Search clinical trials for: pruritus, chronic pruritus, moderate to severe

Total 476869 results

Brigham and Women's Hospital

Not yet recruiting

Study of Novel Therapeutics for Acute Remedy of Colitis (SHARC)

Ulcerative Colitis | Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe

United States
Mesoblast, Ltd.

Not yet recruiting

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain (HyaluronicAcid)

Degenerative Disc Disease
Eli Lilly and Company

Recruiting

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Type 2 Diabetes

United States, Argentina, United Kingdom, Puerto Rico
Jiani Wu

Not yet recruiting

TaVNS Improves the Symptoms of Patients With Moderate to Severe CP/CPPS

Chronic Prostatitis

China
Innovaderm Research Inc.

Not yet recruiting

Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy

Chronic Hand Eczema

Canada
Mabwell (Shanghai) Bioscience Co., Ltd.

Recruiting

Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).

Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

China
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Recruiting

Evaluation of 611 in Chinese Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

China
Merz Therapeutics GmbH

Recruiting

A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury (PaiNT)

Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury

Bulgaria, Germany, Poland, France, Hungary, Spain
Lithuanian University of Health Sciences

Recruiting

Respiratory and Cardiovascular Alterations in Patients With Chronic Obstructive Pulmonary Disease

Cardiovascular Diseases | Quality of Life | Chronic Obstructive Pulmonary Disease Moderate | Chronic Obstructive Pulmonary Disease Severe

Lithuania
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

A Study to Assess the Efficacy and Safety of HRG2005 Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

China
LEO Pharma

Recruiting

A Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Delgocitinib Cream in Chinese Adults and Adolescents With Moderate to Severe Chronic Hand Eczema

Chronic Hand Eczema

China
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary Disease

China
Cara Therapeutics, Inc.

Recruiting

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica

Pruritus | Notalgia Paresthetica

United States, Poland, Spain, Canada, Germany
Ibrahim Talal Elshamy

Recruiting

Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With Polyps

Chronic Rhinosinusitis With Nasal Polyps | Endoscopic Frontal Sinus Surgery | Draf III | Draf I or IIa

Egypt
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque Psoriasis

China
AbbVie

Recruiting

An Observational Study to Validate the Cumulative Life Course Impairment (CLCI) Instrument (DermCLCI-p) in Adult Participants With Moderate to Severe Chronic Plaque Psoriasis (PsO) (IMMagine)

Psoriasis

Canada, Belgium, Germany
Xijing Hospital of Digestive Diseases

Not yet recruiting

Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum for the Topical Treatment of Rectal Mucosal Ulcers

Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe | Rectal Ulcer

China
The First Affiliated Hospital with Nanjing Medical...
Novlead Inc.

Recruiting

A Clinical Study of Inhaled Nitric Oxide in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (NOVEL)

Chronic Obstructive Pulmonary Disease

China
Stephen Robert Marder

Not yet recruiting

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Post Traumatic Stress Disorder

United States
Eli Lilly and Company

Recruiting

A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT-URGE)

Ulcerative Colitis | Ulcerative Colitis Chronic

United Kingdom, United States, Poland, Czechia, Hungary, Italy, France, Slovakia, Germany, Belgium
Nuance Pharma (shanghai) Co., Ltd
Laboratory Corporation of America

Recruiting

A Study to Evaluate the Efficacy and Safety of Ensifentrine for 24 Weeks in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

China
IRCCS San Raffaele

Recruiting

Comparison Between Bowel Ultrasound-based Treat to Target Versus Routine Treat to Target Strategies in Ulcerative Colitis

Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe

Italy
University Hospital, Tours

Recruiting

Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease (THINK)

Uncontrolled Hypertension | Chronic Kidney Disease(CKD)

France
Koite Health Oy
Lithuanian University of Health Sciences; University of Helsinki

Recruiting

Regular Home-use of Dual-light Photodynamic Therapy in the Management of Chronic Stage III-IV Periodontitis

Periodontitis Chronic Generalized Moderate | Periodontitis Chronic Generalized Severe

Lithuania
Taipei Medical University Hospital

Recruiting

Effects of Multiple Mega-dose of Vitamin D3 Supplementation on Ameliorating Moderate to Severe Chronic Pain in Hemodialysis Patients

Hyperparathyroidism | Chronic Pain | Hemodialysis

Taiwan
Randall Debattista
University of Malta, Faculty of Health Sciences

Not yet recruiting

Effect of NMES on Quadriceps Muscle Strength and Endurance in Patients With COPD (NMES)

Chronic Obstructive Pulmonary Disease Moderate | Acute Exacerbation of COPD | Chronic Obstructive Pulmonary Disease Severe
Huabo Biopharm Co., Ltd.

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of HB0017 in Patients With Moderate to Severe Plaque Psoriasis

Plaque Psoriasis

China
University of Aarhus
Aarhus University Hospital; Sygehus Lillebaelt

Recruiting

Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders (OneSTEP)

Irritable Bowel Syndrome | Fibromyalgia | Chronic Fatigue Syndrome | Bodily Distress Disorder Moderate | Bodily Distress Disorder Severe | Somatization

Denmark
Celltrion

Recruiting

To Compare Pharmacokinetics, Efficacy, and Safety of CT-P17 With Humira in Patients With Moderate to Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque Psoriasis

Estonia
LEO Pharma

Recruiting

Efficacy and Safety of Delgocitinib Cream in Adolescents 12-17 Years of Age With Moderate to Severe Chronic Hand Eczema (DELTA TEEN)

Chronic Hand Eczema

Spain, France, Belgium, Australia, Canada, Poland, United Kingdom
Shenzhen University General Hospital

Recruiting

Umbilical Cord Mesenchymal Stem Cells in the Treatment of Moderate/Severe Chronic Graft-versus-host Disease

Graft Vs Host Disease

China
University of Parma
Chiesi Farmaceutici S.p.A.

Not yet recruiting

Effect of BDP/Formoterol/G on Cough Efficacy in Moderate to Severe COPD Patients (EFFICACE) (EFFICACE)

COPD, Chronic Obstructive Pulmonary Disease

Italy
Assistance Publique - Hôpitaux de Paris
Gustave Roussy, Cancer Campus, Grand Paris

Not yet recruiting

Calprotectin, a Biomarker of COVID-19 Severity (CALPRO) (CALPRO)

Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia | Old Age | Severe/Moderate Coronavirus

France
Takeda

Recruiting

A Study of Kynteles Injection (Vedolizumab) in Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease or Chronic Pouchitis

Inflammatory Bowel Diseases | Crohn Disease | Colitis, Ulcerative

Korea, Republic of
Kang Stem Biotech Co., Ltd.

Recruiting

Safety and Explore the Efficacy of Multiple Doses of FURESTEM-AD Inj. for Moderate to Severe Chronic Atopic Dermatitis

Atopic Dermatitis

Korea, Republic of
ShiYue Li
AstraZeneca

Not yet recruiting

The Effects of Inhaled Budesonide-formoterol-glycopyrronium in Moderate-to-severe COPD (OCT)

Pulmonary Disease, Chronic Obstructive

China
Mayo Clinic
Regeneron Pharmaceuticals

Recruiting

Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus

Pruritus

United States
ProgenaBiome

Recruiting

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression

Depression | Depression, Postpartum | Depression, Anxiety | Depression Moderate | Depression Severe | Clinical Depression | Depression in Remission | Depression, Endogenous | Depression Chronic

United States
Fred Hutchinson Cancer Center
AstraZeneca

Recruiting

Acalabrutinib for the Treatment of Chronic Graft Versus Host Disease

Hematopoietic and Lymphoid Cell Neoplasm | Recurrent Moderate-Severe Chronic Graft Versus Host Disease

United States
UCB Biopharma SRL

Recruiting

A Study to Evaluate the Efficacy, Safety, and Drug Concentration of Certolizumab Pegol (CZP) in Children and Adolescent Study Participants With Moderate to Severe Chronic Plaque Psoriasis (PSO) (CIMcare)

Moderate Chronic Plaque Psoriasis | Severe Chronic Plaque Psoriasis | Mixed Guttate/Plaque Psoriasis

United States, Canada, Puerto Rico
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD

Vascular Diseases | Blood Pressure | Oxidative Stress | Kidney Disease

United States
Queen Margaret University
University of Edinburgh; Brunel University; University of Gloucestershire

Recruiting

RaceRunning for Young People With Moderate-to-severe Cerebral Palsy

Cerebral Palsy | Exercise

United Kingdom
Sun Pharmaceutical Industries Limited

Recruiting

A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis

Moderate-to-severe Chronic Plaque Psoriasis

United States, Hungary, India, Poland, Slovakia, Spain
The University of Texas at Arlington

Recruiting

L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients

Chronic Kidney Disease

United States
Hospital Universitario La Paz

Recruiting

Long-term Effect of an Health Education Program on Daily Physical Activity in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (EA-EPOC)

Chronic Obstructive Pulmonary Disease

Spain
University of California, Davis

Recruiting

Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD (ESTEEM-VIDA)

Moderate-severe Chronic Kidney Disease Not Treated With Dialysis | Diabetic Kidney Disease, HgbA1c Less Than 8.5

United States
Novartis Pharmaceuticals

Active, not recruiting

Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant

Graft vs Host Disease

Japan, Slovakia, Taiwan, Spain, Korea, Republic of, Thailand, Canada, Russian Federation, Italy, Turkey, India, Czechia, Brazil, Switzerland
University of Castilla-La Mancha

Completed

Short-term Effects Kinesiology Tape on Sitting Postural Control in Moderate and Severe Cerebral Palsy (KT-SIT_CP)

Cerebral Palsy | Kinesiology Taping | Postural Control

Spain
Sun Pharmaceutical Industries Limited

Active, not recruiting

Efficacy and Safety Study of Tildrakizumab in the Treatment of Nail Psoriasis

Chronic Plaque Psoriasis | Moderate to Severe Nail Psoriasis

United States, Australia
AstraZeneca

Active, not recruiting

Real-world, 52-week Prospective Study to Capture the Reasons for Switch to Triple Combination Therapy, Assess the Clinical and Patient Reported Outcomes in Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece (TRIAENA)

Pulmonary Disease, Chronic Obstructive (COPD)

Greece

Search clinical trials for: pruritus, chronic pruritus, moderate to severe

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