Search clinical trials for: pharmacokinetic mechanism

Total 104552 results

Zhuhai Beihai Biotech Co., Ltd

Not yet recruiting

An Relative Bioavailability Study of BH006 for Injection in Healthy Subjects

Bioavailability
University Hospital, Ghent

Recruiting

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) (PADECMO)

Pharmacokinetics | Vancomycin | Amoxicillin-clavulanate | Piperacillin-tazobactam | Teicoplanin | Meropenem | Ciprofloxacin | Amikacin | Cefazolin

Belgium
Celgene

Not yet recruiting

Study to Evaluate Safety, Drug Levels, Food and Relative Bioavailability of BMS-986365 in Healthy Adult Male Participants

Healthy Participants

United States
Incyte Corporation

Recruiting

A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics When Administered Orally to Healthy Adult Participants

Healthy Participants

United States
AstraZeneca
Parexel

Recruiting

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Opioid Use Disorder

United States
National Cancer Institute (NCI)

Not yet recruiting

A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity

Carcinoma, Neuroendocrine | Tumor, Neuroendocrine | Tumors, Neuroendocrine | Neuroendocrine; Carcinoma | Small Cell; Receptors

United States
Vertex Pharmaceuticals Incorporated

Not yet recruiting

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults

Pain
The Affiliated Hospital Of Guizhou Medical University

Not yet recruiting

Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran

Combined Analysis of Polymorphisms and Dabigatran Pharmacokinetic Parameters
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Not yet recruiting

SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization ((SEEtoTREAT))

Prostate Cancer | Advanced Cancer
Universitair Ziekenhuis Brussel

Recruiting

Pharmacokinetics of Inhaled Levosimendan (Symbiov)

Left Ventricular Dysfunction

Belgium
Fore Biotherapeutics

Recruiting

A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Volunteers.

Healthy Volunteer

United States
University of Redlands

Not yet recruiting

Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations

Sleep

United States
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment

Psoriasis
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage

Psoriasis
Centre Hospitalier Universitaire de Saint Etienne

Recruiting

Pharmacology of Mupirocin in Nasal Application in Healthy Volunteers: Monocentric Study (MUPIPHARM)

Healthy | Staphylococcus Aureus Infection

France
Cerevel Therapeutics, LLC

Not yet recruiting

A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult Participants

Healthy Participants
Peking Union Medical College Hospital
Xiangya Hospital of Central South University; Ruijin Hospital; China-Japan Friendship...

Recruiting

The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics

Pulmonary Embolism

China
PMV Pharmaceuticals, Inc

Recruiting

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Healthy Volunteers

United States
Celgene

Recruiting

A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants

Healthy Volunteers

United States
Peking University Third Hospital

Recruiting

Effect of Oral D-mannose Tablets on Pharmacokinetics of Dabigatranate in Healthy Adults

Health

China
Altria Client Services LLC
Celerion

Recruiting

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

Tobacco Use

United States
AstraZeneca

Recruiting

A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants

Healthy Participants

United States
Shandong Suncadia Medicine Co., Ltd.

Recruiting

Effect of Verapamil Tablets on the Pharmacokinetic of HRS-1893 Tablets in Healthy Subjects

Obstructive Hypertrophic Cardiomyopathy

China
James J. Peters Veterans Affairs Medical Center

Recruiting

Transdermal Administration by a Novel Wireless Iontophoresis Device

Constipation | Spinal Cord Injuries | Neurogenic Bowel | Fecal Incontinence

United States
Samsung Bioepis Co., Ltd.

Recruiting

A Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity Between SB27 and Keytruda in Subjects With Metastatic Non-squamous Non-small Cell Lung Cancer

Non-small Cell Lung Cancer Stage IV

Georgia, India, Romania, Spain, Germany, Japan
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of VX-407 in Healthy Participants

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

United States
Pontificia Universidad Catolica de Chile

Not yet recruiting

Characterization of the Temporal Profile of the Anti-nociceptive Effect of Ketamine Bolus Measured With ANI (Keta-ANI)

Analgesia | Ketamine | Pharmacokinetic

Chile
Valenta Pharm JSC

Recruiting

Pharmacokinetics and Bioequivalence of Doxylamine+Pyridoxine and Diclectin

Nausea

Russian Federation
Handok Inc.

Not yet recruiting

Pharmacokinetics of HD-P023 and Co-administration of Teneligliptin and Empagliflozin High in Healthy Volunteers

Healthy Volunteers
AbbVie

Not yet recruiting

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

Crohn's Disease
Shouyao Holdings (Beijing) Co. LTD

Not yet recruiting

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SY-5007 in Healthy Subjects

Healthy Subjects

China
Rovi Pharmaceuticals Laboratories

Recruiting

Evaluation of the Pharmacokinetics, Safety, and Tolerability of IM Letrozole LEBE in Healthy Post-menopausal Women (LEILA-1)

Healthy

Czechia
University of Washington
Washington State University

Not yet recruiting

Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 (OralT12)

Hypogonadism, Male
Calico Life Sciences LLC
AbbVie

Recruiting

A Thorough QT Study of ABBV-CLS-7262 in Healthy Subjects

Healthy

United States
Shenzhen TargetRx, Inc.
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical...

Recruiting

TGRX-326 Pharmacokinetic Drug Interaction

Non Small Cell Lung Cancer

China
Dong-A ST Co., Ltd.

Not yet recruiting

Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors

Locally Advanced or Metastatic Solid Tumors
Teva Branded Pharmaceutical Products R&D, Inc.

Recruiting

Pharmacokinetic Profile and Safety of Fluticasone Propionate and Albuterol Sulfate in Combination When Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Children Aged 4 to 11 Years Old

Asthma

United States
Peking University Third Hospital

Recruiting

Exploration of the Optimal Dosage of Cetirizine in the Treatment of Allergic Diseases in Chinese Children

Children | Allergic Disease

China
Brigham and Women's Hospital
University of Cape Town; APIN Public Health Initiatives

Not yet recruiting

Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention

Latent Tuberculosis | Pediatric HIV Infection
Rovi Pharmaceuticals Laboratories

Recruiting

Pharmacokinetics, Safety and Tolerability of Different Formulations and Dose Strengths of Quarterly Risperidone (QUAR) in Patients With Schizophrenia (QUARTZ)

Schizophrenia

Jordan
Peking University Third Hospital

Recruiting

Evaluation of the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Diabetic Patients

Diabetes

China
Samsung Bioepis Co., Ltd.

Recruiting

A Study to Compare the Pharmacokinetics, Efficacy, Safety, and Immunogenicity of Pembrolizumab (SB27, EU Sourced Keytruda, and US Sourced Keytruda) in Subjects With Stage II-IIIA NSCLC Following Complete Resection and Adjuvant Platinum-based Chemotherapy

Non-small Cell Lung Cancer Stage IIIA | Non-small Cell Lung Cancer Stage II

Korea, Republic of, Poland, Spain, Turkey
TYK Medicines, Inc

Recruiting

Studies Evaluating the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of TY-9591 Tablets in Healthy Subjects

NSCLC

China
Teva Branded Pharmaceutical Products R&D, Inc.

Recruiting

Safety, Tolerability, and Pharmacokinetic Study of TV-44749 in Chinese Patients With Schizophrenia

Schizophrenia

China
The Affiliated Hospital of Qingdao University

Not yet recruiting

Comparative Pharmacokinetic Study of Aprepitant Injection in Humans

Healthy
Incyte Corporation

Recruiting

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of INCB160058 When Administered Orally to Healthy Adult Participant

Healthy Participants

Australia
Aeovian Pharmaceuticals, Inc.

Recruiting

Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers

Healthy Participants

Australia
Pfizer

Recruiting

A Study to Understand the Effect of Multiple Ascending Doses of PF-07293893 in Healthy Adult Participants

Healthy Participants

Belgium

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