Search clinical trials for: severe chronic

Total 39117 results

Brigham and Women's Hospital

Not yet recruiting

Study of Novel Therapeutics for Acute Remedy of Colitis (SHARC)

Ulcerative Colitis | Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe

United States
Sanofi
Regeneron Pharmaceuticals

Recruiting

Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in France (OPALE)

Chronic Rhinosinusitis With Nasal Polyposis

France, Réunion
Regeneron Pharmaceuticals

Recruiting

Short-Term Linvoseltamab Treatment, on Top of Chronic Dupilumab Treatment, for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy

Food Allergy

United States
Grand Valley State University

Not yet recruiting

Em-power: Maximizing Functional Independence for Children With Severe Cerebral Palsy

Cerebral Palsy

United States
Help Therapeutics
TEDA International Cardiovascular Hospital

Recruiting

Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure

Heart Failure

China
Pulmonx Corporation

Recruiting

Zephyr Valve Japan Post-Marketing Surveillance

Emphysema | COPD | Severe Emphysema

Japan
Mesoblast, Ltd.

Not yet recruiting

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain (HyaluronicAcid)

Degenerative Disc Disease
Eli Lilly and Company

Recruiting

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Type 2 Diabetes

United States, Argentina, United Kingdom, Puerto Rico
Jiani Wu

Not yet recruiting

TaVNS Improves the Symptoms of Patients With Moderate to Severe CP/CPPS

Chronic Prostatitis

China
Innovaderm Research Inc.

Not yet recruiting

Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy

Chronic Hand Eczema

Canada
Fondazione Policlinico Universitario Agostino Gemelli...

Not yet recruiting

Mepolizumab in the Treatment of Patients With Severe Uncontrolled CRSwNP: a Multicentric Real Life Observational Study (MEPOREAL)

Chronic Rhinosinusitis With Nasal Polyps

Italy
Ferran Morell

Not yet recruiting

Severe Prospective Observational COPD Catalonia (SPOCCAT)

Severe Chronic Obstructive Pulmonary Disease
Skane University Hospital
Lund University; The Swedish Research Council; ResMed; Vastra Gotaland Region; Region... and other collaborators

Not yet recruiting

Effect of HIgh-flow Therapy in Long-term Oxygen Therapy (HILOT)

Interstitial Lung Disease | Chronic Respiratory Failure With Hypoxia | Chronic Obstructive Pulmonary Disease Severe
University Hospital, Clermont-Ferrand

Not yet recruiting

Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition (CYTODINE)

Dyspnea | Chronic Obstructive Pulmonary Disease Severe

France
University Hospital, Grenoble

Not yet recruiting

Oral Citrulline Supplementation in COPD Patients With Malnutrition (CITRUS)

Malnutrition | Chronic Obstructive Pulmonary Disease Severe
Li An

Recruiting

Risk Prediction Model for Exacerbating Phenotype in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease Severe

China
Northumbria Healthcare NHS Foundation Trust
GlaxoSmithKline; Newcastle University; Chiesi UK

Recruiting

Eosinopenia in Severe COPD Exacerbation (A-TREC)

Chronic Obstructive Pulmonary Disease

United Kingdom
University Hospital, Limoges

Recruiting

Trial Evaluating the Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction With Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction With One-stage ZEPHYR® Valves (REPEAT)

COPD

France
Mabwell (Shanghai) Bioscience Co., Ltd.

Recruiting

Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).

Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

China
Shanghai Chest Hospital

Not yet recruiting

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema (BTVA)

Severe Emphysema
Merck Sharp & Dohme LLC

Recruiting

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States, Israel, Taiwan, United Kingdom, Chile, Canada, Japan, Brazil, China
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Recruiting

Evaluation of 611 in Chinese Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

China
Merz Therapeutics GmbH

Recruiting

A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury (PaiNT)

Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury

Bulgaria, Germany, Poland, France, Hungary, Spain
Sunnybrook Health Sciences Centre

Not yet recruiting

Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments (PCS-HBOT)

COVID-19 | Fatigue | Fatigue Syndrome, Chronic | Post-COVID-19 Syndrome | Post COVID-19 Condition | Post-COVID Syndrome

Canada
Lithuanian University of Health Sciences

Recruiting

Respiratory and Cardiovascular Alterations in Patients With Chronic Obstructive Pulmonary Disease

Cardiovascular Diseases | Quality of Life | Chronic Obstructive Pulmonary Disease Moderate | Chronic Obstructive Pulmonary Disease Severe

Lithuania
Massachusetts General Hospital
National Institute of Nursing Research (NINR); Dana-Farber Cancer Institute; University... and other collaborators

Recruiting

The PediQUEST Response to Pain Of Children With Neurologic Disability Pilot Randomized Controlled Trial (PQ-ResPOND)

Pain | Disabilities Multiple | Cerebral Palsy Infantile

United States, Australia
National and Kapodistrian University of Athens

Recruiting

Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma (MepoRiNaPAs)

Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis Without Nasal Polyps | Severe Eosinophilic Asthma

Greece
Pharmanovia

Recruiting

An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients With Severe Insomnia (RESTORE)

Insomnia | Insomnia Chronic | Chloral Hydrate

United Kingdom
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

A Study to Assess the Efficacy and Safety of HRG2005 Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

China
Pulmonx Corporation

Recruiting

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema (CONVERT_II)

Emphysema or COPD | Emphysema, Pulmonary

Spain, Germany, Italy, Australia
Lady Reading Hospital, Pakistan
Pakistan Chest Society, Pakistan

Recruiting

Clopidogrel for the Prevention of Exacerbations in Severe COPD (CLOPEX)

COPD | COPD Exacerbation Acute

Pakistan
Postgraduate Institute of Dental Sciences Rohtak

Not yet recruiting

Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker

Gingivitis | Inflammatory Response | Periodontitis Chronic Generalized Severe

India
Food and Health Bureau, Hong Kong
Hospital Authority, Hong Kong

Recruiting

A Decision Aid on End-of-life Care for Patients With Advanced COPD and Their Family

Chronic Obstructive Pulmonary Disease Severe

China
LEO Pharma

Recruiting

A Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Delgocitinib Cream in Chinese Adults and Adolescents With Moderate to Severe Chronic Hand Eczema

Chronic Hand Eczema

China
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary Disease

China
Cara Therapeutics, Inc.

Recruiting

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica

Pruritus | Notalgia Paresthetica

United States, Poland, Spain, Canada, Germany
Ibrahim Talal Elshamy

Recruiting

Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With Polyps

Chronic Rhinosinusitis With Nasal Polyps | Endoscopic Frontal Sinus Surgery | Draf III | Draf I or IIa

Egypt
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque Psoriasis

China
AbbVie

Recruiting

An Observational Study to Validate the Cumulative Life Course Impairment (CLCI) Instrument (DermCLCI-p) in Adult Participants With Moderate to Severe Chronic Plaque Psoriasis (PsO) (IMMagine)

Psoriasis

Canada, Belgium, Germany
Hope Biosciences
The University of Texas Health Science Center, Houston

Recruiting

Autologous Adipose Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

Traumatic Brain Injury

United States
Apreo Health, Inc.

Recruiting

Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema (BREATHE-2)

Emphysema or COPD

United Kingdom, Austria, Netherlands
University Hospital, Ghent

Recruiting

Real Life Study of Biologicals in Patients With Severe CRSwNP (NASUMAB)

Chronic Rhinosinusitis With Nasal Polyps

Belgium
Chinese PLA General Hospital

Recruiting

Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease (ESPTCSCKD)

COVID-19 | Renal Insufficiency, Chronic

China
Italian Academy of Rhinology
Accademia Italiana di Citologia Nasale

Recruiting

Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis (RINET)

Chronic Rhinosinusitis

Italy
Xijing Hospital of Digestive Diseases

Not yet recruiting

Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum for the Topical Treatment of Rectal Mucosal Ulcers

Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe | Rectal Ulcer

China
Centre Hospitalier Universitaire de Nice

Recruiting

Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial (HERPARO)

Periodontitis Chronic Generalized Severe

France
The First Affiliated Hospital with Nanjing Medical...
Novlead Inc.

Recruiting

A Clinical Study of Inhaled Nitric Oxide in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (NOVEL)

Chronic Obstructive Pulmonary Disease

China
Apreo Health, Inc.

Recruiting

First in Human Study to Assess an Implant to Treat Severe Emphysema (BREATHE-1)

Emphysema or COPD

Australia
Assistance Publique - Hôpitaux de Paris

Recruiting

Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (ERASE PH-COPD)

Chronic Obstructive Pulmonary Disease | Pulmonary Hypertension

France
West Park Healthcare Centre

Recruiting

Powered Assist Hip Exoskeleton to Improve Ambulation in Severe Lung Disease

Lung Disease Chronic

Canada

Search clinical trials for: severe chronic

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