quebec-Universite Laval
Canadian Institutes of Health Research (CIHR); Biovalorem

Active, not recruiting

Cholesterol Disruption in Combination With the Standard of Care in Patients With Advanced Pancreatic Adenocarcinoma

Pancreatic Cancer | Metastatic Cancer | Pancreatic Ductal Adenocarcinoma | Pancreas Cancer

Canada
Qianfoshan Hospital

Active, not recruiting

Therapeutic Drug Use for CKD Patients

Chronic Kidney Disease

China
Celldex Therapeutics
Merck Sharp & Dohme LLC

Completed

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

Melanoma | Follicular Lymphoma | Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Pancreatic Adenocarcinoma | Ovarian Cancer | Fallopian Tube Cancer | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Lymphoplasmacytic Lymphoma | Non-Hodgkin Lymphoma | ... and other conditions

United States
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States
OHSU Knight Cancer Institute
Oregon Health and Science University

Active, not recruiting

mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 | Liver and Intrahepatic Bile Duct Carcinoma | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Unresectable Intrahepatic Cholangiocarcinoma

United States
Mayo Clinic
Multiple Myeloma Research Foundation

Completed

Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma

Recurrent Plasma Cell Myeloma | t(11;14)

United States
University of Alberta
Merck Sharp & Dohme LLC

Completed

Combination Antiretroviral Therapy (cART) for PBC

Primary Biliary Cholangitis

Canada
Anne Noonan

Active, not recruiting

Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab

Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Bile Duct Cancer | Gall Bladder Cancer | Metastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage II Colon Cancer | Stage... and other conditions

United States
University of Maryland, Baltimore
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Enrolling by invitation

Genetics of Response to Canagliflozin

Diabetes Mellitus, Type 2
Zhijun Sun

Enrolling by invitation

EMPAGUM: Effects of Empagliflozin on Gut Microbiota in Heart Failure With a Preserved Ejection Fraction

Heart Failure | Heart Failure With Preserved Ejection Fraction

China
Asmaa Abdelfattah Elsayed

Completed

Follow-up of NAFLD Patients With MRI-PDFF

NAFLD | Diabetes Type 2

Egypt
Celgene

Completed

A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677

Healthy Volunteer

United Kingdom
Assiut University

Unknown

Electroclinical Effect of Steroid in Patients With Benign Childhood Epilepsy With Centrotemporal Spikes

Benign Childhood Epilepsy With Centrotemporal Spikes

Egypt
Christopher Bowlus, MD
Bristol-Myers Squibb

Completed

Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis (PBC)

Primary Biliary Cirrhosis

United States
University Hospital, Gentofte, Copenhagen
Eli Lilly and Company

Completed

The Role of Glucagon in the Effects of Dipeptidyl Peptidase-4 Inhibitors and Sodium-glucose Co-transporter-2 Inhibitors

Type 2 Diabetes

Denmark
University of Aarhus

Completed

Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT

Primary Biliary Cirrhosis

Denmark
Montefiore Medical Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy Plus Interferon Alfa Followed by Filgrastim in Treating Patients With Gastrointestinal Tract Cancer

Gastric Cancer | Pancreatic Cancer | Small Intestine Cancer | Liver Cancer | Extrahepatic Bile Duct Cancer | Gastrointestinal Carcinoid Tumor

United States
Chinese PLA General Hospital

Completed

Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease

Dyspepsia | Gastroesophageal Reflux Disease | Bile Reflux

China
GlaxoSmithKline

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus

Cholestasis, Intrahepatic

United Kingdom
Armando Torres Ramírez

Terminated

Optimum Immunosuppression in Renal Transplant Recipients.New Onset Diabetes After Transplantation (01-DMPT)

Diabetes Mellitus, Adult-Onset

Spain
Merck Sharp & Dohme LLC

Completed

A Pharmacokinetic Study to Evaluate the Effect of Antacids on Raltegravir (MK-0518) in HIV-Infected Participants (MK-0518-247)

HIV Infections
Centre Hospitalier Universitaire de Saint Etienne

Completed

Effect of Inhibitors of the Proton Pump on Intestinal Transporters (BIPP)

Healthy

France
Mitsubishi Tanabe Pharma Corporation

Completed

Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on Dialysis

Chronic Kidney Disease

Belarus, Bulgaria, Romania, Malaysia, Singapore, Thailand, Italy, Lithuania, Latvia, Croatia, Denmark, Israel, Indonesia
Effexus Pharmaceutical

Unknown

The Safety and Tolerability of Secretrol in Patients With Barrett's Esophagus

Barrett's Esophagus

United States
Chonbuk National University Hospital

Completed

Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers

Healthy

Korea, Republic of
Mayo Clinic
UCB Pharma

Completed

Moexipril for Primary Biliary Cirrhosis

Primary Biliary Cirrhosis

United States
Kanazawa University

Unknown

Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases

Type 2 Diabetes Mellitus | Chronic Liver Disease

Japan
University Medicine Greifswald

Completed

Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

Pharmacokinetics | Pharmacodynamics | Drug Interactions | Intestinal Transporter Expression

Germany
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Thalidomide and Docetaxel in Treating Patients With Advanced Cancer

Cancer

United States
National Institute of Diabetes and Digestive and...

Completed

Ursodiol-Methotrexate for Primary Biliary Cirrhosis

Liver Cirrhosis, Biliary

United States
National Center for Research Resources (NCRR)
Tufts Medical Center

Completed

Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis

Liver Cirrhosis, Biliary
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University...

Completed

Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis

Liver Cirrhosis, Biliary
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
Rigshospitalet, Denmark
Aarhus University Hospital Skejby

Recruiting

The Nordic Aortic Valve Intervention Trial 4 (NOTION-4) (NOTION-4)

Heart Diseases | Cardiovascular Diseases | Aortic Valve Stenosis | Heart Valve Diseases | Valve Disease, Aortic

Denmark
Pfizer

Not yet recruiting

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Carcinoma, Pancreatic Ductal

Search clinical trials for: intestinal bile acid transporter inhibitor

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